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Cited by 67Nursing care and researchCancer survivorship and careFamily Caregiving in Mental Illness

Multimodal psychosocial intervention for family caregivers of patients undergoing hematopoietic stem cell transplantation: A randomized clinical trial

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El‐Jawahri, Areej, Jacobs, Jamie M., Nelson, Ashley M., Traeger, Lara, Greer, Joseph A., Nicholson, Showly, Waldman, Lauren P., Fenech, Alyssa L. +7 more·2020·Cancer
DOI 10.1002/cncr.32680PMC PMC7103553
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Abstract

BACKGROUND: Caregivers of patients undergoing hematopoietic stem cell transplantation (HCT) experience an immense caregiving burden before, during, and after HCT. METHODS: We conducted an unblinded, randomized trial of a psychosocial intervention (BMT-CARE) for caregivers of patients undergoing autologous and allogeneic HCT at Massachusetts General Hospital. Caregivers were randomly assigned to BMT-CARE or usual care. BMT-CARE was tailored to the HCT trajectory and integrated treatment-related education and self-care with cognitive-behavioral skills to promote coping. Caregivers assigned to BMT-CARE met with a trained interventionist (a psychologist or a social worker) in person, via telephone, or via videoconferencing for 6 sessions starting before HCT and continuing up to day +60 after HCT. The primary endpoint was feasibility, which was defined as at least 60% of eligible caregivers enrolling and completing 50% or more of the intervention sessions. We assesed caregiver quality of life (QOL; Caregiver Oncology Quality of Life Questionnaire), caregiving burden (Caregiver Reaction Assessment), psychological distress (Hospital Anxiety and Depression Scale), self-efficacy (Cancer Self-Efficacy Scale-Transplant), and coping (Measures of Current Status) at baseline and 30 and 60 days after HCT. We used mixed linear effect models to assess the effect of BMT-CARE on outcomes longitudinally. RESULTS: We enrolled 72.5% of eligible caregivers (100 of 138), and 80% attended 50% or more of the intervention sessions. Caregivers randomized to BMT-CARE reported improved QOL (B = 6.11; 95% CI, 3.50-8.71; P < .001), reduced caregiving burden (B = -6.02; 95% CI, -8.49 to -3.55; P < .001), lower anxiety (B = -2.18; 95% CI, -3.07 to -1.28; P < .001) and depression symptoms (B = -1.23; 95% CI, -1.92 to -0.54; P < .001), and improved self-efficacy (B = 7.22; 95% CI, 2.40-12.03; P = .003) and coping skills (B = 4.83; 95% CI, 3.04-6.94; P < .001) in comparison with the usual-care group. CONCLUSIONS: A brief multimodal psychosocial intervention tailored for caregivers of HCT recipients is feasible and may improve QOL, mood, coping, and self-efficacy while reducing the caregiving burden during the acute HCT period.

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  • 13 studies indicated the need of developing coping strategies to improve management and control of both the situation and emotional strain, and to help increase training in caregivers, thus improving self-efficacy while reducing emotional impact.

    “Thirteen studies [23,24,27,30,32,35,37,38,45,46,47,49,54] indicated the need of developing coping strategies to improve the management and control of both the situation and the emotional strain, and also to help increase training in caregivers, thus improving their self-efficacy while reducing the emotional impact.”

    From Quality of Life in Caregivers of Cancer Patients: A Literature Review (2023) · cites this paper as [45]

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Authors
El‐Jawahri, A., Jacobs, J. M., Nelson, A. M., Traeger, L., Greer, J. A., Nicholson, S., Waldman, L. P., Fenech, A. L., Jagielo, A. D., D’Alotto, J., Horick, N., Spitzer, T., DeFilipp, Z., Chen, Y. A., & Temel, J. S.
Affiliations
  • Massachusetts General Hospital Boston Massachusetts
  • Harvard University (US)
ORCID
Venue
Cancer
Publisher
Wiley
Published
2020-01-03
Volume
126
Issue
8
Pages
1758-1765
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
DOI
10.1002/cncr.32680
PMC
PMC7103553
OpenAlex
W2998355238
Cited by
67
References
45
Citations by year
2026: 6 · 2025: 18 · 2024: 12 · 2023: 12 · 2022: 9 · 2021: 5 · 2020: 5
FWCI
11.98
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Leukemia and Lymphoma Society (Scholar in Clinical Research (El‐Jawahri))
  • Division of Cancer Prevention, National Cancer Institute (K12 Career Development Award (El‐Jawahri))
Topics
  • Health Sciences › Health Professions › Pharmacy › Nursing care and research
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
Keywords
hematopoietic stem cell transplantation, family caregivers, caregiver burden, psychosocial interventions, caregiver quality of life, psychological distress, anxiety, depression, self-efficacy, coping, cognitive-behavioral techniques, telephone-delivered intervention, videoconferencing, feasibility, autologous transplantation, allogeneic transplantation
MeSH terms
Social Workers, Adaptation, Psychological, Adult, Aged, Aged, 80 and over, Anxiety, Depression, Female, Humans, Male, Middle Aged, Neoplasms, Quality of Life, Caregivers, Hematopoietic Stem Cell Transplantation, Young Adult

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