Cited by 249Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems

Open access
Ogawa, Sachie K., Cohen, Jeremiah Y., Hwang, Dabin, Uchida, Naoshige, Watabe-Uchida, Mitsuko·2014·Cell Reports

Abstract

Serotonin and dopamine are major neuromodulators. Here, we used a modified rabies virus to identify monosynaptic inputs to serotonin neurons in the dorsal and median raphe (DR and MR). We found that inputs to DR and MR serotonin neurons are spatially shifted in the forebrain, and MR serotonin neurons receive inputs from more medial structures. Then, we compared these data with inputs to dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). We found that DR serotonin neurons receive inputs from a remarkably similar set of areas as VTA dopamine neurons apart from the striatum, which preferentially targets dopamine neurons. Our results suggest three major input streams: a medial stream regulates MR serotonin neurons, an intermediate stream regulates DR serotonin and VTA dopamine neurons, and a lateral stream regulates SNc dopamine neurons. These results provide fundamental organizational principles of afferent control for serotonin and dopamine.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.celrep.2014.06.042

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 70 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ogawa, S. K., Cohen, J. Y., Hwang, D., Uchida, N., & Watabe-Uchida, M.
Affiliations
Harvard University (US)
Corresponding author
Cohen, Jeremiah Y.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2014-08
Volume
8
Issue
4
Pages
1105-1118
ISSN
2211-1247 (ISSN-L)
OpenAlex
W1975379532
Cited by
249
References
70
Citations by year
2026: 13 · 2025: 14 · 2024: 20 · 2023: 23 · 2022: 12 · 2021: 26 · 2020: 19 · 2019: 33 · 2018: 17 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 2
FWCI
10.89
Type
journal article
Language
en
Open access
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • Helen Hay Whitney Foundation
  • National Institutes of Health
  • National Institute of Mental Health (R01MH101207, R01MH095953)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
serotonin, dopamine, monosynaptic input, dorsal raphe nucleus, median raphe, ventral tegmental area, substantia nigra pars compacta, neuromodulatory systems, afferent projections, forebrain, striatum, rabies virus tracing
MeSH terms
Animals, Cerebral Cortex, Dopamine, Female, Mice, Inbred C57BL, Mice, Transgenic, Neural Pathways, Synaptic Transmission, Serotonin, Synapses, Neurotransmitter Agents, Habenula, Dopaminergic Neurons, Serotonergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review