Redefining the serotonergic system by genetic lineage
Open accessAbstract
Central serotonin-producing neurons are heterogeneous-differing in location, morphology, neurotoxin sensitivity and associated clinical disorders-but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.
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To precisely investigate the function of transcriptome-based serotonin neuronal types, an intersectional strategy is needed to target serotonin neurons expressing specific additional markers.
“To precisely investigate the function of transcriptome-based serotonin neuronal types, we need to use an intersectional strategy to target serotonin neurons that express specific additional markers (Jensen et al., 2008).”
From Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei (2019) · cites this paper as Jensen et al., 2008
DR serotonin neurons derive entirely from rhombomere 1, whereas MR serotonin neurons derive predominantly from rhombomeres 1, 2, and 3.
“DR serotonin neurons derive entirely from rhombomere 1 of the developing mouse brain, whereas MR serotonin neurons derive predominantly from rhombomeres 1, 2, and 3 (Alonso et al., 2013; Bang et al., 2012; Jensen et al., 2008).”
From Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei (2019) · cites this paper as Jensen et al., 2008
They could not discern obvious difference in spatial distributions among the four MR types, despite the fact that MR serotonin neurons have heterogenous developmental origin (Jensen et al., 2008).
“By contrast, we could not discern obvious difference in spatial distributions among the four MR types, despite the fact that MR serotonin neurons have heterogenous developmental origin (Jensen et al., 2008).”
From Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei (2019) · cites this paper as Jensen et al., 2008
DRN 5-HT neurons share a common developmental lineage.
“Although DRN 5-HT neurons share a common developmental lineage (Deneris and Gaspar, 2018; Jensen et al., 2008), DRN 5-HT neurons in different subregions express different G protein-coupled receptors and vesicular transporters, suggesting spatial clustering of functionally specialized neurons (Calizo et al., 2011; Fernandez et al., 2016; Lowry et al., 2000; Templin et al., 2012).”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Jensen et al., 2008
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Serotonin Neuron Diversity in the Dorsal Raphe
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Enteroendocrine cell lineages that differentially control feeding and gut motility
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Essentials of Recombinase-Based Genetic Fate Mapping in Mice
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- Authors
- Jensen, P., Farago, A. F., Awatramani, R. B., Scott, M. M., Deneris, E. S., & Dymecki, S. M.
- Affiliations
- Harvard University (US)
- Northwestern University (US)
- Case Western Reserve University (US)
- Corresponding author
- Dymecki, Susan M
- Venue
- Nature Neuroscience
- Published
- 2008-03-16
- Volume
- 11
- Issue
- 4
- Pages
- 417-419
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2897136
- OpenAlex
- W2081784716
- Cited by
- 244
- References
- 15
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 15 · 2018: 15 · 2017: 25 · 2016: 14 · 2015: 22 · 2014: 13 · 2013: 18 · 2012: 18
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH062723)
- National Institute on Drug Abuse (R21DA023643)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067826)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD036379)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonergic system, serotonergic neurons, neuronal heterogeneity, genetic lineages, neural progenitor cells, molecular subtypes, neurogenesis
- MeSH terms
- Animals, Cell Differentiation, Mice, Transgenic, Neurons, Rhombencephalon, Serotonin, Stem Cells, Biomarkers, Gene Expression Regulation, Developmental, Cell Lineage, Transgenes, Gene Expression Profiling, Mice
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