Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons
Open accessAbstract
The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. Using viral tracing combined with electrophysiology, we found that GABA and serotonin neurons in the DR receive excitatory, inhibitory, and peptidergic inputs from the same specific brain regions. Embedded in this overall similarity are important differences. Serotonin neurons are more likely to receive synaptic inputs from anterior neocortex while GABA neurons receive disproportionally higher input from the central amygdala. Local input mapping revealed extensive serotonin-serotonin as well as GABA-serotonin connectivity with a distinct spatial organization. Covariance analysis suggests heterogeneity of both serotonin and GABA neurons with respect to the inputs they receive. These analyses provide a foundation for further functional dissection of the serotonin system.
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DR serotonin neurons as a whole receive monosynaptic inputs from diverse brain regions.
“DR serotonin neurons as a whole receive monosynaptic inputs from diverse brain regions (Ogawa et al., 2014; Pollak Dorocic et al., 2014; Weissbourd et al., 2014).”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Weissbourd et al., 2014
Whole-brain input mapping suggested heterogeneity of DR serotonin neurons with respect to presynaptic inputs.
“Whole-brain input mapping suggested heterogeneity of DR serotonin neurons has also been implicated with respect to presynaptic inputs (Weissbourd et al., 2014).”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Weissbourd et al., 2014
DRSert→OFC neurons and frontal cortex→DRSert neurons may form a reciprocal loop that promotes active coping under challenge.
“Thus, DRSert→OFC neurons and frontal cortex→DRSert neurons may constitute a reciprocal loop to promote active coping in the face of challenge.”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Weissbourd et al., 2014
Frontal cortex inputs to the DR preferentially synapse onto serotonin neurons located in the ventral DR.
“Furthermore, frontal cortex inputs to the DR preferentially synapse onto serotonin neurons that are localize in the ventral DR (Weissbourd et al., 2014), where DRSert→OFC neurons also localize (Figure 1).”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Weissbourd et al., 2014
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- Authors
- Weissbourd, B., Ren, J., DeLoach, K. E., Guenthner, C. J., Miyamichi, K., & Luo, L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Miyamichi, Kazunari
- Luo, Liqun
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 83
- Issue
- 3
- Pages
- 645-662
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4779447
- OpenAlex
- W2080478852
- Cited by
- 337
- References
- 49
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 26 · 2023: 29 · 2022: 23 · 2021: 29 · 2020: 36 · 2019: 40 · 2018: 30 · 2017: 32 · 2016: 26 · 2015: 30 · 2014: 1
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R01NS050835)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dorsal raphe nucleus, serotonergic neurons, GABAergic neurons, central amygdala, neuronal heterogeneity
- MeSH terms
- Animals, gamma-Aminobutyric Acid, Mice, Transgenic, Serotonin, Synapses, Patch-Clamp Techniques, Mice, GABAergic Neurons, Dorsal Raphe Nucleus
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