Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex

Hadzic, Minela; Jack, Alexander; Wahle, Petra

doi:10.1002/cne.24103

Cited by 53

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Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex

Hadzic, Minela, Jack, Alexander, Wahle, Petra·2017·Journal of Comparative Neurology

DOI 10.1002/cne.24103

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Abstract

A multitude of 18 iGluR receptor subunits, many of which are diversified by splicing and RNA editing, localize to >20 excitatory and inhibitory neocortical neuron types defined by physiology, morphology, and transcriptome in addition to various types of glial, endothelial, and blood cells. Here we have compiled the published expression of iGluR subunits in the areas and cell types of developing and adult cortex of rat, mouse, carnivore, bovine, monkey, and human as determined with antibody‐ and mRNA‐based techniques. iGluRs are differentially expressed in the cortical areas and in the species, and all have a unique developmental pattern. Differences are quantitative rather than a mere absence/presence of expression. iGluR are too ubiquitously expressed and of limited use as markers for areas or layers. A focus has been the iGluR profile of cortical interneuron types. For instance, GluK1 and GluN3A are enriched in, but not specific for, interneurons; moreover, the interneurons expressing these subunits belong to different types. Adressing the types is still a major hurdle because type‐specific markers are lacking, and the frequently used neuropeptide/CaBP signatures are subject to regulation by age and activity and vary as well between species and areas. RNA‐seq reveals almost all subunits in the two morphofunctionally characterized interneuron types of adult cortical layer I, suggesting a fairly broad expression at the RNA level. It remains to be determined whether all proteins are synthesized, to which pre‐ or postsynaptic subdomains in a given neuron type they localize, and whether all are involved in synaptic transmission. J. Comp. Neurol. 525:976–1033, 2017. © 2016 Wiley Periodicals, Inc.

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Authors: Hadzic, M., Jack, A., & Wahle, P.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2016-09-27
Volume: 525
Issue: 4
Pages: 976-1033
ISSN: 0021-9967
1096-9861
DOI: 10.1002/cne.24103
Cited by: 53
References: 34
Language: en
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders: Deutsche Forschungsgemeinschaft (WA 541/9‐2, WA 541/10‐1)

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Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex

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