Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Open accessAbstract
GABAergic cortical interneurons underlie the complexity of neural circuits and are particularly numerous and diverse in humans. In rodents, cortical interneurons originate in the subpallial ganglionic eminences, but their developmental origins in humans are controversial. We characterized the developing human ganglionic eminences and found that the subventricular zone (SVZ) expanded massively during the early second trimester, becoming densely populated with neural stem cells and intermediate progenitor cells. In contrast with the cortex, most stem cells in the ganglionic eminence SVZ did not maintain radial fibers or orientation. The medial ganglionic eminence exhibited unique patterns of progenitor cell organization and clustering, and markers revealed that the caudal ganglionic eminence generated a greater proportion of cortical interneurons in humans than in rodents. On the basis of labeling of newborn neurons in slice culture and mapping of proliferating interneuron progenitors, we conclude that the vast majority of human cortical interneurons are produced in the ganglionic eminences, including an enormous contribution from non-epithelial SVZ stem cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several recent studies provide strong evidence that primate interneurons are generated extracortically in the ganglionic eminences, as with rodents.
“However, several recent studies have shown strong evidence that, as with rodents, primate interneurons are generated extracortically in the GEs11,14.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [14]
GABAergic inhibitory interneurons mostly originate from the ganglionic eminences of the ventral telencephalon.
“which recent studies have shown mostly originate from the ganglionic eminences of the ventral telencephalon (i.e., the subpallium) (Fertuzinhos et al., 2009; Hansen et al., 2013; Hansen et al., 2010; Ma et al., 2013).”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Hansen et al., 2013
Human GABAergic interneurons are largely generated ventrally from the ganglionic eminences in the basal ganglia primordia and migrate tangentially into the cortical plate.
“human GABAergic interneurons are largely generated ventrally from the ganglionic eminences in the basal ganglia primordia and migrate tangentially into the CP (Fertuzinhos et al., 2009; Hansen et al., 2013; Hansen et al., 2010; Ma et al., 2013; Radonjic et al., 2014).”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Hansen et al., 2013
The subpallium of rodents and primates, including humans, can be subdivided into progenitor domains each characterized by a specific combination of transcription factors.
“The subpallium of rodents and primates, including humans, can be subdivided into several progenitor domains each characterized by the expression of a specific combination of transcription factors”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Hansen et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works
Self-citationNeurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Self-citationDevelopment and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works
Self-citationThe origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873 · see citing works
Self-citationWichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722 · see citing works
Self-citationOrigin of GABAergic neurons in the human neocortex
Letinić, K., Zoncu, R., & RAKIC, P. T. (2002) · Nature · doi:10.1038/nature00779 · Cited by 718 · see citing works
Origin and Molecular Specification of Striatal Interneurons
Marín, Ó., Anderson, S. A., & Rubenstein, J. L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 627 · see citing works
Self-citationThe temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.034 · Cited by 587 · see citing works
Self-citationFlames, N., Pla, R., Gelman, D. M., Rubenstein, J. L. R., Puelles, L., & Marín, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2750-07.2007 · Cited by 560 · see citing works
Self-citationMiyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
Nery, S., Fishell, G., & Corbin, J. G. (2002) · Nature Neuroscience · doi:10.1038/nn971 · Cited by 558 · see citing works
Roles of bHLH genes in neural stem cell differentiation
Kageyama, R., Ohtsuka, T., Hatakeyama, J., & Ohsawa, R. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.03.015 · Cited by 482 · see citing works
Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system
Guillemot, F., & Joyner, A. L. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90006-j · Cited by 414 · see citing works
Kawaguchi, Y., & Kubota, Y. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02701.1996 · Cited by 380 · see citing works
Petryniak, M. A., Potter, G. B., Rowitch, D. H., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.036 · Cited by 371 · see citing works
Self-citationThe forms of non‐pyramidal neurons in the visual cortex of the rat
Feldman, M. L., & Peters, A. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790406 · Cited by 303 · see citing works
The Division of Neuronal Progenitor Cells during Migration in the Neonatal Mammalian Forebrain
Menezes, J. R. L., Smith, C. M., Nelson, K. C., & Luskin, M. B. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.0002 · Cited by 271 · see citing works
Contributions of cortical subventricular zone to the development of the human cerebral cortex
Zecevic, N., Chen, Y., & Filipovic, R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20714 · Cited by 269 · see citing works
Inta, D., Alfonso, J., von Engelhardt, J., Kreuzberg, M. M., Meyer, A. H., van Hooft, J. A., & Monyer, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807059105 · Cited by 267 · see citing works
Yun, K., Fischman, S., Johnson, J. E. B., de Angelis, M. H., Weinmaster, G., & Rubenstein, J. L. R. (2002) · Development · doi:10.1242/dev.129.21.5029 · Cited by 255 · see citing works
Self-citationSomogyi, P., & Cowey, A. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901950402 · Cited by 234 · see citing works
Deacon, T. W., Pakzaban, P., & Isacson, O. (1994) · Brain Research · doi:10.1016/0006-8993(94)90526-6 · Cited by 224 · see citing works
Ventricle-directed migration in the developing cerebral cortex
Nadarajah, B., Alifragis, P., Wong, R., & Parnavelas, J. G. (2002) · Nature Neuroscience · doi:10.1038/nn813 · Cited by 219 · see citing works
Xu, Q., Guo, L., Moore, H., Waclaw, R. R., Campbell, K., & Anderson, S. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.004 · Cited by 218 · see citing works
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development
Azim, E., Jabaudon, D., Fame, R. M., & Macklis, J. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2387 · Cited by 202 · see citing works
A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
Gelman, D., Griveau, A., Dehorter, N., Teissier, A., Varela, C., Pla, R., Pierani, A., & Marín, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4068-11.2011 · Cited by 179 · see citing works
Flandin, P., Kimura, S., & Rubenstein, J. L. R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4228-09.2010 · Cited by 176 · see citing works
Self-citationKanatani, S., Yozu, M., Tabata, H., & Nakajima, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2132-08.2008 · Cited by 163 · see citing works
Necdin Promotes GABAergic Neuron Differentiation in Cooperation with Dlx Homeodomain Proteins
Kuwajima, T., Nishimura, I., & Yoshikawa, K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1262-06.2006 · Cited by 163 · see citing works
Self-citationDorsal Radial Glia Generate Olfactory Bulb Interneurons in the Postnatal Murine Brain
Ventura, R. E., & Goldman, J. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0399-07.2007 · Cited by 161 · see citing works
Olsson, M. A., Campbell, K., Wictorin, K., & Björklund, A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00325-d · Cited by 155 · see citing works
Interneurons in the developing human neocortex
Zečević, N., Hu, F., & Jakovčevski, I. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20812 · Cited by 153 · see citing works
Clonal production and organization of inhibitory interneurons in the neocortex
Brown, K. N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Zhang, X.-J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., et al. (2011) · Science · doi:10.1126/science.1208884 · Cited by 152 · see citing works
Jeong, J., Li, X., McEvilly, R. J., Rosenfeld, M. G., Lufkin, T., & Rubenstein, J. L. R. (2008) · Development · doi:10.1242/dev.019778 · Cited by 151 · see citing works
Self-citationAlifragis, P., Liapi, A., & Parnavelas, J. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1245-04.2004 · Cited by 143 · see citing works
Origin and molecular specification of globus pallidus neurons
Nóbrega-Pereira, S., Gelman, D., Bartolini, G., Pla, R., Pierani, A., & Marín, O. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4023-09.2010 · Cited by 142 · see citing works
Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
Petanjek, Z., Berger, B., & Esclapez, M. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn078 · Cited by 130 · see citing works
Jakovcevski, I., Mayer, N., & Zecevic, N. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq245 · Cited by 124 · see citing works
Kohtz, J. D., Lee, H. Y., Gaiano, N., Segal, J., Ng, E., Larson, T., Baker, D. P., Garber, E. A., Williams, K. P., & Fishell, G. (2001) · Development · doi:10.1242/dev.128.12.2351 · Cited by 119 · see citing works
Fertuzinhos, S., Krsnik, Ž., Kawasawa, Y. I., Rašin, M.-R., Kwan, K. Y., Chen, J.-G., Judaš, M., Hayashi, M., & Šestan, N. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp009 · Cited by 106 · see citing works
The Origins of Cortical Interneurons: Mouse versus Monkey and Human
Jones, E. G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp088 · Cited by 105 · see citing works
Primate-specific origins and migration of cortical GABAergic neurons
Petanjek, Z. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.026.2009 · Cited by 102 · see citing works
Vasoactive intestinal polypeptide-immunoreactive neurons in rat visual cortex.
Connor, J., & Peters, A. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90002-2 · Cited by 101 · see citing works
Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System
Carney, R. S. E., Alfonso, T. B., Cohen, D., Dai, H., Nery, S. V., Stoica, B. A., Slotkin, J. R., Bregman, B. S., Fishell, G., & Corbin, J. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3092-06.2006 · Cited by 95 · see citing works
Cortical Interneuron Fate Determination: Diverse Sources for Distinct Subtypes?
Xu, Q. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.670 · Cited by 82 · see citing works
Yu, X., & Zečević, N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5249-10.2011 · Cited by 79 · see citing works
Ma, T., Zhang, Q., Cai, Y., You, Y., Rubenstein, J. L. R., & Yang, Z. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr296 · Cited by 79 · see citing works
Self-citationdel Rı́o, M. R., & DeFelipe, J. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)00050-1 · Cited by 61 · see citing works
Battista, D., & Rutishauser, U. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4382-09.2010 · Cited by 60 · see citing works
Cai, Y., Zhang, Q., Wang, C., Zhang, Y., Ma, T., Zhou, X., Tian, M., Rubenstein, J. L. R., & Yang, Z. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23186 · Cited by 53 · see citing works
Self-citationNew Pool of Cortical Interneuron Precursors in the Early Postnatal Dorsal White Matter
Riccio, O., Murthy, S. S., Szabó, G., Vutskits, L., Kiss, J. Z., Vitalis, T., Lebrand, C., & Dayer, A. G. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr086 · Cited by 45 · see citing works
Wu, S., Esumi, S., Watanabe, K., Chen, J., Nakamura, K., Nakamura, K., Kometani, K., Minato, N., Yanagawa, Y., Akashi, K., et al. (2011) · Development · doi:10.1242/dev.063032 · Cited by 32 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Conserved cell types with divergent features in human versus mouse cortex
Hodge, R. D., Bakken, T. E., Miller, J. A., Smith, K. A., Barkan, E. R., Graybuck, L. T., Close, J. L., Long, B., Johansen, N., Penn, O., et al. (2019) · Nature · doi:10.1038/s41586-019-1506-7 · Cited by 1,775 · see citing works
Transcriptional landscape of the prenatal human brain
Miller, J. A., Ding, S.-L., Sunkin, S. M., Smith, K. A., Ng, L., Szafer, A., Ebbert, A., Riley, Z. L., Royall, J. J., Aiona, K., et al. (2014) · Nature · doi:10.1038/nature13185 · Cited by 1,325 · see citing works
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
Lake, B. B., Ai, R., Kaeser, G. E., Salathia, N. S., Yung, Y. C., Liu, R., Wildberg, A., Gao, D., Fung, H.-L., Chen, S., et al. (2016) · Science · doi:10.1126/science.aaf1204 · Cited by 957 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Lake, B. B., Chen, S., Sos, B. C., Fan, J., Kaeser, G. E., Yung, Y. C., Duong, T. E., Gao, D., Chun, J., Kharchenko, P. V., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4038 · Cited by 983 · see citing works
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System
Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M., & Sestan, N. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.008 · Cited by 818 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
Fused cerebral organoids model interactions between brain regions
Bagley, J. A., Reumann, D., Bian, S., Lévi-Strauss, J., & Knoblich, J. A. (2017) · Nature Methods · doi:10.1038/nmeth.4304 · Cited by 790 · see citing works
A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation
Polioudakis, D., de la Torre-Ubieta, L., Langerman, J., Elkins, A. G., Shi, X., Stein, J. L., Vuong, C. K., Nichterwitz, S., Gevorgian, M., Opland, C. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.011 · Cited by 513 · see citing works
hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids
Xiang, Y., Tanaka, Y., Cakir, B., Patterson, B., Kim, K.-Y., Sun, P., Kang, Y.-J., Zhong, M., Liu, X., Patra, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.12.015 · Cited by 485 · see citing works
Self‐organized developmental patterning and differentiation in cerebral organoids
Renner, M., Lancaster, M. A., Bian, S., Choi, H., Ku, T., Peer, A., Chung, K., & Knoblich, J. A. (2017) · The EMBO Journal · doi:10.15252/embj.201694700 · Cited by 389 · see citing works
Extensive migration of young neurons into the infant human frontal lobe
Paredes, M. F., James, D., Gil-Perotin, S., Kim, H., Cotter, J. A., Ng, C., Sandoval, K., Rowitch, D. H., Xu, D., McQuillen, P. S., et al. (2016) · Science · doi:10.1126/science.aaf7073 · Cited by 391 · see citing works
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
He, M., Tucciarone, J., Lee, S., Nigro, M. J., Kim, Y., Levine, J. M., Kelly, S. M., Krugikov, I., Wu, P., Chen, Y., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.021 · Cited by 339 · see citing works
The outer subventricular zone and primate-specific cortical complexification
Dehay, C., Kennedy, H., & Kosik, K. S. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.060 · Cited by 314 · see citing works
A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.035 · Cited by 201 · see citing works
Developmental origins of brain disorders: roles for dopamine
Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221 · see citing works
Cortical interneuron development: a tale of time and space
Hu, J. S., Vogt, D., Sandberg, M., & Rubenstein, J. L. (2017) · Development · doi:10.1242/dev.132852 · Cited by 189 · see citing works
Self-citationSingle-cell analysis of prenatal and postnatal human cortical development
Velmeshev, D., Perez, Y., Yan, Z., Valencia, J. E., Castaneda-Castellanos, D. R., Wang, L., Schirmer, L., Mayer, S., Wick, B., Wang, S., et al. (2023) · Science · doi:10.1126/science.adf0834 · Cited by 204 · see citing works
Self-citationRegulation of cell-type-specific transcriptomes by microRNA networks during human brain development
Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J. A., Leyrat, A., Pollen, A. A., Kriegstein, A. R., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0265-3 · Cited by 166 · see citing works
Self-citationAmplification of human interneuron progenitors promotes brain tumors and neurological defects
Eichmüller, O. L., Corsini, N. S., Vértesy, Á., Morassut, I., Scholl, T., Gruber, V.-E., Peer, A. M., Chu, J., Novatchkova, M., Hainfellner, J. A., et al. (2022) · Science · doi:10.1126/science.abf5546 · Cited by 163 · see citing works
Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor
Manuel, M. N., Mi, D., Mason, J. O., & Price, D. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00070 · Cited by 153 · see citing works
Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015) · Nature Neuroscience · doi:10.1038/nn.3946 · Cited by 117 · see citing works
Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells
Suzuki, I. K., & Vanderhaeghen, P. (2015) · Development · doi:10.1242/dev.120568 · Cited by 110 · see citing works
Thinking out of the dish: what to learn about cortical development using pluripotent stem cells
van den Ameele, J., Tiberi, L., Vanderhaeghen, P., & Espuny-Camacho, I. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.005 · Cited by 110 · see citing works
Decision making during interneuron migration in the developing cerebral cortex
Guo, J., & Anton, E. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.12.001 · Cited by 104 · see citing works
Apical versus basal neurogenesis directs cortical interneuron subclass fate
Petros, T. J., Bultje, R. S., Ross, M. E., Fishell, G., & Anderson, S. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.079 · Cited by 91 · see citing works
Altered cell and RNA isoform diversity in aging Down syndrome brains
Palmer, C. R., Liu, C. S., Romanow, W. J., Lee, M.-H., & Chun, J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114326118 · Cited by 89 · see citing works
Spatio-temporal extension in site of origin for cortical calretinin neurons in primates
Hladnik, A., Džaja, D., Darmopil, S., Jovanov-MiloÅ¡ević, N., & Petanjek, Z. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00050 · Cited by 72 · see citing works
Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution
Libé-Philippot, B., & Vanderhaeghen, P. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071719-020705 · Cited by 78 · see citing works
Kelly, S. M., Raudales, R., He, M., Lee, J. H., Kim, Y., Gibb, L. G., Wu, P., Matho, K., Osten, P., Graybiel, A. M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.021 · Cited by 68 · see citing works
Diversity of Cortical Interneurons in Primates: The Role of the Dorsal Proliferative Niche
Radonjić, N. V., Ayoub, A. E., Memi, F., Yu, X., Maroof, A., Jakovcevski, I., Anderson, S. A., Rakic, P., & Zecevic, N. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.026 · Cited by 74 · see citing works
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62 · see citing works
Developmental specification of forebrain cholinergic neurons
Allaway, K. C., & Machold, R. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.007 · Cited by 68 · see citing works
Conserved rules in embryonic development of cortical interneurons
Laclef, C., & Métin, C. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.09.017 · Cited by 57 · see citing works
Peyre, E., Silva, C. G., & Nguyen, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00129 · Cited by 51 · see citing works
Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity
Anderson, S., & Vanderhaeghen, P. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.012 · Cited by 40 · see citing works
Altered patterning of trisomy 21 interneuron progenitors
Giffin-Rao, Y., Sheng, J., Strand, B., Xu, K., Huang, L., Medo, M., Risgaard, K. A., Dantinne, S., Mohan, S., Keshan, A., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.001 · Cited by 38 · see citing works
Single cell epigenomic atlas of the developing human brain and organoids
Ziffra, R. S., Kim, C. N., Wilfert, A., Turner, T. N., Haeussler, M., Casella, A. M., Przytycki, P. F., Kreimer, A., Pollard, K. S., Ament, S. A., et al. (2019) · doi:10.1101/2019.12.30.891549 · Cited by 33 · see citing works
- Authors
- Hansen, D. V., Lui, J. H., Flandin, P., Yoshikawa, K., Rubenstein, J. L., Alvarez-Buylla, A., & Kriegstein, A. R.
- Affiliations
- University of California, San Francisco (US)
- Institute for Protein Research, The University of Osaka (JP)
- Corresponding author
- Rubenstein, John L
- Kriegstein, Arnold R
- Venue
- Nature Neuroscience
- Published
- 2013-10-06
- Volume
- 16
- Issue
- 11
- Pages
- 1576-1587
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4191718
- OpenAlex
- W2087531974
- Cited by
- 328
- References
- 53
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 24 · 2023: 23 · 2022: 23 · 2021: 27 · 2020: 31 · 2019: 26 · 2018: 17 · 2017: 23 · 2016: 24 · 2015: 24 · 2014: 28 · 2013: 5
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California, San Francisco
- Japan Society for the Promotion of Science (24300134)
- National Institute of Mental Health (R37MH049428)
- National Institute of Neurological Disorders and Stroke (R01NS021223)
- California National Primate Research Center
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cortical interneurons, GABAergic neurons, ganglionic eminence, subventricular zone, neural stem cells, intermediate progenitor cells, human brain development, medial ganglionic eminence, caudal ganglionic eminence, radial glia
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cerebral Ventricles, Fetus, Humans, Interneurons, Nerve Tissue Proteins, Organ Culture Techniques, RNA, Messenger, Transcription Factors, Gene Expression Regulation, Developmental, Neocortex, Multipotent Stem Cells, Mice, GABAergic Neurons, LIM-Homeodomain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
