A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex
Open accessAbstract
GABAergic interneurons can phase the output of principal cells, giving rise to oscillatory activity in different frequency bands. Here we describe a new subtype of GABAergic interneuron, the multipolar bursting (MB) cell in the mouse neocortex. MB cells are parvalbumin positive but differ from fast-spiking multipolar (FS) cells in their morphological, neurochemical, and physiological properties. MB cells are reciprocally connected with layer 2/3 pyramidal cells and are coupled with each other by chemical and electrical synapses. MB cells innervate FS cells but not vice versa. MB to MB cell as well as MB to pyramidal cell synapses exhibit paired-pulse facilitation. Carbachol selectively induced synchronized theta frequency oscillations in MB cells. Synchrony required both gap junction coupling and GABAergic chemical transmission, but not excitatory glutamatergic input. Hence, MB cells form a distinct inhibitory network, which upon cholinergic drive can generate rhythmic and synchronous theta frequency activity, providing temporal coordination of pyramidal cell output.
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- Authors
- Blatow, M., Rozov, A., Katona, I., Hormuzdi, S. G., Meyer, A. H., Whittington, M. A., Caputi, A., & Monyer, H.
- Affiliations
- Heidelberg University (DE)
- University of Leeds (GB)
- Corresponding author
- Monyer, Hannah
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 38
- Issue
- 5
- Pages
- 805-817
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1969073804
- Cited by
- 316
- References
- 42
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2023: 11 · 2022: 7 · 2021: 15 · 2020: 10 · 2019: 10 · 2018: 4 · 2017: 9 · 2016: 13 · 2015: 14 · 2014: 15 · 2013: 23 · 2012: 14
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3699 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- GABAergic interneurons, theta oscillations, neocortex, parvalbumin, fast-spiking interneurons, layer 2/3 pyramidal cells, electrical coupling, electrical synapses, paired-pulse facilitation, carbachol, neuronal synchronization
- MeSH terms
- Action Potentials, Animals, Biological Clocks, Carbachol, Dendrites, gamma-Aminobutyric Acid, Interneurons, Mice, Inbred C57BL, Nerve Net, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Synapses, Theta Rhythm, Gap Junctions, Pyramidal Cells, Mice, Knockout, Cholinergic Agonists, Glutamic Acid, Neocortex, Excitatory Postsynaptic Potentials, Mice
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