Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Hannibal, Jens; Christiansen, Anders Tolstrup; Heegaard, Steffen; Fahrenkrug, Jan; Kiilgaard, Jens Folke

doi:10.1002/cne.24181

Cited by 169Circadian rhythm and melatoninRetinal Development and DisordersVisual perception and processing mechanisms

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Hannibal, Jens, Christiansen, Anders Tolstrup, Heegaard, Steffen, Fahrenkrug, Jan, Kiilgaard, Jens Folke·2017·Journal of Comparative Neurology

DOI 10.1002/cne.24181

Open this paper in CoChat — free account

Abstract

Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex, and sleep/wake cycles. The different functions seem to be associated to different subtypes of melanopsin cells. In rodents, subtype classification has associated subtypes to function. In primate and human retina such classification has so far, not been applied. In the present study using antibodies against N- and C-terminal parts of human melanopsin, confocal microscopy and 3D reconstruction of melanopsin immunoreactive (-ir) RGCs, we applied the criteria used in mouse on human melanopsin-ir RGCs. We identified M1, displaced M1, M2, and M4 cells. We found two other subtypes of melanopsin-ir RGCs, which were named "gigantic M1 (GM1)" and "gigantic displaced M1 (GDM1)." Few M3 cells and no M5 subtypes were labeled. Total cell counts from one male and one female retina revealed that the human retina contains 7283 ± 237 melanopsin-ir (0.63-0.75% of the total number of RGCs). The melanopsin subtypes were unevenly distributed. Most significant was the highest density of M4 cells in the nasal retina. We identified input to the melanopsin-ir RGCs from AII amacrine cells and directly from rod bipolar cells via ribbon synapses in the innermost ON layer of the inner plexiform layer (IPL) and from dopaminergic amacrine cells and GABAergic processes in the outermost OFF layer of the IPL. The study characterizes a heterogenic population of human melanopsin-ir RGCs, which most likely are involved in different functions.

Integrity signals

Registry

Crossref · 10.1002/cne.24181

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Melanopsin is especially sensitive to light with short wavelengths between 446 nm and 480 nm.
“Melanopsin is especially sensitive to light with short wavelengths between 446 nm and 480 nm [18]”
From Preliminary Results: The Impact of Smartphone Use and Short-Wavelength Light during the Evening on Circadian Rhythm, Sleep and Alertness (2021) · cites this paper as [18]

Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734 · see citing works
Topography of ganglion cells in human retina
Curcio, C. A., & Allen, K. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903000103 · Cited by 1,849 · see citing works
Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN
Dacey, D. M., Liao, H.-W., Peterson, B. B., Robinson, F. R., Smith, V. C., Pokorny, J., Yau, K.-W., & Gamlin, P. D. (2005) · Nature · doi:10.1038/nature03387 · Cited by 1,333 · see citing works
Parallel processing in the mammalian retina
Wässle, H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1497 · Cited by 1,253 · see citing works
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245 · see citing works
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996 · see citing works
Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision
Ecker, J. L., Dumitrescu, O. N., Wong, K. Y., Alam, N. M., Chen, S., LeGates, T. A., Renna, J. M., Prusky, G. T., Berson, D. M., & Hattar, S. S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.023 · Cited by 669 · see citing works
RIBEYE, a Component of Synaptic Ribbons
Schmitz, F., Königstorfer, A., & Südhof, T. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)00159-8 · Cited by 581 · see citing works
The Murine Cone Photoreceptor
Applebury, M. L., Antoch, M. P., Baxter, L. C., Chun, L. L. Y., Falk, J. D., Farhangfar, F., Kage, K., Krzystolik, M. G., Lyass, L., & Robbins, J. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)00062-3 · Cited by 566 · see citing works
Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions
Schmidt, T. M., Chen, S., & Hattar, S. S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.001 · Cited by 553 · see citing works
Intrinsically Photosensitive Retinal Ganglion Cells
Do, M. T. H., & Yau, K. (2010) · Physiological Reviews · doi:10.1152/physrev.00013.2010 · Cited by 477 · see citing works
Photoreceptive net in the mammalian retina
Provencio, I., Rollag, M. D., & Castrucci, A. M. D. L. (2002) · Nature · doi:10.1038/415493a · Cited by 472 · see citing works
Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs
Chen, S., Badea, T. C., & Hattar, S. S. (2011) · Nature · doi:10.1038/nature10206 · Cited by 436 · see citing works
Rod bipolar cells in the mammalian retina show protein kinase C‐like immunoreactivity
Greferath, U., Grünert, U., & Wässle, H. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903010308 · Cited by 420 · see citing works
Molecular dissection of the photoreceptor ribbon synapse
Dieck, S. T., Altrock, W. D., Kessels, M. M., Qualmann, B., Regus‐Leidig, H., Brauner, D., Fejtová, A., Bracko, O., Gundelfinger, E. D., & Brandstätter, J. H. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408157 · Cited by 401 · see citing works
Melanopsin retinal ganglion cell loss in A lzheimer disease
Morgia, C. L., Ross‐Cisneros, F. N., Koronyo, Y., Hannibal, J., Gallassi, R., Cantalupo, G., Sambati, L., Pan, B. X., Tozer, K. R., Barboni, P., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24548 · Cited by 389 · see citing works
Self-citation
Immunocytochemical identification of cone bipolar cells in the rat retina
Euler, T., & Wässle, H. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610310 · Cited by 347 · see citing works
The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract
Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B., & Fahrenkrug, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-j0002.2002 · Cited by 339 · see citing works
Self-citation
Two types of melanopsin retinal ganglion cell differentially innervate the hypothalamic suprachiasmatic nucleus and the olivary pretectal nucleus
Baver, S. B., Pickard, G. E., Sollars, P. J., & Pickard, G. E. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06149.x · Cited by 312 · see citing works
Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons
Zhang, D.-Q., Wong, K. Y., Sollars, P. J., Berson, D. M., Pickard, G. E., & McMahon, D. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803893105 · Cited by 287 · see citing works
Melanopsin retinal ganglion cells receive bipolar and amacrine cell synapses
Belenky, M. A., Smeraski, C. A., Provencio, I., Sollars, P. J., & Pickard, G. E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10652 · Cited by 284 · see citing works
Synaptic influences on rat ganglion‐cell photoreceptors
Wong, K. Y., Dunn, F. A., Graham, D. M., & Berson, D. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.133751 · Cited by 265 · see citing works
Melanopsin Contributions to Irradiance Coding in the Thalamo-Cortical Visual System
Brown, T. M., Gias, C., Hatori, M., Keding, S. R., Semo, M., Coffey, P. J., Gigg, J., Piggins, H. D., Panda, S., & Lucas, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000558 · Cited by 259 · see citing works
Glycine and GABA receptors in the mammalian retina
Wässle, H., Koulen, P., Brandstätter, J. H., Fletcher, E. L., & Becker, C. (1998) · Vision Research · doi:10.1016/s0042-6989(97)00300-3 · Cited by 256 · see citing works
Melanopsin-Positive Intrinsically Photosensitive Retinal Ganglion Cells: From Form to Function
Schmidt, T. M., Do, M. T. H., Dacey, D. M., Lucas, R. J., Hattar, S. S., & Matynia, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4132-11.2011 · Cited by 255 · see citing works
A Role for Melanopsin in Alpha Retinal Ganglion Cells and Contrast Detection
Schmidt, T. M., Alam, N. M., Chen, S., Kofuji, P., Li, W., Prusky, G. T., & Hattar, S. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.022 · Cited by 254 · see citing works
Morphology and mosaics of melanopsin‐expressing retinal ganglion cell types in mice
Berson, D. M., Castrucci, A. M. D. L., & Provencio, I. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22381 · Cited by 239 · see citing works
The acute light-induction of sleep is mediated by OPN4-based photoreception
Lupi, D., Oster, H., Thompson, S., & Foster, F. (2008) · Nature Neuroscience · doi:10.1038/nn.2179 · Cited by 236 · see citing works
Functional and Morphological Differences among Intrinsically Photosensitive Retinal Ganglion Cells
Schmidt, T. M., & Kofuji, P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4117-08.2009 · Cited by 233 · see citing works
Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision
Stabio, M. E., Fogerson, P. M., Ilardi, M. C., Borghuis, B. G., Chan, E., Weng, S.-J., Auferkorte, O. N., Demb, J. B., & Berson, D. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1422-12.2012 · Cited by 229 · see citing works
Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice
Tsai, J. W., Hannibal, J., Hagiwara, G., Colas, D., Ruppert, É., Ruby, N. F., Heller, H. C., Franken, P., & Bourgin, P. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000125 · Cited by 226 · see citing works
Self-citation
Melanopsin Is Expressed in PACAP-Containing Retinal Ganglion Cells of the Human Retinohypothalamic Tract
Hannibal, J., Hindersson, P., Østergaard, J., Georg, B., Heegaard, S., Larsen, P. J., & Fahrenkrug, J. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0313 · Cited by 213 · see citing works
Self-citation
Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies
Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., Hannibal, J., Munarini, A., Mantovani, V., Barboni, P., Cantalupo, G., Tozer, K. R., Sancisi, E., et al. (2010) · Brain · doi:10.1093/brain/awq155 · Cited by 191 · see citing works
Self-citation
Local Retinal Circuits of Melanopsin-Containing Ganglion Cells Identified by Transsynaptic Viral Tracing
Viney, T. J., Bálint, K., Hillier, D., Siegert, S., Boldogkői, Z., Enquist, L. W., Meister, M., Cepko, C. L., & Roska, B. (2007) · Current Biology · doi:10.1016/j.cub.2007.04.058 · Cited by 189 · see citing works
The rod pathway of the macaque monkey retina: Identification of AII‐amacrine cells with antibodies against calretinin
Wässle, H., Grünert, U., Chun, M., & Boycott, B. B. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610315 · Cited by 188 · see citing works
Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells
Zhao, X., Stafford, B. K., Godin, A. L., King, W. M., & Wong, K. Y. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.262782 · Cited by 174 · see citing works
Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: Contacts with dopaminergic amacrine cells and melanopsin ganglion cells
Dumitrescu, O. N., Pucci, F. G., Wong, K. Y., & Berson, D. M. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22158 · Cited by 171 · see citing works
cFos immunoreactivity is enhanced with biotin amplification.
Berghorn, K. A., Bonnett, J. H., & Hoffman, G. E. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.12.7983364 · Cited by 161 · see citing works
Central projections of intrinsically photosensitive retinal ganglion cells in the macaque monkey
Hannibal, J., Kankipati, L., Strang, C. E., Peterson, B. B., Dacey, D. M., & Gamlin, P. D. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23555 · Cited by 153 · see citing works
Self-citation
Melanopsin‐expressing ganglion cells on macaque and human retinas form two morphologically distinct populations
Liao, H., Ren, X., Peterson, B. B., MARSHAK, D. W., Yau, K., Gamlin, P. D., & Dacey, D. M. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23995 · Cited by 153 · see citing works
Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells
Sakamoto, K., Liu, C., Kasamatsu, M., Pozdeyev, N. V., Iuvone, P. M., & Tosini, G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04512.x · Cited by 147 · see citing works
ON Inputs to the OFF Layer: Bipolar Cells That Break the Stratification Rules of the Retina
Hoshi, H., Liu, W.-L., Massey, S. C., & Mills, S. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0912-09.2009 · Cited by 132 · see citing works
M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina
Prigge, C. L., Yeh, P., Liou, N.-F., Lee, C. C., You, S., Liu, L.-L., McNeill, D. S., Chew, K. S., Hattar, S. S., Chen, S., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3500-15.2016 · Cited by 131 · see citing works
Characterization and synaptic connectivity of melanopsin‐containing ganglion cells in the primate retina
Jusuf, P. R., Lee, S., Hannibal, J., & Grünert, U. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05924.x · Cited by 129 · see citing works
Self-citation
Glycinergic transmission in the mammalian retina
Wässle, H. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.006.2009 · Cited by 126 · see citing works
Light and Darkness Regulate Melanopsin in the Retinal Ganglion Cells of the Albino Wistar Rat
Hannibal, J., Georg, B., Hindersson, P., & Fahrenkrug, J. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:2:147 · Cited by 115 · see citing works
Self-citation
The injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Cui, Q., Ren, C., Sollars, P. J., Pickard, G. E., & So, K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.002 · Cited by 110 · see citing works
Nonuniform Distribution and Spectral Tuning of Photosensitive Retinal Ganglion Cells of the Mouse Retina
Hughes, S., Watson, T. S., Foster, F., Peirson, S. N., & Hankins, M. W. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.010 · Cited by 110 · see citing works
Intrinsically photosensitive retinal ganglion cells
Pickard, G. E., & Sollars, P. J. (2010) · Science China Life Sciences · doi:10.1007/s11427-010-0024-5 · Cited by 106 · see citing works
Differential Cone Pathway Influence on Intrinsically Photosensitive Retinal Ganglion Cell Subtypes
Schmidt, T. M., & Kofuji, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3656-10.2010 · Cited by 104 · see citing works
Synaptic inputs to retinal ganglion cells that set the circadian clock
Perez‐Leon, J. A., Warren, E., Allen, C. N., Robinson, D. W., & Brown, R. L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04999.x · Cited by 99 · see citing works
Synaptic Contact between Melanopsin-Containing Retinal Ganglion Cells and Rod Bipolar Cells
Østergaard, J., Hannibal, J., & Fahrenkrug, J. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1322 · Cited by 98 · see citing works
Self-citation
Dopaminergic modulation of ganglion‐cell photoreceptors in rat
Hook, M. J. V., Wong, K. Y., & Berson, D. M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07975.x · Cited by 97 · see citing works
Differential Expression of Two Distinct Functional Isoforms of Melanopsin (Opn4) in the Mammalian Retina
Pires, S. S., Hughes, S., Turton, M., Melyan, Z., Peirson, S. N., Zheng, L., Kosmaoglou, M., Bellingham, J., Cheetham, M. E., Lucas, R. J., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2036-09.2009 · Cited by 94 · see citing works
Melanopsin Mediates Retrograde Visual Signaling in the Retina
Zhang, D.-Q., Belenky, M. A., Sollars, P. J., Pickard, G. E., & McMahon, D. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042647 · Cited by 94 · see citing works
Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina
Vugler, A., Redgrave, P., Semo, M., Lawrence, J. M., Greenwood, J., & Coffey, P. J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.032 · Cited by 92 · see citing works
Tracer coupling of intrinsically photosensitive retinal ganglion cells to amacrine cells in the mouse retina
Müller, L. P. D. S., Do, M. T. H., Yau, K., He, S., & Baldridge, W. H. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22490 · Cited by 89 · see citing works
Mouse Ganglion-Cell Photoreceptors Are Driven by the Most Sensitive Rod Pathway and by Both Types of Cones
Weng, S.-J., Stabio, M. E., & Berson, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066480 · Cited by 86 · see citing works
Displaced retinal ganglion cells in albino and pigmented rats
Nadal-Nicolás, F. M., Salinas‐Navarro, M., Jiménez-López, M., Sobrado‐Calvo, P., Villegas-PÃ©rez, M. P., Vidal‐Sanz, M., & Agudo‐Barriuso, M. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00099 · Cited by 85 · see citing works
Bipolar input to melanopsin containing ganglion cells in primate retina
Grünert, U., Jusuf, P. R., Lee, S., & Nguyen, D. (2010) · Visual Neuroscience · doi:10.1017/s095252381000026x · Cited by 80 · see citing works
Number and spatial distribution of intrinsically photosensitive retinal ganglion cells in the adult albino rat
Galindo‐Romero, C., Jiménez-López, M., García‐Ayuso, D., Salinas‐Navarro, M., Nadal-Nicolás, F. M., Agudo‐Barriuso, M., Villegas-Pérez, M. P., Avilés‐Trigueros, M., & Vidal‐Sanz, M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2012.12.010 · Cited by 79 · see citing works
Recurrent axon collaterals of intrinsically photosensitive retinal ganglion cells
Joo, H. R., Peterson, B. B., Dacey, D. M., Hattar, S. S., & Chen, S. (2013) · Visual Neuroscience · doi:10.1017/s0952523813000199 · Cited by 79 · see citing works
Distribution of melanopsin positive neurons in pigmented and albino mice: evidence for melanopsin interneurons in the mouse retina
Valiente‐Soriano, F. J., García‐Ayuso, D., Ortín-Martínez, A., Jiménez-López, M., Galindo‐Romero, C., Villegas-PÃ©rez, M. P., Agudo‐Barriuso, M., Vugler, A., & Vidal‐Sanz, M. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00131 · Cited by 71 · see citing works
The rat retina has five types of ganglion-cell photoreceptors
Reifler, A. N., Chervenak, A. P., Dolikian, M. E., Benenati, B. A., Meyers, B. S., Demertzis, Z. D., Lynch, A. M., Li, B. Y., Wachter, R. D., Abufarha, F. S., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.11.010 · Cited by 68 · see citing works
Expression of melanopsin during development of the rat retina
Fahrenkrug, J., Nielsen, H. S., & Hannibal, J. (2004) · Neuroreport · doi:10.1097/00001756-200404090-00008 · Cited by 53 · see citing works
Self-citation
Identification of AⅡ amacrine, displaced amacrine, and bistratified ganglion cell types in human retina with antibodies against calretinin
Lee, S., Weltzien, F., Madigan, M. C., Martin, P. R., & Grünert, U. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23821 · Cited by 52 · see citing works
Immunohistochemical Evidence of a Melanopsin Cone in Human Retina
Dkhissi‐Benyahya, O., Rieux, C., Hut, R. A., & Cooper, H. M. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1459 · Cited by 47 · see citing works
Differential expression of melanopsin mRNA and protein in Brown Norwegian rats
Hannibal, J., Georg, B., & Fahrenkrug, J. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.11.006 · Cited by 46 · see citing works
Self-citation
Central melanopsin projections in the diurnal rodent, Arvicanthis niloticus
Langel, J., Smale, L., Esquiva, G., & Hannibal, J. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00093 · Cited by 38 · see citing works
Self-citation
Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones
Procyk, C. A., Eleftheriou, C. G., Storchi, R., Allen, A. E., Milosavljevic, N., Brown, T. M., & Lucas, R. J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00368.2015 · Cited by 37 · see citing works
Melanopsin changes in neonatal albino rat independent of rods and cones
Hannibal, J., Georg, B., & Fahrenkrug, J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e328010ff56 · Cited by 36 · see citing works
Self-citation
Regulation of Melanopsin Expression
Hannibal, J. (2006) · Chronobiology International · doi:10.1080/07420520500464544 · Cited by 36 · see citing works
Self-citation
ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina
Lauritzen, J. S., Anderson, J. R., Jones, B. W., Watt, C. B., Shoeb, M., Hoang, J. V., & Marc, R. E. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23244 · Cited by 36 · see citing works
Differential Expression of Melanopsin Isoforms Opn4L and Opn4S during Postnatal Development of the Mouse Retina
Hughes, S., Welsh, L., Katti, C., González-Menéndez, I., Turton, M., Halford, S., Sekaran, S., Peirson, S. N., Hankins, M. W., & Foster, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034531 · Cited by 32 · see citing works
Morphology of human retinal ganglion cells with intraretinal axon collaterals
Peterson, B. B., & Dacey, D. M. (1998) · Visual Neuroscience · doi:10.1017/s0952523898152161 · Cited by 32 · see citing works
Heterogeneity of intrinsically photosensitive retinal ganglion cells in the mouse revealed by molecular phenotyping
Karnas, D., Mordel, J., Bonnet, D., Pévet, P., Hicks, D., & Meissl, H. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23210 · Cited by 28 · see citing works
Non-image Forming Light Detection by Melanopsin, Rhodopsin, and Long-Middlewave (L/W) Cone Opsin in the Subterranean Blind Mole Rat, Spalax Ehrenbergi: Immunohistochemical Characterization, Distribution, and Connectivity
Esquiva, G., Avivi, A., & Hannibal, J. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00061 · Cited by 25 · see citing works
Self-citation
Characterizing and modeling the intrinsic light response of rat ganglion-cell photoreceptors
Walch, O., Zhang, L. S., Reifler, A. N., Dolikian, M. E., Forger, D. B., & Wong, K. Y. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00544.2015 · Cited by 21 · see citing works
The spino-bulbar-cerebellar pathway: organization and neurochemical properties of spinal cells that project to the lateral reticular nucleus in the rat
Huma, Z., & Maxwell, D. J. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00001 · Cited by 20 · see citing works
Intrinsically photosensitive ganglion cells of the primate retina express distinct combinations of inhibitory neurotransmitter receptors
Neumann, S., Haverkamp, S., & Auferkorte, O. N. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.027 · Cited by 17 · see citing works

Flagged first, then by citations

1 of the 82 references couldn’t be matched to a known paper.

Sorted by citations

LEDs for photons, physiology and food
Pattison, P. M., Tsao, J. Y., Brainard, G. C., & Bugbee, B. (2018) · Nature · doi:10.1038/s41586-018-0706-x · Cited by 410 · see citing works
Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Do, M. T. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.016 · Cited by 305 · see citing works
A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy
Huang, L., Xi, Y., Peng, Y., Yang, Y., Huang, X., Fu, Y., Tao, Q., Xiao, J., Yuan, T., An, K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.037 · Cited by 300 · see citing works
A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions
Vetter, C., Pattison, P. M., Houser, K. W., Herf, M., Phillips, A. J. K., Wright, K. P., Skene, D. J., Brainard, G. C., Boivin, D. B., & Glickman, G. L. (2021) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2021.1872383 · Cited by 226 · see citing works
Cell types and cell circuits in human and non-human primate retina
Grünert, U., & Martin, P. R. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100844 · Cited by 182 · see citing works
Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions
Aranda, M. L., & Schmidt, T. M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03641-5 · Cited by 164 · see citing works
Circadian Photoentrainment in Mice and Humans
Foster, F., Hughes, S., & Peirson, S. N. (2020) · Biology · doi:10.3390/biology9070180 · Cited by 163 · see citing works
Ocular and systemic melatonin and the influence of light exposure
Ostrin, L. A. (2018) · Clinical and Experimental Optometry · doi:10.1111/cxo.12824 · Cited by 166 · see citing works
Reducing nighttime light exposure in the urban environment to benefit human health and society
Zielińska-Dąbkowska, K. M., Schernhammer, E. S., Hanifin, J. P., & Brainard, G. C. (2023) · Science · doi:10.1126/science.adg5277 · Cited by 158 · see citing works
Retinal Ganglion Cells—Diversity of Cell Types and Clinical Relevance
Kim, U. S., Mahroo, O. A., Mollon, J. D., & Yu‐Wai‐Man, P. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.661938 · Cited by 157 · see citing works
Intrinsically photosensitive retinal ganglion cells of the human retina
Mure, L. S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.636330 · Cited by 151 · see citing works
Functional diversity of human intrinsically photosensitive retinal ganglion cells
Mure, L. S., Vinberg, F., Hanneken, A. M., & Panda, S. (2019) · Science · doi:10.1126/science.aaz0898 · Cited by 124 · see citing works
Light modulation of human clocks, wake, and sleep
Prayag, A. S., Münch, M., Aeschbach, D., Chellappa, S. L., & Gronfier, C. (2019) · Clocks & Sleep · doi:10.3390/clockssleep1010017 · Cited by 122 · see citing works
Optic neuropathies: the tip of the neurodegeneration iceberg
Carelli, V., Morgia, C. L., Ross‐Cisneros, F. N., & Sadun, A. A. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx273 · Cited by 114 · see citing works
Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease
Ortuño‐Lizarán, I., Esquiva, G., Beach, T. G., Serrano, G. E., Adler, C. H., Lax, P., & Cuenca, N. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0596-z · Cited by 87 · see citing works
Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases
Rukmini, A. V., Miléa, D., & Gooley, J. J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00076 · Cited by 76 · see citing works
A Color Vision Circuit for Non-Image-Forming Vision in the Primate Retina
Patterson, S. S., Kuchenbecker, J. A., Anderson, J. R., Neitz, M., & Jay Neitz, A. (2020) · Current Biology · doi:10.1016/j.cub.2020.01.040 · Cited by 68 · see citing works
Attenuation of short wavelengths alters sleep and the ip <scp>RGC</scp> pupil response
Ostrin, L. A., Abbott, K. S., & Queener, H. M. (2017) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12385 · Cited by 69 · see citing works
Macular Carotenoid Supplementation Improves Visual Performance, Sleep Quality, and Adverse Physical Symptoms in Those with High Screen Time Exposure
Stringham, J. M., Stringham, N. T., & O’Brien, K. (2017) · Foods · doi:10.3390/foods6070047 · Cited by 71 · see citing works
Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology
Morgia, C. L., Carelli, V., & Carbonelli, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01047 · Cited by 66 · see citing works
Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image‐forming and non‐image‐forming vision
Sondereker, K. B., Stabio, M. E., & Renna, J. M. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24873 · Cited by 63 · see citing works
A Comprehensive Overview of the Neural Mechanisms of Light Therapy
Huang, X., Tao, Q., & Ren, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01089-8 · Cited by 71 · see citing works
Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms
Lax, P., Ortuño‐Lizarán, I., Maneu, V., Vidal‐Sanz, M., & Cuenca, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133164 · Cited by 65 · see citing works
Preliminary Results: The Impact of Smartphone Use and Short-Wavelength Light during the Evening on Circadian Rhythm, Sleep and Alertness
Höhn, C., Schmid, S. R., Plamberger, C. P., Bothe, K., Angerer, M., Gruber, G., Pletzer, B., & Hoedlmoser, K. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3010005 · Cited by 61 · see citing works
“Melanopsin is especially sensitive to light with short wavelengths between 446 nm and 480 nm [18], thus to light emitted preferentially by LED screens (e.”
Background
Quantifying biologically essential aspects of environmental light
Nilsson, D., & Smolka, J. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0184 · Cited by 58 · see citing works
Differential susceptibility of retinal ganglion cell subtypes in acute and chronic models of injury and disease
VanderWall, K. B., Lu, B., Alfaro, J. S., Allsop, A. R., Carr, A. S., Wang, S., & Meyer, J. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-71460-6 · Cited by 60 · see citing works
No evidence for an S cone contribution to acute neuroendocrine and alerting responses to light
Spitschan, M., Lazar, R., Yetik, E., & Cajochen, C. (2019) · Current Biology · doi:10.1016/j.cub.2019.11.031 · Cited by 54 · see citing works
Molecular Fingerprinting of On–Off Direction-Selective Retinal Ganglion Cells Across Species and Relevance to Primate Visual Circuits
Dhande, O. S., Stafford, B. K., Franke, K., El-Danaf, R. N., Percival, K. A., Phan, A. H., Li, P., Hansen, B. J., Nguyen, P. L., Berens, P., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1784-18.2018 · Cited by 54 · see citing works
Dynamics of Non-visual Responses in Humans: As Fast as Lightning?
Prayag, A. S., Jost, S., Avouac, P., Dumortier, D., & Gronfier, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00126 · Cited by 54 · see citing works
Biophysical Variation within the M1 Type of Ganglion Cell Photoreceptor
Emanuel, A. J., Kapur, K., & Do, M. T. H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.095 · Cited by 48 · see citing works
Methods to Describe and Measure Lighting Conditions in Experiments on Non-Image-Forming Aspects
Knoop, M., Broszio, K., Diakite, A., Liedtke, C., Niedling, M., Rothert, I., Rudawski, F., & Weber, N. (2019) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2018.1518716 · Cited by 51 · see citing works
Fundamentals of circadian entrainment by light
Foster, F. (2021) · Lighting Research & Technology · doi:10.1177/14771535211014792 · Cited by 47 · see citing works
Narrative review: The role of circadian rhythm on sports performance, hormonal regulation, immune system function, and injury prevention in athletes
Nobarı, H., Azarian, S., Saedmocheshi, S., Valdés-Badilla, P., & García‐Calvo, T. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19636 · Cited by 53 · see citing works
S‐cone contribution to the acute melatonin suppression response in humans
Brown, T. M., Thapan, K., Arendt, J., Revell, V. L., & Skene, D. J. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12719 · Cited by 46 · see citing works
Timing is everything: Circadian rhythms and their role in the control of sleep
Pandi-Perumal, S. R., Cardinali, D. P., Zaki, N. F. W., Ramanujam, K., Spence, D. W., Reiter, R. J., & Brown, G. M. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100978 · Cited by 50 · see citing works
Subtype-specific survival and regeneration of retinal ganglion cells in response to injury
Tapia, M. L., Nascimento‐dos‐Santos, G., & Park, K. K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.956279 · Cited by 45 · see citing works
Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
Oh, A. J., Amore, G., Sultan, W., Asanad, S., Park, J. C., Romagnoli, M., Morgia, C. L., Karanjia, R., Harrington, M. G., & Sadun, A. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226197 · Cited by 45 · see citing works
Modeling Circadian Phototransduction: Retinal Neurophysiology and Neuroanatomy
Rea, M. S., Nagare, R., & Figueiro, M. G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.615305 · Cited by 44 · see citing works
The photobiology of the human circadian clock
Schoonderwoerd, R. A., de Rover, M., Janse, J. A. M., Hirschler, L., Willemse, C. R., Scholten, L., Klop, I., van Berloo, S., van Osch, M. J. P., Swaab, D. F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118803119 · Cited by 40 · see citing works
Morphology, Molecular Characterization, and Connections of Ganglion Cells in Primate Retina
Grünert, U., & Martin, P. R. (2021) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100419-115801 · Cited by 41 · see citing works
Direct effects of the light environment on daily neuroendocrine control
Paul, S., & Brown, T. M. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0302 · Cited by 41 · see citing works
Melanopsin: From a small molecule to brain functions
Duda, M., Domagalik, A., Orlowska‐Feuer, P., Krzysztynska‐Kuleta, O. I., Beldzik, E., Smyk, M. K., Stachurska, A., Ogińska, H., Jeczmien‐Lazur, J. S., Fąfrowicz, M., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.012 · Cited by 39 · see citing works
Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults
Eto, T., & Higuchi, S. (2023) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-023-00328-1 · Cited by 37 · see citing works
The ip RGC ‐driven pupil response with light exposure and refractive error in children
Ostrin, L. A. (2018) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12583 · Cited by 34 · see citing works
Light Pollution and Oxidative Stress: Effects on Retina and Human Health
Salceda, R. (2024) · Antioxidants · doi:10.3390/antiox13030362 · Cited by 40 · see citing works
Selective amplification of ipRGC signals accounts for interictal photophobia in migraine
McAdams, H. M., Kaiser, E. A., Igdalova, A., Haggerty, E. B., Cucchiara, B. L., Brainard, D. H., & Aguirre, G. K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007402117 · Cited by 33 · see citing works
Melanopsin and calbindin immunoreactivity in the inner retina of humans and marmosets
Chandra, A. J., Lee, S., & Grünert, U. (2019) · Visual Neuroscience · doi:10.1017/s0952523819000087 · Cited by 32 · see citing works
Chromatic Pupillometry Findings in Alzheimer’s Disease
Romagnoli, M., Maserati, M. S., Matteis, M. D., Capellari, S., Carbonelli, M., Amore, G., Cantalupo, G., Zenesini, C., Liguori, R., Sadun, A. A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00780 · Cited by 31 · see citing works
How Smart Is It to Go to Bed with the Phone? The Impact of Short-Wavelength Light and Affective States on Sleep and Circadian Rhythms
Schmid, S. R., Höhn, C., Bothe, K., Plamberger, C., Angerer, M., Pletzer, B. A., & Hoedlmoser, K. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3040040 · Cited by 32 · see citing works
Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision
Uprety, S., Adhikari, P., Feigl, B., & Zele, A. J. (2022) · iScience · doi:10.1016/j.isci.2022.104529 · Cited by 31 · see citing works
Adenosine receptor distribution in Rhesus monkey ocular tissue
Beach, K. M., Hung, L., Arumugam, B., Smith, E. L., & Ostrin, L. A. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.05.020 · Cited by 30 · see citing works
Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew
Johnson, E. N., Westbrook, T., Shayesteh, R., Chen, E., Schumacher, J. W., Fitzpatrick, D., & Field, G. D. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24377 · Cited by 27 · see citing works
Melanopsin+RGCs Are fully Resistant to NMDA-Induced Excitotoxicity
Vidal‐Villegas, B., Pierdomenico, J. D., de Imperial‐Ollero, J. A. M., Ortín-Martínez, A., Nadal-Nicolás, F. M., Bernal-Garro, J. M., Cuenca, N., Villegas‐Pérez, M. P., & Vidal‐Sanz, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123012 · Cited by 27 · see citing works
Light modulates oscillatory alpha activity in the occipital cortex of totally visually blind individuals with intact non-image-forming photoreception
Vandewalle, G., van Ackeren, M. J., Daneault, V., Hull, J. T., Albouy, G., Leporé, F., Doyon, J., Czeisler, C. A., Dumont, M., Carrier, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35400-9 · Cited by 24 · see citing works
Retinal ganglion cells and the magnocellular, parvocellular, and koniocellular subcortical visual pathways from the eye to the brain
Solomon, S. G. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-821377-3.00018-0 · Cited by 26 · see citing works
Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients
Barboni, M. T. S., Bueno, C., Nagy, B. V., Maia, P. L., Vidal, K. S. M., Alves, R. C., Reiter, R. J., do Amaral, F. G., Cipolla‐Neto, J., & Ventura, D. F. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22612 · Cited by 25 · see citing works
Intrinsically photosensitive retinal ganglion cells in glaucoma
Gao, J., Provencio, I., & Liu, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.992747 · Cited by 24 · see citing works
Therapeutic Effects of Melatonin on Ocular Diseases: Knowledge Map and Perspective
Yu, H., Wang, Q., Wu, W., Zeng, W., & Feng, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.721869 · Cited by 26 · see citing works
Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always
Georg, B., Ghelli, A. M., Giordano, C., Ross‐Cisneros, F. N., Sadun, A. A., Carelli, V., Hannibal, J., & Morgia, C. L. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.04.003 · Cited by 22 · see citing works
Self-citation
Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
Amorim‐de‐Sousa, A., Schilling, T., Fernandes, P. R. B., Seshadri, Y., Bahmani, H., & González‐Méijome, J. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-88459-2 · Cited by 22 · see citing works
Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain
Wu, X., Tan, B., Du, Y., Yang, L. C., Hu, T., Ding, Y.-L., Qiu, X.-Y., Moutal, A., Khanna, R., Yu, J., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106164 · Cited by 21 · see citing works
The Newborn's Reaction to Light as the Determinant of the Brain's Activation at Human Birth
Polese, D., Riccio, M. L., Fagioli, M., Mazzetta, A., Fagioli, F., Parisi, P., & Fagioli, M. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.933426 · Cited by 22 · see citing works
Selective synaptic connections in the retinal pathway for night vision
Beaudoin, D. L., Kupershtok, M., & Demb, J. B. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24313 · Cited by 21 · see citing works
Functional characterisation of naturally occurring mutations in human melanopsin
Rodgers, J., Peirson, S. N., Hughes, S., & Hankins, M. W. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2813-0 · Cited by 21 · see citing works
Examination of sleep in relation to dietary and lifestyle behaviors during Ramadan: A multi-national study using structural equation modeling among 24,500 adults amid COVID-19
Khan, M. A. B., BaHammam, A. S., Amanatullah, A., Obaideen, K., Arora, T., Ali, H. I., Ismail, L. C., Abdelrahim, D. N., Al‐Houqani, M., Allaham, K., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1040355 · Cited by 20 · see citing works
Comparative Neurology of Circadian Photoreception: The Retinohypothalamic Tract (RHT) in Sighted and Naturally Blind Mammals
Hannibal, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.640113 · Cited by 19 · see citing works
Self-citation
Melanopsin‐mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma
Ahmadi, H. Z., Lund‐Andersen, H., Kolko, M., Bach‐Holm, D., Alberti, M., & Ba‐Ali, S. (2019) · Acta Ophthalmologica · doi:10.1111/aos.14133 · Cited by 18 · see citing works
Larger interface area at the human myotendinous junction in type 1 compared with type 2 muscle fibers
Jakobsen, J. R., Mackey, A. L., Koch, M., Imhof, T., Hannibal, J., Kjær, M., & Krogsgaard, M. R. (2022) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14246 · Cited by 17 · see citing works
Self-citation
Melatonin mends adverse temporal effects of bright light at night partially independent of its effect on stress responses in captive birds
MALEK, I., Haim, A., & Izhaki, I. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1698590 · Cited by 17 · see citing works
Relevance of Electrical Light on Circadian, Neuroendocrine, and Neurobehavioral Regulation in Laboratory Animal Facilities
Hanifin, J. P., Dauchy, R. T., Blask, D. E., Hill, S. M., & Brainard, G. C. (2019) · ILAR Journal · doi:10.1093/ilar/ilaa010 · Cited by 19 · see citing works
Relative light sensitivities of four retinal hemi-fields for suppressing the synthesis of melatonin at night
Rea, M. S., Nagare, R., & Figueiro, M. G. (2021) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2021.100066 · Cited by 17 · see citing works
Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder
Morgia, C. L., Romagnoli, M., Pizza, F., Biscarini, F., Filardi, M., Donadio, V. A., Carbonelli, M., Amore, G., Park, J. C., Tinazzi, M., et al. (2021) · Movement Disorders · doi:10.1002/mds.28809 · Cited by 17 · see citing works
S-cone circuits in the primate retina for non-image-forming vision
Patterson, S. S., Neitz, M., & Jay Neitz, A. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.004 · Cited by 16 · see citing works
Melanopsin Vision
Joyce, D. S., Houser, K. W., Peirson, S. N., Zeitzer, J. M., & Zele, A. J. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009029865 · Cited by 16 · see citing works
Pupillometric evaluation of the melanopsin containing retinal ganglion cells in mitochondrial and non-mitochondrial optic neuropathies
Ba‐Ali, S., & Lund‐Andersen, H. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.07.003 · Cited by 16 · see citing works
Vivarium Lighting as an Important Extrinsic Factor Influencing Animal-based Research
Dauchy, R. T., & Blask, D. E. (2023) · Journal of the American Association for Laboratory Animal Science · doi:10.30802/aalas-jaalas-23-000003 · Cited by 15 · see citing works
Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease
Morgia, C. L., Mitolo, M., Romagnoli, M., Maserati, M. S., Evangelisti, S., Matteis, M. D., Capellari, S., Bianchini, C., Testa, C. M., Vandewalle, G., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51773 · Cited by 16 · see citing works
Circadian rhythms in the blind
Allen, A. E. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.06.003 · Cited by 16 · see citing works
Localization of the neuropeptides pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal peptide, and their receptors in the basal brain blood vessels and trigeminal ganglion of the mouse CNS; an immunohistochemical study
Lund, A. M., & Hannibal, J. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.991403 · Cited by 15 · see citing works
Self-citation
Increase in choroidal thickness after blue light stimulation of the blind spot in young adults
Hoseini-Yazdi, S. H., Read, S. A., Collins, M. J., Bahmani, H., Ellrich, J., & Schilling, T. (2024) · Bioelectronic Medicine · doi:10.1186/s42234-024-00146-5 · Cited by 15 · see citing works
Modeling extracellular stimulation of retinal ganglion cells: theoretical and practical aspects
Kish, K. E., Lempka, S. F., & Weiland, J. D. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acbf79 · Cited by 13 · see citing works
Blue light stimulation of the blind spot in human: from melanopsin to clinically relevant biomarkers of myopia
Amorim‐de‐Sousa, A., Chakraborty, R., Collins, M. J., Fernandes, P. R. B., González‐Méijome, J. M., Hannibal, J., Hoseini-Yazdi, S. H., Read, S. A., Ellrich, J., & Schilling, T. (2024) · Bioelectronic Medicine · doi:10.1186/s42234-024-00159-0 · Cited by 13 · see citing works
Self-citation
Satb1 expression in retinal ganglion cells of marmosets, macaques, and humans
Nasir‐Ahmad, S., Vanstone, K. A., Novelli, M., Lee, S., Do, M. T. H., Martin, P. R., & Grünert, U. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25258 · Cited by 13 · see citing works
Chromatic pupillometry for evaluating melanopsin retinal ganglion cell function in Alzheimer’s disease and other neurodegenerative disorders: a review
Romagnoli, M., Amore, G., Avanzini, P., Carelli, V., & Morgia, C. L. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1295129 · Cited by 12 · see citing works
Retinal ganglion cells expressing CaM kinase II in human and nonhuman primates
Baldicano, A. K., Nasir‐Ahmad, S., Novelli, M., Lee, S. C. S., Do, M. T. H., Martin, P. R., & Grünert, U. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25292 · Cited by 12 · see citing works
Burning the candle at both ends: Intraretinal signaling of intrinsically photosensitive retinal ganglion cells
Raja, S., Milosavljevic, N., Allen, A. E., & Cameron, M. A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1095787 · Cited by 13 · see citing works
Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures
Nagare, R., Rea, M. S., & Figueiro, M. G. (2021) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2021.100071 · Cited by 12 · see citing works
Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects
Kubota, N., Tamori, Y., Baba, K., & Yamanaka, Y. (2022) · Sleep and Biological Rhythms · doi:10.1007/s41105-021-00360-7 · Cited by 10 · see citing works
Retina and melanopsin neurons
Morgia, C. L., Carelli, V., & Sadun, A. A. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00020-0 · Cited by 10 · see citing works
Melanopsin retinal ganglion cell function in Alzheimer's vs. Parkinson's disease an exploratory meta-analysis and review of pupillometry protocols
Steiner, O. L., & de Zeeuw, J. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.106063 · Cited by 9 · see citing works
Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling
Hannibal, J., Bisgaard, T. H., Georg, B., & Fahrenkrug, J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14482 · Cited by 9 · see citing works
Self-citation
Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids
Sharma, K., Habibey, R., Ribeiro, M. M., Cui, B., Siwicki, R. A., Striebel, J., Pawlick, J. S., Zorn, J., Utz, L., Renner, M., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2025.12.013 · Cited by 10 · see citing works
Pupillary response to chromatic light stimuli as a possible biomarker at the early stage of glaucoma: a review
Arévalo-López, C., Gleitze, S., Madariaga, S., & Plaza-Rosales, I. (2022) · International Ophthalmology · doi:10.1007/s10792-022-02381-8 · Cited by 8 · see citing works
Assessing the Effects of Polychromatic Light Exposure on Mood in Adults: A Systematic Review Contrasting α-opic Equivalent Daylight Illuminances
Nixon, A., Robillard, R., Leveille, C., Douglass, A. B., Porteous, M., & Veitch, J. A. (2023) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2023.2219017 · Cited by 8 · see citing works
Perfect appearance match between self-luminous and surface colors can be performed with isomeric spectra
Kagimoto, A., & Okajima, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-75510-x · Cited by 8 · see citing works
Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas—A comparative study
Christiansen, A. T., Kiilgaard, J. F., Klemp, K., Woldbye, D. P. D., & Hannibal, J. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24455 · Cited by 8 · see citing works
Self-citation
Differential diagnosis and theories of pathophysiology of post-traumatic photophobia: A review
Theis, J. (2022) · Neurorehabilitation · doi:10.3233/nre-228014 · Cited by 7 · see citing works
Brain functional MRI responses to blue light stimulation in Leber’s hereditary optic neuropathy
Evangelisti, S., Morgia, C. L., Testa, C. M., Manners, D. N., Brizi, L., Bianchini, C., Carbonelli, M., Barboni, P., Sadun, A. A., Tonon, C., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114488 · Cited by 7 · see citing works
Photosensitive ganglion cells: A diminutive, yet essential population
Vidal‐Villegas, B., Gallego‐Ortega, A., de Imperial‐Ollero, J. A. M., de la Casa, J. M. M., Feijoo, J. G., & Vidal‐Sanz, M. (2020) · Archivos de la Sociedad Española de Oftalmología (English Edition) · doi:10.1016/j.oftale.2020.06.020 · Cited by 7 · see citing works
Method to Quickly Map Multifocal Pupillary Response Fields (mPRF) Using Frequency Tagging
Lorenceau, J., Ajasse, S., Barbet, R., Boucart, M., Chavane, F., Lamirel, C., Legras, R., Matonti, F., Rateaux, M., Rouland, J., et al. (2024) · Vision · doi:10.3390/vision8020017 · Cited by 6 · see citing works

Localization of melanopsin-immunoreactive cells in the Mongolian gerbil retina
Jeong, M., & Jeon, C. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.06.002 · Cited by 11 · see citing works
Diverse types of ganglion cell photoreceptors in the mammalian retina
Sand, A., Schmidt, T. M., & Kofuji, P. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.03.003 · Cited by 94 · see citing works
Two types of melanopsin retinal ganglion cell differentially innervate the hypothalamic suprachiasmatic nucleus and the olivary pretectal nucleus
Baver, S. B., Pickard, G. E., Sollars, P. J., & Pickard, G. E. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06149.x · Cited by 312 · see citing works
Melanopsin‐Expressing Intrinsically Photosensitive Retinal Ganglion Cells in Retinal Disease
Feigl, B., & Zele, A. J. (2014) · Optometry and Vision Science · doi:10.1097/opx.0000000000000284 · Cited by 117 · see citing works
Melanopsin‐expressing ganglion cells on macaque and human retinas form two morphologically distinct populations
Liao, H., Ren, X., Peterson, B. B., MARSHAK, D. W., Yau, K., Gamlin, P. D., & Dacey, D. M. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23995 · Cited by 153 · see citing works

Authors: Hannibal, J., Christiansen, A. T., Heegaard, S., Fahrenkrug, J., & Kiilgaard, J. F.
Affiliations: University of Copenhagen (DK)
Corresponding author: Hannibal, Jens
ORCID: Hannibal, Jens
Christiansen, Anders Tolstrup
Heegaard, Steffen
Kiilgaard, Jens Folke
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2017-03-10
Volume: 525
Issue: 8
Pages: 1934-1961
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.24181
OpenAlex: W2583910918
Cited by: 169
References: 82
Citations by year: 2026: 15 · 2025: 7 · 2024: 18 · 2023: 18 · 2022: 22 · 2021: 30 · 2020: 13 · 2019: 20 · 2018: 15 · 2017: 11
FWCI: 9.87
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords: intrinsically photosensitive retinal ganglion cells, melanopsin, human retina, inner plexiform layer, AII amacrine cells, rod bipolar cells, ribbon synapses, dopaminergic amacrine cells, circadian photoreception
MeSH terms: Melanopsin, Aged, Aged, 80 and over, Female, Humans, Immunohistochemistry, Male, Middle Aged, Retinal Ganglion Cells, Rod Opsins, Microscopy, Confocal, Imaging, Three-Dimensional

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks