Neuronal migration and its disorders affecting the CA3 region
Open accessAbstract
In this review, we focus on CA3 neuronal migration disorders in the rodent. We begin by introducing the main steps of hippocampal development, and we summarize characteristic hippocampal malformations in human. We then describe various mouse mutants showing structural hippocampal defects. Notably, genes identified in human cortical neuronal migration disorders consistently give rise to a CA3 phenotype when mutated in the mouse. We successively describe their molecular, physiological and behavioral phenotypes that together contribute to a better understanding of CA3-dependent functions. We finally discuss potential factors underlying the CA3 vulnerability revealed by these mouse mutants and that may also contribute to other human neurological and psychiatric disorders.
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The CA3 field of the hippocampus has been implicated as one of the first sites of neuronal dysfunction and neuronal death in Alzheimer's disease.
“This region has been implicated as one of the first sites of neuronal dysfunction and neuronal death in AD (Belvindrah et al., 2014; Padurariu et al., 2012; Zhang et al., 2013).”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Belvindrah et al., 2014
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Neuronal migration disorders: Focus on the cytoskeleton and epilepsy
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Roy, B., Wang, Q., & Dwivedi, Y. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy010 · Cited by 38 · see citing works
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny
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Exposure to homocysteine leads to cell cycle damage and reactive gliosis in the developing brain
Cecchini, M. S., Bourckhardt, G. F., Jaramillo, M. L., Ammar, D., Müller, Y. M. R., & Nazari, E. M. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.05.054 · Cited by 14 · see citing works
Early born neurons are abnormally positioned in the doublecortin knockout hippocampus
Khalaf‐Nazzal, R., Stouffer, M. A., Olaso, R., Mureşan, L., Roumegous, A., Lavilla, V., Carpentier, W., Moutkine, I., Dumont, S., Albaud, B., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw370 · Cited by 12 · see citing works
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Seizure outcome in drug-resistant epilepsy in the setting of polymicrogyria
Aung, T., Jin, B., Bingaman, W. E., Najm, I., Alexopoulos, A. V., & Bulacio, J. C. (2024) · Seizure · doi:10.1016/j.seizure.2024.08.016 · Cited by 5 · see citing works
The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it?
(2015) · Frontiers research topics · doi:10.3389/978-2-88919-631-9 · Cited by 2 · see citing works
Sex and Age Differences in Apoptosis in the Developing Mouse Hippocampus and Cerebral Cortex
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- Authors
- Belvindrah, R., Nosten-Bertrand, M., & Francis, F.
- Affiliations
- Inserm (FR)
- Corresponding author
- Francis, Fiona
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-03-04
- Volume
- 8
- Pages
- 63-63
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3941003
- OpenAlex
- W2060532411
- Cited by
- 18
- References
- 188
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-08-MNP-013)
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Fondation Bettencourt Schueller
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- neuronal migration disorders, CA3 region, hippocampal development, mouse mutants
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