Hair cell innervation by spiral ganglion neurons in the mouse

Berglund, A. M.; Ryugo, D. K.

doi:10.1002/cne.902550408

Cited by 172Hearing, Cochlea, Tinnitus, GeneticsVestibular and auditory disordersHearing Loss and Rehabilitation

Hair cell innervation by spiral ganglion neurons in the mouse

Berglund, A. M., Ryugo, D. K.·1987·Journal of Comparative Neurology

DOI 10.1002/cne.902550408

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Abstract

Horseradish peroxidase (HRP) was injected extracellularly into the auditory nerve of adult mice so that the enzyme could infuse individual spiral ganglion neurons. Forty-two well-stained neurons were reconstructed through serial sections from their cell bodies to peripheral terminations in the organ of Corti with the aid of a light microscope and drawing tube. No neuron was observed to innervate both inner and outer hair cells (IHCs and OHCs). Previous observations from neonatal mammals that reported that IHCs and OHCs were innervated by the same neuron are thus presumed to describe a transient developmental phenomenon. Two populations of spiral ganglion neurons were determined on the basis of the differences in receptor innervation. The type I neurons innervated exclusively IHCs by way of thick (1-2 microns) radial fibers, whereas the type II neurons innervated only OHCs by way of thin (approximately 0.5 micron) outer spiral fibers. Certain features of the peripheral process in the vicinity of the cell body were highly correlated with fiber type. This pattern of separate innervation of IHCs and OHCs by type I and type II neurons, respectively, may represent the general plan of afferent organization for the adult mammalian cochlea.

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Type II cochlear afferents have small caliber, unmyelinated processes that extend hundreds of microns toward the cochlear base, contacting dozens of outer hair cells enroute.
“Type II cochlear afferents have small caliber, unmyelinated processes that extend hundreds of microns toward the cochlear base, contacting dozens of outer hair cells enroute (27–29).”
From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [28]

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Authors: Berglund, A. M., & Ryugo, D. K.
Affiliations: Massachusetts Eye and Ear Infirmary (US)
ORCID: Ryugo, D. K.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1987-01-22
Volume: 255
Issue: 4
Pages: 560-570
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.902550408
OpenAlex: W2119585553
Cited by: 172
References: 34
Citations by year: 2026: 6 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 3 · 2018: 7 · 2016: 7 · 2015: 10 · 2014: 3 · 2013: 1 · 2012: 9
FWCI: 3.33
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6470 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM-07258)
National Institute of Neurological Disorders and Stroke (NS 20156, NS 13126)
Topics: Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
Keywords: spiral ganglion neurons, inner hair cells, outer hair cells, auditory nerve, radial fibers, hair cell innervation, mouse cochlea
MeSH terms: Animals, Ganglia, Hair Cells, Auditory, Male, Medical Illustration, Mice, Inbred Strains, Neurons, Mice

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Hair cell innervation by spiral ganglion neurons in the mouse

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