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Genomics and Genetics in the Biology of Adaptation to Exercise
Abstract
This article is devoted to the role of genetic variation and gene‐exercise interactions in the biology of adaptation to exercise. There is evidence from genetic epidemiology research that DNA sequence differences contribute to human variation in physical activity level, cardiorespiratory fitness in the untrained state, cardiovascular and metabolic response to acute exercise, and responsiveness to regular exercise. Methodological and technological advances have made it possible to undertake the molecular dissection of the genetic component of complex, multifactorial traits, such as those of interest to exercise biology, in terms of tissue expression profile, genes, and allelic variants. The evidence from animal models and human studies is considered. Data on candidate genes, genome‐wide linkage results, genome‐wide association findings, expression arrays, and combinations of these approaches are reviewed. Combining transcriptomic and genomic technologies has been shown to be more powerful as evidenced by the development of a recent molecular predictor of the ability to increase o 2 max with exercise training. For exercise as a behavior and physiological fitness as a state to be major players in public health policies will require that the role of human individuality and the influence of DNA sequence differences be understood. Likewise, progress in the use of exercise in therapeutic medicine will depend to a large extent on our ability to identify the favorable responders for given physiological properties to a given exercise regimen. © 2011 American Physiological Society. Compr Physiol 1:1603‐1648, 2011.
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“This is since the internal load borne by an individual athlete corresponding to a specific stimulus will vary depending on the specific contextual factors of their internal environment, such as achieving sufficient sleep and energy balance, along with the nature of the sport [152,156,157,158,159], thus highlighting the importance of both sleep and nutrition in facilitating recovery to minimise an”
From Sleep, Nutrition, and Injury Risk in Adolescent Athletes: A Narrative Review (2023) · cites this paper as [157]
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- Bouchard, C., Rankinen, T., & Timmons, J. A.
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2011-07
- Pages
- 1603-1648
- Cited by
- 136
- References
- 79
- Language
- en
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
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