Cited by 136

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Genomics and Genetics in the Biology of Adaptation to Exercise

Bouchard, Claude, Rankinen, Tuomo, Timmons, James A.·2011·Comprehensive Physiology

Open this paper in CoChat — free account

Abstract

This article is devoted to the role of genetic variation and gene‐exercise interactions in the biology of adaptation to exercise. There is evidence from genetic epidemiology research that DNA sequence differences contribute to human variation in physical activity level, cardiorespiratory fitness in the untrained state, cardiovascular and metabolic response to acute exercise, and responsiveness to regular exercise. Methodological and technological advances have made it possible to undertake the molecular dissection of the genetic component of complex, multifactorial traits, such as those of interest to exercise biology, in terms of tissue expression profile, genes, and allelic variants. The evidence from animal models and human studies is considered. Data on candidate genes, genome‐wide linkage results, genome‐wide association findings, expression arrays, and combinations of these approaches are reviewed. Combining transcriptomic and genomic technologies has been shown to be more powerful as evidenced by the development of a recent molecular predictor of the ability to increase o 2 max with exercise training. For exercise as a behavior and physiological fitness as a state to be major players in public health policies will require that the role of human individuality and the influence of DNA sequence differences be understood. Likewise, progress in the use of exercise in therapeutic medicine will depend to a large extent on our ability to identify the favorable responders for given physiological properties to a given exercise regimen. © 2011 American Physiological Society. Compr Physiol 1:1603‐1648, 2011.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/cphy.c100059

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 1×
“For example, lifestyle interventions (including physical activity) undoubtedly prevent or delay the development of type 2 diabetes in subjects with impaired glucose tolerance (151, 348).”
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
A genome-wide association study identifies novel risk loci for type 2 diabetes
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287
Listening to silence and understanding nonsense: exonic mutations that affect splicing
Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics · doi:10.1038/nrg775 · Cited by 2,209
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194
Exome sequencing identifies the cause of a mendelian disorder
Ng, S. B., Buckingham, K. J., Lee, C., Bigham, A. W., Tabor, H. K., Dent, K. M., Huff, C. D., Shannon, P. T., Jabs, E. W., Nickerson, D. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.499 · Cited by 1,957
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900
Structural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · cited 1×
“So far, CNVs have been reported to be associated with developmental and neuropsychiatric disorders (188, 199, 366), while their contribution to more common diseases is still unclear (66).”
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
Yi, X., Liang, Y., Huerta-Sanchez, E., Jin, X., Cuo, Z. X. P., Pool, J. E., Xu, X., Jiang, H., Vinckenbosch, N., Korneliussen, T. S., et al. (2010) · Science · doi:10.1126/science.1190371 · Cited by 1,611 · cited 1×
“Exome sequencing has been used successfully to identify causal mutations for rare Mendelian diseases [e.g., (217, 272)], as well as genes contributing to adaptation to high altitude (384).”
Effects of the amount and intensity of exercise on plasma lipoproteins
Kraus, W. E., Houmard, J. A., Duscha, B. D., Knetzger, K. J., Wharton, M. B., McCartney, J. S., Bales, C. W., Henes, S., Samsa, G. P., Otvos, J. D., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020194 · Cited by 1,554
Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399
Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans
Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142109 · Cited by 1,257
A General Test of Association for Quantitative Traits in Nuclear Families
Abecasis, G. R., Cardon, L. R., & Cookson, W. O. C. (2000) · The American Journal of Human Genetics · doi:10.1086/302698 · Cited by 1,126 · cited 1×
“The TDT models were later extended to families with multiple offspring and to quantitative traits (1, 254).”
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083
Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
Gibala, M. J., Little, J. P., Van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., Raha, S., & Tarnopolsky, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112094 · Cited by 1,082
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson, V., Ghosh, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2043 · Cited by 1,072
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896
Familial aggregation ofV˙ o 2 max response to exercise training: results from the HERITAGE Family Study
Bouchard, C., An, P., Rice, T., Skinner, J. S., Wilmore, J. H., Gagnon, J., Pérusse, L., Leon, A. S., & Rao, D. C. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.1003 · Cited by 875
Self-citation
Rare Variants Create Synthetic Genome-Wide Associations
Dickson, S. P., Wang, K., Krantz, I., Hakonarson, H., & Goldstein, D. B. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000294 · Cited by 857
A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs
Mosher, D. S., Quignon, P., Bustamante, C. D., Sutter, N. B., Mellersh, C. S., Parker, H. G., & Ostrander, E. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030079 · Cited by 826
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium (2010) · Nature · doi:10.1038/nature08979 · Cited by 807
Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes
Mefford, H. C., Sharp, A. J., Baker, C., Itsara, A., Jiang, Z., Buysse, K., Huang, S., Maloney, V. K., Crolla, J. A., Baralle, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805384 · Cited by 804
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine · doi:10.1038/78693 · Cited by 743
Metabolic Adaptations to Short-term High-Intensity Interval Training: A Little Pain for a Lot of Gain?
Gibala, M. J., & McGee, S. L. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318168ec1f · Cited by 682
Modeling the Heart--from Genes to Cells to the Whole Organ
Noble, D. (2002) · Science · doi:10.1126/science.1069881 · Cited by 622
Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes
Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F. P., & Dela, F. (2004) · Diabetes · doi:10.2337/diabetes.53.2.294 · Cited by 615 · cited 2×
“Indeed, strength training appears effective at reversing muscle insulin resistance in type 2 diabetes patients, inducing molecular changes common to those observed with endurance exercise (124).”
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.
Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611
Fitness versus physical activity patterns in predicting mortality in men
Myers, J., Kaykha, A., George, S., Abella, J., Zaheer, N., Lear, S., Yamazaki, T., & Froelicher, V. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.06.047 · Cited by 521
Human variation in skeletal muscle fiber-type proportion and enzyme activities
Simoneau, J. A., & Bouchard, C. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.4.e567 · Cited by 484
Self-citation
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Rung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proença, C., Bacot, F., Balkau, B., Belisle, A., Borch-Johnsen, K., et al. (2009) · Nature Genetics · doi:10.1038/ng.443 · Cited by 479
Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis
Drummond, M. J., Fry, C. S., Glynn, E. L., Dreyer, H. C., Dhanani, S., Timmerman, K. L., Volpi, E., & Rasmussen, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163816 · Cited by 439
Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis
Petrella, J. K., Kim, J.-S., Mayhew, D. L., Cross, J. M., & Bamman, M. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01215.2007 · Cited by 435
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
Gibala, M. J., McGee, S. L., Garnham, A. P., Howlett, K. F., Snow, R. J., & Hargreaves, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90880.2008 · Cited by 427
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., Carr, S. A., Thadhani, R., Gerszten, R. E., & Mootha, V. K. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.50 · Cited by 399
High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression
Davidsen, P. K., Gallagher, I. J., Hartman, J. W., Tarnopolsky, M. A., Dela, F., Helge, J. W., Timmons, J. A., & Phillips, S. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00901.2010 · Cited by 385
Self-citation
Exercise, MAPK, and NF-κB signaling in skeletal muscle
Kramer, H. F., & Goodyear, L. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00085.2007 · Cited by 375
Extremely short duration high intensity interval training substantially improves insulin action in young healthy males
Babraj, J. A., Vollaard, N. B., Keast, C., Guppy, F. M., Cottrell, G., & Timmons, J. A. (2009) · BMC Endocrine Disorders · doi:10.1186/1472-6823-9-3 · Cited by 374
Self-citation
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
Timmons, J. A., Knudsen, S., Rankinen, T., Koch, L. G., Sarzynski, M., Jensen, T., Keller, P., Scheele, C., Vollaard, N. B. J., Nielsen, S., et al. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01295.2009 · Cited by 358
Self-citation
Effects of Exercise Training on Glucose Homeostasis
Boulé, N. G., Weisnagel, S. J., Lakka, T. A., Tremblay, A., Bergman, R. N., Rankinen, T., Leon, A. S., Skinner, J. S., Wilmore, J. H., Rao, D. C., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.108 · Cited by 356
Self-citation
Exercise Training Amount and Intensity Effects on Metabolic Syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise)
Johnson, J. L., Slentz, C. A., Houmard, J. A., Samsa, G. P., Duscha, B. D., Aiken, L. B., McCartney, J. S., Tanner, C. J., & Kraus, W. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.07.027 · Cited by 347
Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans
Duggirala, R., Blangero, J., Almasy, L., Dyer, T. D., Williams, K. L., Leach, R. J., O'Connell, P., & Stern, M. P. (1999) · The American Journal of Human Genetics · doi:10.1086/302316 · Cited by 337
Acute IL-6 Treatment Increases Fatty Acid Turnover in Elderly Humans in Vivo and in Tissue Culture in Vitro
Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., & Pedersen, B. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2004 · Cited by 311
Angiogenic growth factor mRNA responses in muscle to a single bout of exercise
Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., & Wagner, P. D. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.355 · Cited by 302 · cited 1×
“Expression of the VEGF gene is increased at the mRNA level 4 h after a single bout of treadmill running in rats (46) in a manner that may be oxygen dependent.”
Exercise-induced histone modifications in human skeletal muscle
McGee, S. L., Fairlie, E., Garnham, A. P., & Hargreaves, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181065 · Cited by 296
Resistance exercise‐induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men
West, D. W. D., Kujbida, G. W., Moore, D. R., Atherton, P., Burd, N. A., Padzik, J. P., De Lisio, M., Tang, J. E., Parise, G., Rennie, M. J., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.177220 · Cited by 289
Significance of skeletal muscle oxidative enzyme enhancement with endurance training.
Gollnick, P. D., & Saltin, B. (1982) · Clinical Physiology · doi:10.1111/j.1475-097x.1982.tb00001.x · Cited by 277
Physiological activation of hypoxia inducible factor‐1 in human skeletal muscle
Ameln, H., Gustafsson, T., Sundberg, C. J., Okamoto, K., Jansson, E., Poellinger, L., & Makino, Y. (2005) · The FASEB Journal · doi:10.1096/fj.04-2304fje · Cited by 276
Effects of α‐AMPK knockout on exercise‐induced gene activation in mouse skeletal muscle
Jørgensen, S. B., Wojtaszewski, J. F. P., Viollet, B., Andreelli, F., Birk, J. B., Hellsten, Y., Schjerling, P., Vaulont, S., Neufer, P. D., Richter, E. A., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3144fje · Cited by 274
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
Keller, P., Vollaard, N. B. J., Gustafsson, T., Gallagher, I. J., Sundberg, C. J., Rankinen, T., Britton, S. L., Bouchard, C., Koch, L. G., & Timmons, J. A. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00634.2010 · Cited by 261
Self-citation
Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia
Longley, M. J., Clark, S., Yu Wai Man, C., Hudson, G., Durham, S. E., Taylor, R. W., Nightingale, S., Turnbull, D. M., Copeland, W. C., & Chinnery, P. F. (2006) · The American Journal of Human Genetics · doi:10.1086/504303 · Cited by 248
Ca2+–calmodulin‐dependent protein kinase expression and signalling in skeletal muscle during exercise
Rose, A. J., Kiens, B., & Richter, E. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.111757 · Cited by 247
Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling
Fujita, S., Rasmussen, B. B., Cadenas, J. G., Drummond, M. J., Glynn, E. L., Sattler, F. R., & Volpi, E. (2007) · Diabetes · doi:10.2337/db06-1566 · Cited by 224
Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans
Bamman, M. M., Petrella, J. K., Kim, J.-S., Mayhew, D. L., & Cross, J. M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00024.2007 · Cited by 216
Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans
Mayhew, D. L., Kim, J.-S., Cross, J. M., Ferrando, A. A., & Bamman, M. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91234.2008 · Cited by 215
Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.
Vollaard, N. B. J., Constantin-Teodosiu, D., Fredriksson, K., Rooyackers, O., Jansson, E., Greenhaff, P. L., Timmons, J. A., & Sundberg, C. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91453.2008 · Cited by 205 · cited 5×
“Somewhat in contrast to this, a single weekly bout of high-intensity exercise appears to reduce the risk of cardiovascular death, with no additional impact being noted for a higher volume of physical activity (379) (97, 363).”
InfluentialSelf-citation
Effects of Exercise Training Intensity on Pancreatic β-Cell Function
Slentz, C. A., Tanner, C. J., Bateman, L. A., Durheim, M. T., Huffman, K. M., Houmard, J. A., & Kraus, W. E. (2009) · Diabetes Care · doi:10.2337/dc09-0032 · Cited by 192
Sensitivity of maximal aerobic power to training is genotype-dependent
PRUD?? HOMME, D., BOUCHARD, C., LEBLANC, C., LANDRY, F., & FONTAINE, E. (1984) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198410000-00012 · Cited by 180
Self-citation
Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects
Hautala, A. J., Mäkikallio, T. H., Kiviniemi, A., Laukkanen, R. T., Nissilä, S., Huikuri, H. V., & Tulppo, M. P. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00202.2003 · Cited by 167 · cited 1×
“Similar heterogeneity in responsiveness to exercise training has been reported also in other populations (117, 154).”
Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032938 · Cited by 152
Responses of Maximal Aerobic Power and Capacity to Aerobic Training
Lortie, G., Simoneau, J., Hamel, P., Boulay, M., Landry, F., & Bouchard, C. (1984) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025911 · Cited by 141
Self-citation
Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans
Timmons, J. A., Jansson, E., Fischer, H., Gustafsson, T., Greenhaff, P. L., Ridden, J., Rachman, J., & Sundberg, C. J. (2005) · BMC Biology · doi:10.1186/1741-7007-3-19 · Cited by 135
Self-citation
Heredity and muscle adaptation to endurance training
HAMEL, P., SIMONEAU, J.-A., LORTIE, G., BOULAY, M. R., & BOUCHARD, C. (1986) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198612000-00015 · Cited by 116
Self-citation
Endurance training-induced changes in insulin sensitivity and gene expression
Teran-Garcia, M., Rankinen, T., Koza, R. A., Rao, D. C., & Bouchard, C. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00467.2004 · Cited by 116
Self-citation
Inheritance of Human Skeletal Muscle and Anaerobic Capacity Adaptation to High-Intensity Intermittent Training*
Simoneau, J., Lortie, G., Boulay, M., Marcotte, M., Thibault, M., & Bouchard, C. (1986) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025756 · Cited by 115
Self-citation
Global gene expression in skeletal muscle from well-trained strength and endurance athletes
STEPTO, N. K., COFFEY, V. G., CAREY, A. L., PONNAMPALAM, A. P., CANNY, B. J., POWELL, D., & HAWLEY, J. A. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31818c6be9 · Cited by 108
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
Mustelin, L., Pietiläinen, K. H., Rissanen, A., Sovijärvi, A. R., Piirilä, P., Naukkarinen, J., Peltonen, L., Kaprio, J., & Yki-Järvinen, H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00580.2007 · Cited by 85
Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes.
Timmons, J. A., Norrbom, J., Schéele, C., Thonberg, H., Wahlestedt, C., & Tesch, P. (2006) · Genomics · doi:10.1016/j.ygeno.2005.09.007 · Cited by 79
Runx1 is involved in primitive erythropoiesis in the mouse
Yokomizo, T., Hasegawa, K., Ishitobi, H., Osato, M., Ema, M., Ito, Y., Yamamoto, M., & Takahashi, S. (2008) · Blood · doi:10.1182/blood-2007-05-091637 · Cited by 78
Gene powered? Where to go from heritability (h2) in muscle strength and power
Beunen, G., & Thomis, M. (2004) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200410000-00005 · Cited by 34

Research works printed but not linked: 312

10.1186/ar2267 · DOI
10.1136/bjsm.2008.051540 · DOI
10.1109/TAC.1974.1100705 · DOI · Paper page
10.1074/jbc.M408862200 · DOI · Paper page
10.1016/S0065-2660(07)00408-7 · DOI
10.1055/s-2003-37200 · DOI
10.1055/s-2003-37200 · DOI
10.1055/s-2000-12983 · DOI
10.1002/1531-8249(199901)45:1<127::AID-ART20>3.0.CO;2-Y · DOI
10.1212/WNL.51.5.1444 · DOI
10.1056/NEJM199909303411404 · DOI · Paper page
10.1002/1531-8249(199906)45:6<820::AID-ANA22>3.0.CO;2-W · DOI
Annex BH, 1998, Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle, Am J Physiol, 274, H860‐H867
10.1152/physiolgenomics.00003.2008 · DOI
Astrand A, 2004, Mice lacking melanin‐concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity, Am J Physiol Regul Integr Comp Physiol, 287, R749‐R758, 10.1152/ajpregu.00134.2004 · DOI
10.1152/jappl.1998.85.2.530 · DOI
10.1007/s004240100628 · DOI
10.1123/pes.15.2.128 · DOI
10.1016/0002-8703(91)90021-9 · DOI
10.1249/00005768-199111000-00009 · DOI
10.1111/j.1742-4658.2005.04779.x · DOI
10.1006/mgme.1999.2938 · DOI
10.1152/physiolgenomics.00174.2006 · DOI
10.1016/j.mito.2009.01.006 · DOI
BouchardC.Human adaptability may have a genetic basis. In:LandryF editor.Health Risk Estimation Risk Reduction and Health Promotion: Proceedings of the 18th Annual Meeting of the Society of Prospective Medicine. Ottowa: Canadian Public Health Association 1983 p.463‐476.
Bouchard C, 1995, Individual differences in the response to regular exercise, Int J Obes Relat Metab Disord, 19, S5‐S8
10.1097/00005768-199802000-00013 · DOI · Paper page
Bouchard C, 1992, Genetics of aerobic and anaerobic performances, Exerc Sport Sci Rev, 20, 27
10.1002/9781444327335 · DOI
10.1249/00005768-198612000-00006 · DOI · Paper page
10.1080/03014468400007201 · DOI
Bouchard C, 1997, Genetics of Fitness and Physical Performance
10.1097/00005768-200106001-00013 · DOI · Paper page
Bouchard C, 2009, Olympic Textbook of Science in Sport, 181
10.1152/jappl.2000.88.2.551 · DOI
10.1139/y86-210 · DOI
10.1002/9780470694930.ch15 · DOI
10.1249/MSS.0b013e3181844179 · DOI · Paper page
10.1006/bbrc.1998.9211 · DOI
10.1002/mus.10429 · DOI
10.1152/japplphysiol.01095.2004 · DOI · Paper page
10.1038/oby.2006.184 · DOI
10.1152/japplphysiol.01231.2007 · DOI · Paper page
10.1111/j.1600-0404.1995.tb05845.x · DOI
10.1002/mus.10012 · DOI
10.1007/BF01065971 · DOI
10.1007/s00125-003-1063-2 · DOI
10.1152/japplphysiol.00015.2005 · DOI
10.1113/jphysiol.2002.024760 · DOI
10.1101/gad.12.16.2499 · DOI · Paper page
10.1017/S1368980008003583 · DOI
10.1073/pnas.0810339105 · DOI · Paper page
10.1152/japplphysiol.01139.2004 · DOI · Paper page
10.1002/ana.1095 · DOI
10.1038/76211 · DOI · Paper page
10.1152/physiolgenomics.90252.2008 · DOI
10.1136/jmg.2007.055277 · DOI
10.1249/MSS.0b013e3181a2f646 · DOI
10.1038/sj.ejhg.5201907 · DOI
10.1375/twin.10.6.812 · DOI
10.1007/s10654-006-9088-8 · DOI
10.1093/eurheartj/ehi737 · DOI
10.2337/diab.44.2.221 · DOI
10.1093/gerona/62.2.206 · DOI
10.1007/s00421-008-0763-1 · DOI
10.1055/s-0029-1220731 · DOI
10.1152/jappl.1991.70.1.357 · DOI · Paper page
10.2337/diabetes.53.7.1643 · DOI · Paper page
10.1097/00003677-200507000-00003 · DOI · Paper page
10.1007/s00125-008-0998-8 · DOI
10.1038/nature06067 · DOI · Paper page
10.1172/JCI36277 · DOI
10.1126/science.283.5400.397 · DOI · Paper page
10.1186/gm130 · DOI · Paper page
10.1097/00005768-200111000-00006 · DOI
10.1093/brain/awm054 · DOI · Paper page
10.2337/dc08-0494 · DOI
10.1152/jappl.1973.34.1.107 · DOI · Paper page
10.1152/japplphysiol.01527.2005 · DOI
10.1038/ng2119 · DOI · Paper page
10.1023/A:1025960300710 · DOI
10.1152/ajpendo.90411.2008 · DOI · Paper page
10.1086/513908 · DOI
10.1371/journal.pone.0005767 · DOI
10.2741/gustafss · DOI
Gustafsson T, 1999, Exercise‐induced expression of angiogenesis‐related transcription and growth factors in human skeletal muscle, Am J Physiol, 276, H679‐H685
10.1016/S0960-8966(99)00039-5 · DOI
10.1016/S0026-0495(99)90185-3 · DOI
10.1212/WNL.54.5.1188 · DOI
10.1086/301910 · DOI
Hao H, 1995, Segregation patterns of a novel mutation in the mitochondrial tRNA glutamic acid gene associated with myopathy and diabetes mellitus, Am J Hum Genet, 56, 1017
Hardie DG, 2008, AMPK: A key regulator of energy balance in the single cell and the whole organism, Int J Obes (Lond), 32, S7‐S12
10.1139/H09-023 · DOI · Paper page
10.1111/j.1651-2227.2004.tb02689.x · DOI
10.1152/japplphysiol.00809.2001 · DOI
10.1152/jappl.1988.65.5.2285 · DOI · Paper page
10.1096/fj.03-1259fje · DOI · Paper page
10.1152/ajpendo.00274.2004 · DOI
10.2337/diabetes.55.04.06.db05-0727 · DOI
10.1016/j.nmd.2005.09.005 · DOI
10.1152/japplphysiol.00707.2003 · DOI · Paper page
10.1152/japplphysiol.00556.2002 · DOI
10.1001/archneur.62.12.1920 · DOI
10.1139/h04-014 · DOI
10.1152/classicessays.00010.2004 · DOI
10.1016/j.ymgme.2005.06.002 · DOI
10.1111/j.1748-1716.2009.01979.x · DOI
10.1096/fj.03-1228fje · DOI · Paper page
10.1111/j.1469-7793.2000.00157.x · DOI
10.1212/WNL.55.5.644 · DOI
10.1016/S0960-8966(02)00072-X · DOI
10.1093/gerona/56.12.B497 · DOI
10.1097/00005768-200003000-00010 · DOI
10.1086/316900 · DOI
Keller P, 2005, Interleukin‐6 receptor expression in contracting human skeletal muscle: Regulating role of IL6, FASEB J, 19, 1181, 10.1096/fj.04-3278fje · DOI
10.1042/BST0351306 · DOI
10.1523/JNEUROSCI.18-09-03470.1998 · DOI · Paper page
10.1152/physiolgenomics.00028.2010 · DOI
10.1126/science.1109557 · DOI · Paper page
10.1152/jappl.1971.31.3.338 · DOI
Klissouras V, 1973, Adaptation to maximal effort: Genetics and age, J Appl Physiol, 35, 288, 10.1152/jappl.1973.35.2.288 · DOI
10.1113/jphysiol.2007.144709 · DOI
Koch LG, 1998, Heritability of treadmill running endurance in rats, Am J Physiol, 275, R1455‐1460
Kohrt WM, 1991, Effects of gender, age, and fitness level on response of VO2max to training in 60‐71 yr olds, J Appl Physiol, 71, 2004, 10.1152/jappl.1991.71.5.2004 · DOI · Paper page
10.1152/ajpregu.00861.2004 · DOI
10.1056/NEJMoa066691 · DOI
10.1073/pnas.86.22.8927 · DOI
Kriketos AD, 1996, Interrelationships between muscle morphology, insulin action, and adiposity, Am J Physiol, 270, R1332‐1339
10.1161/01.CIR.103.4.485 · DOI · Paper page
10.1016/S0960-8966(01)00244-9 · DOI
10.1038/35057062 · DOI · Paper page
10.1111/j.1600-0838.2009.00988.x · DOI
Leick L, 2008, PGC‐1alpha is not mandatory for exercise‐ and training‐induced adaptive gene responses in mouse skeletal muscle, Am J Physiol Endocrinol Metab, 294, E463‐474, 10.1152/ajpendo.00666.2007 · DOI
10.1016/S0026-0495(00)80018-9 · DOI · Paper page
10.1159/000153540 · DOI
10.1152/japplphysiol.00525.2010 · DOI
10.1152/japplphysiol.01328.2006 · DOI
10.1083/jcb.200408128 · DOI
10.1038/sj.ijo.0802869 · DOI
Lortie G, 1982, Familial similarity in aerobic power, Hum Biol, 54, 801
10.1055/s-2006-923862 · DOI
10.1152/ajpendo.90653.2008 · DOI
10.1016/0006-291X(90)92374-9 · DOI
Maes H, 1993, Kinanthropometry IV, 140
10.1097/00005768-199612000-00007 · DOI
10.1096/fj.04-3149fje · DOI · Paper page
10.1016/S0022-510X(02)00462-8 · DOI
10.1056/NEJMra0905980 · DOI · Paper page
10.1038/336348a0 · DOI · Paper page
10.1073/pnas.052706899 · DOI · Paper page
Martin MA, 2000, Identification of novel mutations in Spanish patients with muscle carnitine palmitoyltransferase II deficiency, Hum Mutat, 15, 579, 10.1002/1098-1004(200006)15:6<579::AID-HUMU14>3.0.CO;2-H · DOI
10.1371/journal.pgen.1000459 · DOI · Paper page
10.1093/hmg/ddl046 · DOI · Paper page
McArdle B, 1951, Myopathy due to a defect in muscle glycogen breakdown, Clin Sci, 10, 13
10.1007/s00421-009-1340-y · DOI
10.1113/expphysiol.2008.043075 · DOI
10.1016/j.nmd.2003.10.011 · DOI
10.1242/jeb.028886 · DOI
10.1055/s-2002-32374 · DOI
10.1161/01.CIR.96.3.741 · DOI · Paper page
Montoye HJ, 1978, Familial relationships in maximal oxygen uptake, Hum Biol, 50, 241
10.1016/S0022-3476(05)80485-8 · DOI · Paper page
10.1038/sj.ejhg.5201724 · DOI
10.1002/(SICI)1097-4598(200004)23:4<538::AID-MUS12>3.0.CO;2-T · DOI
10.1113/jphysiol.2009.174888 · DOI
10.1097/MCO.0b013e3283374d19 · DOI
10.1086/302927 · DOI
10.1016/j.nmd.2005.02.008 · DOI
10.1161/01.CIR.103.2.226 · DOI
Neale MC, 2002, Mx: Statistical Modeling
10.1038/sj.ejhg.5201438 · DOI · Paper page
10.1152/japplphysiol.91435.2008 · DOI
10.1152/japplphysiol.00765.2003 · DOI · Paper page
Norrbom J, Training response of mitochondrial transcription factors in human skeletal muscle, Acta Physiol (Oxf), 198, 71, 10.1111/j.1748-1716.2009.02030.x · DOI
10.1113/jphysiol.2008.164384 · DOI
10.1016/S0092-8674(00)80880-6 · DOI · Paper page
10.1006/abbi.1996.0089 · DOI
10.1126/science.277.5327.834 · DOI · Paper page
10.1371/journal.pgen.0040034 · DOI
10.1111/j.1469-7793.1998.889ba.x · DOI · Paper page
10.1002/1098-2272(200012)19:4<456::AID-GEPI15>3.0.CO;2-N · DOI
10.1093/hmg/ddi341 · DOI
Pantoja‐Martinez J, 2004, Myoadenylate deaminase deficiency in a child with myalgias induced by physical exercise, Rev Neurol, 39, 431
10.1055/s-2007-965339 · DOI
10.1079/PNS2004338 · DOI · Paper page
10.1159/000235695 · DOI
10.1097/00005768-200104000-00014 · DOI
Perusse L, 1988, Familial resemblance in lifestyle components: Results from the Canada Fitness Survey, Can J Public Health, 79, 201
Perusse L, 1988, Inter‐generation transmission of physical fitness in the Canadian population, Can J Sport Sci, 13, 8
10.1080/03014468700009241 · DOI
10.1093/oxfordjournals.aje.a115205 · DOI · Paper page
10.1007/BFb0036123 · DOI · Paper page
10.1038/oby.2006.96 · DOI
10.1210/jc.2005-2848 · DOI
10.1371/journal.pmed.0050051 · DOI · Paper page
Pietilainen KH, 2005, Acquired obesity is associated with increased liver fat, intra‐abdominal fat, and insulin resistance in young adult monozygotic twins, Am J Physiol Endocrinol Metab, 288, E768‐E774, 10.1152/ajpendo.00381.2004 · DOI
10.1371/journal.pone.0000218 · DOI · Paper page
10.1161/01.CIR.101.7.828 · DOI · Paper page
10.1172/JCI31960 · DOI · Paper page
10.1002/gepi.10208 · DOI

200 of 312 shown

Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152
Human Heat Adaptation
Taylor, N. A. S. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130022 · Cited by 331
Refuting the myth of non‐response to exercise training: ‘non‐responders’ do respond to higher dose of training
Montero, D., & Lundby, C. (2017) · The Journal of Physiology · doi:10.1113/jp273480 · Cited by 327
Molecular Networks of Human Muscle Adaptation to Exercise and Age
Phillips, B. E., Williams, J. P., Gustafsson, T., Bouchard, C., Rankinen, T., Knudsen, S., Smith, K., Timmons, J. A., & Atherton, P. J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003389 · Cited by 199
Self-citation
Do Non-Responders to Exercise Exist—and If So, What Should We Do About Them?
Pickering, C., & Kiely, J. (2019) · Sports Medicine · doi:10.1007/s40279-018-01041-1 · Cited by 165

See all 136

Authors: Bouchard, C., Rankinen, T., & Timmons, J. A.
Venue: Comprehensive Physiology
Publisher: Wiley
Published: 2011-07
Pages: 1603-1648
DOI: 10.1002/cphy.c100059
Cited by: 136
References: 79
Language: en
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Genomics and Genetics in the Biology of Adaptation to Exercise

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources