Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety
Abstract
BACKGROUND: Trait anxiety is considered a susceptible factor for stress-related disorders, and is characterized by abnormal brain activity and connectivity in the regions related to emotional processing (e.g., the amygdala). However, only a few studies have examined the static and dynamic changes of functional connectivity in trait anxiety. METHOD: We compared the resting-state static and dynamic functional connectivity (sFC/dFC) in individuals with high trait anxiety (HTA, n = 257) and low trait anxiety (LTA, n = 264) using bilateral amygdala subregions as the seeds, that is, the centromedial amygdala (CMA), basolateral amygdala (BLA), and superficial amygdala (SFA). RESULTS: The CMA, BLA, and SFA all showed reduced sFC with the executive control network (ECN) and anomalous dFC with the default mode network (DMN) in individuals with HTA. The CMA only showed reduced sFC with the ECN and reduced dFC with the DMN in individuals with HTA. The BLA showed reduced sFC with the salience network (mainly in the anterior and median cingulate), and increased dFC between the BLA and the DMN in individuals with HTA compared to those with LTA. Notably, HTA showed widespread anomalous functional connectivity in the SFA, including the visual network, mainly in the calcarine fissure, limbic system (olfactory cortex), and basal ganglia (putamen). CONCLUSION: The anomalous sFC and dFC in individuals with HTA may reflect altered mechanisms in prefrontal control, salient stimuli processing, and amygdaloidal responsivity to potential threats, leading to alterations in associative, attentional, interpretative, and regulating processes that sustain a threat-related processing bias in HTA individuals.
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The neural correlates of trait anxiety can predict pathological anxiety-driven behaviors.
“Ongoing research has shown that the neural correlates of trait anxiety can predict pathological anxiety-driven behaviors (32)”
From Anticipatory threat responses mediate the relationship between mindfulness and anxiety: A cross-sectional study (2022) · cites this paper as [32]
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Background
- Authors
- Wang, C., Wang, Y., Lau, W. K. W., Wei, X., Feng, X., Zhang, C., Liu, Y., Huang, R., & Zhang, R.
- Affiliations
- Southern Medical University (CN)
- Zhujiang Hospital (CN)
- Education University of Hong Kong (HK)
- Department of Radiology Guangzhou First Affiliated Hospital Guangzhou China
- South China Normal University (CN)
- Corresponding author
- Zhang, Ruibin
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2021-07-12
- Volume
- 38
- Issue
- 8
- Pages
- 860-873
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- OpenAlex
- W3181719997
- Cited by
- 31
- References
- 70
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 1
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- trait anxiety, amygdala subregions, centromedial amygdala, basolateral amygdala, superficial amygdala, dynamic functional connectivity, resting-state functional connectivity, default mode network, frontoparietal network, salience network, threat processing, stress-related disorders
- MeSH terms
- Amygdala, Anxiety, Anxiety Disorders, Brain Mapping, Humans, Magnetic Resonance Imaging, Neural Pathways
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