Identification of the Novel Synthetic Opioid N ‐Pyrrolidino Isotonitazene at an Australian Drug Checking Service

Curtis, Blake; Lawes, Douglas J.; Caldicott, David; McLeod, Malcolm D.

doi:10.1002/dta.3910

Cited by 19Forensic Toxicology and Drug AnalysisOpioid Use Disorder TreatmentHIV, Drug Use, Sexual Risk

Identification of the Novel Synthetic Opioid N ‐Pyrrolidino Isotonitazene at an Australian Drug Checking Service

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Curtis, Blake, Lawes, Douglas J., Caldicott, David, McLeod, Malcolm D.·2025·Drug Testing and Analysis

DOI 10.1002/dta.3910PMC PMC12489282

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Abstract

2‐Benzylbenzimidazole opioids and related derivatives, also known as ‘nitazenes’, present a growing threat to public health. Emerging in Europe in 2019, the nitazene group of drugs is a recent addition to the novel synthetic opioid class and has been associated internationally with adverse effects in drug users, overdose clusters and significant mortality. The high potency of many nitazene derivatives, which can in many cases exceed that of fentanyl, poses a significant challenge to the public health and early warning systems used to detect and respond to the emergence of new high‐risk substances. This report describes close collaboration between an Australian drug checking service and a nearby university laboratory to identify and characterise the novel synthetic opioid N ‐pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public. Though no prior publications are available describing the presence of this nitazene in the drug market, previously reported in vitro evaluation of this compound reveals it to be among the most potent nitazene opioid agonists known. The study highlights the rapid response possible though engaging drug users with drug checking services as a market monitor and early warning system to alert health services and the broader community to the presence of unexpected, high‐risk substances. Integration of well‐resourced and supported drug checking services provides a powerful approach to tackle the public health threats associated with novel synthetic opioids and other drugs of concern.

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Green, T. C., Park, J. N., Gilbert, M., McKenzie, M., Struth, E., Lucas, R., Clarke, W., & Sherman, S. G. (2020) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2020.102661 · Cited by 211 · see citing works
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Krotulski, A. J., Papsun, D. M., Kacinko, S. L., & Logan, B. K. (2020) · Journal of Analytical Toxicology · doi:10.1093/jat/bkaa016 · Cited by 146 · see citing works
DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles
Ujváry, I., Christie, R., Evans-Brown, M., Gallegos, A., Jorge, R., de Morais, J., & Sedefov, R. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00037 · Cited by 141 · see citing works
Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene
Blanckaert, P., Cannaert, A., Van Uytfanghe, K., Hulpia, F., Deconinck, E., Van Calenbergh, S., & Stove, C. (2020) · Drug Testing and Analysis · doi:10.1002/dta.2738 · Cited by 116 · see citing works
Acute Intoxications and Fatalities Associated With Benzimidazole Opioid (Nitazene Analog) Use: A Systematic Review
Montanari, E., Madeo, G., Pichini, S., Busardò, F. P., & Carlier, J. (2022) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000970 · Cited by 89 · see citing works
Will growth in cryptomarket drug buying increase the harms of illicit drugs?
Aldridge, J. A., Stevens, A., & Barratt, M. J. (2017) · Addiction · doi:10.1111/add.13899 · Cited by 87 · see citing works
Naloxone Use in Novel Potent Opioid and Fentanyl Overdoses in Emergency Department Patients
Amaducci, A., Aldy, K., Campleman, S. L., Li, S., Meyn, A., Abston, S., Culbreth, R. E., Krotulski, A., Logan, B., Wax, P., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.31264 · Cited by 84 · see citing works
Isotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland
Mueller, F., Bogdal, C., Pfeiffer, B., Andrello, L., Ceschi, A., Thomas, A., & Grata, E. (2021) · Forensic Science International · doi:10.1016/j.forsciint.2021.110686 · Cited by 82 · see citing works
A new quantitative drug checking technology for harm reduction: Pilot study in Vancouver, Canada using paper spray mass spectrometry
Borden, S. A., Saatchi, A., Vandergrift, G. W., Palaty, J., Lysyshyn, M., & Gill, C. G. (2021) · Drug and Alcohol Review · doi:10.1111/dar.13370 · Cited by 82 · see citing works
Old Drugs and New Challenges: A Narrative Review of Nitazenes
Pergolizzi Jr, J., Raffa, R., LeQuang, J. A. K., Breve, F., & Varrassi, G. (2023) · Cureus · doi:10.7759/cureus.40736 · Cited by 81 · see citing works
The Rise and Fall of Isotonitazene and Brorphine: Two Recent Stars in the Synthetic Opioid Firmament
Vandeputte, M. M., Krotulski, A. J., Papsun, D. M., Logan, B. K., & Stove, C. P. (2022) · Journal of Analytical Toxicology · doi:10.1093/jat/bkab082 · Cited by 71 · see citing works
Quantification of new psychoactive substances in Australian wastewater utilising direct injection liquid chromatography coupled to tandem mass spectrometry
Bade, R., Eaglesham, G. K., Shimko, K. M., & Mueller, J. F. (2022) · Talanta · doi:10.1016/j.talanta.2022.123767 · Cited by 63 · see citing works
Intoxications in an Australian Emergency Department Involving ‘Nitazene’ Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene)
Schumann, J. L., Syrjanen, R., Alford, K., Mashetty, S., Castle, J. W., Rotella, J., Maplesden, J., & Greene, S. L. (2023) · Journal of Analytical Toxicology · doi:10.1093/jat/bkac062 · Cited by 61 · see citing works
In vitro structure–activity relationships and forensic case series of emerging 2-benzylbenzimidazole ‘nitazene’ opioids
De Vrieze, L. M., Walton, S. E., Pottie, E., Papsun, D., Logan, B. K., Krotulski, A. J., Stove, C. P., & Vandeputte, M. M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03774-7 · Cited by 58 · see citing works
Mu-Opioid Receptor Selective Superagonists Produce Prolonged Respiratory Depression
Malcolm, N. J., Palkovic, B., Sprague, D. J., Calkins, M. M., Lanham, J. K., Halberstadt, A. L., Stucke, A. G., & McCorvy, J. D. (2023) · iScience · doi:10.1016/j.isci.2023.107121 · Cited by 53 · see citing works
Alkoxy chain length governs the potency of 2-benzylbenzimidazole ‘nitazene’ opioids associated with human overdose
Glatfelter, G. C., Vandeputte, M. M., Chen, L., Walther, D., Tsai, M.-H. M., Shi, L., Stove, C. P., & Baumann, M. H. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06451-2 · Cited by 52 · see citing works
Paper spray mass spectrometry: A new drug checking tool for harm reduction in the opioid overdose crisis
Vandergrift, G. W., & Gill, C. G. (2019) · Journal of Mass Spectrometry · doi:10.1002/jms.4431 · Cited by 51 · see citing works
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De Luca, M. A., Tocco, G., Mostallino, R., Laus, A., Caria, F., Musa, A., Pintori, N., Ucha, M., Poza, C., Ambrosio, E., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109263 · Cited by 48 · see citing works
Pharmacologic Characterization of Substituted Nitazenes at μ, κ, and Δ Opioid Receptors Suggests High Potential for Toxicity
Kozell, L. B., Eshleman, A. J., Wolfrum, K. M., Swanson, T. L., Bloom, S. H., Benware, S., Schmachtenberg, J. L., Schutzer, K. A., Schutzer, W. E., Janowsky, A., et al. (2024) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.002052 · Cited by 42 · see citing works
The Emerging Drugs Network of Australia: A toxicosurveillance system of illicit and emerging drugs in the emergency department
Smith, J. L., Soderstrom, J., Dawson, A. H., Alfred, S., Greene, S. L., Isoardi, K., McCutcheon, D., Oosthuizen, F. J., Ezard, N., Burcham, J., et al. (2021) · Emergency Medicine Australasia · doi:10.1111/1742-6723.13839 · Cited by 41 · see citing works
Analytical characterization of “etonitazepyne,” a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online
Blanckaert, P., Balcaen, M., Vanhee, C., Risseeuw, M., Canfyn, M., Desmedt, B., Van Calenbergh, S., & Deconinck, E. (2021) · Drug Testing and Analysis · doi:10.1002/dta.3113 · Cited by 39 · see citing works
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West, H., FitzGerald, J., Hopkins, K., Li, E., Clark, N. C., Tzanetis, S., Greene, S. L., & Reid, G. E. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00232 · Cited by 38 · see citing works
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Killoran, S., McNamara, S., Kavanagh, P., O'Brien, J., & Lakes, R. (2025) · Drug Testing and Analysis · doi:10.1002/dta.3707 · Cited by 34 · see citing works
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De Vrieze, L. M., Stove, C. P., & Vandeputte, M. M. (2024) · Harm Reduction Journal · doi:10.1186/s12954-024-01078-8 · Cited by 34 · cited 1× · see citing works
“[25, 26].”
Wastewater-Based Monitoring of the Nitazene Analogues: First Detection of Protonitazene in Wastewater
Bade, R., Nadarajan, D., Driver, E. M., Halden, R. U., Gerber, C., Krotulski, A., Hall, W., & Mueller, J. F. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170781 · Cited by 33 · see citing works
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Killeen, N., Lakes, R., Webster, M., Killoran, S., McNamara, S., Kavanagh, P., Eagleton, M., McCormack, S., Micheau, E., Moughty, A., et al. (2024) · Addiction · doi:10.1111/add.16525 · Cited by 22 · see citing works
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Trace residue identification, characterization, and longitudinal monitoring of the novel synthetic opioid β‐U10, from discarded drug paraphernalia
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Man, N., Sadaphale, V., Barratt, M. J., Bruno, R., Sutherland, R., & Peacock, A. (2024) · UNSWorks (University of New South Wales, Sydney, Australia) · doi:10.26190/unsworks/30235 · Cited by 6 · see citing works
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Authors: Curtis, B., Lawes, D. J., Caldicott, D., & McLeod, M. D.
Affiliations: Australian National University (AU)
Corresponding author: McLeod, Malcolm D.
ORCID: Curtis, Blake
Lawes, Douglas J.
Caldicott, David
McLeod, Malcolm D.
Venue: Drug Testing and Analysis
Publisher: Wiley
Published: 2025-05-19
Volume: 17
Issue: 10
Pages: 1996-2004
ISSN: 1942-7603 (ISSN-L)
1942-7611
DOI: 10.1002/dta.3910
PMC: PMC12489282
OpenAlex: W4410480035
Cited by: 19
References: 36
Citations by year: 2026: 11 · 2025: 8
FWCI: 9.65
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (vor)
Locations: Drug Testing and Analysis (publishedVersion, cc-by-nc)
ChemRxiv (acceptedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
ANU Open Research (Australian National University) (submittedVersion, cc-by-nc)
Funders: ACT Health
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Keywords: nitazenes, synthetic opioids, drug checking, opioid potency, early warning systems, opioid overdose
MeSH terms: Analgesics, Opioid, Australia, Humans, Pyrrolidines, Illicit Drugs, Substance Abuse Detection

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Identification of the Novel Synthetic Opioid N ‐Pyrrolidino Isotonitazene at an Australian Drug Checking Service

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