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Cited by 19Mangiferin and Mango ExtractsNatural Compound Pharmacology StudiesBioactive natural compounds

Therapeutic potential of mangiferin in cancer: Unveiling regulatory pathways, mechanisms of action, and bioavailability enhancements – An updated review

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Iqbal, Humaira, Inam‐Ur‐Raheem, Muhammad, Munir, Seemal, Rabail, Roshina, Kafeel, Sadia, Shahid, Arashi, Mousavi Khaneghah, Amin, Aadil, Rana Muhammad·2024·Food Science & Nutrition
DOI 10.1002/fsn3.3869PMC PMC10916574
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Abstract

Mangiferin (MGF) is a phenolic compound, which is a major source of MGF is the mango tree. MGF possesses some antioxidant, anti‐inflammatory, and cytoprotective properties, enabling it to play its role against various diseases such as diabetes, obesity, lung injuries, and cancer. The word “Cancer” depicts an uncontrolled and abnormal growth of cells. This review paper reveals MGF's therapeutic, curative and protective potential impact against lung, liver, ovarian, prostate, breast, stomach, and oral cancers. MGF is used in various types of research in the form of powder, liquid extract, intramuscular, intravenous, nanoparticles coated with gold, in the form of a solution, or in combination with other drugs to evaluate synergistic effects. Many studies showed that MGF is safe to use but has less bioavailability in the body and 0.111 mg/mL solubility in water. However, certain studies indicated that its bioavailability and retention time increased when taken in the form of nanoparticles and in combination with other drugs. MGF also increases the sensitivity of other drugs (i.e., cisplatin) resistant to tumors. MGF has different mechanisms of action for different cancers. It mainly targets enzymes, interleukins, tumor growth factors, signaling pathways, apoptotic proteins, and genes to inhibit the growth of tumors, volume, angiogenesis, cellular functionality, further progression, and movement to other areas of the body. Moreover, MGF increases apoptosis and body weight with no or fewer side effects on normal cells. MGF unveiled a novel gate toward the treatment of cancer. Further research and human trials are needed in this regard.

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Crossref · 10.1002/fsn3.3869

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107 of 107 references verified0 citation errors · 0 not checkable

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  • MGF's anticancer mechanisms include induction of cell cycle arrest, promotion of apoptosis, inhibition of tumor invasion and metastasis, modulation of immune responses, and enhancement of radiosensitivity in glioblastoma.

    “These include the induction of cell cycle arrest, the promotion of apoptosis through various intracellular pathways, the inhibition of tumor invasion and metastasis, the modulation of immune responses, and the enhancement of radiosensitivity in cancer such as glioblastoma (GBM) (36,37).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [36]

    The Introduction and Mechanism of Action sections describe cell-cycle arrest, apoptosis, reduced tumor invasion or migration, and immune modulation. The reviewed studies are in cells and animals, and the passages found on radiation and treatment sensitivity do not report enhanced radiosensitivity in glioblastoma. That part of the claim is unsupported by our copy (page numbers unavailable). (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • By sensitizing tumor cells to radiation-induced DNA damage, MGF improves therapeutic outcomes without necessitating an increase in radiation dose.

    “By sensitizing tumor cells to radiation-induced DNA damage, MGF improves therapeutic outcomes without necessitating an increase in radiation dose (36).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [36]

    The Mechanism of Action section (page unavailable) reports that MGF may cause ROS-mediated DNA damage and inhibit cancer-cell growth. The review does not link that damage to radiation or report improved radiotherapy outcomes at an unchanged radiation dose; its discussion of treatment sensitization concerns chemotherapy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • MGF exerts protective effects across a broad spectrum of pathological conditions, including inflammatory, neurodegenerative, ocular, renal, cardiovascular, dermatological and infectious diseases.

    “In addition to its well-characterized roles in diabetes and cancer, MGF exerts protective effects across a broad spectrum of pathological conditions. These include inflammatory, neurodegenerative, ocular, renal, cardiovascular, dermatological and infectious diseases (7,36,106,115-118).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [36]

    The Introduction (page unavailable) describes anti-inflammatory, neuroprotective and cardioprotective potential, and says MGF protected mice against infection. It also mentions photoprotection, but does not establish protection against dermatological disease. The passages do not support the claimed ocular or renal protection. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • MGF exerts potent anticancer activity through multiple mechanisms that target key cellular processes underlying tumor initiation and progression.

    “MGF exerts potent anticancer activity through multiple mechanisms that target key cellular processes underlying tumor initiation and progression.”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [36]

  • MGF selectively inhibits the nonhomologous end joining pathway, a major DNA repair mechanism in GBM cells, thereby impairing DNA repair following radiation and enhancing radiotherapeutic efficacy.

    “Notably, MGF selectively inhibits the nonhomologous end joining pathway, a major DNA repair mechanism in GBM cells, thereby impairing DNA repair following radiation and enhancing radiotherapeutic efficacy.”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [36]

    The Mechanism of Action section (page unavailable) says MGF-induced ROS may damage cancer-cell DNA, but it does not discuss inhibition of DNA repair. A separate section mentions a glioblastoma cell line in nanoparticle assays. Searches for nonhomologous end joining, GBM DNA repair, radiation, and radiosensitization found no passage supporting the claimed mechanism or radiotherapeutic benefit. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

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Cites

2 retracted

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2 of the 109 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Elsayed, A., Elkomy, A., Alkafafy, M., Elkammar, R., Fadl, S. E., Abdelhiee, E. Y., Abdeen, A., Youssef, G., Shaheen, H., Soliman, A., & Aboubakr, M. (2022). Ameliorating effect of lycopene and N‐acetylcysteine against cisplatin‐induced cardiac injury in rats. Pakistan Veterinary Journal, 42, 107– 111.
  2. Othman, S. N. N., & Seka, M. (2019). In‐vitro antioxidant and cytotoxic activities of silver nanoparticles of mangiferin isolated from Mangifera indica. Journal of Global Pharma Technology, 11(6), 10– 15.
  3. Rehman, T. U., El‐Mansi, A. A., Sadeq, K. A., Laila, A. A., Zohaib, S., Muhammad, A., Muhammad, R., Ahmad, B. Z., & Arfan, Z. M. (2023). Antiparasitic activity of methanolic and ethyl acetate extracts of Azadirachta indica against Haemonchus contortus. Pakistan Veterinary Journal, 43(1), 199– 203.

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Authors
Iqbal, H., Inam‐Ur‐Raheem, M., Munir, S., Rabail, R., Kafeel, S., Shahid, A., Mousavi Khaneghah, A., & Aadil, R. M.
Affiliations
  • University of Agriculture Faisalabad (PK)
  • Department of Fruit and Vegetable Product Technology Prof. Wacław Dąbrowski Institute of Agricultural and Food Biotechnology – State Research Institute Warsaw Poland
Corresponding author
  • Inam‐Ur‐Raheem, Muhammad
  • Aadil, Rana Muhammad
ORCID
Venue
Food Science & Nutrition
Publisher
Wiley
Published
2023-12-20
Volume
12
Issue
3
Pages
1413-1429
ISSN
2048-7177 (ISSN-L)
DOI
10.1002/fsn3.3869
PMC
PMC10916574
OpenAlex
W4392506424
Cited by
19
References
109
Citations by year
2026: 7 · 2025: 8 · 2024: 3 · 2023: 1
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Food Science & Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
mangiferin, mango, anticancer activity, bioavailability enhancement, nanoparticles, drug resistance, cisplatin resistance, apoptosis, angiogenesis, signaling pathways, oral cancer, breast cancer, lung cancer, liver cancer, ovarian cancer, prostate cancer, gastric cancer, synergistic drug combination, antioxidant and anti-inflammatory effects

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