The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Comparison of polarization properties of human adult microglia and blood‐derived macrophages
Open accessAbstract
Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood‐derived macrophages participate in inflammatory responses in the CNS. Macrophages can be polarized into M1 and M2 phenotypes, which have been linked to functional properties including production of inflammation association molecules and phagocytic activity. We compare phenotypic and functional properties of microglia derived from the adult human CNS with macrophages derived from peripheral blood monocytes in response to M1 and M2 polarizing conditions. Under M1 conditions, microglia and macrophages upregulate expression of CCR7 and CD80. M2 treatment of microglia‐induced expression of CD209 but not additional markers CD23, CD163, and CD206 expressed by M2 macrophages. M1‐polarizing conditions induced production of IL‐12p40 by both microglia and macrophages; microglia produced higher levels of IL‐10 under M1 conditions than did macrophages. Under M2 conditions, microglia ± LPS produced comparable levels of IL‐10 under M1 conditions whereas IL‐10 was induced by LPS in M2 macrophages. Myelin phagocytosis was greater in microglia than macrophages under all conditions; for both cell types, activity was higher for M2 cells. Our findings delineate distinctive properties of microglia compared with exogenous myeloid cells in response to signals derived from an inflammatory environment in the CNS. © 2012 Wiley Periodicals, Inc.
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The chemokine system in diverse forms of macrophage activation and polarization
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1
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Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
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Type II monocytes modulate T cell–mediated central nervous system autoimmune disease
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Cited by
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Self-citationMicroglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762
Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748
Microglial and macrophage polarization—new prospects for brain repair
Hu, X., Leak, R. K., Shi, Y., Suenaga, J., Gao, Y., Zheng, P., & Chen, J. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.207 · Cited by 1,366
Metadata
- Authors
- Durafourt, B. A., Moore, C. S., Zammit, D. A., Johnson, T. A., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2012-01-30
- Volume
- 60
- Issue
- 5
- Pages
- 717-727
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2095444837
- Cited by
- 477
- References
- 12
- FWCI
- 18.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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