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Cited by 280

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Bone marrow derived elements and resident microglia in brain inflammation

Lassmann, Hans, Schmied, Mascha, Vass, Karl, Hickey, William F.·1993·Glia
DOI 10.1002/glia.440070106
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Abstract

Infection of the central nervous (CNS) system by the human immunodeficiency virus (HIV) depends on the migration of infected hematogenous cells into the brain. We thus used quantitative light and electron microscopic immunocytochemistry to study the homing and turnover of bone marrow derived cells in the CNS in radiation bone marrow chimeras under normal conditions and in experimental autoimmune encephalomyelitis (EAE) as an experimental model of brain inflammation. Our studies suggest the following conclusions. First, the central nervous system is continuously patrolled by a small number of T‐lymphocytes and monocytes. Meningeal and perivascular monocytes are slowly replaced by hematogenous cells under normal conditions, and this turnover is accelerated in the course of inflammation. In contrast, resident microglia represent a very stable cell pool, which in adult animals is only exceptionally replaced by hematogenous cells, even after recovery from severe brain inflammation. Second, although in bone‐marrow‐chimeric animals resident microglia, astrocytes, and ependymal cells are not able to present antigen to Lewis T‐lymphocytes, the inflammatory reaction in EAE is qualitatively and quantitatively similar in these animals compared to fully histocompatible Lewis rats. Finally, resident microglia express the macrophage activation antigen ED1. Thus, microglia cells appear to function as effector cells in EAE lesions.

Overview

Integrity signals

Registry

Crossref · 10.1002/glia.440070106

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

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Claims other papers make about this one

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Citations

Cites

Research works printed but not linked: 1

  1. Matsumoto Y., 1991, Proc. XI Int Congr Neuropath, 288

Cited by

See all 280

Metadata

Authors
Lassmann, H., Schmied, M., Vass, K., & Hickey, W. F.
Venue
Glia
Publisher
Wiley
Published
1993-01
Volume
7
Issue
1
Pages
19-24
ISSN
  • 0894-1491
  • 1098-1136
DOI
10.1002/glia.440070106
Cited by
280
References
38
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4302 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.