Resilience predicts remission in antidepressant treatment of geriatric depression
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Objectives: With the world population rapidly aging, it is increasingly important to identify sociodemographic, cognitive, and clinical features that predict poor outcome in geriatric depression. Self‐report measures of resilience—ie, the ability to adapt and thrive in the face of adversity—may identify those depressed older adults with more favorable prognoses. Methods: We investigated the utility of baseline variables including 4 factors of resilience (grit, active coping self‐efficacy, accommodative coping self‐efficacy, and spirituality) for predicting treatment response and remission in a 16‐week randomized controlled trial of methylphenidate, citalopram, or their combination in 143 adults over the age of 60 with MDD. Results: Final logistic regression models revealed that greater total baseline resilience (Wald χ2 = 3.8,P = 0.05) significantly predicted both treatment response and remission. Specifically, a 20% increase in total resilience predicted nearly 2 times greater likelihood of remission (OR = 1.98, 95% CI = [1.01, 3.91]). Examining the individual factors of resilience, only accommodative coping self‐efficacy (Wald χ2 = 3.7,P = 0.05; OR = 1.41 [1.00‐2.01]) was significantly associated with remission. We found no relation between baseline sociodemographic factors (age, sex, race, education level) or measures of cognitive performance and posttreatment depressive symptoms. Conclusions: Self‐reported resilience may predict greater responsivity to antidepressant medication in older adults with MDD. Future research should investigate the potential for resilience training—and in particular, interventions designed to increase accommodative coping—to promote sustained remission of geriatric depression.
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Greater baseline accommodative coping self-efficacy predicted antidepressant treatment responsivity.
“In addition, greater baseline accommodative coping self-efficacy predicted antidepressant treatment responsivity50.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [50]
Accommodative coping self-efficacy was uniquely predictive of subsequent remission in LLD.
“Another study of LLD found that accommodative coping self-efficacy was uniquely predictive of subsequent remission50.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [50]
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- Authors
- Laird, K. T., Lavretsky, H., St. Cyr, N., & Siddarth, P.
- Affiliations
- University of California, Los Angeles (US)
- Department of Psychiatry Semel Institute for Neuroscience and Human Behavior at UCLA Los Angeles CA USA
- Corresponding author
- Lavretsky, Helen
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2018-07-23
- Volume
- 33
- Issue
- 12
- Pages
- 1596-1603
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- PMC
- PMC6246780
- OpenAlex
- W2883408198
- Cited by
- 23
- References
- 84
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH National Center for Complementary and Integrative Health (AT009198)
- NIH National Institute of Mental Health Grant (MH077650)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- resilience, geriatric depression, major depressive disorder, antidepressant response, remission prediction, spirituality, grit, methylphenidate, citalopram, older adults, resilience training
- MeSH terms
- Adaptation, Psychological, Aged, Aged, 80 and over, Antidepressive Agents, Depressive Disorder, Female, Geriatric Psychiatry, Humans, Male, Methylphenidate, Middle Aged, Citalopram, Logistic Models, Treatment Outcome, Self Efficacy, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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