Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Open accessAbstract
Executive dysfunction (ED) in geriatric depression (GD) is common, predicts poor clinical outcomes and often persists despite remission of symptoms. Here we develop a neuroplasticity-based computerized cognitive remediation-geriatric depression treatment (nCCR-GD) to target ED in GD. Our assumption is that remediation of these deficits may modulate the underlying brain network abnormalities shared by ED and depression. We compare nCCR-GD to a gold-standard treatment (escitalopram: 20 mg per 12 weeks) in 11 treatment-resistant older adults with major depression; and 33 matched historical controls. We find that 91% of participants complete nCCR-GD. nCCR-GD is equally as effective at reducing depressive symptoms as escitalopram but does so in 4 weeks instead of 12. In addition, nCCR-GD improves measures of executive function more than the escitalopram. We conclude that nCCR-GD may be equally effective as escitalopram in treating GD. In addition, nCCR-GD participants showed greater improvement in executive functions than historical controls treated with escitalopram.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Two proof of concept studies showed that computerized cognitive remediation improved both depressive symptoms and executive functions in late-life major depression and in the DED syndrome more than the comparison conditions.
“Two proof of concept studies showed that such training improved both depressive symptoms and executive functions in late-life major depression179 and in the DED syndrome180 more than the comparison conditions.”
From Mechanisms and treatment of late-life depression (2019) · cites this paper as [180]
Clinical research indicates that cognitive training, mindfulness meditation, and aerobic exercise reduce depressive symptoms and improve executive dysfunction or neuroticism in late-life depression.
“clinical studies suggest cognitive training, mindfulness meditation, and aerobic exercise improve depression symptoms and executive dysfunction or neuroticism in LLD 17, 40, 41.”
From State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome (2018) · cites this paper as [40]
Among older adults with late-life depression who had not responded to at least one antidepressant, 30 hours of computerized cognitive training over one month reduced depression more than three months of escitalopram.
“Findings revealed that 30 CCT hours completed over one month resulted in a greater decrease in depression compared to treatment with escitalopram over three months.”
From State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome (2018) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Persson, J., & Reuter‐Lorenz, P. A. (2008) · Psychological Science · doi:10.1111/j.1467-9280.2008.02172.x · Cited by 100 · see citing works
RetractedFolstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
Reitan, R. M., & Wolfson, D. E. (1993) · Medical Entomology and Zoology · Cited by 3,413 · see citing works
Alexopoulos, G. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66665-2 · Cited by 2,024 · see citing works
Self-citationLingjærde, O., Ahlfors, U. G., Bech, P., Dencker, S. J., & Elgen, K. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb10566.x · Cited by 1,705 · see citing works
Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors
Thase, M. E., Entsuah, A. R., & Rudolph, R. L. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.3.234 · Cited by 801 · see citing works
Smith, G. E., Housen, P., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke, H. W., & Zelinski, E. M. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02167.x · Cited by 785 · see citing works
Mahncke, H. W., Connor, B., Appelman, J., Ahsanuddin, O. N., Hardy, J. L., Wood, R. A., Joyce, N. M., Boniske, T., Atkins, S. M., & Merzenich, M. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605194103 · Cited by 679 · see citing works
Cortical remodelling induced by activity of ventral tegmental dopamine neurons
Bao, S., Chan, V. T., & Merzenich, M. M. (2001) · Nature · doi:10.1038/35083586 · Cited by 569 · see citing works
Cognitive Neuroscience of Aging
Grady, C. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.009 · Cited by 548 · see citing works
Training of Working Memory Impacts Structural Connectivity
Takeuchi, H., Sekiguchi, A., Taki, Y., Yokoyama, S., Yomogida, Y., Komuro, N., Yamanouchi, T., Suzuki, S., & Kawashima, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4611-09.2010 · Cited by 531 · see citing works
Brain plasticity and functional losses in the aged: scientific bases for a novel intervention.
Mahncke, H., Bronstone, A., & Merzenich, M. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)57006-2 · Cited by 517 · see citing works
Executive Dysfunction and Long-term Outcomes of Geriatric Depression
Alexopoulos, G. S., Meyers, B. S., Young, R. C., Kalayam, B., Kakuma, T., Gabrielle, M., Sirey, J. A., & Hull, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.285 · Cited by 486 · see citing works
Self-citationMora, F., Segovia, G., & Arco, A. D. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.03.011 · Cited by 401 · see citing works
Changes in Cognitive Functioning Following Treatment of Late-Life Depression
Butters, M. A., Becker, J. T., Nebes, R. D., Zmuda, M. D., Mulsant, B. H., Pollock, B. G., & Reynolds, C. F. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.12.1949 · Cited by 365 · see citing works
Clinical Presentation of the "Depression-Executive Dysfunction Syndrome" of Late Life
Alexopoulos, G. S., Kiosses, D. N., Klimstra, S., Kalayam, B., & BRUCE, M. L. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200201000-00012 · Cited by 363 · see citing works
Self-citationExecutive dysfunction and the course of geriatric depression
Alexopoulos, G. S., Kiosses, D. N., Heo, M., Murphy, C. F., Shanmugham, B., & Gunning-Dixon, F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.024 · Cited by 317 · see citing works
Self-citationAlexopoulos, G. S., Kiosses, D. N., Choi, S. J., Murphy, C. F., & Lim, K. O. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1929 · Cited by 307 · see citing works
Self-citationMicrostructural White Matter Abnormalities and Remission of Geriatric Depression
Alexopoulos, G. S., Murphy, C. F., Gunning‐Dixon, F. M., Latoussakis, V., Kanellopoulos, D., Klimstra, S., Lim, K. O., & Hoptman, M. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050744 · Cited by 297 · see citing works
Self-citationNebes, R. D., Pollock, B. G., Houck, P. R., Butters, M. A., Mulsant, B. H., Zmuda, M. D., & Reynolds, C. F. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00085-7 · Cited by 275 · see citing works
Temporal plasticity in the primary auditory cortex induced by operant perceptual learning
Bao, S., Chang, E. F., Woods, J., & Merzenich, M. M. (2004) · Nature Neuroscience · doi:10.1038/nn1293 · Cited by 265 · see citing works
Prefrontal Dysfunction and Treatment Response in Geriatric Depression
Kalayam, B., & Alexopoulos, G. S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.8.713 · Cited by 263 · see citing works
Self-citationTraining-induced plasticity in older adults: Effects of training on hemispheric asymmetry
Erickson, K. I., Colcombe, S. J., Wadhwa, R., Bherer, L., Peterson, M. S., Scalf, P. E., Kim, J., Alvarado, M., & Kramer, A. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.012 · Cited by 250 · see citing works
Bherer, L., Kramer, A. F., Peterson, M. S., Colcombe, S. J., Erickson, K. I., & Becic, E. (2008) · Experimental Aging Research · doi:10.1080/03610730802070068 · Cited by 250 · see citing works
The Influence of Perceptual Training on Working Memory in Older Adults
Berry, A. S., Zanto, T. P., Clapp, W. C., Hardy, J. L., Delahunt, P. B., Mahncke, H. W., & Gazzaley, A. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011537 · Cited by 241 · see citing works
The human perirhinal cortex and semantic memory
Davies, R. R., Graham, K. S., Xuereb, J. H., Williams, G. B., & Hodges, J. R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03710.x · Cited by 238 · see citing works
Zimmerman, M., Posternak, M. A., & Chelminski, I. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.03.007 · Cited by 229 · see citing works
Experience-dependent plasticity of white-matter microstructure extends into old age
Lövdén, M., Bodammer, N. C., Kühn, S., Kaufmann, J., Schütze, H., Tempelmann, C., Heinze, H.-J., Düzel, E., Schmiedek, F., & Lindenberger, U. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.08.026 · Cited by 222 · see citing works
A Group Version of the Stroop Color and Word Test
Golden, C. J. (1975) · Journal of Personality Assessment · doi:10.1207/s15327752jpa3904_10 · Cited by 213 · see citing works
White matter structures associated with creativity: Evidence from diffusion tensor imaging
Takeuchi, H., Taki, Y., Sassa, Y., Hashizume, H., Sekiguchi, A., Fukushima, A., & Kawashima, R. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.035 · Cited by 213 · see citing works
de Villers‐Sidani, E., Alzghoul, L., Zhou, X., Simpson, K. L., Lin, R. C. S., & Merzenich, M. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007885107 · Cited by 196 · see citing works
Reward/punishment reversal learning in older suicide attempters
Dombrovski, A. Y., Clark, L., Siegle, G. J., Butters, M. A., Ichikawa, N., Sahakian, B. J., & Szanto, K. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030407 · Cited by 193 · see citing works
Intrinsic motivation and learning in a schizophrenia spectrum sample
Choi, J., & Medalia, A. A. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.001 · Cited by 169 · see citing works
Testing the limits of cognitive plasticity in older adults: Application to attentional control
Bherer, L., Kramer, A. F., Peterson, M. S., Colcombe, S., Erickson, K., & Becic, E. (2006) · Acta Psychologica · doi:10.1016/j.actpsy.2006.01.005 · Cited by 155 · see citing works
Response Inhibition Predicts Poor Antidepressant Treatment Response in Very Old Depressed Patients
Sneed, J. R., Roose, S. P., Keilp, J. G., Krishnan, K. R. R., Alexopoulos, G. S., & Sackeim, H. A. (2007) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180302513 · Cited by 146 · see citing works
Self-citationPrefrontal cortical involvement in verbal encoding strategies
Bor, D., Cumming, N., Scott, C. E. L., & Owen, A. M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03438.x · Cited by 145 · see citing works
A cognitive training intervention increases resting cerebral blood flow in healthy older adults
Mozolic, J. L. (2010) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.016.2010 · Cited by 142 · see citing works
Mozolic, J. L., Long, A. B., Morgan, A. R., Rawley‐Payne, M., & Laurienti, P. J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.013 · Cited by 138 · see citing works
Prefrontal Neuropsychological Predictors of Treatment Remission in Late-Life Depression
Potter, G. G., Kittinger, J. D., Ryan Wagner, H., Steffens, D. C., & Ranga Rama Krishnan, K. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300551 · Cited by 132 · see citing works
Executive Dysfunction and Disability in Elderly Patients With Major Depression
Kiosses, D. N., Klimstra, S., Murphy, C., & Alexopoulos, G. S. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200108000-00011 · Cited by 129 · see citing works
Self-citationExecutive Dysfunction, Heart Disease Burden, and Remission of Geriatric Depression
Alexopoulos, G. S., Kiosses, D. N., Murphy, C., & Heo, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300557 · Cited by 117 · see citing works
Self-citationNeurocognitive Correlates of Response to Treatment in Late-Life Depression
Story, T. J., Potter, G. G., Attix, D. K., Welsh-Bohmer, K. A., & Steffens, D. C. (2008) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31817e739a · Cited by 117 · see citing works
Anterior cingulate cortical volumes and treatment remission of geriatric depression
Gunning, F. M., Cheng, J., Murphy, C. F., Kanellopoulos, D., Acuna, J., Hoptman, M. J., Klimstra, S., Morimoto, S., Weinberg, J., & Alexopoulos, G. S. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2290 · Cited by 106 · see citing works
Self-citationBDNF Val66met polymorphism, white matter abnormalities and remission of geriatric depression
Alexopoulos, G. S., Glatt, C. E., Hoptman, M. J., Kanellopoulos, D., Murphy, C. F., Kelly, R. E., Morimoto, S. S., Lim, K. O., & Gunning, F. M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.115 · Cited by 97 · see citing works
Self-citationKiosses, D. N., Leon, A. C., & Areán, P. A. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.03.001 · Cited by 91 · see citing works
MRI signal hyperintensities and treatment remission of geriatric depression
Gunning‐Dixon, F. M., Walton, M. F., Cheng, J., Acuna, J., Klimstra, S., Zimmerman, M. E., Brickman, A. M., Hoptman, M. J., Young, R. C., & Alexopoulos, G. S. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.004 · Cited by 83 · see citing works
Self-citationLongitudinal Association of Initiation/Perseveration and Severity of Geriatric Depression
Murphy, C. F., & Alexopoulos, G. S. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200401000-00007 · Cited by 65 · see citing works
Self-citationExecutive Function and Short-Term Remission of Geriatric Depression: The Role of Semantic Strategy
Morimoto, S. S., Gunning, F. M., Murphy, C. F., Kanellopoulos, D., Kelly, R. E., & Alexopoulos, G. S. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e751c4 · Cited by 57 · see citing works
Self-citationSemantic organizational strategy predicts verbal memory and remission rate of geriatric depression
Morimoto, S. S., Gunning, F. M., Kanellopoulos, D., Murphy, C. F., Klimstra, S. A., Kelly, R. E., & Alexopoulos, G. S. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2743 · Cited by 44 · see citing works
Self-citationNeuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto, S. S., Wexler, B. E., & Alexopoulos, G. S. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3776 · Cited by 36 · see citing works
Self-citationSneed, J. R., Keilp, J. G., Brickman, A. M., & Roose, S. P. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1889 · Cited by 35 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [15]Morimoto SS Executive function and short-term remission of geriatric depression: the role of semantic strategy Am J Geriatr Psychiatry 19 115 122 10.1097/JGP.0b013e3181e751c4 2011 20808124 PMC3628617 · DOI
- [16]Morimoto SS Semantic organizational strategy predicts verbal memory and remission rate of geriatric depression Int J Geriatr Psychiatry 27 506 512 10.1002/gps.2743 2012 21618287 PMC3188360 · DOI · Paper page
Cited by
Sorted by citations
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592 · see citing works
Self-citationWorld Health Organization disability assessment schedule 2.0: An international systematic review
Federici, S., Bracalenti, M., Meloni, F., & Luciano, J. V. (2016) · Disability and Rehabilitation · doi:10.1080/09638288.2016.1223177 · Cited by 516 · see citing works
Koster, E. H. W., Hoorelbeke, K., Onraedt, T., Owens, M., & Derakshan, N. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.02.002 · Cited by 267 · see citing works
Diagnosis and treatment of depression and cognitive impairment in late life
Morimoto, S. S., Kanellopoulos, D., Manning, K. J., & Alexopoulos, G. S. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12669 · Cited by 144 · see citing works
Self-citation(2022) · doi:10.1016/j.biopsych.2022.08.026 · Cited by 113 · see citing works
Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression
Riddle, M., Potter, G. G., McQuoid, D. R., Steffens, D. C., Beyer, J. L., & Taylor, W. D. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.03.016 · Cited by 107 · see citing works
Influences of dopaminergic system dysfunction on late-life depression
Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89 · see citing works
Effectiveness of cognitive remediation in depression: a meta-analysis
Legemaat, A. M., Semkovska, M., Brouwer, M. E., Geurtsen, G. J., Burger, H., Denys, D. A. J. P., & Bockting, C. (2021) · Psychological Medicine · doi:10.1017/s0033291721001100 · Cited by 79 · see citing works
Health-Promoting Strategies for the Aging Brain
Chen, S. T., Volle, D. C., Jalil, J., Wu, P., & Small, G. W. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.12.016 · Cited by 74 · see citing works
Caraci, F., Calabrese, F., Molteni, R., Bartova, L., Dold, M., Leggio, G. M., Fabbri, C., Mendlewicz, J., Racagni, G., Kasper, S. F., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014977 · Cited by 73 · see citing works
Salagre, E., Solé, B., Tomioka, Y., Fernandes, B. S., Hidalgo-Mazzei, D., Garriga, M., Jimenez, E., Sanchez-Moreno, J., Vieta, E., & Grande, I. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.034 · Cited by 71 · see citing works
A Systematic Review and Meta-Analysis of Cognitive Training in Adults with Major Depressive Disorder
Woolf, C., Lampit, A., Shahnawaz, Z., Sabatés, J., Norrie, L. M., Burke, D., Naismith, S. L., & Mowszowski, L. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09487-3 · Cited by 66 · see citing works
Late Life Depression: The Essentials and the Essential Distinctions
Husain-Krautter, S., & Ellison, J. M. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20210006 · Cited by 56 · see citing works
Yao, S., Wang, Y., Liang, Y., Yu, H., Majeed, A., Shen, X., Li, T., & Qin, S. (2021) · Ceramics International · doi:10.1016/j.ceramint.2021.06.114 · Cited by 55 · see citing works
Definition of treatment-resistant depression – Asia Pacific perspectives
Ng, C. H., Kato, T., Han, C., Wang, G., Trivedi, M. H., Ramesh, V., Shao, D., Gala, S. G., Narayanan, S., Tan, W., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.038 · Cited by 55 · see citing works
Knight, M. J., & Baune, B. T. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00280 · Cited by 54 · see citing works
Morimoto, S. S., Altizer, R., Gunning, F. M., Hu, W., Liu, J., Cote, S. E., Nitis, J., & Alexopoulos, G. S. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.05.023 · Cited by 51 · see citing works
Self-citationCognitive Priming and Cognitive Training: Immediate and Far Transfer to Academic Skills in Children
Wexler, B. E., Iseli, M., Leon, S., Zaggle, W., Rush, C., Goodman, A., Esat Imal, A., & Bo, E. (2016) · Scientific Reports · doi:10.1038/srep32859 · Cited by 46 · see citing works
Self-citationRavindran, E., Baek, H. E., Son, H. W., Park, J. H., Kim, Y., & Suh, M. C. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202213461 · Cited by 46 · see citing works
Cognitive control training for children with anxiety and depression: A systematic review
Edwards, E. J., Zec, D., Campbell, M. A., Hoorelbeke, K., Koster, E. H. W., Derakshan, N., & Wynne, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.12.108 · Cited by 41 · see citing works
Cognitive remediation for depressed inpatients: Results of a pilot randomized controlled trial
Trapp, W., Engel, S., Hajak, G., Lautenbacher, S., & Gallhofer, B. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415622271 · Cited by 40 · see citing works
Morimoto, S. S., Gunning, F. M., Wexler, B. E., Hu, W., Ilieva, I., Liu, J., Nitis, J., & Alexopoulos, G. S. (2016) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.06.010 · Cited by 35 · see citing works
Self-citationManning, K. J., & Steffens, D. C. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15353 · Cited by 33 · see citing works
Jaywant, A., DelPonte, L., Kanellopoulos, D., O’Dell, M. W., & Gunning, F. M. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720968270 · Cited by 33 · see citing works
Hagen, B. I., Lau, B., Joormann, J., Småstuen, M. C., Landrø, N. I., & Stubberud, J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.015 · Cited by 32 · see citing works
Mendes, L., Oliveira, J., Barbosa, F., & Castelo-Branco, M. S. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.844725 · Cited by 30 · see citing works
Manning, K. J., Wang, L., & Steffens, D. C. (2019) · F1000Research · doi:10.12688/f1000research.17399.1 · Cited by 27 · see citing works
Wang, C., Cárdenas, A., Hutchinson, J. N., Just, A. C., Heiss, J. A., Hou, L., Zheng, Y., Coull, B. A., Kosheleva, A., Koutrakis, P., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106955 · Cited by 26 · see citing works
Patrick, R. E., Dickinson, R. A., Gentry, M. T., Kim, J. U., Oberlin, L. E., Park, S., Principe, J. L., Teixeira, A. L., & Weisenbach, S. L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.017 · Cited by 25 · see citing works
Brain Mechanisms of Change in Addiction Treatment: Models, Methods, and Emerging Findings
Chung, T. A., Noronha, A., Carroll, K. M., Potenza, M. N., Hutchison, K. E., Calhoun, V. D., Gabrieli, J. D. E., Morgenstern, J., Nixon, S. J., Wexler, B. E., et al. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0113-z · Cited by 25 · see citing works
Self-citationDepressive symptom complexes of community-dwelling older adults: a latent network model
Murri, M. B., Grassi, L. G., Caruso, R., Nanni, M. G., Zerbinati, L., Andreas, S., Ausín, B., Canuto, A., Härter, M. C., López, M. M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01310-y · Cited by 25 · see citing works
Self-citationWexler, B. E., Vitulano, L. A., Moore, C. C., Katsovich, L., Smith, S. D., Rush, C., Grantz, H., Dong, J., & Leckman, J. F. (2020) · Psychological Medicine · doi:10.1017/s0033291720000288 · Cited by 24 · see citing works
Self-citationResilience predicts remission in antidepressant treatment of geriatric depression
Laird, K. T., Lavretsky, H., St. Cyr, N., & Siddarth, P. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4953 · Cited by 23 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2021) · Focus · doi:10.1176/appi.focus.19304 · Cited by 22 · see citing works
Self-citationGrinberg, A., Egglefield, D. A., Schiff, S., Motter, J. N., & Sneed, J. R. (2021) · Journal of Cognitive Enhancement · doi:10.1007/s41465-021-00209-4 · Cited by 22 · see citing works
Stubberud, J., Huster, R. J., Hoorelbeke, K., Hammar, Å., & Hagen, B. I. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103991 · Cited by 22 · see citing works
Neuroanatomical Abnormalities in Older Depressed Adults With Apathy: A Systematic Review
Pimontel, M. A., Kanellopoulos, D., & Gunning, F. M. (2019) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719882100 · Cited by 22 · see citing works
Computerized Cognitive Training for Major Depressive Disorder: What’s Next?
Motter, J. N., Devanand, D. P., Doraiswamy, P. M., & Sneed, J. R. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00137 · Cited by 22 · see citing works
Paroxetine induced larva zebrafish cardiotoxicity through inflammation response
Zhu, Y., Song, F., Gu, J., Lin-lin, W., Wu, W., & Ji, G. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115096 · Cited by 21 · see citing works
Kargar, B. A. H., & Mahoor, M. H. (2017) · IEEE-RAS International Conference on Humanoid Robots (Humanoids) · doi:10.1109/humanoids.2017.8246957 · Cited by 21 · see citing works
Douglas, K. M., Milanovic, M., Porter, R., & Bowie, C. R. (2020) · BJPsych Open · doi:10.1192/bjo.2020.53 · Cited by 20 · see citing works
Shu, M., Feng, S., & Liu, J. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114742 · Cited by 18 · see citing works
Self-citationSociali, A., Borgi, M., Pettorruso, M., Carlo, F. D., Natale, C. D., Tambelli, A., Alessi, M. C., Ciavoni, L., Mosca, A., Miuli, A., et al. (2022) · Depression and Anxiety · doi:10.1002/da.23263 · Cited by 18 · see citing works
Using Cognitive Neuroscience to Improve Mental Health Treatment: A Comprehensive Review
Wojtalik, J. A., Eack, S. M., Smith, M. J., & Keshavan, M. S. (2018) · Journal of the Society for Social Work and Research · doi:10.1086/697566 · Cited by 16 · see citing works
Hoorelbeke, K., Vervaeke, J., Siegle, G. J., Baeken, C., & Koster, E. H. W. (2022) · Internet Interventions · doi:10.1016/j.invent.2022.100507 · Cited by 15 · see citing works
Klojčnik, M., & Bakračevič, K. (2021) · Applied Neuropsychology Adult · doi:10.1080/23279095.2021.1941965 · Cited by 15 · see citing works
An inverse relationship between cortical plasticity and cognitive inhibition in late-life depression
Lissemore, J. I., Shanks, H. R. C., Butters, M. A., Bhandari, A., Zomorrodi, R., Rajji, T. K., Karp, J. F., Reynolds, C. F., Lenze, E. J., Daskalakis, Z. J., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0413-9 · Cited by 14 · see citing works
Few Effects of a 5-Week Adaptive Computerized Cognitive Training Program in Healthy Older Adults
Rabipour, S., Morrison, C., Crompton, J., Petrucelli, M., Germano, M. D. O. G., Popescu, A., & Davidson, P. S. R. (2019) · Journal of Cognitive Enhancement · doi:10.1007/s41465-019-00147-2 · Cited by 13 · see citing works
Kim, J., Park, S., Kim, H., Roh, D. D., & Kim, D. H. (2023) · Clinical EEG and Neuroscience · doi:10.1177/15500594231215847 · Cited by 12 · see citing works
Bursky, M., Egglefield, D. A., Schiff, S., Premnath, P. Y., & Sneed, J. R. (2022) · Brain Sciences · doi:10.3390/brainsci12050663 · Cited by 12 · see citing works
Brouwer, J., van den Berg, F., Knooihuizen, R., Loerts, H., & Keijzer, M. C. J. (2020) · Behavioral Sciences · doi:10.3390/bs10090132 · Cited by 11 · see citing works
Neural correlates of graphic cigarette warning labels predict smoking cessation relapse
Owens, M. M., MacKillop, J., Gray, J. C., Hawkshead, B. E., Murphy, C. M., & Sweet, L. H. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.02.005 · Cited by 10 · see citing works
Cognitive Deficits in Late-Life Depression: From Symptoms and Assessment to Therapeutics
Teixeira, A. L., Gregg, A. P., Gentry, M. T., Gujral, S., Rapp, E., Oberlin, L. E., Ajilore, O., Weisenbach, S. L., & Patrick, R. E. (2025) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20240046 · Cited by 8 · see citing works
Vega, J. N., NEWHOUSE, P. A., Conley, A. C., Szymkowicz, S. M., Gong, X., Cote, S. E., Mayer, I. A., Taylor, W. D., & Morimoto, S. S. (2023) · Digital Health · doi:10.1177/20552076231192754 · Cited by 8 · see citing works
Self-citationAttarha, M., Mahncke, H. W., & Merzenich, M. M. (2024) · JMIR Formative Research · doi:10.2196/53623 · Cited by 8 · see citing works
Neuroplasticity in the Biopsychosocial Framework: A Foundational Theory for Intervention
Honarvar, R. L., Prince, D. M., & Romaniuk, J. R. (2025) · Social Work Research · doi:10.1093/swr/svae029 · Cited by 6 · see citing works
Wexler, B. E. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221078291 · Cited by 6 · see citing works
Self-citationTang, H., Wang, X., Lü, Q., Zhao, S., Zou, H., Hua, L., Chen, Z., Shi, J., & Yao, Z. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07180-w · Cited by 5 · see citing works
Woolf, C., Kaplan, L., Norrie, L. M., Burke, D., Cunich, M. M., Mowszowski, L., & Naismith, S. L. (2024) · BMC Psychiatry · doi:10.1186/s12888-023-05391-7 · Cited by 5 · see citing works
Hagen, B. I., Landrø, N. I., Lau, B., Koster, E. H. W., & Stubberud, J. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.02232 · Cited by 5 · see citing works
Zhang, P., Chen, L., Qin, Q., Liu, C., Zhu, H., Hu, W., He, X., Tang, K., Yan, Q., & Shen, H. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1477285 · Cited by 4 · see citing works
Self-citationCognitive Training to Increase Resilience
Young, L. R., Rule, G., Lundie, M., Zientz, J., Terrell, K. H., Vleet, T. V., Tate, A., & Spence, J. S. (2025) · Military Medicine · doi:10.1093/milmed/usaf292 · Cited by 4 · see citing works
Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression
Taylor, W. D., Gerlach, A., Szymkowicz, S. M., Gujral, S., & Andreescu, C. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02324-2 · Cited by 3 · see citing works
Neuromodulation and cognition in late-life depression
Mirjalili, M., Blumberger, D. M., Brunoni, A. R., Mulsant, B. H., & Rajji, T. K. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02323-3 · Cited by 3 · see citing works
Treatments for vascular depression in older adults: A systematic review
Flôr-Rodrigues, B., Aissa, S. B., Miranda, D., Compagne, C., Vandel, P., von Gunten, A., Orgeta, V., Mueller, C., Swierkosz-Lenart, K., & Moyano, B. P. (2026) · International Psychogeriatrics · doi:10.1016/j.inpsyc.2026.100249 · Cited by 3 · see citing works
Dotson, V. M., Szymkowicz, S. M., Kim, J. U., & McClintock, S. M. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0159-4 · Cited by 3 · see citing works
Decreasing Fall Risk: Intensive Cognitive Training and Blood Pressure Control
Manning, K. J., & WOLFSON, L. I. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14896 · Cited by 3 · see citing works
Adverse Effects of Pharmacological Treatments of Major Depression in Older Adults
Sobieraj, D. M. (2019) · doi:10.23970/ahrqepccer215 · Cited by 3 · see citing works
Tiba, A., & Manea, L. (2022) · Journal of Evidence-Based Psychotherapies · doi:10.24193/jebp.2022.1.8 · Cited by 2 · see citing works
Wang, X., Zhou, J., Zhu, K., Wang, Y., Ma, X., Ren, L., Chengwei, G., Zhang, Z., Lü, P., & Zhang, Q. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06276-z · Cited by 2 · see citing works
Moving Beyond Mood: Is it Time to Recommend Cognitive Training for Depression in Older Adults?
Naismith, S. L., & Mowszowski, L. (2016) · Springer eBooks · doi:10.1007/978-3-319-32480-7_21 · Cited by 2 · see citing works
Morimoto, S. S., Manning, K. J., Kim, J. U., & Cote, S. E. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0158-5 · Cited by 2 · see citing works
Self-citationCognitive Impairment and Older Age Bipolar Disorder
Weisenbach, S. L., & Carns, D. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-48912-4_6 · Cited by 2 · see citing works
Computerized Cognitive Remediation for Geriatric Depression: Dawn of a New Treatment Modality?
Taylor, W. D. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.07.007 · Cited by 2 · see citing works
Neural Effects of a Cognitive Remediation Intervention for Late-Life Depression
Manning, K. J., Wang, L., Steffens, D. C., Litt, M. D., Altizer, R., & Morimoto, S. S. (2025) · The American Journal of Geriatric Psychiatry Open Science Education and Practice · doi:10.1016/j.osep.2025.09.001 · Cited by 1 · see citing works
Self-citationSchaham, N. G., Pasqualotto, A., Lerner, N., Fanourakis, M., Menestrina, Z., Bavelier, D., & Nahum, M. (2025) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2025.152645 · Cited by 1 · see citing works
The complex conundrum of geriatric depression and dementias
Mukhopadhyay, S., & Banerjee, D. (2021) · Journal of Geriatric Mental Health · doi:10.4103/jgmh.jgmh_21_21 · Cited by 1 · see citing works
Computerized cognitive remediation of Long COVID in older adults
Lindbergh, C. A., Altizer, R., Grady, J. J., Diniz, B. S., Kamath, J., Steffens, D. C., & Morimoto, S. S. (2024) · International Psychogeriatrics · doi:10.1017/s1041610224000139 · Cited by 1 · see citing works
Self-citationModerators of Remission in Patients With Late-Life Depression
Taylor, W. D. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.3458
Integrative Approaches for Geriatric Depression
Mehl‐Madrona, L., Mainguy, B., & Shah, A. (2015) · CRC Press eBooks · doi:10.1201/b19089-31
Theory of mind, social cognition, and neural functioning in schizophrenia spectrum disorders
Burns, A. M. N. (2016) · cIRcle (University of British Columbia) · doi:10.14288/1.0319165
Computer-Based Programs as Suitable Intervention Tools for Older People with Mental Disorders
Klímová, B. (2018) · Lecture notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering · doi:10.1007/978-3-319-74935-8_1
Promoting Health Behaviors For Aging Persons
Alexopoulos, G. S. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.12.024
Self-citationCerebrovascular Disease, Aging, and Depression: Clinical Features, Pathophysiology, and Treatment
Gunning, F. M., & Jaywant, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108552684.037
Scheurich, A. (2017) · Springer eBooks · doi:10.1007/978-3-662-53697-1_5
Brouwer, J. (2024) · doi:10.33612/diss.972213572
Cho, M., Hwang, S., Kim, Y. J., & Lee, D. (2025) · SAGE Open · doi:10.1177/21582440251370833
Morimoto, S. S., Lindbergh, C. A., Conley, A. C., Jones, D. R., & Steffens, D. C. (2026) · JMIR Mental Health · doi:10.2196/94246
Self-citationKodancha, P., Kashyap, H., & Desai, G. (2026) · medRxiv · doi:10.64898/2026.08.12.26360264
Depresión en el adulto mayor: Una aproximación desde la neuropsicología
Ferrari-Díaz, M., & Luna-Padilla, J. A. (2026) · DIVULGARE Boletín Científico de la Escuela Superior de Actopan · doi:10.29057/esa.v14iespecial.18278
- Authors
- Morimoto, S. S., Wexler, B. E., Liu, J., Hu, W., Seirup, J., & Alexopoulos, G. S.
- Affiliations
- Cornell University (US)
- Yale University (US)
- Corresponding author
- Morimoto, Sarah Shizuko
- Venue
- Nature Communications
- Published
- 2014-08-05
- Volume
- 5
- Issue
- 1
- Pages
- 4579-4579
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4139707
- OpenAlex
- W2068566265
- Cited by
- 91
- References
- 51
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 4
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (L30 AG040834)
- National Institute of Mental Health (P30MH068638, K23MH095830)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- geriatric depression, executive dysfunction, neuroplasticity, treatment-resistant depression, escitalopram, antidepressant efficacy, executive function, brain network abnormalities
- MeSH terms
- Aged, Aged, 80 and over, Cognition, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Geriatrics, Humans, Male, Middle Aged, Neuronal Plasticity, Software, Citalopram, Cognitive Behavioral Therapy, Case-Control Studies, Treatment Outcome, Antidepressive Agents, Second-Generation, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
