Loss of white matter integrity in major depressive disorder: evidence using tract-based spatial statistical analysis of diffusion tensor imaging

Korgaonkar, Mayuresh S.; Grieve, Stuart M.; Koslow, Stephen H.; Gabrieli, John D.E.; Gordon, Evian; Williams, Leanne M.

doi:10.1002/hbm.21178

Cited by 205Advanced Neuroimaging Techniques and ApplicationsTreatment of Major DepressionFunctional Brain Connectivity Studies

Loss of white matter integrity in major depressive disorder: evidence using tract-based spatial statistical analysis of diffusion tensor imaging

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Korgaonkar, Mayuresh S., Grieve, Stuart M., Koslow, Stephen H., Gabrieli, John D.E., Gordon, Evian, Williams, Leanne M.·2011·Human Brain Mapping

DOI 10.1002/hbm.21178PMC PMC6870076

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Abstract

White matter (WM) has been shown to be affected in elderly patients with major depressive disorders (MDD). There is only limited evidence of WM structural abnormalities in nongeriatric MDD patients. This study investigates WM microstructural integrity in nongeriatric MDD patients recruited as part of the International Study to Predict Optimized Treatment in Depression clinical trial and establishes the validity of diffusion tensor imaging measures for the investigation of depression. Baseline diffusion tensor imaging data from 29 nongeriatric MDD participants (11 with melancholia) and 39 healthy control participants were used in this analysis. We performed tract-based spatial statistics analyses to evaluate WM microstructural integrity (1) between all healthy controls and all MDD participants, (2) between melancholic and nonmelancholic MDD participants, and (3) between each subgroup (melancholic and nonmelancholic) and controls. Significant WM integrity deficits were seen only for the melancholic MDD participants compared with controls. Compared with controls, melancholic participants showed an average reduction of 7.8% in fractional anisotropy over WM regions associated with the limbic system, dorsolateral prefrontal cortex, thalamic projection fibers, corpus callosum, and other association fibers. These fractional anisotropy deficits were also associated with decreased axial and increased radial diffusivity in these WM regions, suggesting a pattern of decreased myelination or other degeneration change. Our findings of WM structural abnormalities associated with the limbic system, the frontal cortex, and the thalamus support the prevailing theory of limbic-dorsolateral prefrontal cortex-thalamic dysfunction in depression. Our results also suggest that these deficits are most prominent in the melancholic subtype of MDD.

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A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Untitled work
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Untitled work
(1998) · PubMed · Cited by 10,216 · see citing works
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676 · see citing works
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250 · see citing works
Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo
Basser, P. J., Mattiello, J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1037 · Cited by 3,656 · see citing works
Characterization and propagation of uncertainty in diffusion-weighted MR imaging
Behrens, T. E. J., Woolrich, M. W., Jenkinson, M., Johansen‐Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M., & Smith, S. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10609 · Cited by 3,038 · see citing works
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582 · see citing works
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 3× · see citing works
“The other brain regions considered to be an integral part of this depression-related limbic-cortical network are the basal ganglia and the thalamus [Drevets et al., 2008; Lafer et al., 1997].”
Background
The validity of the Mini International Neuropsychiatric Interview (MINI) according to the SCID-P and its reliability
Sheehan, D., Lecrubier, Y., Harnett Sheehan, K., Janavs, J., Weiller, E., Keskiner, A., Schinka, J., Knapp, E., Sheehan, M., & Dunbar, G. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)83297-x · Cited by 2,149 · see citing works
Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template
Mori, S., Oishi, K., Jiang, H., Jiang, L., Li, X., Akhter, K., Hua, K., Faria, A. V., Mahmood, A., Woods, R. P., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.035 · Cited by 1,832 · see citing works
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738 · see citing works
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
Segmentation of subcomponents within the superior longitudinal fascicle in humans: A quantitative, in vivo, DT-MRI study.
Makris, N., Kennedy, D. N., McInerney, S., Sorensen, A. G., Wang, R., Caviness, V. S., & Pandya, D. N. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh186 · Cited by 1,146 · see citing works
Modulation of Cortical-Limbic Pathways in Major Depression: Treatment-Specific Effects of Cognitive Behavior Therapy
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068 · see citing works
Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression
Johnstone, T., van Reekum, C. M., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2063-07.2007 · Cited by 1,051 · see citing works
Course of illness, hippocampal function, and hippocampal volume in major depression
MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980 · see citing works
Economic burden of depression
Greenberg, P. E., Stiglin, L. E., Finkelstein, S. N., & Berndt, E. R. (1994) · PharmacoResources · doi:10.1007/bf03289581 · Cited by 974 · see citing works
The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex
Koenigs, M., & Grafman, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.004 · Cited by 956 · cited 1× · see citing works
“…tract connecting the frontal cortex with the temporal, occipital, and parietal lobes, with a particular bias toward fibers originating or terminating in the DLPFC. Frontal lobe dysfunction and its association with depression symptomology has been well established [Koenigs and Grafman, 2009].”
Background
The cortico-basal ganglia integrative network: The role of the thalamus
Haber, S. N., & Calzavara, R. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.09.013 · Cited by 721 · see citing works
Changes in Regional Brain Glucose Metabolism Measured With Positron Emission Tomography After Paroxetine Treatment of Major Depression
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
Drevets, W. C. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26027-5 · Cited by 659 · see citing works
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525 · see citing works
Self-citation
Age‐related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging
Bennett, I. J., Madden, D. J., Vaidya, C. J., Howard, D. V., & Howard, J. H. (2009) · Human Brain Mapping · doi:10.1002/hbm.20872 · Cited by 485 · see citing works
Depression-Related Variation in Brain Morphology Over 3 Years: Effects of Stress?
Frodl, T. S., Koutsouleris, N., Bottlender, R., Born, C., Jäger, M., Scupin, I., Reiser, M., Möller, H.-J., & Meisenzahl, E. M. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.10.1156 · Cited by 359 · see citing works
Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study.
Grieve, S. M., Williams, L. M., Paul, R. H., Clark, C. R., & Gordon, E. (2007) · PubMed Central · Cited by 350 · see citing works
Self-citation
Frontal White Matter Microstructure and Treatment Response of Late-Life Depression: A Preliminary Study
Alexopoulos, G. S., Kiosses, D. N., Choi, S. J., Murphy, C. F., & Lim, K. O. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1929 · Cited by 307 · see citing works
Microstructural White Matter Abnormalities and Remission of Geriatric Depression
Alexopoulos, G. S., Murphy, C. F., Gunning‐Dixon, F. M., Latoussakis, V., Kanellopoulos, D., Klimstra, S., Lim, K. O., & Hoptman, M. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050744 · Cited by 297 · see citing works
Preservation of limbic and paralimbic structures in aging
Grieve, S. M., Clark, C. R., Williams, L. M., Peduto, A. J., & Gordon, E. (2005) · Human Brain Mapping · doi:10.1002/hbm.20115 · Cited by 293 · see citing works
Self-citation
Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex White Matter Alterations in Late-Life Depression
Bae, J. N., MacFall, J. R., Krishnan, K. R. R., Payne, M. E., Steffens, D. C., & Taylor, W. D. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.052 · Cited by 288 · see citing works
Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter
Taylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Provenzale, J. M., Steffens, D. C., & Krishnan, K. R. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1293 · Cited by 230 · see citing works
Reduced amygdala–prefrontal coupling in major depression: association with MAOA genotype and illness severity
Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., Hohoff, C., Schöning, S., Kersting, A., Baune, B. T., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008973 · Cited by 216 · see citing works
Melancholia: A Disorder of Movement and Mood
(1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511759024 · Cited by 205 · see citing works
The varied clinical presentations of major depressive disorder.
Rush, A. J. (2007) · PubMed · Cited by 200 · see citing works
Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta-analysis
Steffens, D. C., Krishnan, K. R., & Helms, M. J. (1997) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1997)6:1 · Cited by 194 · see citing works
Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression—A longitudinal evaluation
Hickie, I. B., Scott, E. M., Wilhelm, K. A., & Brodaty, H. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00363-0 · Cited by 191 · see citing works
Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study
Nobuhara, K. (2006) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.055129 · Cited by 191 · see citing works
White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
Ma, N., Li, L., Shu, N., 刘, J. 军. L., Gong, G., He, Z., Li, Z., Tan, L., Stone, W. S., Zhang, Z., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.823 · Cited by 191 · see citing works
Major depressive disorder and white matter abnormalities: A diffusion tensor imaging study with tract-based spatial statistics
Kieseppä, T., Eerola, M., Mäntylä, R., Neuvonen, T., Poutanen, V.-P., Luoma, K., Tuulio‐Henriksson, A., Jylhä, P. J., Mantere, O., Melartin, T. K., et al. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.023 · Cited by 181 · see citing works
White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
Ma, N. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.5.823 · Cited by 152 · see citing works
Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study
Zou, K., Huang, X., Li, T., Gong, Q., Li, Z., Ouyang, L., Deng, W., Chen, Q., Li, C., Ding, Y., et al. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0850 · Cited by 146 · see citing works
Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study
Li, L., Ma, N., Li, Z., Tan, L., Liu, J., Gong, G., Shu, N., He, Z., Jiang, T., & Xu, L. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.094 · Cited by 133 · see citing works
Diffuse Microstructural Abnormalities of Normal-Appearing White Matter in Late Life Depression: A Diffusion Tensor Imaging Study
Shimony, J. S., Sheline, Y. I., D’Angelo, G., Epstein, A. A., Benzinger, T. L. S., Mintun, M. A., McKinstry, R. C., & Snyder, A. Z. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.032 · Cited by 130 · see citing works
Microstructural Correlates of Infant Functional Development: Example of the Visual Pathways
Dubois, J., Dehaene‐Lambertz, G., Soarès, C., Cointepas, Y., Bihan, D. L., & Hertz‐Pannier, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5145-07.2008 · Cited by 125 · see citing works
Regional Cerebral Blood Flow Changes after Low-Frequency Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in Treatment-Resistant Depression
Kito, S., Fujita, K., & Koga, Y. (2008) · Neuropsychobiology · doi:10.1159/000154477 · Cited by 114 · see citing works
Response to a Selective Serotonin Reuptake Inhibitor (Citalopram) in Major Depressive Disorder With Melancholic Features
McGrath, P. J., Khan, A. Y., Trivedi, M. H., Stewart, J. W., Morris, D. W., Wisniewski, S. R., Miyahara, S., Nierenberg, A. A., D, M. F. M., & Rush, A. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1201 · Cited by 105 · see citing works
The Limbic Thalamus
Taber, K. H., Wen, C., Khan, A., & Hurley, R. A. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.2.127 · Cited by 104 · see citing works
White matter microstructural abnormalities in late-life depression
Yang, Q., Huang, X., Hong, N., & Yu, X. (2007) · International Psychogeriatrics · doi:10.1017/s1041610207004875 · Cited by 100 · see citing works
Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression
Hooley, J. M., Gruber, S. A., Parker, H. A., Guillaumot, J., Rogowska, J., & Yurgelun-Todd, D. A. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.04.001 · Cited by 92 · see citing works
Hippocampal volume in first episode and recurrent depression
Kronmüller, K., Schröder, J., Köhler, S., Götz, B., Victor, D., Unger, J., Giesel, F., Magnotta, V. A., Mundt, C., Essig, M., et al. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.08.001 · Cited by 92 · see citing works
Cortex, IV; Regional Cerebral Blood Flow
Grafman, J. H., & Tamminga, C. A. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.163 · Cited by 86 · see citing works
Atypical depression: current status and relevance to melancholia
Stewart, J. W., McGrath, P. J., Quitkin, F. M., & Klein, D. F. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00964.x · Cited by 64 · see citing works
Anisotropic Diffusion Properties in Infants with Hydrocephalus: A Diffusion Tensor Imaging Study
Yuan, W., Mangano, F., Air, E., Holland, S., Jones, B., Altaye, M., & Bierbrauer, K. S. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1663 · Cited by 60 · see citing works
MAJOR DEPRESSION AND THE BASAL GANGLIA
Lafer, B., Renshaw, P. F., & Sachs, G. S. (1997) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70350-6 · Cited by 48 · see citing works
Possible structural abnormality of the brainstem in unipolar depressive illness: a transcranial ultrasound and diffusion tensor magnetic resonance imaging study
Steele, J. D. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.057612 · Cited by 37 · see citing works

Flagged first, then by citations

1 of the 61 references couldn’t be matched to a known paper.

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Deprez, S., Amant, F. C., Smeets, A., Peeters, R. R., Leemans, A., Hecke, W. V., Verhoeven, J. S., Christiaens, M.-R., Vandenberghe, J. U., Vandenbulcke, M., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.8571 · Cited by 391 · see citing works
Widespread reductions in gray matter volume in depression
Grieve, S. M., Korgaonkar, M. S., Koslow, S. H., Gordon, E., & Williams, L. M. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.08.016 · Cited by 388 · see citing works
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Korgaonkar, M. S., Fornito, A., Williams, L. M., & Grieve, S. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.018 · Cited by 367 · see citing works
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Wise, T., Raduà, J., Nortje, G., Cleare, A. J., Young, A. H., & Arnone, D. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.004 · Cited by 304 · see citing works
Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches
Phillips, M. L., Chase, H. W., Sheline, Y. I., Etkin, A., Almeida, J. R. C., Deckersbach, T., & Trivedi, M. H. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010076 · Cited by 267 · see citing works
Relation Between Structural and Functional Connectivity in Major Depressive Disorder
de Kwaasteniet, B., Ruhe, E., Caan, M., Rive, M., Olabarriaga, S., Groefsema, M., Heesink, L., van Wingen, G., & Denys, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.024 · Cited by 229 · see citing works
Anterior Cingulate Cortexγ-Aminobutyric Acid in Depressed Adolescents: Relationship to Anhedonia
Gabbay, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.131 · Cited by 201 · see citing works
Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression
Murphy, M. L., & Frodl, T. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-3 · Cited by 195 · see citing works
Biomarkers of increased diffusion anisotropy in semi-acute mild traumatic brain injury: a longitudinal perspective
Ling, J. M., Peña, A., Yeo, R. A., Merideth, F. L., Klimaj, S. D., Gasparovic, C., & Mayer, A. R. (2012) · Brain · doi:10.1093/brain/aws073 · Cited by 180 · see citing works
A review of white matter microstructure alterations of pathways of the reward circuit in depression
Bracht, T., Linden, D. E. J., & Keedwell, P. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.041 · Cited by 172 · see citing works
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Dellarole, A., Morton, P. D., Brambilla, R., Walters, W. M., Summers, S. H., Bernardes, D., Grilli, M., & Bethea, J. R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.003 · Cited by 164 · see citing works
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Self-citation
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Lyden, H. M., Espinoza, R. T., Pirnia, T., Clark, K., Joshi, S. K., Leaver, A. M., Woods, R. P., & Narr, K. L. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.21 · Cited by 141 · see citing works
Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
Shen, X., Reus, L. M., Cox, S. R., Adams, M. J., Liewald, D. C. M., Bastin, M. E., Smıth, D. J., Deary, I. J., Whalley, H. C., & McIntosh, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-05507-6 · Cited by 129 · see citing works
Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression
Kochunov, P., Glahn, D. C., Rowland, L. M., Olvera, R. L., Winkler, A., Yang, Y.-H., Sampath, H., Carpenter, W. T., Duggirala, R., Curran, J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.002 · Cited by 118 · see citing works
Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: Influence of white matter anisotropic conductivity
Lee, W. H., Deng, Z., Kim, T., Laine, A. F., Lisanby, S. H., & Peterchev, A. V. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.029 · Cited by 113 · see citing works
Diagnostic and therapeutic utility of neuroimaging in depression: an overview
Arnone, D., Wise, T., Cleare, A. J., Young, A. H., & Herane-Vives, A. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s50156 · Cited by 104 · see citing works
Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: A resting-state fMRI study
Guo, W., Liu, F., Chen, J., Gao, K., Xue, Z., Xu, X., Wu, R., Tan, C., Sun, X., Liu, Z., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.07.003 · Cited by 105 · see citing works
Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank
Reus, L. M., Shen, X., Gibson, J., Wigmore, E. M., Ligthart, L., Adams, M. J., Davies, G., Cox, S. R., Hagenaars, S. P., Bastin, M. E., et al. (2017) · Scientific Reports · doi:10.1038/srep42140 · Cited by 94 · see citing works
Alterations in white matter micro-integrity of the superior longitudinal fasciculus and anterior thalamic radiation of young adult patients with depression
Lai, C., & Wu, Y. (2014) · Psychological Medicine · doi:10.1017/s0033291714000440 · Cited by 97 · see citing works
A Preliminary Study of White Matter in Adolescent Depression: Relationships with Illness Severity, Anhedonia, and Irritability
Henderson, S. E., Johnson, A. R., Vallejo, A. I., Katz, L., Wong, E. W., & Gabbay, V. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00152 · Cited by 101 · see citing works
A diffusion tensor imaging study of suicide attempters
Olvet, D. M., Peruzzo, D., Thapa-Chhetry, B., Sublette, M. E., Sullivan, G. M., Oquendo, M. A., Mann, J. J., & Parsey, R. V. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.002 · Cited by 97 · see citing works
Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder
Won, E., Choi, S., Kang, J. C., Kim, A., Han, K.-M., Chang, H.-S., Tae, W., Son, K. R., Joe, S.-H., Lee, M.-S., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.137 · Cited by 97 · see citing works
In pursuit of neuroimaging biomarkers to guide treatment selection in major depressive disorder: a review of the literature
Lener, M. S., & Iosifescu, D. V. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12759 · Cited by 96 · see citing works
Deviant white matter structure in adults with attention-deficit/hyperactivity disorder points to aberrant myelination and affects neuropsychological performance
Onnink, A. M. H., Zwiers, M. P., Hoogman, M., Mostert, J. C., Dammers, J., Kan, C. C., Vasquez, A. A., Schene, A. H., Buitelaar, J., & Franke, B. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.008 · Cited by 93 · see citing works
Altered white matter integrity in young adults with first-episode, treatment-naive, and treatment-responsive depression
Guo, W., Liu, F., Xue, Z., Gao, K., Wu, R., Ma, C., Liu, Z., Xiao, C., Chen, H., & Zhao, J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.06.027 · Cited by 91 · see citing works
Cortico-Cortical White Matter Motor Pathway Microstructure Is Related to Psychomotor Retardation in Major Depressive Disorder
Bracht, T., Federspiel, A., Schnell, S., Horn, H., Höfle, O., Wiest, R., Dierks, T., Strik, W. K., Müller, T., & Walther, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052238 · Cited by 88 · see citing works
Magnetic Resonance Imaging Measures of Brain Structure to Predict Antidepressant Treatment Outcome in Major Depressive Disorder
Korgaonkar, M. S., Rekshan, W. R., Gordon, E., Rush, A. J., Williams, L. M., Blasey, C. M., & Grieve, S. M. (2014) · EBioMedicine · doi:10.1016/j.ebiom.2014.12.002 · Cited by 90 · see citing works
Self-citation
White matter microstructure alterations of the medial forebrain bundle in melancholic depression
Bracht, T., Horn, H., Strik, W. K., Federspiel, A., Schnell, S., Höfle, O., Stegmayer, K., Wiest, R., Dierks, T., Müller, T., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.048 · Cited by 90 · see citing works
White matter abnormalities in depression: A categorical and phenotypic diffusion MRI study
Coloigner, J., Batail, J.-M. V., Commowick, O., Corouge, I., Robert, G., Barillot, C., & Drapier, D. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101710 · Cited by 88 · see citing works
Altered white-matter architecture in treatment-naive adolescents with clinical depression
Aghajani, M., Veer, I. M., van Lang, N. D. J., Meens, P. H. F., van den Bulk, B. G., Rombouts, S. A. R. B., Vermeiren, R. R. J. M., & van der Wee, N. J. (2013) · Psychological Medicine · doi:10.1017/s0033291713003000 · Cited by 89 · see citing works
Magnetic seizure therapy reduces suicidal ideation and produces neuroplasticity in treatment-resistant depression
Sun, Y., Blumberger, D. M., Mulsant, B. H., Rajji, T. K., Fitzgerald, P. B., Barr, M. S., Downar, J., Wong, W., Farzan, F., & Daskalakis, Z. J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0302-8 · Cited by 85 · see citing works
Altered white matter integrity of forebrain in treatment-resistant depression: A diffusion tensor imaging study with tract-based spatial statistics
Guo, W., Liu, F., Chen, J., Xu, X., Wu, R., Ma, C., Gao, K., Tan, C., Sun, X., Xiao, C., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.012 · Cited by 84 · see citing works
Abnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication
Fan, Q., Yan, X., Wang, J., Chen, Y., Wang, X., Li, C., Tan, L., You, C., Zhang, T., Zuo, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035889 · Cited by 84 · see citing works
Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
Anderson, G., Maes, M. H. J., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.016 · Cited by 83 · see citing works
Intrinsic disruption of white matter microarchitecture in first-episode, drug-naive major depressive disorder: A voxel-based meta-analysis of diffusion tensor imaging
Chen, G., Guo, Y., Zhu, H., Kuang, W., Bi, F., Ai, H., Gu, Z., Huang, X., Lui, S., & Gong, Q. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.011 · Cited by 81 · see citing works
The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction
Kennedy, S. H., Downar, J. H., Evans, K., Feilotter, H. E., Lam, R. W. M., MacQUEEN, G. M., Milev, R. V., Parikh, S. V., Rotzinger, S., & Soares, C. N. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523635 · Cited by 76 · see citing works
White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study
Zuo, N., Fang, J., Lv, X., Zhou, Y., Yang, H., Li, T., Tong, H., Wang, X., Wang, W.-D., & Jiang, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037561 · Cited by 74 · see citing works
Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder
Repple, J., Mauritz, M., Meinert, S., de Lange, S. C., Grotegerd, D., Opel, N., Redlich, R., Hahn, T., Förster, K., Leehr, E. J., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0603-1 · Cited by 71 · see citing works
Measures of Retinal Structure and Function as Biomarkers in Neurology and Psychiatry
Silverstein, S. M., Demmin, D. L., Schallek, J. B., & Fradkin, S. I. (2020) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2020.100018 · Cited by 74 · see citing works
A framework for interpreting functional networks in schizophrenia
Williamson, P., & Allman, J. M. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00184 · Cited by 72 · see citing works
White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study
Ota, M., Noda, T., Sato, N., Hattori, K., Hori, H., Sasayama, D., Teraishi, T., Nagashima, A., Obu, S., Higuchi, T., et al. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12255 · Cited by 68 · see citing works
Shared and distinct homotopic connectivity changes in melancholic and non-melancholic depression
Shan, X., Cui, X., Liu, F., Li, H., Huang, R., Tang, Y., Chen, J., Zhao, J., Guo, W., & Xie, G. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.03.038 · Cited by 69 · see citing works
Gray Matter Abnormalities in Pediatric Mild Traumatic Brain Injury
Mayer, A. R., Hanlon, F. M., & Ling, J. M. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3534 · Cited by 66 · see citing works
Reconciling Variable Findings of White Matter Integrity in Major Depressive Disorder
Choi, K. S., Holtzheimer, P. E., Franco, A. R., Kelley, M. E., Dunlop, B. W., Hu, X. P., & Mayberg, H. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.345 · Cited by 66 · see citing works
Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics
Sugimoto, K., Kakeda, S., Watanabe, K., Katsuki, A., Ueda, I., Igata, N., Igata, R., Abe, O., Yoshimura, R., & Korogi, Y. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0174-y · Cited by 62 · see citing works
Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression
Yang, R., Zhang, H., Wu, X., Yang, J.-L., Ma, M., Gao, Y., Liu, H., & Li, S. (2014) · BioMed Research International · doi:10.1155/2014/915026 · Cited by 62 · see citing works
Impaired interhemispheric connectivity in medication-naive patients with major depressive disorder
Xu, K., Jiang, W., Ren, L., Ouyang, X., Jiang, Y., Wu, F., Kong, L., Womer, F. Y., Liu, Z., Blumberg, H. P., et al. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110132 · Cited by 60 · see citing works
Mapping inter-regional connectivity of the entire cortex to characterize major depressive disorder
Korgaonkar, M. S., Cooper, N. J., Williams, L. M., & Grieve, S. M. (2012) · Neuroreport · doi:10.1097/wnr.0b013e3283546264 · Cited by 57 · see citing works
Self-citation
White matter microstructural abnormalities and their association with anticipatory anhedonia in depression
Yang, X., Wang, Y., Wang, D.-F., Tian, K., Cheung, E. F. C., Xie, G., & Chan, R. C. K. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.04.005 · Cited by 57 · see citing works
Right temporal activation differs between melancholia and nonmelancholic depression: A multichannel near-infrared spectroscopy study
Tsujii, N., Mikawa, W., Akashi, H., Tsujimoto, E., Adachi, T., Kirime, E., Takaya, M., Yanagi, M., & Shirakawa, O. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.003 · Cited by 56 · see citing works
Increased cerebrospinal fluid fibrinogen in major depressive disorder
Hattori, K., Ota, M., Sasayama, D., Yoshida, S., Matsumura, R., Miyakawa, T., Yokota, Y., Yamaguchi, S., Noda, T., Teraishi, T., et al. (2015) · Scientific Reports · doi:10.1038/srep11412 · Cited by 55 · see citing works
Habitual sleep durations and subjective sleep quality predict white matter differences in the human brain
Khalsa, S., Hale, J. R., Goldstone, A., Wilson, R. S., Mayhew, S. D., Bagary, M. S., & Bagshaw, A. P. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2017.03.001 · Cited by 52 · see citing works
The medial forebrain bundle as a deep brain stimulation target for treatment resistant depression: A review of published data
Gálvez, J. F., Keser, Z., Mwangi, B., Ghouse, A. A., Fenoy, A. J., Schulz, P. E., Sanches, M., Quevedo, J., Selvaraj, S., Gajwani, P., et al. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.12.003 · Cited by 52 · see citing works
A COMPREHENSIVE EXAMINATION OF WHITE MATTER TRACTS AND CONNECTOMETRY IN MAJOR DEPRESSIVE DISORDER
Olvet, D. M., Delaparte, L., Yeh, F.-C. F., DeLorenzo, C., McGrath, P. J., Weissman, M. M., Adams, P., D, M. F. M., Deckersbach, T., McInnis, M. G., et al. (2015) · Depression and Anxiety · doi:10.1002/da.22445 · Cited by 53 · see citing works
Relationship between white matter integrity and serum cortisol levels in drug-naive patients with major depressive disorder: Diffusion tensor imaging study using tract-based spatial statistics
Liu, X., Watanabe, K., Kakeda, S., Yoshimura, R., Abe, O., Ide, S., Hayashi, K., Katsuki, A., Umene‐Nakano, W., Watanabe, R., et al. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.155689 · Cited by 53 · see citing works
White matter integrity affected by depressive symptoms in migraine without aura: a tract‐based spatial statistics study
Yu, D., Yuan, K., Zhao, L., Dong, M., Liu, P., Yang, X., Liu, J., Sun, J., Zhou, G., Xue, T., et al. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2924 · Cited by 51 · see citing works
Altered white matter integrity in individuals with cognitive vulnerability to depression: a tract-based spatial statistics study
Xiao, J., He, Y., McWhinnie, C. M., & Yao, S. (2015) · Scientific Reports · doi:10.1038/srep09738 · Cited by 53 · see citing works
Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies
Rahimi, R., Dolatshahi, M., Abbasi-Feijani, F., Momtazmanesh, S., Cattarinussi, G., Aarabi, M. H., & Pini, L. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00690-1 · Cited by 50 · see citing works
Fronto-limbic disconnection in patients with multiple sclerosis and depression
van Geest, Q., Boeschoten, R., Keijzer, M. J., Steenwijk, M., Pouwels, P., Twisk, J., Smit, J., Uitdehaag, B., Geurts, J., van Oppen, P., et al. (2018) · Multiple Sclerosis · doi:10.1177/1352458518767051 · Cited by 46 · see citing works
Development and evaluation of a multimodal marker of major depressive disorder
Yang, J., Zhang, M., Ahn, H., Zhang, Q., Jin, T. B., Li, I., Nemesure, M. D., Joshi, N., Jiang, H., Miller, J. M., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24282 · Cited by 48 · see citing works
Different functioning of prefrontal cortex predicts treatment response after a selective serotonin reuptake inhibitor treatment in patients with major depression
Masuda, K., Nakanishi, M., Okamoto, K., Kawashima, C., Oshita, H., Inoue, A., Takita, F., Izumi, T., Ishitobi, Y., Higuma, H., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.034 · Cited by 47 · see citing works
Assessment of abnormal brain structures and networks in major depressive disorder using morphometric and connectome analyses
Chen, V. C., Shen, C., Liang, S. H., Li, Z., Tyan, Y., Liao, Y., Huang, Y.-C., Lee, Y. L., McIntyre, R. S., & Weng, J. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.06.066 · Cited by 46 · see citing works
Limbic white matter microstructure plasticity reflects recovery from depression
Bracht, T., Jones, D. K., Müller, T., Wiest, R., & Walther, S. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.08.031 · Cited by 46 · see citing works
White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms
Tatham, E. L., Ramasubbu, R., Gaxiola‐Valdez, I., Cortese, F., Clark, D., Goodyear, B. G., Foster, J. A., & Hall, G. B. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.04.014 · Cited by 46 · see citing works
Impaired long contact white matter fibers integrity is related to depression in Parkinson's disease
Wu, J., Zhang, Y., Wu, W., Hu, G., & Xu, Y. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12778 · Cited by 46 · see citing works
White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study
Davis, A. D., Hassel, S., Arnott, S. R., Harris, J. K., Lam, R. W. M., Milev, R. V., Rotzinger, S., Zamyadi, M., Frey, B. N., Minuzzi, L., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.016 · Cited by 46 · see citing works
Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder
Choi, S., Han, K., Kang, J. C., Won, E., Chang, H. S., Tae, W., Son, K. R., Kim, S. J., Lee, M.-S., & Ham, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164301 · Cited by 45 · see citing works
Tractography of the Brainstem in Major Depressive Disorder Using Diffusion Tensor Imaging
Song, Y. J. C., Korgaonkar, M. S., Armstrong, L. V., Eagles, S., Williams, L. M., & Grieve, S. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084825 · Cited by 45 · see citing works
Self-citation
Brain imaging predictors and the international study to predict optimized treatment for depression: study protocol for a randomized controlled trial
Grieve, S. M., Korgaonkar, M. S., Etkin, A., Harris, A., Koslow, S. H., Wisniewski, S., Schatzberg, A. F., Nemeroff, C. B., Gordon, E., & Williams, L. M. (2013) · Trials · doi:10.1186/1745-6215-14-224 · Cited by 44 · see citing works
Self-citation
A Diffusion-Tensor-Based White Matter Atlas for Rhesus Macaques
Zakszewski, E., Adluru, N., Tromp, D., Kalin, N. H., & Alexander, A. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107398 · Cited by 44 · see citing works
Potential structural and functional biomarkers of upper motor neuron dysfunction in ALS
Grieve, S. M., Menon, P., Korgaonkar, M. S., Gomes, L. J., Foster, S., Kiernan, M. C., & Vucic, S. (2015) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2015.1074707 · Cited by 43 · see citing works
Self-citation
Early Exposure to Traumatic Stressors Impairs Emotional Brain Circuitry
Korgaonkar, M. S., Antees, C., Williams, L. M., Gatt, J. M., Bryant, R. A., Cohen, R. A., Paul, R. H., O'Hara, R. M., & Grieve, S. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075524 · Cited by 43 · see citing works
Self-citation
Hedonic tone is associated with left supero-lateral medial forebrain bundle microstructure
Bracht, T., Doidge, A. N., Keedwell, P. A., & Jones, D. K. (2014) · Psychological Medicine · doi:10.1017/s0033291714001949 · Cited by 44 · see citing works
Alterations in White Matter Integrity in Young Adults with Smartphone Dependence
Hu, Y., Long, X., Lyu, H., Zhou, Y., & Chen, J. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00532 · Cited by 43 · see citing works
Thalamic volume and thalamo-cortical white matter tracts correlate with motor and verbal memory performance
Philp, D. J., Korgaonkar, M. S., & Grieve, S. M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.057 · Cited by 42 · see citing works
Self-citation
Neuroimaging biomarkers in bipolar disorder
Houenou, J. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/402 · Cited by 40 · see citing works
Mild White Matter Changes in Un-medicated Obsessive-Compulsive Disorder Patients and Their Unaffected Siblings
Fan, S., van den Heuvel, O. A., Cath, D. C., van der Werf, Y. D., de Wit, S. J., de Vries, F. E., Veltman, D. J., & Pouwels, P. J. W. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00495 · Cited by 41 · see citing works
White matter alterations in the internal capsule and psychomotor impairment in melancholic depression
Hyett, M. P., Perry, A., Breakspear, M. J., Wen, W. X., & Parker, G. B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195672 · Cited by 41 · see citing works
White matter integrity in medication-free women with peripartum depression: a tract-based spatial statistics study
Silver, M., Moore, C. M., Villamarin, V., Jaitly, N., Hall, J. E., Rothschild, A. J., & Deligiannidis, K. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0023-y · Cited by 39 · see citing works
Functional and Structural Connectivity Between the Left Dorsolateral Prefrontal Cortex and Insula Could Predict the Antidepressant Effects of Repetitive Transcranial Magnetic Stimulation
Fu, Y., Long, Z., Luo, Q., Xu, Z., Xiang, Y., Du, W., Cao, Y., Cheng, X., & Du, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.645936 · Cited by 38 · see citing works
Associations between anterior cingulate thickness, cingulum bundle microstructure, melancholia and depression severity in unipolar depression
Mertse, N., Denier, N., Walther, S., Breit, S., Grosskurth, E. D., Federspiel, A., Wiest, R., & Bracht, T. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.01.035 · Cited by 38 · see citing works
Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
Alves, G. S., Karakaya, T., Fußer, F., Kordulla, M., O’Dwyer, L., Christl, J., Magerkurth, J., Oertel‐Knöchel, V., Knöchel, C., Prvulovic, D., et al. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.12.006 · Cited by 35 · see citing works
Sleep characteristics and white matter hyperintensities among midlife women
Thurston, R. C., Wu, M., Aizenstein, H. J., Chang, Y., Barinas‐Mitchell, E., Derby, C. A., & Maki, P. M. (2019) · SLEEP · doi:10.1093/sleep/zsz298 · Cited by 37 · see citing works
Anticipatory reward deficits in melancholia.
Liu, H., Sarapas, C., & Shankman, S. A. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000172 · Cited by 36 · see citing works
Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression
Tsujii, N., Mikawa, W., Tsujimoto, E., Akashi, H., Adachi, T., Kirime, E., & Shirakawa, O. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.04.015 · Cited by 36 · see citing works
White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder
Lim, J., Sohn, H., Kwon, M., & Kim, B. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.3.449 · Cited by 36 · see citing works
Altered white matter microstructural connectivity in cluster headaches: A longitudinal diffusion tensor imaging study
Chou, K., Yang, F., Fuh, J., Huang, C., Lirng, J.-F., Lin, Y., Lee, P., Kao, H., Lin, C., & Wang, S. (2014) · Cephalalgia · doi:10.1177/0333102414527649 · Cited by 36 · see citing works
Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
Tha, K. K., Terae, S., Nakagawa, S., Inoue, T., Kitagawa, N., Kako, Y., Nakato, Y., Popy, K. A., Fujima, N., Zaitsu, Y., et al. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.07.004 · Cited by 35 · see citing works
Cognitive and emotional biomarkers of melancholic depression: An iSPOT-D report
Day, C. V., Gatt, J. M., Etkin, A., DeBattista, C., Schatzberg, A. F., & Williams, L. M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.061 · Cited by 34 · see citing works
Self-citation
White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study
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Investigation of White Matter with Tract-based Spatial Statistics in Patients with Major Depressive Disorder
Yao, S. (2011) · Zhongguo linchuang xinlixue zazhi

Authors: Korgaonkar, M. S., Grieve, S. M., Koslow, S. H., Gabrieli, J. D. E., Gordon, E., & Williams, L. M.
Affiliations: The University of Sydney (AU)
American Foundation for Suicide Prevention (US)
Massachusetts Institute of Technology (US)
ORCID: Korgaonkar, Mayuresh S.
Grieve, Stuart M.
Gabrieli, John D.E.
Williams, Leanne M.
Venue: Human Brain Mapping
Publisher: Wiley
Published: 2010-12-17
Volume: 32
Issue: 12
Pages: 2161-2171
ISSN: 1065-9471 (ISSN-L)
1097-0193
DOI: 10.1002/hbm.21178
PMC: PMC6870076
OpenAlex: W2064383989
Cited by: 205
References: 61
Citations by year: 2026: 2 · 2025: 8 · 2024: 8 · 2023: 9 · 2022: 17 · 2021: 12 · 2020: 9 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 12 · 2015: 17 · 2014: 24 · 2013: 15 · 2012: 22
FWCI: 11.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Human Brain Mapping (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: major depressive disorder, white matter integrity, endogenous depression, fractional anisotropy, diffusion tensor imaging, tract-based spatial statistics, limbic system, dorsolateral prefrontal cortex, thalamus, corpus callosum, myelination, axial and radial diffusivity, structural brain abnormalities
MeSH terms: Adolescent, Adult, Aged, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Young Adult, Diffusion Tensor Imaging

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Loss of white matter integrity in major depressive disorder: evidence using tract-based spatial statistical analysis of diffusion tensor imaging

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