Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression
Open accessAbstract
Background Elevated rate of aging-related biological and functional decline, termed "accelerated aging," is reported in patients with schizophrenia (SCZ) and major depressive disorder (MDD). We used diffusion tensor imaging derived fractional anisotropy (FA) as a biomarker of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD. Methods The SCZ cohort comprised 58 SCZ patients and 60 controls (aged 20-60 years). The MDD cohort comprised 136 MDD patients and 351 controls (aged 20-79 years). The main outcome measures were the diagnosis-by-age interaction on whole-brain-averaged WM FA values and FA values from 12 major WM tracts. Results Diagnosis-by-age interaction for the whole-brain average FA was significant for the SCZ (p = .04) but not the MDD (p = .80) cohort. Diagnosis-by-age interaction was nominally significant (p<.05) for five WM tracts for SCZ and for none of the tracts in the MDD cohort. Tract-specific heterochronicity of the onset of age-related decline in SCZ demonstrated strong negative correlations with the age-of-peak myelination and the rates of age-related decline obtained from normative sample (r =-.61 and-.80, p<.05, respectively). No such trends existed for MDD cohort. Conclusions Cerebral WM showed accelerated aging in SCZ but not in MDD, suggesting some difference in the pathophysiology underlying their WM aging changes. Tract-specific heterochronicity of WM development modulated presentation of accelerated aging in SCZ: WM tracts that matured later in life appeared more sensitive to the pathophysiology of SCZ and demonstrated more susceptibility to disorder-related accelerated decline in FA values with age. This trend was not observed in MDD cohort.
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The greater sensitivity of white matter to aging in schizophrenia may account for the greater prevalence of cingulum changes in those with well-established psychotic states.
“may account for the greater prevalence of cingulum changes in those with well-established psychotic states.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kochunov et al., 2013
The Results and Discussion report accelerated white-matter aging in schizophrenia and greater vulnerability in some tracts. They do not establish a greater prevalence of cingulum changes in people with well-established psychotic states, or test whether accelerated aging accounts for that prevalence. (LLM, conf=0.85)
Experimental — accuracy not yet measuredWhite matter, including the cingulum, is especially sensitive to the effects of aging in schizophrenia.
“Evidence that white matter, including the cingulum, is especially sensitive to the effects of aging in schizophrenia (Kochunov et al., 2013)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kochunov et al., 2013
The Results (page unavailable) report accelerated age-related white-matter decline in schizophrenia, with numerically greater decline across all twelve tracts. They do not identify the cingulum as especially sensitive: the regional Results name five tracts with nominally significant age-by-diagnosis interactions, and the cingulum is not among them. (LLM, conf=0.83)
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Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
nlme : Linear and nonlinear mixed effects models
DebRoy, S. (2006) · Medical Entomology and Zoology · Cited by 10,009 · see citing works
nlme: Linear and Nonlinear Mixed Effects Models
Pinheiro, J., R Core Team, & Bates, D. (1999) · doi:10.32614/cran.package.nlme · Cited by 6,867 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
Saha, S., Chant, D., & McGrath, J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1123 · Cited by 2,065 · see citing works
Fiber Tract–based Atlas of Human White Matter Anatomy
Wakana, S., Jiang, H., Nagae‐Poetscher, L. M., van Zijl, P. C. M., & Mori, S. (2004) · Radiology · doi:10.1148/radiol.2301021640 · Cited by 2,023 · see citing works
Neuromorphic Silicon Neuron Circuits
Indiveri, G., Linares-Barranco, B., Hamilton, T. J., André, V. S., Etienne‐Cummings, R., Delbrück, T., Liu, S., Dudek, P., Hafliger, P. D., Renaud, S., et al. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00073 · Cited by 1,836 · see citing works
Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738 · see citing works
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658 · see citing works
Fiber tract-based atlas of human white matter anatomy
Wakana, S. (2006) · Medical Entomology and Zoology · Cited by 1,531 · see citing works
Schizophrenia and increased risks of cardiovascular disease
Hennekens, C. H., Hennekens, A. R., Hollar, D., & Casey, D. E. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.02.007 · Cited by 1,070 · see citing works
Excess mortality of schizophrenia: A meta-analysis
Brown, S. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.171.6.502 · Cited by 869 · see citing works
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.443 · Cited by 793 · see citing works
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659 · see citing works
COPD as a Disease of Accelerated Lung Aging
Ito, K., & Barnes, P. J. (2009) · CHEST Journal · doi:10.1378/chest.08-1419 · Cited by 620 · see citing works
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.004 · Cited by 516 · see citing works
Hof, P. R., Haroutunian, V., Friedrich, V. L., Byne, W., Buitron, C., Perl, D. P., & Davis, K. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00237-3 · Cited by 433 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Normal aging in the central nervous system: Quantitative MR diffusion-tensor analysis
Abe, O., Aoki, S., Hayashi, N., Yamada, H., Kunimatsu, A., Mori, H., Yoshikawa, T., Okubo, T., & Ohtomo, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00318-9 · Cited by 420 · see citing works
Genetic and Environmental Contributions to Cardiovascular Risk Factors in Mexican Americans
Mitchell, B. D., Kammerer, C. M., Blangero, J., Mahaney, M. C., Rainwater, D. L., Dyke, B., Hixson, J. E., Henkel, R. D., Sharp, R. M., Comuzzie, A. G., et al. (1996) · Circulation · doi:10.1161/01.cir.94.9.2159 · Cited by 364 · see citing works
Self-citationFractional anisotropy of water diffusion in cerebral white matter across the lifespan
Kochunov, P., Williamson, D. E., Lancaster, J., Fox, P. T., Cornell, J. E., Blangero, J., & Glahn, D. C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.01.014 · Cited by 363 · see citing works
Self-citationDEVELOPMENTAL (MYELOGENETIC) LOCALISATION OF THE CEREBRAL CORTEX IN THE HUMAN SUBJECT.
Leipsic, P. F. O. (1901) · The Lancet · doi:10.1016/s0140-6736(01)01429-5 · Cited by 339 · see citing works
Is schizophrenia a syndrome of accelerated aging?
Kirkpatrick, B., Messias, E., Harvey, P. D., Fernandez-Egea, E., & Bowie, C. R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm140 · Cited by 335 · see citing works
Diffusion Tensor Imaging in Schizophrenia
Kanaan, R., Kim, J.-S., Kaufmann, W. E., Pearlson, G. D., Barker, G. J., & McGuire, P. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.015 · Cited by 332 · see citing works
Gao, W., Lin, W., Chen, Y., Gerig, G., Smith, J. K., Jewells, V. L., & Gilmore, J. H. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1363 · Cited by 299 · see citing works
Kochunov, P., Thompson, P. M., Lancaster, J. L., Bartzokis, G., Smith, S., Coyle, T., Royall, D. R., Laird, A., & Fox, P. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.021 · Cited by 250 · see citing works
Self-citationDiffusion Tensor Imaging Findings in First-Episode and Chronic Schizophrenia Patients
Friedman, J. I., Tang, C. Y., Carpenter, D. M., Buchsbaum, M. S., Schmeidler, J., Flanagan, L., Golembo-Smith, S., Kanellopoulou, I., Ng, J., Hof, P. R., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101640 · Cited by 238 · see citing works
Jones, D. K., Catani, M., Pierpaoli, C. M., Reeves, S., Shergill, S. S., O'Sullivan, M. J., Golesworthy, P., McGuire, P. K., Horsfield, M. A., Simmons, A., et al. (2005) · Human Brain Mapping · doi:10.1002/hbm.20179 · Cited by 233 · see citing works
Of sound mind and body: depression, disease, and accelerated aging
Wolkowitz, O. M., Reus, V. I., & Mellon, S. H. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/owolkowitz · Cited by 213 · see citing works
Korgaonkar, M. S., Grieve, S. M., Koslow, S. H., Gabrieli, J. D. E., Gordon, E., & Williams, L. M. (2011) · Human Brain Mapping · doi:10.1002/hbm.21178 · Cited by 205 · see citing works
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn, D. C., Curran, J. E., Winkler, A. M., Carless, M. A., Kent, J. W., Charlesworth, J., Johnson, M. P., Göring, H. H. H., Cole, S. A., Dyer, T. D., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.022 · Cited by 184 · see citing works
Self-citationKieseppä, T., Eerola, M., Mäntylä, R., Neuvonen, T., Poutanen, V.-P., Luoma, K., Tuulio‐Henriksson, A., Jylhä, P. J., Mantere, O., Melartin, T. K., et al. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.023 · Cited by 181 · see citing works
Wolkowitz, O. M., Burke, H., Epel, E. S., & Reus, V. I. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04980.x · Cited by 180 · see citing works
Diffusion Tensor Imaging in Psychiatric Disorders
White, T. J. H., Nelson, M., & Lim, K. O. (2008) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e3181809f1e · Cited by 177 · see citing works
Excess Mortality in Schizophrenia and Affective Disorders
Tsuang, M. T. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770340031002 · Cited by 176 · see citing works
Divergent trajectories of physical, cognitive, and psychosocial aging in schizophrenia
Jeste, D. V., Wolkowitz, O. M., & Palmer, B. W. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr026 · Cited by 176 · see citing works
Cigarette smoking is associated with reduced microstructural integrity of cerebral white matter
Gons, R. A. R., van Norden, A. G. W., de Laat, K. F., van Oudheusden, L. J. B., van Uden, I. W. M., Zwiers, M. P., Norris, D. G., & de Leeuw, F. (2011) · Brain · doi:10.1093/brain/awr145 · Cited by 175 · see citing works
Kochunov, P., Glahn, D. C., Lancaster, J. L., Thompson, P. M., Kochunov, V., Rogers, B. G., Fox, P. T., Blangero, J., & Williamson, D. E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.050 · Cited by 160 · see citing works
Self-citationWhite Matter Integrity and Cognitive Impairment in First-Episode Psychosis
Pérez‐Iglesias, R., Tordesillas‐Gutiérrez, D., McGuire, P. K., Barker, G. J., Roiz‐Santiáñez, R., Mata, I. F., de Lucas, E. M., Rodríguez-Sánchez, J. M., Ayesa‐Arriola, R., Vázquez‐Barquero, J. L., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09050716 · Cited by 148 · see citing works
Hasan, K. M., Kamali, A., Iftikhar, A., Kramer, L. A., Papanicolaou, A. C., Fletcher, J. M., & Ewing‐Cobbs, L. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.026 · Cited by 138 · see citing works
Mechanisms of cardiovascular disease in accelerated aging syndromes
Capell, B. C., Collins, F. S., & Nabel, E. G. (2007) · Circulation Research · doi:10.1161/circresaha.107.153692 · Cited by 134 · see citing works
Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
Mori, T., Ohnishi, T., Hashimoto, R., Nemoto, K., Moriguchi, Y., Noguchi, H., Nakabayashi, T., Hori, H., Harada, S., Saitoh, O., et al. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2006.09.004 · Cited by 132 · see citing works
Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
森, 健. (2007) · Medical Entomology and Zoology · Cited by 127 · see citing works
Blood, A. J., Iosifescu, D. V., Makris, N., Perlis, R. H., Kennedy, D. N., Dougherty, D. D., Kim, B. W., Lee, M. J., Wu, S., Lee, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013945 · Cited by 126 · see citing works
Zhang, A., Leow, A., Ajilore, O., Lamar, M., Yang, S., Joseph, J., Medina, J., Zhan, L., & Kumar, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.279 · Cited by 121 · see citing works
Genetic pathway of major depressive disorder in shortening telomeric length
Lung, F., Chen, N. C., & Shu, B. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32808374f6 · Cited by 118 · see citing works
Mulkern, R. V., Zengingönül, H. P., Robertson, R. L., Bogner, P., Zou, K. H., Guðbjartsson, H., Guttmann, C. R. G., Holtzman, D. H., Kyriakos, W. E., Jolesz, F. A., et al. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200008)44:2 · Cited by 109 · see citing works
Mitkus, S. N., Hyde, T. M., Vakkalanka, R., Kolachana, B. S., Weinberger, D. R., Kleinman, J. E., & Lipska, B. K. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.032 · Cited by 107 · see citing works
Fernandez-Egea, E., Bernardo, M., Heaphy, C. M., Griffith, J. K., Parellada, E., Esmatjes, E., Conget, I., Nguyen, L., George, V., Stoppler, H., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn169 · Cited by 103 · see citing works
Dalby, R. B., Frandsen, J., Chakravarty, M. M., Ahdidan, J., Sørensen, L., Rosenberg, R., Videbech, P., & Østergaard, L. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.06.008 · Cited by 96 · see citing works
Cigarette smoking and white matter microstructure
Hudkins, M., O’Neill, J., Tobias, M. C., Bartzokis, G., & London, E. D. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2621-9 · Cited by 95 · see citing works
Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
Roussos, P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.110 · Cited by 93 · see citing works
Olvera, R. L., Bearden, C. E., Velligan, D. I., Almasy, L. A., Carless, M. A., Curran, J. E., Williamson, D. E., Duggirala, R., Blangero, J., & Glahn, D. C. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31196 · Cited by 71 · see citing works
Self-citationHuman p53 tumor suppressor gene (TP53) and schizophrenia: Case–control and family studies
Ni, X., Trakalo, J., Valente, J., de Azevedo, M. H. P., Pato, M. T., Pato, C. N., & Kennedy, J. L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.050 · Cited by 62 · see citing works
Genetic Analysis of Cortical Thickness and Fractional Anisotropy of Water Diffusion in the Brain
Kochunov, P., Glahn, D. C., Nichols, T. E., Winkler, A. M., Hong, E. L., Holcomb, H. H., Stein, J. L., Thompson, P. M., Curran, J. E., Carless, M. A., et al. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00120 · Cited by 61 · see citing works
Self-citationLiao, Y., Tang, J., Deng, Q., Deng, Y., Luo, T., Wang, X., Chen, H., Liu, T., Chen, X., Brody, A. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026460 · Cited by 48 · see citing works
Fernandez-Egea, E., García-Rizo, C., Miller, B., Parellada, E., Justicia, A., Bernardo, M., & Kirkpatrick, B. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318230343f · Cited by 43 · see citing works
Blood pressure and cerebral white matter share common genetic factors in Mexican Americans
Kochunov, P., Glahn, D. C., Lancaster, J., Winkler, A., Karlsgodt, K., Olvera, R. L., Curran, J. E., Carless, M. A., Dyer, T. D., Almasy, L., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.162206 · Cited by 38 · see citing works
Self-citationDoes the Framingham Stroke Risk Profile predict white-matter changes in late-life depression?
Allan, C. L., Sexton, C. E., Kalu, U. G., McDermott, L. M., Mika Kivimaki, B., Singh‐Manoux, A., Mackay, C. E., & Ebmeier, K. P. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211002183 · Cited by 32 · see citing works
Association of DRD4 uVNTR and TP53 codon 72 polymorphisms with schizophrenia: a case-control study
Lung, F., Shu, B., Kao, W.-T., Chen, C. N., Ku, Y.-C., & Tzeng, D. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-147 · Cited by 26 · see citing works
Age-dependent association between cigarette smoking on white matter hyperintensities
Kim, S. H., Yun, C., Lee, S., Choi, K.-H., Kim, M. B., & Park, H.-K. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0617-1 · Cited by 25 · see citing works
Molina, V., Papiol, S., Sanz, J., Rosa, A., Arias, B., Fatjó‐Vilas, M., Calama, J., Hernández, A. I., Bécker, J., & Fañanás, L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.076 · Cited by 23 · see citing works
Seo, Y., Shinar, H., Morita, Y., & Navon, G. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199909)42:3 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 67 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [13]Pfefferbaum A Sullivan EV Hedehus M Lim KO Adalsteinsson E Moseley M 2000 Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging Magn Reson Med 44 259 268 10918325
- [37]Jones DK Horsfield MA Simmons A 1999 Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging Magn Reson Med 42 515 525 10467296
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Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
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Koutsouleris, N., Davatzikos, C., Borgwardt, S., Gaser, C., Bottlender, R., Frodl, T., Falkai, P., Riecher-Rossler, A., Moller, H.-J., Reiser, M., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt142 · Cited by 448 · see citing works
Jahanshad, N., Kochunov, P. V., Sprooten, E., Mandl, R. C., Nichols, T. E., Almasy, L., Blangero, J., Brouwer, R. M., Curran, J. E., de Zubicaray, G. I., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.061 · Cited by 393 · see citing works
Self-citationvan Velzen, L. S., Kelly, S., Isaev, D., Aleman, A., Aftanas, L. I., Bauer, J., Baune, B. T., Brak, I. V., Carballedo, A., Connolly, C. G., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0477-2 · Cited by 358 · see citing works
Self-citationLindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
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Liu, H., Yang, Y., Xia, Y., Zhu, W., Leak, R. K., Wei, Z., Wang, J., & Hu, X. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.006 · Cited by 257 · see citing works
Self-citationNeurodevelopmental and neurodegenerative models of schizophrenia: white matter at the center stage
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Cropley, V. L., Klauser, P., Lenroot, R. K., Bruggemann, J., Sundram, S., Bousman, C., Pereira, A., Di Biase, M. A., Weickert, T. W., Weickert, C. S., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16050610 · Cited by 217 · see citing works
Kochunov, P., Jahanshad, N., Marcus, D., Winkler, A., Sprooten, E., Nichols, T. E., Wright, S. N., Hong, L. E., Patel, B., Behrens, T., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.050 · Cited by 215 · see citing works
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Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia
Kochunov, P. V., Coyle, T. R., Rowland, L. M., Jahanshad, N., Thompson, P. M., Kelly, S., Du, X. M., Sampath, H., Bruce, H. A., Chiappelli, J., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2228 · Cited by 145 · see citing works
Self-citationKochunov, P., Jahanshad, N., Sprooten, E., Nichols, T. E., Mandl, R. C., Almasy, L., Booth, T., Brouwer, R. M., Curran, J. E., de Zubicaray, G. I., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.03.033 · Cited by 133 · see citing works
Self-citationMyelin, myelin-related disorders, and psychosis
Mighdoll, M. I., Tao, R., Kleinman, J. E., & Hyde, T. M. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.040 · Cited by 135 · see citing works
Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population
Faye, C., McGowan, J. C., Denny, C. A., & David, D. J. P. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170818095105 · Cited by 137 · see citing works
Neurodegenerative model of schizophrenia: Growing evidence to support a revisit
Stone, W. S., Phillips, M. R., Yang, L. H., Kegeles, L. S., Susser, E., & Lieberman, J. A. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.03.004 · Cited by 110 · see citing works
Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress
Okusaga, O. O. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500256 · Cited by 96 · see citing works
Brain age in mood and psychotic disorders: a systematic review and meta‐analysis
Ballester, P. L., Romano, M. T., Cardoso, T. D. A., Hassel, S., Strother, S. C., Kennedy, S. H., & Frey, B. N. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13371 · Cited by 89 · see citing works
Cortical network dysfunction caused by a subtle defect of myelination
Poggi, G., Boretius, S., Möbius, W., Moschny, N., Baudewig, J., Ruhwedel, T., Hassouna, I. A., Wieser, G. L., Werner, H. B., Goebbels, S., et al. (2016) · Glia · doi:10.1002/glia.23039 · Cited by 74 · see citing works
Diffusion Imaging of White Matter in Schizophrenia: Progress and Future Directions
Karlsgodt, K. H. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.12.001 · Cited by 67 · see citing works
Diffusion Tensor Imaging findings and their implications in schizophrenia
Kubicki, M. R., & Shenton, M. E. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000053 · Cited by 65 · see citing works
Tønnesen, S., Kaufmann, T., de Lange, A. G., Richard, G., Doan, N. T., Alnæs, D., van der Meer, D., Rokicki, J., Moberget, T., Maximov, I. I., et al. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.014 · Cited by 66 · see citing works
Guo, M., Yang, G., Meng, X., Zhang, T., Li, C., Bai, S., & Zhao, X. (2023) · Environment International · doi:10.1016/j.envint.2023.108144 · Cited by 64 · see citing works
Kochunov, P., Ganjgahi, H., Winkler, A. M., Kelly, S., Shukla, D. K., Du, X. M., Jahanshad, N., Rowland, L. M., Sampath, H., Patel, B., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23336 · Cited by 62 · see citing works
Self-citationAccelerated aging of the putamen in patients with major depressive disorder
Sacchet, M. D., Camacho, M. C., Livermore, E. E., Thomas, E. A. C., & Gotlib, I. H. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160010 · Cited by 62 · see citing works
Chen, C., Hsu, Y., Yang, L., Tung, Y.-H., Luo, W., Liu, C., Hwang, T., Hwu, H., & Tseng, W. I. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116831 · Cited by 60 · see citing works
A White Matter Connection of Schizophrenia and Alzheimer’s Disease
Kochunov, P. V., Zavaliangos‐Petropulu, A., Jahanshad, N., Thompson, P. M., Ryan, M. C., Chiappelli, J., Chen, S., Du, X. M., Hatch, K. S., Adhikari, B. M., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa078 · Cited by 55 · see citing works
Self-citationTønnesen, S., Kaufmann, T., Doan, N. T., Alnæs, D., Córdova‐Palomera, A., van der Meer, D., Rokicki, J., Moberget, T., Gurholt, T. P., Haukvik, U. K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32355-9 · Cited by 54 · see citing works
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
Campos, P. B., Paulsen, B. S., & Rehen, S. K. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00292 · Cited by 52 · see citing works
Transdiagnostic neuroimaging in psychiatry: a review
Mitelman, S. A. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.01.026 · Cited by 50 · see citing works
Czepielewski, L. S., Massuda, R., Panizzutti, B., Grün, L. K., Barbé‐Tuana, F. M., Teixeira, A. L., Barch, D. M., & Gama, C. S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx015 · Cited by 49 · see citing works
Kerr, B., Schwilk, D. W., Bergman, A., & Feldman, M. W. (1999) · Evolutionary ecology research · Cited by 50 · see citing works
Kuo, C.-Y., Lee, P., Hung, S., Liu, L.-K., Lee, W., Chung, C., Yang, A. C., Tsai, S., Wang, P., Chen, L., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa161 · Cited by 48 · see citing works
Anatomy and White Matter Connections of the Parahippocampal Gyrus
Lin, Y., Dhanaraj, V., Mackenzie, A., Young, I. M., Tanglay, O., Briggs, R. G., Chakraborty, A. R., Hormovas, J., Fonseka, R. D., Kim, S. J., et al. (2021) · World Neurosurgery · doi:10.1016/j.wneu.2020.12.136 · Cited by 48 · see citing works
Evidence for Accelerated Decline of Functional Brain Network Efficiency in Schizophrenia
Sheffield, J. M., Repovš, G., Harms, M. P., Carter, C. S., Gold, J. M., MacDonald, A. W., Ragland, J. D., Silverstein, S. M., Godwin, D., & Barch, D. M. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv148 · Cited by 47 · see citing works
Leukocyte telomere length: Effects of schizophrenia, age, and gender
Wolkowitz, O. M., Jeste, D. V., Martin, A. S., Lin, J., Daly, R. E., Reuter, C., & KRAEMER, H. C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.10.015 · Cited by 47 · see citing works
White matter connectivity disruptions in early and chronic schizophrenia
Biase, M. A. D., Cropley, V., Baune, B. T., Olver, J. S., Amminger, G. P., Phassouliotis, C., Bousman, C., McGorry, P. D., Everall, I., Pantelis, C., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717001313 · Cited by 47 · see citing works
Chiappelli, J., Hong, L. E., Wijtenburg, S. A., Du, X. M., Gaston, F. E., Kochunov, P., & Rowland, L. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.43 · Cited by 48 · see citing works
Self-citationAccelerated white matter aging in schizophrenia: role of white matter blood perfusion
Wright, S. N., Kochunov, P., Chiappelli, J., McMahon, R. P., Muellerklein, F., Wijtenburg, S. A., White, M. G., Rowland, L. M., & Hong, L. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.016 · Cited by 46 · see citing works
Self-citationAcheson, A., Wijtenburg, S. A., Rowland, L. M., Winkler, A., Mathias, C. W., Hong, L. E., Jahanshad, N., Patel, B., Thompson, P. M., McGuire, S. A., et al. (2017) · Brain and Behavior · doi:10.1002/brb3.615 · Cited by 43 · see citing works
Self-citationThe Processing-Speed Impairment in Psychosis Is More Than Just Accelerated Aging
Mathias, S., Knowles, E., Barrett, J., Leach, O. K., Buccheri, S., Beetham, T., Blangero, J., Poldrack, R., & Glahn, D. (2017) · Schizophrenia bulletin · doi:10.1093/schbul/sbw168 · Cited by 39 · see citing works
Self-citationWhite matter brain aging in relationship to schizophrenia and its cognitive deficit
Wang, J., Kochunov, P. V., Sampath, H., Hatch, K. S., Ryan, M. C., Xue, F., Jahanshad, N., Thompson, P. M., Hahn, B., Gold, J. M., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.02.003 · Cited by 41 · see citing works
Self-citationChiapponi, C., Piras, F., Piras, F., Fagioli, S., Caltagirone, C., & Spalletta, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075115 · Cited by 39 · see citing works
Kochunov, P., Chiappelli, J., Wright, S. N., Rowland, L. M., Patel, B., Wijtenburg, S. A., Nugent, K. L., McMahon, R. P., Carpenter, W. T., Muellerklein, F., et al. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.05.004 · Cited by 40 · see citing works
Self-citationNugent, K. L., Chiappelli, J., Sampath, H., Rowland, L. M., Thangavelu, K., Davis, B. J., Du, X. M., Muellerklein, F., Daughters, S. B., Kochunov, P., et al. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000215 · Cited by 38 · see citing works
Self-citationAge or age at onset? Which of them really matters for neuro and social cognition in schizophrenia?
Linke, M., Jankowski, K. S., Ciołkiewicz, A., Jędrasik-Styła, M., Parnowska, D., Gruszka, A., Denisiuk, M., Jarema, M., & Wichniak, A. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.024 · Cited by 38 · see citing works
Savransky, A., Chiappelli, J., Rowland, L. M., Wisner, K., Shukla, D. K., Kochunov, P., & Hong, L. E. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000487 · Cited by 36 · see citing works
Self-citationTelomere length in psychiatric disorders: Is it more than an ageing marker?
Monroy‐Jaramillo, N., Dyukova, E., & Walss‐Bass, C. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1273550 · Cited by 37 · see citing works
Accelerated Aging of Functional Brain Networks Supporting Cognitive Function in Psychotic Disorders
Sheffield, J. M., Rogers, B. P., Blackford, J. U., Heckers, S., & Woodward, N. D. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.016 · Cited by 35 · see citing works
Shahab, S., Stefanik, L., Foussias, G., Lai, M., Anderson, K. K., & Voineskos, A. N. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx049 · Cited by 34 · see citing works
Alloza, C., Cox, S. R., Blesa, M., Redmond, P. H., Whalley, H. C., Ritchie, S. J., Maniega, S. M., Hernández, M. D. C. V., Tucker–Drob, E. M., Lawrie, S. M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.075 · Cited by 34 · see citing works
Bathelt, J., Koolschijn, P. C. M. P., & Geurts, H. M. (2020) · Molecular Autism · doi:10.1186/s13229-020-0316-y · Cited by 31 · see citing works
Abnormal microglial reactivity in gray matter of the prefrontal cortex in schizophrenia
Uranova, N. A., Vikhreva, O. V., & Рахманова, В. И. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102752 · Cited by 32 · see citing works
Alloza, C., Blesa, M., Bastin, M. E., Madole, J. W., Buchanan, C. R., Janssen, J., Gibson, J., Deary, I. J., Tucker–Drob, E. M., Whalley, H. C., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0794-x · Cited by 29 · see citing works
Du, X. M., Choa, F., Chiappelli, J., Wisner, K., Wittenberg, G. F., Adhikari, B. M., Bruce, H. A., Rowland, L. M., Kochunov, P. V., & Hong, L. E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.007 · Cited by 31 · see citing works
Self-citationGenetics of aging, health, and survival: dynamic regulation of human longevity related traits
Yashin, A. I., Wu, D., Arbeeva, L. S., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Kovtun, M., Culminskaya, I. V., Stallard, E., Li, M., et al. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00122 · Cited by 28 · see citing works
de Leeuw, M., Bohlken, M. M., Mandl, R. C. W., Kahn, R. S., & Vink, M. (2015) · Schizophrenia · doi:10.1038/npjschz.2015.1 · Cited by 25 · see citing works
Kochunov, P. V., Patel, B., Ganjgahi, H., Donohue, B., Ryan, M. C., Hong, L. E., Chen, X., Adhikari, B. M., Jahanshad, N., Thompson, P. M., et al. (2019) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2019.00016 · Cited by 26 · see citing works
Self-citationGene Expression Profiles Associated with Brain Aging are Altered in Schizophrenia
Sabunciyan, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-42308-5 · Cited by 25 · see citing works
Kochunov, P. V., Chiappelli, J., & Hong, L. E. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.06.019 · Cited by 25 · see citing works
Self-citationGómez‐Gastiasoro, A., Zubiaurre‐Elorza, L., Peña, J., Ibarretxe‐Bilbao, N., Rilo, O., Schretlen, D. J., & Ojeda, N. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101781 · Cited by 23 · see citing works
Β-Amyloid Burden is Not Associated with Cognitive Impairment in Schizophrenia: A Systematic Review
Chung, J. K., Nakajima, S., Plitman, E., Iwata, Y., Uy, D., Gerretsen, P., Caravaggio, F., Chakravarty, M. M., & Graff‐Guerrero, A. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.03.013 · Cited by 24 · see citing works
Bruce, H. A., Kochunov, P. V., Paciga, S. A., Hyde, C. L., Chen, X., Zhi, X., Zhang, B., Xi, H. S., O’Donnell, P., Whelan, C. D., et al. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12372 · Cited by 24 · see citing works
Self-citationWei, S., Womer, F. Y., Geng, H., Jiang, X., Zhou, Q., Chang, M., Zhou, Y., Tang, Y., & Wang, F. (2017) · Scientific Reports · doi:10.1038/srep44316 · Cited by 24 · see citing works
White matter deficits in schizophrenia are global and don’t progress with age
Kanaan, R., Picchioni, M., McDonald, C., Shergill, S. S., & McGuire, P. K. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417700729 · Cited by 24 · see citing works
Alloza, C., Cox, S. R., Duff, B. J., Semple, S. I. K., Bastin, M. E., Whalley, H. C., & Lawrie, S. M. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.05.008 · Cited by 24 · see citing works
Ryan, M. C., Hong, L. E., Hatch, K. S., Gao, S., Chen, S., Haerian, K., Wang, J., Goldwaser, E. L., Du, X. M., Adhikari, B. M., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.25769 · Cited by 21 · see citing works
Self-citationTransdiagnostic structural neuroimaging features in depression and psychosis: A systematic review
Lalousis, P. A., Wood, S. J., Reniers, R. L. E. P., Schmaal, L., Azam, H., Mazziota, A., Saeed, H., Wragg, C., & Upthegrove, R. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103388 · Cited by 21 · see citing works
Sun, Y., Zhang, Z., Kakkos, I., Matsopoulos, G. K., Yuan, J., Suckling, J., Xu, L., Cao, S., Chen, W., Hu, X., et al. (2022) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2021.3139701 · Cited by 20 · see citing works
Joo, S. W., Yoon, W., Shon, S., Kim, H., Cha, S., Park, K. J., & Lee, J. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205369 · Cited by 18 · see citing works
White matter abnormalities in 22q11.2 deletion syndrome patients showing cognitive decline
Nuninga, J. O., Bohlken, M. M., Koops, S., Fiksinski, A., Mandl, R. C. W., Breetvelt, E., Duijff, S. N., Kahn, R. S., Sommer, I. E., & Vorstman, J. A. S. (2017) · Psychological Medicine · doi:10.1017/s0033291717003142 · Cited by 18 · see citing works
Bendix, I., Hadamitzky, M., Herz, J., & Felderhoff‐Müser, U. (2018) · Pediatric Research · doi:10.1038/s41390-018-0222-6 · Cited by 18 · see citing works
N-Methyl- -Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia
Rahman, T., Purves-Tyson, T. D., Geddes, A. E., Huang, X., Newell, K. A., & Weickert, C. S. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.11.045 · Cited by 17 · see citing works
Burzynska, A. Z., Wong, C. N., Chaddock‐Heyman, L., Olson, E. A., Gothe, N. P., Knecht, A. M., Voss, M. W., McAuley, E., & Kramer, A. F. (2015) · Neurocase · doi:10.1080/13554794.2015.1074709 · Cited by 17 · see citing works
Leukocyte telomere length in Hispanic schizophrenia patients under treatment with olanzapine
Monroy‐Jaramillo, N., Rodríguez‐Agudelo, Y., Aviña-Cervantes, L. C., Roberts, D. L., Velligan, D. I., & Walss‐Bass, C. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.02.007 · Cited by 17 · see citing works
McNabb, C. B., Kydd, R. R., Sundram, F., Soosay, I., & Russell, B. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.11.002 · Cited by 15 · see citing works
Ageing: live faster, die younger
Anthes, E. (2014) · Nature · doi:10.1038/508s16a · Cited by 16 · see citing works
Peripheral inflammation levels associated with degree of advanced brain aging in schizophrenia
Klaus, F., Nguyen, T. T., Thomas, M. L., Liou, S. C., Soontornniyomkij, B., Mitchell, K. R., Daly, R., Sutherland, A. N., Jeste, D. V., & Eyler, L. T. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.966439 · Cited by 16 · see citing works
Sun, Y. M., Zhang, Z., Kakkos, I., Matsopoulos, G. K., Yuan, J., John Suckling, A., Xu, L., Cao, S., Chen, W., Hu, X., et al. (2022) · Apollo (University of Cambridge) · doi:10.17863/cam.82105 · Cited by 15 · see citing works
The implication of a diversity of non-neuronal cells in disorders affecting brain networks
Carrier, M., Dolhan, K., Bobotis, B. C., Desjardins, M., & Tremblay, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1015556 · Cited by 15 · see citing works
The role of white matter microstructure in inhibitory deficits in patients with schizophrenia
Du, X. M., Kochunov, P. V., Summerfelt, A. T., Chiappelli, J., Choa, F., & Hong, L. E. (2016) · Brain stimulation · doi:10.1016/j.brs.2016.11.006 · Cited by 14 · see citing works
Self-citationAssessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia
Chiappelli, J., Quinton, M. S., Volfson, D., Cwik, M., Marshall, W., Bruce, H. A., Goldwaser, E. L., Kvarta, M. D., Summerfelt, A. T., Kochunov, P. V., et al. (2020) · Schizophrenia · doi:10.1038/s41537-020-00121-4 · Cited by 13 · see citing works
Self-citationUranova, N. A., Vikhreva, O. V., & Рахманова, В. И. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01621-x · Cited by 12 · see citing works
Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings
Harms, M. P., Akhter, K. D., Csernansky, J. G., Mori, S., & Barch, D. M. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.10.009 · Cited by 11 · see citing works
Shared co-expression networks in frontal cortex of the normal aged brain and schizophrenia
Kim, S., Jo, Y., Webster, M. J., & Lee, D. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.09.010 · Cited by 11 · see citing works
Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood
Schwehm, A. J., Robinson, D. G., Gallego, J. A., Karlsgodt, K. H., Ikuta, T., Peters, B. D., Malhotra, A. K., & Szeszko, P. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.47 · Cited by 11 · see citing works
He, M., Shen, Z., Ping, L., Zhou, C., Cheng, Y., & Xu, X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.02.036 · Cited by 9 · see citing works
White Matter Pathology in Schizophrenia
Biase, M. A. D., Pantelis, C., & Zalesky, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-35206-6_4 · Cited by 9 · see citing works
Accelerated aging signatures in subjects with schizophrenia and their unaffected siblings
Rebouças, D. B., Sartori, J., Librenza‐Garcia, D., Rabelo‐da‐Ponte, F. D., Massuda, R., Czepielewski, L. S., Passos, I. C., & Gama, C. S. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.04.029 · Cited by 9 · see citing works
Gallucci, J., Pomarol‐Clotet, E., Voineskos, A. N., Guerrero‐Pedraza, A., Alonso-Lana, S., Vieta, E., Salvador, R. M., & Hawco, C. S. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103269 · Cited by 9 · see citing works
Telomere quantification in frontal and temporal brain tissue of patients with schizophrenia
van Mierlo, H. C., Wichers, C. G. K., He, Y., Sneeboer, M. A. M., Radstake, T. R. D. J., Kahn, R. S., Broen, J. C. A., & de Witte, L. D. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.09.006 · Cited by 9 · see citing works
Schizophrenia and accelerated ageing: systematic review and future research directions
Fernández-Egea, E., García‐Rizo, C., & Kirkpatrick, B. W. (2026) · The British Journal of Psychiatry · doi:10.1192/bjp.2026.10606 · Cited by 8 · see citing works
Cai, J. C., Xie, M., Zhao, L., Li, X., Liang, S., Deng, W., Guo, W., Ma, X., Sham, P. C., Wang, Q., et al. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103482 · Cited by 7 · see citing works
Langhein, M., Lyall, A. E., Steinmann, S., Seitz‐Holland, J., Nägele, F. L., Karayumak, S. C., Zhang, F., Rauh, J., Mußmann, M., Billah, T., et al. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2112974 · Cited by 7 · see citing works
Masuda, Y., Okada, G., Takamura, M., Shibasaki, C., Yoshino, A., Yokoyama, S., Ichikawa, N., Okuhata, S., Kobayashi, T., Yamawaki, S., et al. (2020) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13166 · Cited by 7 · see citing works
Bang, M., Heo, Y., Choi, T. K., & Lee, S. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae008 · Cited by 6 · see citing works
Li, J., Huang, M., Pan, F., Li, Z., Shen, Z., Jin, K., Zhao, H., Lu, S., Shang, D., Xu, Y., et al. (2021) · Brain Connectivity · doi:10.1089/brain.2021.0088 · Cited by 4 · see citing works
Stable White Matter Structure in the First Three Years After Psychosis Onset
Dyken, P. C. V., Yang, K., Faria, A. V., Sawa, A., Mackinley, M., KHAN, A. R., & Palaniyappan, L. K. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100472 · Cited by 4 · see citing works
Accelerated biological brain aging in major depressive disorder
How, E. H., Chin, S.-M., Teo, C. H., Parhar, I. S., & Soga, T. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0025 · Cited by 4 · see citing works
- Authors
- Kochunov, P., Glahn, D. C., Rowland, L. M., Olvera, R. L., Winkler, A., Yang, Y.-H., Sampath, H., Carpenter, W. T., Duggirala, R., Curran, J., Blangero, J., & Hong, L. E.
- Affiliations
- University of Maryland, Baltimore (US)
- Texas Biomedical Research Institute (US)
- Corresponding author
- Kochunov, Peter
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 73
- Issue
- 5
- Pages
- 482-491
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3645491
- OpenAlex
- W2015990930
- Cited by
- 118
- References
- 67
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 15 · 2016: 13 · 2015: 9 · 2014: 13 · 2013: 4 · 2012: 1
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- National Institute of Mental Health (R01-MH0708143, R01MH078111, R37MH059490, R01MH083824, R01MH085646)
- National Institute on Drug Abuse (R01DA027680)
- National Institute of Biomedical Imaging and Bioengineering (K01EB006395, R01EB015611)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- accelerated aging, schizophrenia, major depressive disorder, white matter aging, fractional anisotropy, white matter integrity, white matter tracts, heterochrony, brain aging biomarkers
- MeSH terms
- Adult, Aged, Aging, Brain, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Nerve Fibers, Myelinated, Schizophrenia, Diffusion Tensor Imaging
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