Cited by 137Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

Motion artifact in studies of functional connectivity: Characteristics and mitigation strategies

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Satterthwaite, Theodore D., Ciric, Rastko, Roalf, David R., Davatzikos, Christos, Bassett, Danielle S., Wolf, Daniel H.·2019·Human Brain Mapping

Abstract

Motion artifacts are now recognized as a major methodological challenge for studies of functional connectivity. As in-scanner motion is frequently correlated with variables of interest such as age, clinical status, cognitive ability, and symptom severity, in-scanner motion has the potential to introduce systematic bias. In this article, we describe how motion-related artifacts influence measures of functional connectivity and discuss the relative strengths and weaknesses of commonly used denoising strategies. Furthermore, we illustrate how motion can bias inference, using a study of brain development as an example. Finally, we highlight directions of ongoing and future research, and provide recommendations for investigators in the field. Hum Brain Mapp, 40:2033-2051, 2019. © 2017 Wiley Periodicals, Inc.

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  • Studies of the whole-brain functional connectome demonstrate a developmental trend toward segregation and integration.

    “Studies of the whole-brain functional connectome demonstrate a trend towards ‘segregation’ (decrease in correlation strength between anatomically close regions) and ‘integration’ (increase in correlation strength between anatomically distant regions) across development (50,51).”

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Authors
Satterthwaite, T. D., Ciric, R., Roalf, D. R., Davatzikos, C., Bassett, D. S., & Wolf, D. H.
Affiliations
  • University of Pennsylvania (US)
  • Department of Psychiatry, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania
Corresponding author
Satterthwaite, Theodore D.
Venue
Human Brain Mapping
Publisher
Wiley
Published
2017-11
Volume
40
Issue
7
Pages
2033-2051
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
OpenAlex
W2766922554
Cited by
137
References
85
Citations by year
2026: 13 · 2025: 17 · 2024: 16 · 2023: 9 · 2022: 17 · 2021: 17 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 1
FWCI
1.47
Type
journal article
Language
en
Open access
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (R01MH107703, R01MH101111, R21MH106799, K01MH102609, R01EB022573)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
motion artifacts, functional connectivity, systematic bias, brain development, functional MRI, motion correction
MeSH terms
Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Motion, Nerve Net, Artifacts, Head Movements

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