Cited by 504Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

Neuroimaging of the Philadelphia Neurodevelopmental Cohort

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Satterthwaite, Theodore D., Elliott, Mark A., Ruparel, Kosha, Loughead, James, Prabhakaran, Karthik, Calkins, Monica E., Hopson, Ryan, Jackson, Chad +9 more·2014·NeuroImage

Abstract

The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.

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Authors
Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Loughead, J., Prabhakaran, K., Calkins, M. E., Hopson, R., Jackson, C., Keefe, J., Riley, M., Mentch, F. D., Sleiman, P., Verma, R., Davatzikos, C., Hakonarson, H., Gur, R. C., & Gur, R. E.
Affiliations
  • University of Pennsylvania (US)
  • Children's Hospital of Philadelphia (US)
  • Philadelphia VA Medical Center (US)
Corresponding author
Satterthwaite, Theodore D.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2014-02
Volume
86
Pages
544-553
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2069088601
Cited by
504
References
64
Citations by year
2026: 21 · 2025: 28 · 2024: 39 · 2023: 50 · 2022: 49 · 2021: 51 · 2020: 49 · 2019: 58 · 2018: 43 · 2017: 44 · 2016: 24 · 2015: 27 · 2014: 19 · 2013: 2
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Lincoln (University of Nebraska) (submittedVersion)
Funders
  • Brain and Behavior Research Foundation (K08MH79364)
  • Children's Hospital of Philadelphia
  • National Institute of Mental Health (MH089924, T32 MH019112, MH089983, K23MH098130)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
Philadelphia Neurodevelopmental Cohort, brain development, brain maturation, cognitive development, psychiatric vulnerability, adolescents, T1-weighted structural MRI, diffusion tensor imaging, arterial spin labeling, perfusion imaging, working memory, emotion recognition, resting-state functional connectivity, multimodal neuroimaging, data sharing
MeSH terms
Adolescent, Adult, Brain, Child, Cognition, Female, Humans, Research Design, Philadelphia, Cohort Studies, Young Adult, Neuroimaging, Multimodal Imaging

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