Brain structural correlates of irritability: Findings in a large healthy cohort
Open accessAbstract
Irritability and nonviolent aggression are common behavioral features across the population, yet there is limited neurobiological research into subclinical phenotypes representing the lower edge of a symptom continuum ranging from slight irritability to criminal violence. We studied brain structural correlates of irritability in a large healthy cohort to test the hypothesis of associations with fronto‐limbic brain structures implicated in mood regulation. In a large multicenter effort, we recruited 409 mentally healthy adults from the community, who received T1‐weighted high‐resolution 3 T MRI scans. These structural scans were automatically preprocessed for voxel‐ and surface‐based morphometry measurements with the CAT 12 toolbox implemented in SPM 12. Subclinical aggressive symptoms were assessed using the SCL‐90‐R aggression/hostility subscale and then correlated with cortical volume (VBM), and cortical thickness and gyrification. VBM analysis showed significant (P < 0.05, FDR‐corrected at peak‐level) positive correlations of cortical volume with SCL‐90‐R aggression subscale values in large clusters spanning bilateral anterior cingulate and orbitofrontal cortices and left lingual and postcentral gyri. Surface‐based morphometry yielded mostly uncorrected positive correlations with cortical thickness in bilateral precentral gyri and with gyrification in left insula and superior temporal gyrus. Our findings imply an association of subclinical aggressive symptoms with cortical volume in areas important for emotion awareness and regulation, which might also be related to cortical adaptation to mental stress. These results overlap with several findings on impulsive aggression in patients suffering from affective and disruptive behavior disorders. They also suggest a biological symptom continuum manifesting in these brain areas. Hum Brain Mapp 38:6230–6238, 2017. © 2017 Wiley Periodicals, Inc.
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The lingual gyrus, a component of the visual cortex underlying word identification and recognition, has also been implicated in irritability and impulsive aggression in subclinical samples.
“The lingual gyrus, a component of the visual cortex underlying word identification and recognition, has also been implicated in irritability and impulsive aggression in subclinical samples”
From Overlapping and differential neuropharmacological mechanisms of stimulants and nonstimulants for attention-deficit/hyperactivity disorder: A comparative neuroimaging analysis (2024) · cites this paper as Besteher et al., 2017
The Abstract and Discussion (page not provided) report a positive correlation between left lingual gyrus volume and self-reported aggression/hostility in healthy adults, supporting its implication in subclinical irritability and aggression. The study does not establish that this association concerns impulsive aggression specifically, and the cited passages do not support the claim about word identification and recognition. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMedication responses in the lingual gyrus may reflect symptom amelioration of disruptive behavior within the domain of cognitive control.
“Thus, medication responses in the lingual gyrus may reflect symptom amelioration of disruptive behavior within the domain of cognitive control.”
From Overlapping and differential neuropharmacological mechanisms of stimulants and nonstimulants for attention-deficit/hyperactivity disorder: A comparative neuroimaging analysis (2024) · cites this paper as Besteher et al., 2017
The Voxel-Based Morphometry Analysis reports an association between left lingual-gyrus volume and aggression/hostility scores in healthy adults. It does not study medication responses or symptom improvement, and the cited passages do not link the lingual-gyrus finding specifically to cognitive control. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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Measures of Irritability and Proneness to Anger: Links with Age and Mood
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Measures of Irritability and Proneness to Anger: Links with Age and Mood
Bell, E., & Malhi, G. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-31547-3_124
- Authors
- Besteher, B., Squarcina, L., Spalthoff, R., Bellani, M., Gaser, C., Brambilla, P., & Nenadić, I.
- Affiliations
- Jena University Hospital (DE)
- IRCCS Eugenio Medea (IT)
- University of Verona (IT)
- Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany
- University of Milan (IT)
- Philipps University of Marburg (DE)
- Corresponding author
- Besteher, Bianca
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2017-09-25
- Volume
- 38
- Issue
- 12
- Pages
- 6230-6238
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6866715
- OpenAlex
- W2757652074
- Cited by
- 48
- References
- 54
- Citations by year
- 2025: 1 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 2
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- IZKF Jena
- Young Scientist Grant of Friedrich-Schiller-University (DRM 210070/87)
- Italian Ministry of Health (RF-2011-02352308, GR-2010-2319022)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- irritability, aggression-hostility, cortical thickness, cortical folding, cortical volume, anterior cingulate cortex, orbitofrontal cortex, insula, mood regulation, healthy adults, SCL-90-R
- MeSH terms
- Adolescent, Adult, Aged, Brain, Female, Humans, Image Processing, Computer-Assisted, Irritable Mood, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Pattern Recognition, Automated, Personality, Case-Control Studies, Young Adult
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