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Cited by 257

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B

Open access
van der Molen, Renate G., Sprengers, Dave, Binda, Rekha S., de Jong, Esther C., Niesters, Hubert G. M., Kusters, Johannes G., Kwekkeboom, Jaap, Janssen, Harry L. A.·2004·Hepatology
DOI 10.1002/hep.20366
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Abstract

Dendritic cells (DC) play an important role in the induction of T-cell responses. We hypothesize that the hampered antiviral T-cell response in chronic hepatitis B patients is a result of impaired dendritic cell function. In this study, we compared the number, phenotype and functionality of two important blood precursor DC, myeloid DC (mDC) and plasmacytoid DC (pDC), of chronic hepatitis B patients with healthy volunteers. No differences in percentages of mDC and pDC in peripheral blood mononuclear cells were observed between chronic hepatitis B patients and healthy controls. The allostimulatory capacity of isolated and in vitro matured mDC, but not of pDC, was significantly decreased in patients compared to controls. Accordingly, a decreased percentage of mDC expressing CD80 and CD86 was observed after maturation, compared to controls. In addition, mDC of patients showed a reduced capacity to produce tumor necrosis factor α after a stimulus with synthetic double-stranded RNA and interferon γ. Purified pDC from patients produced less interferon α, an important antiviral cytokine, in response to stimulation with Staphylococcus aureus Cowan strain I than pDC isolated from controls. In conclusion, mDC and pDC are functionally impaired in patients with chronic hepatitis B. This might be an important way by which hepatitis B virus evades an adequate immune response, leading to viral persistence and disease chronicity. (Hepatology 2004;40:738-746.)

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Metadata

Authors
van der Molen, R. G., Sprengers, D., Binda, R. S., de Jong, E. C., Niesters, H. G. M., Kusters, J. G., Kwekkeboom, J., & Janssen, H. L. A.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-09
Volume
40
Issue
3
Pages
738-746
ISSN
0270-9139 (ISSN-L)
DOI
10.1002/hep.20366
OpenAlex
W2129651659
Cited by
257
References
33
FWCI
8.55
Type
journal article
Language
en
Open access
bronze

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