The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

Péan, Noémie; Doignon, Isabelle; Garcin, Isabelle; Besnard, Aurore; Julien, Boris; Liu, Bingkaï; Branchereau, Sophie; Spraul, Anne; Guettier, Catherine; Humbert, Lydie; Schoonjans, Kristina; Rainteau, Dominique; Tordjmann, Thierry

doi:10.1002/hep.26463

Cited by 193Liver physiology and pathologyDrug Transport and Resistance MechanismsOrgan Transplantation Techniques and Outcomes

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

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Péan, Noémie, Doignon, Isabelle, Garcin, Isabelle, Besnard, Aurore, Julien, Boris, Liu, Bingkaï, Branchereau, Sophie, Spraul, Anne +5 more·2013·Hepatology

DOI 10.1002/hep.26463

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Abstract

Unlabelled Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids (BAs), whose levels rise in the blood early after PH, stimulate both hepatocyte proliferation and protection, in part through their binding to the nuclear farnesoid X receptor (FXR). However, the effect of the BA receptor, TGR5 (G-protein-coupled BA receptor 1) after PH remains to be studied. Liver histology, hepatocyte proliferation, BA concentrations (plasma, bile, liver, urine, and feces), bile flow and composition, and cytokine production were studied in wild-type (WT) and TGR5 KO (knockout) mice before and after PH. BA composition (plasma, bile, liver, urine, and feces) was more hydrophobic in TGR5 KO than in WT mice. After PH, severe hepatocyte necrosis, prolonged cholestasis, exacerbated inflammatory response, and delayed regeneration were observed in TGR5 KO mice. Although hepatocyte adaptive response to post-PH BA overload was similar in WT and TGR5 KO mice, kidney and biliary adaptive responses were strongly impaired in TGR5 KO mice. Cholestyramine treatment, as well as Kupffer cell depletion, significantly improved the post-PH TGR5 KO mice phenotype. After bile duct ligation or upon a cholic acid-enriched diet, TGR5 KO mice exhibited more severe liver injury than WT as well as impaired BA elimination in urine. Conclusion TGR5 is crucial for liver protection against BA ov…

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Acute increases in bile acid levels act as a key pro-regenerative signal for liver regeneration after PHx.
“Notably, acute increases in bile acid (BA) levels act as a key pro-regenerative signal for this process.3, 4, 5”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [4]
Elevated concentrations and a more hydrophilic BA pool promote liver regeneration after PHx.
“Growing evidence shows that elevated concentrations and a more hydrophilic BA pool promote liver regeneration after PHx.4,26,27”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [4]
Bile acids are transiently elevated following PHx and promote liver regeneration, whereas CAR prevents BA hepatotoxicity.
“It is known that BAs are transiently elevated following PHx and promote liver regeneration,3,4 whereas CAR has been shown to prevent BA hepatotoxicity.10”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [4]

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885 · see citing works
Self-citation
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628 · see citing works
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567 · see citing works
Identification of membrane-type receptor for bile acids (M-BAR)
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993 · see citing works
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science · doi:10.1126/science.1121435 · Cited by 645 · see citing works
TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading
Pols, T. W. H., Nomura, M., Harach, T., Sasso, G. L., Oosterveer, M. H., Thomas, C., Rizzo, G., Gioiello, A., Adorini, L., Pellicciari, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.006 · Cited by 622 · see citing works
Self-citation
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
Mitchell, C., & Willenbring, H. (2008) · Nature Protocols · doi:10.1038/nprot.2008.80 · Cited by 577 · see citing works
The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice
Wang, Y., Chen, W., Yu, D. D., FORMAN, B. M., & Huang, W. (2011) · Hepatology · doi:10.1002/hep.24525 · Cited by 488 · see citing works
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
Pols, T. W. H., Noriega, L. G., Nomura, M., Auwerx, J., & Schoonjans, K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.12.004 · Cited by 454 · see citing works
Self-citation
Expression and function of the bile acid receptor TGR5 in Kupffer cells
Keitel, V., Donner, M., Winandy, S., Kubitz, R., & Häussinger, D. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.171 · Cited by 418 · see citing works
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
Sato, H., Genet, C., Strehle, A., Thomas, C., Lobstein, A., Wagner, A., Mioskowski, C., Auwerx, J. H., & Saladin, R. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.130 · Cited by 341 · see citing works
A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
Hohenester, S., de Buy Wenniger, L. M., Paulusma, C. C., van Vliet, S. J., Jefferson, D. M., Oude Elferink, R. P., & Beuers, U. (2012) · Hepatology · doi:10.1002/hep.24691 · Cited by 315 · see citing works
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
Geier, A., Wagner, M., Dietrich, C. G., & Trauner, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.04.014 · Cited by 313 · see citing works
Ursodeoxycholic acid aggravates bile infarcts in bile duct–ligated and Mdr2 knockout mice via disruption of cholangioles
Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Weiglein, A. H., Lammert, F., Marschall, H., Tsybrovskyy, O., Zatloukal, K., Denk, H., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.35948 · Cited by 312 · see citing works
The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
Keitel, V., Reinehr, R., Gatsios, P., Rupprecht, C., Görg, B., Selbach, O., Häussinger, D., & Kubitz, R. (2007) · Hepatology · doi:10.1002/hep.21458 · Cited by 308 · see citing works
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders #
Keitel, V., Cupisti, K., Ullmer, C., Knoefel, W. T., Kubitz, R., & Häussinger, D. (2009) · Hepatology · doi:10.1002/hep.23032 · Cited by 285 · see citing works
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
Vassileva, G., Golovko, A., Markowitz, L., Abbondanzo, S. J., Zeng, M., Yang, S., Hoos, L. M., Tetzloff, G. G., Levitan, D. J., Murgolo, N., et al. (2006) · Biochemical Journal · doi:10.1042/bj20060537 · Cited by 277 · see citing works
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
Modica, S., Petruzzelli, M., Bellafante, E., Murzilli, S., Salvatore, L., Celli, N., Di Tullio, G., Palasciano, G., Moustafa, T., Halilbasic, E., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.028 · Cited by 275 · see citing works
The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling
Li, T., Holmstrom, S. R., Kır, S., Umetani, M., Schmidt, D. R., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0460 · Cited by 267 · see citing works
Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− ( Abcb4 −/−) mouse cholangiopathy model by promoting biliary HCO Symbol output
Baghdasaryan, A., Claudel, T., Gumhold, J., Silbert, D., Adorini, L., Roda, A., Vecchiotti, S., Gonzalez, F. J., Schoonjans, K., Strazzabosco, M., et al. (2011) · Hepatology · doi:10.1002/hep.24537 · Cited by 222 · see citing works
Self-citation
Lithocholic Acid Feeding Induces Segmental Bile Duct Obstruction and Destructive Cholangitis in Mice
Fickert, P., Fuchsbichler, A., Marschall, H., Wagner, M., Zollner, G., Krause, R. G. E., Zatloukal, K., Jaeschke, H., Denk, H., & Trauner, M. A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050404 · Cited by 189 · see citing works
Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients
Humbert, L., Maubert, M.-A., Wolf, C., Duboc, H., Mahé, M., Farabos, D., Seksik, P., Mallet, J., Trugnan, G., Masliah, J., et al. (2012) · Journal of Chromatography B · doi:10.1016/j.jchromb.2012.05.015 · Cited by 175 · see citing works
Self-citation
Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice
Song, P., Zhang, Y., & Klaassen, C. D. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr177 · Cited by 155 · see citing works
Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATPchannels
Lavoie, B. A., Balemba, O. B., Godfrey, C. B., Watson, C. A., Vassileva, G., Corvera, C. U., Nelson, M. T., & Mawe, G. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.192146 · Cited by 130 · see citing works
Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium
Spirlı̀, C., Nathanson, M. H., Fiorotto, R., Duner, E., Denson, L. A., Sanz, J. M., Virgilio, F. D., Okolicsànyi, L., Casagrande, F., & Strazzabosco, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.25516 · Cited by 126 · see citing works
Agonist-induced Coordinated Trafficking of Functionally Related Transport Proteins for Water and Ions in Cholangiocytes
Tietz, P. S., Marinelli, R. A., Chen, X., Huang, B. Q., Cohn, J. A., Kole, J., McNiven, M. A., Alper, S. L., & LaRusso, N. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302108200 · Cited by 118 · see citing works
ATP release after partial hepatectomy regulates liver regeneration in the rat
Gonzales, E. M., Julien, B., Serrière-Lanneau, V., Nicou, A., Doignon, I., Lagoudakis, L., Garcin, I., Azoulay, D., Duclos‐Vallée, J., Castaing, D., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.10.005 · Cited by 112 · see citing works
Self-citation
Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis
Doignon, I., Julien, B., Serrière-Lanneau, V., Garcin, I., Alonso, G., Nicou, A., Monnet, F., Gigou, M., Humbert, L., Rainteau, D., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.07.012 · Cited by 87 · see citing works
Self-citation
Mouse Organic Solute Transporter α Deficiency Enhances Renal Excretion of Bile Acids and Attenuates Cholestasis
Soroka, C. J., Mennone, A., Hagey, L. R., Ballatori, N., & Boyer, J. L. (2009) · Hepatology · doi:10.1002/hep.23265 · Cited by 80 · see citing works
Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis
Park, Y. J., Qatanani, M., Chua, S. S., LaRey, J. L., Johnson, S. A., Watanabe, M., Moore, D. D., & Lee, Y. K. (2008) · Hepatology · doi:10.1002/hep.22196 · Cited by 68 · see citing works
Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice
Csanaky, I. L., Aleksunes, L. M., Tanaka, Y., & Klaassen, C. D. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90728.2008 · Cited by 62 · see citing works
Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation
Jang, J., Rickenbacher, A., Humar, B., Weber, A., Raptis, D. A., Lehmann, K., Stieger, B., Moritz, W., Soll, C., Georgiev, P., et al. (2012) · Hepatology · doi:10.1002/hep.25626 · Cited by 58 · see citing works
Protein kinase Cδ mediates cyclic adenosine monophosphate–stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes†
Schonhoff, C. M., Gillin, H., Webster, C. R. L., & Anwer, M. S. (2008) · Hepatology · doi:10.1002/hep.22162 · Cited by 36 · see citing works

Flagged first, then by citations

1 of the 34 references couldn’t be matched to a known paper.

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Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998 · see citing works
Targeting hepatic macrophages to treat liver diseases
Tacke, F. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.026 · Cited by 1,003 · see citing works
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935 · see citing works
Bile Acid Metabolism in Liver Pathobiology
Chiang, J. Y. L., & Ferrell, J. M. (2018) · Gene Expression · doi:10.3727/105221618x15156018385515 · Cited by 552 · see citing works
New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond
Beuers, U., Trauner, M., Jansen, P., & Poupon, R. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.023 · Cited by 537 · see citing works
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Fuchs, C. D., & Trauner, M. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00566-7 · Cited by 490 · see citing works
Molecular physiology of bile acid signaling in health, disease, and aging
Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481 · see citing works
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The bile acid TGR5 membrane receptor: from basic research to clinical application
Duboc, H., Taché, Y., & Hofmann, A. F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.021 · Cited by 473 · see citing works
Hepatostat: Liver regeneration and normal liver tissue maintenance
Michalopoulos, G. K. (2017) · Hepatology · doi:10.1002/hep.28988 · Cited by 444 · see citing works
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Li, T., & Apte, U. M. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.003 · Cited by 335 · see citing works
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Discovery of farnesoid X receptor and its role in bile acid metabolism
Chiang, J. Y. L., & Ferrell, J. M. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111618 · Cited by 298 · see citing works
Mechanisms of bile acid mediated inflammation in the liver
Li, M., Cai, S., & Boyer, J. L. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.001 · Cited by 268 · see citing works
TGR5, Not Only a Metabolic Regulator
Guo, C., Chen, W.-D., & Wang, Y.-D. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00646 · Cited by 231 · see citing works
New therapeutic concepts in bile acid transport and signaling for management of cholestasis
Trauner, M., Fuchs, C. D., Halilbasic, E., & Paumgartner, G. (2017) · Hepatology · doi:10.1002/hep.28991 · Cited by 227 · see citing works
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.
Perino, A., Pols, T. W., Nomura, M., Stein, S., Pellicciari, R., & Schoonjans, K. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76289 · Cited by 209 · see citing works
Self-citation
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Dianat, N., Dubois‐Pot‐Schneider, H., Steichen, C., Desterke, C., Leclerc, P., Raveux, A., Combettes, L., Weber, A., Corlu, A., & Dubart‐Kupperschmitt, A. (2014) · Hepatology · doi:10.1002/hep.27165 · Cited by 213 · see citing works
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Reich, M., Deutschmann, K., Sommerfeld, A., Klindt, C., Kluge, S., Kubitz, R., Ullmer, C., Knoefel, W. T., Herebian, D. A., Mayatepek, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309458 · Cited by 210 · see citing works
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Assessment of serum bile acid profiles as biomarkers of liver injury and liver disease in humans
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Update on the Mechanisms of Liver Regeneration
Preziosi, M., & Monga, S. P. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1601351 · Cited by 86 · see citing works
Protective effects of taurocholic acid on excessive hepatic lipid accumulation via regulation of bile acid metabolism in grouper
Xu, J., Xie, S., Chi, S., Zhang, S., Cao, J., & Tan, B. (2022) · Food & Function · doi:10.1039/d1fo04085e · Cited by 84 · see citing works
Bile Acids, Their Receptors, and the Gut Microbiota
Poland, J. C., & Flynn, C. R. (2021) · Physiology · doi:10.1152/physiol.00028.2020 · Cited by 85 · see citing works
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
Ghallab, A., Hassan, R. A. R. A., Hofmann, U., Friebel, A., Hobloss, Z., Brackhagen, L., Begher‐Tibbe, B., Myllys, M., Reinders, J., Overbeck, N., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.01.020 · Cited by 82 · see citing works
Bile acid-mediated signaling in cholestatic liver diseases
Zeng, J., Fan, J., & Zhou, H. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01035-1 · Cited by 78 · see citing works
Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development
Li, T., & Chiang, J. Y. L. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.000978 · Cited by 83 · see citing works
Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
Li, G., & Guo, G. L. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.005 · Cited by 77 · see citing works
Na + -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice
Slijepcevic, D., Roscam Abbing, R. L. P., Fuchs, C. D., Haazen, L. C. M., Beuers, U., Trauner, M., Oude Elferink, R. P. J., & van de Graaf, S. F. J. (2018) · Hepatology · doi:10.1002/hep.29888 · Cited by 73 · see citing works
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function
Merlen, G., Kahale, N., Bedoya, J. U., Bidault, V., Simerabet, H., Doignon, I., Tanfin, Z., Garcin, I., Pean, N., Gautherot, J., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316975 · Cited by 72 · see citing works
Self-citation
Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling
Ciaula, A. D., Bonfrate, L., Baj, J., Khalil, M., Garruti, G., Stellaard, F., Wang, H. H., Wang, D. Q. ‐., & Portincasa, P. (2022) · Nutrients · doi:10.3390/nu14234950 · Cited by 73 · see citing works
A synthetic biology-based device prevents liver injury in mice
Bai, P., Ye, H., Xie, M., Saxena, P., Zulewski, H., Hamri, G. C., Djonov, V., & Fussenegger, M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.03.020 · Cited by 69 · see citing works
Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling
Kuang, J., Zheng, X., Huang, F., Wang, S., Li, M., Zhao, M., Sang, C., Ge, K., Li, Y., Li, J., et al. (2020) · Metabolites · doi:10.3390/metabo10110475 · Cited by 67 · see citing works
Bile acids regulation of cellular stress responses in liver physiology and diseases
Li, T., Hasan, M. N., & Gu, L. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100074 · Cited by 69 · see citing works
Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids
Woolbright, B. L., & Jaeschke, H. (2019) · Gene Expression · doi:10.3727/105221619x15614873062730 · Cited by 66 · see citing works
Bile Acid Flux Is Necessary for Normal Liver Regeneration
Naugler, W. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097426 · Cited by 65 · see citing works
Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice
Baptissart, M., Vega, A., Martinot, E., Pommier, A., Houten, S. M., Marceau, G., Haze, A. D., Baron, S., Schoonjans, K., Lobaccaro, J. A., et al. (2014) · Hepatology · doi:10.1002/hep.27204 · Cited by 65 · see citing works
Self-citation
Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor
Khamphaya, T., Chukijrungroat, N., Saengsirisuwan, V., Mitchell-Richards, K., Robert, M. E., Mennone, A., Ananthanarayanan, M., Nathanson, M. H., & Weerachayaphorn, J. (2017) · Hepatology · doi:10.1002/hep.29588 · Cited by 64 · see citing works
Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases
Yang, T., Khan, G. J., Wu, Z., Wang, X., Zhang, L., & Jiang, Z. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.09.007 · Cited by 64 · see citing works
Molecular pathways of liver regeneration: A comprehensive review
Kiseleva, Y. V., Antonyan, S. Z., Zharikova, T. S., Tupikin, K. A., Kalinin, D. V., & Zharikov, Y. O. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i3.270 · Cited by 62 · see citing works
TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
Bidault, V., Merlen, G., Glénisson, M., Doignon, I., Garcin, I., Pean, N., Boisgard, R., Bedoya, J. U., Sérino, M., Ullmer, C., et al. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100214 · Cited by 58 · see citing works
Self-citation
Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury
Zhang, Y., Lu, Y., Ji, H. L., & Li, Y. (2019) · BioScience Trends · doi:10.5582/bst.2018.01247 · Cited by 56 · see citing works
Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome
Portincasa, P., Ciaula, A. D., Garruti, G., Vacca, M., Angelis, M. D., & Wang, D. Q. ‐. (2020) · Nutrients · doi:10.3390/nu12123709 · Cited by 55 · see citing works
Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases
Stanimirov, B., Stankov, K., & Mikov, M. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60307-6 · Cited by 55 · see citing works
The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver
Klindt, C., Reich, M., Hellwig, B., Stindt, J., Rahnenführer, J., Hengstler, J. G., Köhrer, K., Schoonjans, K., Häussinger, D., & Keitel, V. (2019) · Cells · doi:10.3390/cells8111467 · Cited by 55 · see citing works
Self-citation
Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis
Spatz, M., Ciocan, D. M., Merlen, G., Rainteau, D. P., Humbert, L., Gomes-Rochette, N. F., Hugot, C., Trainel, N., Mercier‐Nomé, F., Domenichini, S., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100230 · Cited by 54 · see citing works
Self-citation
Therapeutic targets for cholestatic liver injury
Woolbright, B. L., & Jaeschke, H. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1103735 · Cited by 54 · see citing works
Role of the G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage
Reich, M., Klindt, C., Deutschmann, K., Spomer, L., Häussinger, D., & Keitel, V. (2017) · Digestive Diseases · doi:10.1159/000450917 · Cited by 52 · see citing works
MicroRNA-194 inhibition improves dietary-induced non-alcoholic fatty liver disease in mice through targeting on FXR
Nie, H., Song, C., Wang, D., Cui, S., Ren, T., Cao, Z., Liu, Q., Chen, Z., Chen, X., & Zhou, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.020 · Cited by 52 · see citing works
Fibroblast Growth Factor 15–Dependent and Bile Acid–Independent Promotion of Liver Regeneration in Mice
Kong, B., Sun, R., Huang, M., Chow, M. D., Zhong, X., Xie, W., Lee, Y., & Guo, G. L. (2018) · Hepatology · doi:10.1002/hep.30041 · Cited by 52 · see citing works
Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications
Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Jiménez, M., Bárcena‐Varela, M., Santamaría, E., Urtasun, R., Rodríguez‐Ortigosa, C. M., Prìeto, J., Berraondo, P., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.025 · Cited by 50 · see citing works
Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice
Frano, M. R. L., Hernandez, A. M., Weber, N., Borkowski, K., Pedersen, T. L., Osborn, O., & Newman, J. W. I. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.07.006 · Cited by 51 · see citing works
TGR5 in inflammation and cardiovascular disease
Pols, T. W. H. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130279 · Cited by 50 · see citing works
The gut microbiota-bile acid axis in cholestatic liver disease
Sun, D.-Y., Xie, C., Zhao, Y., Liao, J.-M., Li, S.-S., Zhang, Y.-N., Wang, D.-D., Hua, K., Gu, Y.-C., Du, J.-B., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00830-x · Cited by 53 · see citing works
Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations
Liu, Q., Wang, S., Fu, J., Chen, Y., Xu, J., Wei, W., Song, H., Zhao, X., & Wang, H. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1812 · Cited by 49 · see citing works
Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study
Dong, Q., Li, N., Li, Q., Zhang, C.-E., Feng, W., Li, G.-Q., Li, R., Tu, C., Han, X., Bai, Z., et al. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00217 · Cited by 49 · see citing works
Bile acids and their receptors during liver regeneration: “Dangerous protectors”
Merlen, G., Bedoya, J. U., Bidault, V., Kahale, N., Glénisson, M., Doignon, I., Rainteau, D. P., & Tordjmann, T. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.002 · Cited by 48 · see citing works
Self-citation
Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration
Liu, H., Hu, Y. C., & Wan, Y. Y. (2015) · Oncotarget · doi:10.18632/oncotarget.6665 · Cited by 46 · see citing works
Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development
Jiang, C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16464 · Cited by 46 · see citing works
Metabolic Effects of Bile Acids: Potential Role in Bariatric Surgery
Flynn, C. R., Albaugh, V. L., & Abumrad, N. N. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.014 · Cited by 46 · see citing works
The role of microbiota in tissue repair and regeneration
Shavandi, A., Saeedi, P., Gérard, P., Jalalvandi, E., Cannella, D., & Bekhit, A. E. A. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3009 · Cited by 46 · see citing works
The role of bile salts in liver regeneration
van de Laarschot, L. F. M., Jansen, P. L. M., Schaap, F. G., & Damink, S. W. M. O. (2016) · Hepatology International · doi:10.1007/s12072-016-9723-8 · Cited by 45 · see citing works
Functions of the Gallbladder
Housset, C., Chrétien, Y., Debray, D., & Chignard, N. (2016) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2016.tb00717.x · Cited by 173 · see citing works
The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis
Besnard, A., Gautherot, J., Julien, B., Tebbi, A., Garcin, I., Doignon, I., Pean, N., Gonzales, E. M., Cassio, D., Grosse, B., et al. (2016) · Hepatology · doi:10.1002/hep.28675 · Cited by 44 · see citing works
Self-citation
FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis
van Golen, R. F., Olthof, P. B., Lionarons, D. A., Reiniers, M. J., Alles, L. K., Uz, Z., de Haan, L. R., Ergin, B., de Waart, D. R., Maas, M. A. W., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33070-1 · Cited by 44 · see citing works
Update on the development of TGR5 agonists for human diseases
Jin, W., Zheng, M., Chen, Y., & Xiong, H. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116462 · Cited by 41 · see citing works
Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration
Meyer, K., Morales‐Navarrete, H., Seifert, S., Wilsch‐Braeuninger, M., Dahmen, U., Tanaka, E. M., Brusch, L., Kalaidzidis, Y., & Zerial, M. (2020) · Molecular Systems Biology · doi:10.15252/msb.20198985 · Cited by 39 · see citing works
Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment
Zaborska, K. E., & Cummings, B. P. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1092-3 · Cited by 39 · see citing works
The role of gut microbiota in liver regeneration
Xu, Z., Jiang, N., Xiao, Y., Yuan, K., & Wang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1003376 · Cited by 39 · see citing works
Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products
Zhao, Y., Wei, S., Chen, L., Zhou, X., & Ma, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1164202 · Cited by 38 · see citing works
Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
Wu, Y., Zhou, A., Tang, L., Lei, Y., Tang, B., & Zhang, L. (2020) · Journal of Diabetes Research · doi:10.1155/2020/6138438 · Cited by 38 · see citing works
Cholesterol attenuates cytoprotective effects of phosphatidylcholine against bile salts
Ikeda, Y., Morita, S., & Terada, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-00476-2 · Cited by 37 · see citing works
Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver
Woolbright, B. L., & Jaeschke, H. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.001 · Cited by 37 · see citing works
Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment
Manco, R., Leclercq, I. A., & Clerbaux, L.-A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124115 · Cited by 36 · see citing works
The Bile Acid Receptor TGR5 and Liver Regeneration
Bidault, V., Pean, N., Doignon, I., Humbert, L., Rainteau, D. P., & Tordjmann, T. (2015) · Digestive Diseases · doi:10.1159/000371668 · Cited by 35 · see citing works
Self-citation
Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis
de Haan, L. R., van der Lely, S. J., Warps, A. K., Hofsink, Q., Olthof, P. B., de Keijzer, M. J., Lionarons, D. A., Dias, L. M., Bruinsma, B. G., Uygun, K., et al. (2018) · Journal of Clinical and Translational Research · doi:10.18053/jctres.04.201801.001 · Cited by 33 · see citing works
Phytosterols Alleviate Hyperlipidemia by Regulating Gut Microbiota and Cholesterol Metabolism in Mice
Lv, W., Huang, J.-Y., Lin, J., Ma, Y., He, S.-Q., Zhang, Y., Wang, T.-Z., Cheng, K., Xiong, Y., Sun, F., et al. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/6409385 · Cited by 33 · see citing works
Novel therapeutics for primary biliary cholangitis: Toward a disease-stage-based approach
Mousa, H. S., Carbone, M., Malinverno, F., Ronca, V., Gershwin, M. E., & Invernizzi, P. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.07.003 · Cited by 33 · see citing works

The Bile Acid Receptor TGR5 and Liver Regeneration
Bidault, V., Pean, N., Doignon, I., Humbert, L., Rainteau, D. P., & Tordjmann, T. (2015) · Digestive Diseases · doi:10.1159/000371668 · Cited by 35 · see citing works
Self-citation
Hepatoprotective impact of the bile acid receptor TGR5
Merlen, G., Bidault, V., Kahale, N., Glénisson, M., Bedoya, J. U., Doignon, I., Garcin, I., Humbert, L., Rainteau, D. P., & Tordjmann, T. (2020) · Liver International · doi:10.1111/liv.14427 · Cited by 30 · see citing works
Self-citation
Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration
Keitel, V., Reich, M., Sommerfeld, A., Kluge, S., Kubitz, R., & Häussinger, D. (2014) · European journal of medical research · doi:10.1186/2047-783x-19-s1-s21 · Cited by 2 · see citing works
TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
Bidault, V., Merlen, G., Glénisson, M., Doignon, I., Garcin, I., Pean, N., Boisgard, R., Bedoya, J. U., Sérino, M., Ullmer, C., et al. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100214 · Cited by 58 · see citing works
Self-citation
Role of the G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage
Reich, M., Klindt, C., Deutschmann, K., Spomer, L., Häussinger, D., & Keitel, V. (2017) · Digestive Diseases · doi:10.1159/000450917 · Cited by 52 · see citing works

Authors: Péan, N., Doignon, I., Garcin, I., Besnard, A., Julien, B., Liu, B., Branchereau, S., Spraul, A., Guettier, C., Humbert, L., Schoonjans, K., Rainteau, D., & Tordjmann, T.
Affiliations: Université Paris-Sud (FR)
Bicêtre Hospital (FR)
Centre National de la Recherche Scientifique (FR)
École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Tordjmann, Thierry
ORCID: Branchereau, Sophie
Spraul, Anne
Guettier, Catherine
Schoonjans, Kristina
Rainteau, Dominique
Tordjmann, Thierry
Venue: Hepatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-10
Volume: 58
Issue: 4
Pages: 1451-1460
ISSN: 0270-9139 (ISSN-L)
DOI: 10.1002/hep.26463
OpenAlex: W1523071223
Cited by: 193
References: 34
Citations by year: 2026: 8 · 2025: 11 · 2024: 11 · 2023: 8 · 2022: 15 · 2021: 14 · 2020: 21 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 16 · 2015: 24 · 2014: 14
FWCI: 11.22
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 700 d)
Locations: Hepatology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: TGR5, G protein-coupled bile acid receptor, liver regeneration, partial hepatectomy, liver necrosis, cholestasis, bile flow, hepatocyte proliferation, Kupffer cells, cholestyramine, bile duct ligation, cholic acid, liver injury
MeSH terms: Animals, Bile Acids and Salts, Cholestyramine Resin, Disease Models, Animal, Hepatectomy, Hepatitis, Liver, Liver Regeneration, Male, Mice, Inbred C57BL, Necrosis, Phenotype, Cytokines, Mice, Knockout, Receptors, G-Protein-Coupled, Cell Proliferation, Mice

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The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

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