Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis
Open accessAbstract
The early detection of liver fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) is an important clinical need. In view of the suggested role played by bacterial translocation in liver disease and obesity, we sought to investigate the relationship between blood microbiota and liver fibrosis (LF) in European cohorts of patients with severe obesity. We carried out a cross‐sectional study of obese patients, well characterized with respect to the severity of the NAFLD, in the cohort FLORINASH. This cohort has been divided into a discovery cohort comprising 50 Spanish patients and then in a validation cohort of 71 Italian patients. Blood bacterial DNA was analyzed both quantitatively by 16S ribosomal DNA (rDNA) quantitative polymerase chain reaction and qualitatively by 16S rDNA targeted metagenomic sequencing and functional metagenome prediction. Spanish plasma bile acid contents were analyzed by liquid chromatography/mass spectrometry. The 16S rDNA concentration was significantly higher in patients of the discovery cohort with LF. By 16S sequencing, we found specific differences in the proportion of several bacterial taxa in both blood and feces that correlate with the presence of LF, thus defining a specific signature of the liver disease. Several secondary/primary bile acid ratios were also decreased with LF in the discovery cohort. We confirmed, in the validation cohort, the correlation between blood 16S rDNA concentration and LF, whereas we did not confirm the specific bacterial taxa signature, despite a similar trend in patients with more‐severe fibrosis. Conclusion: Changes in blood microbiota are associated with LF in obese patients. Blood microbiota analysis provides potential biomarkers for the detection of LF in this population. (H epatology 2016;64:2015‐2027).
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MASH fibrosis is linked to a unique gut microbiome.
“MASH fibrosis is linked to a unique gut microbiome (193-197), and specific microbiome signatures can distinguish human MASH from MASLD (4, 198, 199).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [194]
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- Authors
- Lelouvier, B., Servant, F., Païssé, S., Brunet, A., Benyahya, S., Serino, M., Valle, C., Ortiz, M. R., Puig, J., Courtney, M., Federici, M., Fernández‐Real, J., Burcelin, R., & Amar, J.
- Affiliations
- Vaiomer SAS,Labège,France
- Université Toulouse III - Paul Sabatier (FR)
- INSERM U1048, I2MC,Toulouse,France
- Department of Diabetes, Endocrinology, and Nutrition,IDIBGI,Girona,Spain - CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
- Institut d'Investigació Biomèdica de Girona (ES)
- University of Rome Tor Vergata (IT)
- Instituto de Salud Carlos III (ES)
- Inserm (FR)
- Corresponding author
- Lelouvier, Benjamin
- Amar, Jacques
- ORCID
- Venue
- Hepatology
- Published
- 2016-11-18
- Volume
- 64
- Issue
- 6
- Pages
- 2015-2027
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- OpenAlex
- W2523689809
- Cited by
- 242
- References
- 50
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 20 · 2023: 24 · 2022: 24 · 2021: 52 · 2020: 39 · 2019: 31 · 2018: 19 · 2017: 14 · 2016: 1
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Funders
- European Commission (241913)
- Instituto de Salud Carlos III
- European Regional Development Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- liver fibrosis, non-alcoholic fatty liver disease, morbid obesity, blood microbiota, gut microbiota, bacterial translocation, plasma bile acids, biomarkers, metagenomics
- MeSH terms
- Cross-Sectional Studies, Feces, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Obesity, Pilot Projects, Microbiota
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