Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome.

Liu, Zhong-Hua; Smith, Carolyn Beebe

doi:10.1016/j.neulet.2009.02.066

Cited by 112Genetics and Neurodevelopmental DisordersNeuroendocrine regulation and behaviorNeuroscience and Neuropharmacology Research

Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome.

Open access

Liu, Zhong-Hua, Smith, Carolyn Beebe·2009·Neuroscience Letters

DOI 10.1016/j.neulet.2009.02.066PMC PMC3092374

Open this paper in CoChat — free account

Abstract

Anxiety is a common symptom in fragile X patients. However, an anxiety-prone phenotype in mouse models of fragile X syndrome is not clear. In most studies of fmr1 knockout mice, decreased anxiety-like responses in exploratory-based models are found, but mice also exhibit abnormal social interactions. We hypothesize the coexistence of elevated social anxiety and reduced nonsocial anxiety in fmr1 knockout mice. In the present study, we applied an automated three-chambered social approach method and the elevated zero maze test to further investigate social interactions and general anxiety, respectively. Results indicate lower levels of both social approach behavior and response to social novelty in fmr1 knockout mice compared with wild-type littermates in the social interaction test. In the elevated zero maze, fmr1 knockout mice spent a greater percent time in open quadrants than wild-type mice, suggesting reduced nonsocial anxiety. These findings support the hypothesis that social and nonsocial anxiety can be dissociated and that in the fragile X mouse model, behavior consistent with hyper-social anxiety coexists with hypo-nonsocial anxiety.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neulet.2009.02.066

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Fmr1 knockout mouse model lacks FMRP and recapitulates the main FXS phenotype, including deficiency in learning and memory, social behavior, and sensory processing.
“The mouse model of FXS, the Fmr1 knockout (KO) mice, lacks FMRP and recapitulates the main phenotype, including deficiency in learning and memory, social behavior, and sensory processing (Bassell and Warren, 2008; Liu and Smith, 2009).”
From Astrocytes in fragile X syndrome (2024) · cites this paper as Liu and Smith, 2009
The paper’s opening passage (section labeled Abstract; page unavailable) says Fmr1 knockout mice lack FMRP and show some learning impairments and social abnormalities comparable to those in people with FXS. It does not establish memory deficiency or impaired sensory processing in the knockout mice; its mention of low visual acuity concerns the background strain, not a knockout-specific deficit. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997 · see citing works
Retinal degeneration mutants in the mouse
Chang, B., Hawes, N. L., Hurd, R. E., Davisson, M. T., Nusinowitz, S., & Heckenlively, J. R. (2002) · Vision Research · doi:10.1016/s0042-6989(01)00146-8 · Cited by 840 · see citing works
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812 · see citing works
Automated apparatus for quantitation of social approach behaviors in mice
Nadler, J. J., Moy, S. S., Dold, G., Trang, D., Simmons, N., Perez, A., Young, N. B., Barbaro, R. P., Piven, J., Magnuson, T. R., et al. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00071.x · Cited by 775 · see citing works
Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety
Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J., & Dourish, C. T. (1994) · Psychopharmacology · doi:10.1007/bf02244871 · Cited by 739 · see citing works
Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium.
(1994) · PubMed · Cited by 565 · see citing works
Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
Fragile X Syndrome: Diagnosis, Treatment, And Research
Silverman, & Cronister, A. (1991) · Johns Hopkins University Press eBooks · Cited by 481 · see citing works
Research Review: Williams syndrome: a critical review of the cognitive, behavioral, and neuroanatomical phenotype
Martens, M. A., Wilson, S. J., & Reutens, D. C. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01887.x · Cited by 479 · see citing works
Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model
Bilousova, T. V., Dansie, L., Ngo, M., Aye, J., Charles, J. R., Ethell, D. W., & Ethell, I. M. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.061796 · Cited by 465 · see citing works
Altered anxiety‐related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
Moretti, P. M., Bouwknecht, J. A., Teague, R. M., Paylor, R. E., & Zoghbi, H. Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi016 · Cited by 343 · see citing works
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome
Restivo, L., Ferrari, F., Passino, E., Sgobio, C., Bock, J., Oostra, B. A., Bagni, C., & Ammassari-Teule, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504984102 · Cited by 299 · see citing works
(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features
Peier, A. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.8.1145 · Cited by 285 · see citing works
Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
Zhao, M.-G., Toyoda, H., Ko, S. W., Ding, H.-K., Wu, L.-J., & Zhuo, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1520-05.2005 · Cited by 258 · see citing works
Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions
Prather, M. D., Lavenex, P., Mauldin-Jourdain, M. L., Mason, W. A., Capitanio, J. P., Mendoza, S. P., & Amaral, D. G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00445-6 · Cited by 248 · see citing works
Social stress in mice
Palanza, P., Gioiosa, L., & Parmigiani, S. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00494-2 · Cited by 244 · see citing works
Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse
Mineur, Y. S., Sluyter, F., de Wit, S., Oostra, B. A., & Crusio, W. E. (2002) · Hippocampus · doi:10.1002/hipo.10005 · Cited by 216 · see citing works
Towards the neural basis for hypersociability in a genetic syndrome
Bellugi, U., Adolphs, R., Cassady, C., & Chiles, M. (1999) · NeuroReport · doi:10.1097/00001756-199906030-00006 · Cited by 207 · see citing works
Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., 三島, 健., Iwasaki, K., & Fujiwara, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.009 · Cited by 193 · see citing works
Visual detection, pattern discrimination and visual acuity in 14 strains of mice
Wong, A. A., & Brown, R. E. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00173.x · Cited by 188 · see citing works
FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain
Wang, H., Wu, L.-J., Kim, S. S., Lee, F. J. S., Gong, B., Toyoda, H., Ren, M., Shang, Y.-Z., Xu, H., Liu, F., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.027 · Cited by 186 · see citing works
Social behavior deficits in the Fmr1 mutant mouse
Mineur, Y. S., Huynh, L. X., & Crusio, W. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.004 · Cited by 177 · see citing works
Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.
McNaughton, C. H., Moon, J., Strawderman, M. S., Maclean, K. N., Evans, J., & Strupp, B. J. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.293 · Cited by 174 · see citing works
Fragile X syndrome: diagnosis, treatment and research
Vries, B. B. A. D. (2003) · Human Genetics · doi:10.1007/s00439-002-0888-y · Cited by 163 · see citing works
Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome
Nielsen, D. M., Derber, W. J., McClellan, D. A., & Crnic, L. S. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03309-1 · Cited by 154 · see citing works
Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior
Page, D. T., Kuti, O. J., Prestia, C., & Sur, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804428106 · Cited by 149 · see citing works
Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation
Qin, M., Kang, J. Y., & Smith, C. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242377399 · Cited by 93 · see citing works
Self-citation
Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene.
Spencer, C. M., Graham, D. F., Yuva-Paylor, L. A., Nelson, D. L., & Paylor, R. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.3.710 · Cited by 91 · see citing works
A null mutation for Fmr1 in female mice: Effects on regional cerebral metabolic rate for glucose and relationship to behavior
Qin, M., Kang, J. Y., & Smith, C. B. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.081 · Cited by 64 · see citing works
Self-citation
Social organization and aggression in a group of olfactory bulbectomized male mice
Liebenauer, L. L., & Slotnick, B. M. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)80011-4 · Cited by 51 · see citing works
Unaltered hormonal response to stress in a mouse model of fragile X syndrome
Qin, M., & Smith, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.010 · Cited by 28 · see citing works
Self-citation
Untitled work
Hopko (2000) · doi:10.1002/1520-6394(2000)12:4

Flagged first, then by citations

Research works printed but not linked: 1

[8]Garau A Martí MA Sala J Balada F Age effects on the social interaction test in early adulthood male rats. Depress Anxiety 2000 12 226 31 11195759

Sorted by citations

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N.-P., Guo, W., Birnbaum, S. G., Hu, J.-H., Worley, P. F., Gibson, J. R., & Huber, K. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3033 · Cited by 251 · see citing works
Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA B Receptors with Arbaclofen
Henderson, C., Wijetunge, L., Kinoshita, M. N., Shumway, M., Hammond, R. S., Postma, F. R., Brynczka, C., Rush, R., Thomas, A., Paylor, R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004218 · Cited by 249 · see citing works
Modeling fragile X syndrome in the Fmr1 knockout mouse
Kazdoba, T. M., Leach, P. T., Silverman, J. L., & Crawley, J. N. (2014) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2014.01024 · Cited by 241 · see citing works
Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress
Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017) · BMC Medicine · doi:10.1186/s12916-016-0771-7 · Cited by 236 · see citing works
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Chiu, C., & Chuang, D. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.006 · Cited by 227 · see citing works
Dissecting the contribution of host genetics and the microbiome in complex behaviors
Buffington, S. A., Dooling, S. W., Sgritta, M., Noecker, C. A., Murillo, O. D., Felice, D., Turnbaugh, P. J., & Costa‐Mattioli, M. (2021) · Cell · doi:10.1016/j.cell.2021.02.009 · Cited by 221 · see citing works
Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic‐like responses
Spencer, C. M., Alekseyenko, O. V., Hamilton, S. M., Thomas, A. M., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. E. (2011) · Autism Research · doi:10.1002/aur.168 · Cited by 215 · see citing works
GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism
Mines, M. A., Yuskaitis, C. J., King, M. K., Beurel, E., & Jope, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009706 · Cited by 208 · see citing works
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome
Yuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., & Jope, R. S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.023 · Cited by 187 · see citing works
Behavioral phenotypes of genetic mouse models of autism
Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 179 · see citing works
What Can We Learn about Autism from Studying Fragile X Syndrome?
Budimirovic, D. B., & Kaufmann, W. E. (2011) · Developmental Neuroscience · doi:10.1159/000330213 · Cited by 176 · see citing works
High-fat diet selectively protects against the effects of chronic social stress in the mouse
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.072 · Cited by 161 · see citing works
Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome
Liu, Z., Chuang, D., & Smith, C. B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000520 · Cited by 159 · see citing works
Self-citation
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150 · see citing works
Social fearfulness in the human brain
Miskovic, V., & Schmidt, L. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.08.002 · Cited by 126 · see citing works
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
Goebel‐Goody, S. M., Wilson‐Wallis, E. D., Royston, S., Tagliatela, S. M., Naegele, J. R., & Lombroso, P. J. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00781.x · Cited by 108 · see citing works
Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
Gantois, I., Pop, A. S., de Esch, C. E. F., Buijsen, R. A. M., Pooters, T., Gomez-Mancilla, B., Gasparini, F., Oostra, B. A., D’Hooge, R., & Willemsen, R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.059 · Cited by 100 · see citing works
Rescue of fragile X syndrome phenotypes in Fmr1KO mice by a BKCa channel opener molecule
Hébert, B., Pietropaolo, S., Même, S., Laudier, B., Laugeray, A., Doisne, N., Quartier, A., Lefeuvre, S., Got, L., Cahard, D., et al. (2014) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-014-0124-6 · Cited by 100 · see citing works
Embryological exposure to valproic acid induces social interaction deficits in zebrafish (Danio rerio): A developmental behavior analysis
Zimmermann, F. F., Gaspary, K. V., Leite, C. E., Cognato, G. D. P., & Bonan, C. D. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.10.002 · Cited by 92 · see citing works
A mouse model of the fragile X premutation: Effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis
Qin, M., Entezam, A., Usdin, K., Huang, T., Liu, Z., Hoffman, G. E., & Smith, C. B. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.008 · Cited by 91 · see citing works
Self-citation
Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach usPreprint
Santos, A. R., Kanellopoulos, A. K., & Bagni, C. (2014) · Learning & Memory · doi:10.1101/lm.035956.114 · Cited by 86 · see citing works
Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development
Lai, J., Sobala-Drozdowski, M., Zhou, L., Doering, L. C., Faure, P. A., & Foster, J. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.049 · Cited by 84 · see citing works
Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice
Qin, M., Xia, Z., Huang, T., & Smith, C. B. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.047 · Cited by 83 · see citing works
Self-citation
Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats
Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00269 · Cited by 82 · see citing works
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
Bostrom, C. A., Yau, S., Majaess, N. M., Vetrici, M. A., Gil‐Mohapel, J., & Christie, B. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.033 · Cited by 79 · see citing works
Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome.
Yuskaitis, C. J., Beurel, E., & Jope, R. S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.015 · Cited by 79 · see citing works
Neuroprotective action of lithium in disorders of the central nervous system.
Chiu, C., & Chuang, D. (2011) · PubMed · doi:10.3969/j.issn.1672-7347.2011.06.001 · Cited by 78 · see citing works
How Many Ways Can Mouse Behavioral Experiments Go Wrong? Confounding Variables in Mouse Models of Neurodegenerative Diseases and How to Control Them
Schellinck, H. M., Cyr, D. P., & Brown, R. E. (2010) · Advances in the study of behavior · doi:10.1016/s0065-3454(10)41007-4 · Cited by 77 · see citing works
Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk
Oliver, P., & Davies, K. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp425 · Cited by 79 · see citing works
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome
Qin, M., Zeidler, Z., Moulton, K., Krych, L., Xia, Z., & Smith, C. B. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.003 · Cited by 69 · see citing works
Self-citation
Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome
Mines, M. A., & Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00035 · Cited by 68 · see citing works
FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype
Arsenault, J., Gholizadeh, S., Niibori, Y., Pacey, L. K. K., Halder, S. K., Koxhioni, E., Konno, A., Hirai, H., & Hampson, D. R. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.090 · Cited by 66 · see citing works
The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice
Veloz, M. F. V., Buijsen, R. A. M., Willemsen, R., Cupido, A., Bosman, L. W. J., Koekkoek, S. K. E., Potters, J.-W., Oostra, B. A., & Zeeuw, C. I. D. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00763.x · Cited by 65 · see citing works
Behavioral abnormalities in the Fmr1‐KO2 mouse model of fragile X syndrome: The relevance of early life phases
Gaudissard, J., Ginger, M. R., Premoli, M., Memo, M., Frick, A., & Pietropaolo, S. (2017) · Autism Research · doi:10.1002/aur.1814 · Cited by 64 · see citing works
R-Baclofen Reverses a Social Behavior Deficit and Elevated Protein Synthesis in a Mouse Model of Fragile X Syndrome
Qin, M., Huang, T., Kader, M., Krych, L., Xia, Z., Burlin, T., Zeidler, Z., Zhao, T., & Smith, C. B. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv034 · Cited by 62 · see citing works
Self-citation
Sociability and brain development in BALB/cJ and C57BL/6J mice
Fairless, A. H., Dow, H. C., Kreibich, A. S., Torre, M., Kuruvilla, M., Gordon, E., Morton, E. A., Tan, J., Berrettini, W. H., Li, H., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.001 · Cited by 60 · see citing works
What we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works
Emerging Pharmacotherapies for Neurodevelopmental Disorders
Wetmore, D. Z., & Garner, C. C. (2010) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e3181ee3833 · Cited by 54 · see citing works
Deficient Sleep in Mouse Models of Fragile X Syndrome
Saré, R. M., Harkless, L. H., Levine, M., Torossian, A., Sheeler, C. A., & Smith, C. B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00280 · Cited by 54 · see citing works
Self-citation
Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse
Sørensen, E. M., Bertelsen, F., Weikop, P., Skovborg, M. M., Banke, T. G., Drasbek, K. R., & Scheel‐Krüger, J. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000152 · Cited by 53 · see citing works
Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice
Zhang, C., Chua, B. E., Yang, A., Shabanpoor, F., Hossain, M. A., Wade, J. D., Rosengren, K. J., Smith, C. M., & Gundlach, A. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.010 · Cited by 52 · see citing works
Self-citation
Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice
Guo, W., Molinaro, G., Collins, K. A., Hays, S. A., Paylor, R. E., Worley, P. F., Szumlinski, K. K., & Huber, K. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2921-15.2016 · Cited by 51 · see citing works
Fragile X syndrome: From targets to treatments
Wijetunge, L. S., Chattarji, S., Wyllie, D. J. A., & Kind, P. C. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.028 · Cited by 49 · see citing works
Deletion of Fmr1 results in sex‐specific changes in behavior
Nolan, S. O., Reynolds, C. D., Smith, G. D., Holley, A. J., Escobar, B., Chandler, M. A., Volquardsen, M., Jefferson, T. S., Pandian, A., Smith, T., et al. (2017) · Brain and Behavior · doi:10.1002/brb3.800 · Cited by 50 · see citing works
Metabotropic Glutamate Receptors in Central Nervous System Diseases
Golubeva, A. V., Moloney, R. D., O’Connor, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Current Drug Targets · doi:10.2174/1389450116666150316224011 · Cited by 49 · see citing works
Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome
Maurin, T., Melancia, F., Jarjat, M., Castro, L. R., Costa, L., Delhaye, S., Khayachi, A., Castagnola, S., Mota, É., Giorgio, A. D., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy192 · Cited by 49 · see citing works
Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis
De Rubeis, S., Fernández, E., Buzzi, A., Di Marino, D., & Bagni, C. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_23 · Cited by 48 · see citing works
Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice
Fairless, A. H., Katz, J. M., Safi, N., Dow, H. C., Kreibich, A. S., Berrettini, W. H., Abel, T. G., & Brodkin, E. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.051 · Cited by 46 · see citing works
Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse
Pacey, L. K. K., Doss, L., Cifelli, C., van der Kooy, D., Heximer, S. P., & Hampson, D. R. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.12.005 · Cited by 46 · see citing works
Translational validity and methodological underreporting in animal research: A systematic review and meta-analysis of the Fragile X syndrome (Fmr1 KO) rodent model
Kat, R., Arroyo-Araujo, M., de Vries, R. B. M., Koopmans, M. A., de Boer, S. F., & Kas, M. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104722 · Cited by 42 · see citing works
Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges
Duvoisin, R. M., Villasana, L., Davis, M. J., Winder, D. G., & Raber, J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.049 · Cited by 40 · see citing works
Functional Magnetic Resonance Imaging in Awake Transgenic Fragile X Rats: Evidence of Dysregulation in Reward Processing in the Mesolimbic/Habenular Neural Circuit
Kenkel, W. M., Yee, J. R., Moore, K., Madularu, D., Kulkarni, P., Gamber, K., Nedelman, M., & Ferris, C. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.15 · Cited by 39 · see citing works
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders
Kim, K. C., Gonzales, E. L., Lázaro, M. T., Choi, C. S., Bahn, G. H., Yoo, H. J., & Shin, C. Y. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.061 · Cited by 40 · see citing works
Lithium: A Promising Treatment for Fragile X Syndrome
Liu, Z., & Smith, C. B. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500077p · Cited by 35 · see citing works
Self-citation
The Application of Adeno-Associated Viral Vector Gene Therapy to the Treatment of Fragile X Syndrome
Hampson, D. R., Hooper, A. W. M., & Niibori, Y. (2019) · Brain Sciences · doi:10.3390/brainsci9020032 · Cited by 36 · see citing works
The neurochemical basis for the treatment of autism spectrum disorders and Fragile X syndrome
Hampson, D. R., Adusei, D. C., & Pacey, L. K. K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.005 · Cited by 34 · see citing works
Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype
Bernard, P. B., Castano, A. M., Beitzel, C. S., Carlson, V. B., & Benke, T. A. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.01.006 · Cited by 34 · see citing works
Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders
Robertson, H. R., & Feng, G. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02380.x · Cited by 33 · see citing works
Behavioral responses to physical vs. social novelty in male and female laboratory rats
Cavigelli, S. A., Michael, K. C., West, S. G., & Klein, L. C. (2011) · Behavioural Processes · doi:10.1016/j.beproc.2011.06.006 · Cited by 33 · see citing works
Fragile X syndrome neurobiology translates into rational therapy
Braat, S., & Kooy, R. F. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.01.013 · Cited by 32 · see citing works
Modelling fragile X syndrome in the laboratory setting: A behavioral perspective
Melancia, F., & Trezza, V. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.042 · Cited by 29 · see citing works
Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome
Wong, H., Hooper, A. W. M., Niibori, Y., Lee, S. J., Hategan, L. A., Zhang, L., Karumuthil‐Melethil, S., Till, S. M., Kind, P. C., Danos, O., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105118 · Cited by 27 · see citing works
Stem cells and modeling of autism spectrum disorders
Freitas, B. C. G., Trujillo, C. A., Carromeu, C., Yusupova, M., Herai, R. H., & Muotri, A. R. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.017 · Cited by 27 · see citing works
New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model
Busquets-García, A., Maldonado, R. J., & Ozaita, A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.004 · Cited by 27 · see citing works
Behavioral Phenotype ofFmr1Knock-Out Mice during Active Phase in an Altered Light/Dark Cycle
Saré, R. M., Levine, M., & Smith, C. B. (2016) · eNeuro · doi:10.1523/eneuro.0035-16.2016 · Cited by 25 · see citing works
Self-citation
The other side of the coin: Hypersociability
Tóth, M. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12512 · Cited by 24 · see citing works
Effects of chronic inhibition of phosphodiesterase-4D on behavior and regional rates of cerebral protein synthesis in a mouse model of fragile X syndrome
Rosenheck, M., Sheeler, C. A., Saré, R. M., Gurney, M. E., & Smith, C. B. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105485 · Cited by 19 · see citing works
Self-citation
Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: Age, sex and region-specific changes
Scremin, O. U., Roch, M., Norman, K. M., Djazayeri, S., & Liu, Y.-Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.036 · Cited by 19 · see citing works
Chronic minocycline treatment improves social recognition memory in adult male Fmr1 knockout mice
Yau, S., Chiu, C., Vetrici, M. A., & Christie, B. R. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.015 · Cited by 18 · see citing works
Loss of Sodium-Activated Potassium Channel Slack and FMRP Differentially Affect Social Behavior in Mice
Bausch, A. E., Ehinger, R., Straubinger, J., Zerfass, P., Nann, Y., & Łukowski, R. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.040 · Cited by 18 · see citing works
Paradoxical effect of baclofen on social behavior in the fragile X syndrome mouse model
Zeidler, S., Pop, A. S., Jaafar, I. A., de Boer, H., Buijsen, R. A. M., de Esch, C. E. F., Nieuwenhuizen‐Bakker, I., Hukema, R. K., & Willemsen, R. (2018) · Brain and Behavior · doi:10.1002/brb3.991 · Cited by 16 · see citing works
Brief Report: Altered Social Behavior in Isolation-Reared Fmr1 Knockout Mice
Heitzer, A. M., Roth, A. K., Nawrocki, L., Wrenn, C. C., & Valdovinos, M. G. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1670-1 · Cited by 17 · see citing works
The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model
Li, X., Feng, T., & Lu, W. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109783 · Cited by 17 · see citing works
Programming social behavior by the maternal fragile X protein
Zupan, B., Sharma, A., Frazier, A., Klein, S. L., & Tóth, M. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12298 · Cited by 13 · see citing works
Mouse Behavior and Models for Autism Spectrum Disorders
Ricceri, L., Michetti, C., & Scattoni, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00017-0 · Cited by 11 · see citing works
MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo
Kelly-Castro, E. C., Shear, R., Dindigal, A. H., Bhagwat, M., & Zhang, H. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114752 · Cited by 10 · see citing works
The mGluR Theory of Fragile X: From Mice to Men
Stoppel, L. J., Osterweil, E. K., & Bear, M. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00009-3 · Cited by 9 · see citing works
Effects of a social stimulus on gene expression in a mouse model of fragile X syndrome
Rogers, T. D., Anacker, A. M. J., Kerr, T. M., Forsberg, C. G., Wang, J., Zhang, B., & Veenstra-VanderWeele, J. M. (2017) · Molecular Autism · doi:10.1186/s13229-017-0148-6 · Cited by 10 · see citing works
The Endocannabinoid System in Prefrontal Synaptopathies
Scheyer, A. F., Martin, H. G. S., & Manzoni, O. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_7 · Cited by 10 · see citing works
The same stress elicits different effects on anxiety-like behavior in rat models of Fmr1 and Pten
Dey, R., & Chattarji, S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113892 · Cited by 9 · see citing works
Dietary rescue of adult behavioral deficits in the Fmr1 knockout mouse
Nolan, S. O., Hodges, S. L., Binder, M. S., Smith, G. D., Okoh, J. T., Jefferson, T. S., Escobar, B., & Lugo, J. N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262916 · Cited by 9 · see citing works
Astrocytes in fragile X syndrome
Talvio, K., & Castrén, M. L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1322541 · Cited by 8 · see citing works
“The mouse model of FXS, the Fmr1 knockout (KO) mice, lacks FMRP and recapitulates the main phenotype, including deﬁciency in learning and memory, social behavior, and sensory processing (Bassell and Warren, 2008; Liu and Smith, 2009).”
Method
The role of the dorsal striatum in a mouse model for fragile X syndrome: Behavioral and dendritic spine assessment
Huebschman, J. L., Monterrey, C. A., Foster, D. M., Omoregie, C. C., Cakir, A. E., Sevilla-Gutierrez, A., Chow, E. C., Essoh, A., Guo, Y., & Smith, L. N. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148060 · Cited by 6 · see citing works
Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2
Caiola, H., Wu, Q., Li, J., Wang, X., Soni, S., Monahan, K., Wagner, G. C., Pang, Z. P., & Zhang, H. (2024) · The FASEB Journal · doi:10.1096/fj.202400454r · Cited by 8 · see citing works
The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice
Veloz, M. F. V., Buijsen, R. A. M., Willemsen, R., Cupido, A., Bosman, L. W. J., Koekkoek, S. K. E., Potters, J.-W., Oostra, B. A., & Zeeuw, C. I. D. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00763.x · Cited by 8 · see citing works
The novel potent GSK3 inhibitor AF3581 reverts fragile X syndrome phenotype
Porceddu, P. F., Ciampoli, M., Romeo, E., Garrone, B., Durando, L., Milanese, C., Giorgio, F. P. D., & Reggiani, A. M. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab251 · Cited by 6 · see citing works
Altered anxiety and social behaviors in a mouse model of Fragile X syndrome treated with hyperbaric oxygen therapy
Luo, C.-W., Deng, X., Cheng, J.-L., Xiao, D.-X., Zhang, C., Feng, J., Chen, S., & Hu, N. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.02.004 · Cited by 6 · see citing works
Prepartum bumetanide treatment reverses altered neonatal social communication but nonspecifically reduces postpubertal social behavior in a mouse model of fragile X syndrome
Sakamoto, Y., Takano, T., Shimoyama, S., Hiramoto, T., Hiroi, N., & Nakamura, K. (2024) · Genomic psychiatry : · doi:10.61373/gp024h.0094 · Cited by 4 · see citing works
A Candidate Circuit Approach to Investigating Autism
Page, D. T. (2011) · The Anatomical Record · doi:10.1002/ar.21473 · Cited by 4 · see citing works
Is There a Dissociative Subtype of Generalized Social Phobia?
(2014) · African Journal of Psychiatry · doi:10.4172/psychiatry.1000168 · Cited by 4 · see citing works
SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome
Stamenković, V., Lautz, J. D., Harsh, F. M., & Smith, S. E. P. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02418-7 · Cited by 3 · see citing works
Three‐dimensional quantification of oxytocin neurons in the hypothalamic paraventricular nucleus reveals sex‐ and subregion‐specific differences in two genetic mouse models of autism
Patwardhan, A., Li, S., Chen, J. A., & Choe, K. Y. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70092 · Cited by 2 · see citing works
Autism and Fragile X Syndrome
O’Leary, H., & Benke, T. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804066-9.00074-2 · Cited by 2 · see citing works
Discovering functional interactions among schizophrenia-risk genes by combining behavioral genetics with cell biology
Ma, D., & Gu, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105897 · Cited by 2 · see citing works
CA2 neurons show abnormal responses to social stimuli in a rat model of Fragile X syndromePreprint
Donahue, M. M., Robson, E., Marron, A. M., Fernandez, E. J., Hill, M., Mably, A. J., Trimper, J. B., Brager, D. H., & Colgin, L. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.10.674743 · Cited by 2 · see citing works
Brain X chromosome inactivation is not random and can protect from paternally inherited neurodevelopmental diseasePreprint
Szelenyi, E. R., Fisenne, D., Knox, J. E., Harris, J. A., Gornet, J., Palaniswamy, R., Kim, Y., Venkataraju, K. U., & Osten, P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/458992 · Cited by 2 · see citing works
ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome
Wang, S., Wu, X., Dong, S., Zheng, L., Pan, L., Zhan, L., Xiao, H., Yang, L., Wang, X., Ma, H., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106478 · Cited by 1 · see citing works
Evidence for Phosphorylation-Dependent, Dynamic, Regulation of mGlu5 and Homer2 in Expression of Cocaine Aversion in Mice
Szumlinski, K. K., Beltran, J., Doren, E. V., Chavez, C. L. J., Domingo-Gonzalez, R. D., Reyes, C. M., Ary, A. W., Lang, A., Guo, W., Worley, P. F., et al. (2023) · eNeuro · doi:10.1523/eneuro.0423-22.2023 · Cited by 1 · see citing works
Adaptive group behavior of Fragile X mice in unfamiliar environments
Giua, G., Strauss, B., Lassalle, O., Chavis, P., & Manzoni, O. J. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111111 · Cited by 1 · see citing works
Behavioral and Molecular Consequences of Chronic Sleep Restriction During Development in Fragile X Mice
Saré, R. M., Song, A., Levine, M., Lemons, A. H. S., Loutaev, I., Sheeler, C. A., Hildreth, C., Mfon, A., & Smith, C. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.834890 · Cited by 1 · see citing works
Self-citation

Altered anxiety‐related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.
McNaughton, C. H., Moon, J., Strawderman, M. S., Maclean, K. N., Evans, J., & Strupp, B. J. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.293 · Cited by 174 · see citing works
SEE PROFILE
Alekseyenko, O. V., Serysheva, E., & Profile, S. (2016)
Social Behavior in FMR1 KO Mice: a Model of Fragile X Syndrome
McNaughton, C. H. (2006) · eCommons (Cornell University)
Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008).
Brodkin, E. S. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.483 · Cited by 23 · see citing works

Authors: Liu, Z.-H., & Smith, C. B.
Affiliations: United States Department of Health and Human Services (US)
Corresponding author: Smith, Carolyn Beebe
ORCID: Smith, Carolyn Beebe
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 2009-04
Volume: 454
Issue: 1
Pages: 62-66
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/j.neulet.2009.02.066
PMC: PMC3092374
OpenAlex: W2089667232
Cited by: 112
References: 35
Citations by year: 2026: 1 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 2 · 2012: 11
FWCI: 6.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (ZIAMH000889)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: fragile X syndrome, social anxiety, social approach behavior, social novelty, elevated zero maze, anxiety-like behavior, social interaction
MeSH terms: Animals, Anxiety, Behavior, Animal, Disease Models, Animal, Female, Fragile X Syndrome, Male, Social Behavior, Mice, Knockout, Mice, Fragile X Mental Retardation Protein, Fragile X Messenger Ribonucleoprotein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks