Social behavior deficits in the Fmr1 mutant mouse

Mineur, Yann S.; Huynh, Linh X.; Crusio, Wim E.

doi:10.1016/j.bbr.2005.11.004

Cited by 177Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchNeuroendocrine regulation and behavior

Social behavior deficits in the Fmr1 mutant mouse

Mineur, Yann S., Huynh, Linh X., Crusio, Wim E.·2006·Behavioural Brain Research

DOI 10.1016/j.bbr.2005.11.004

Open this paper in CoChat — free account

Abstract

Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social interactions with an ovariectomized female over four subsequent 2min sessions, returning to initial levels when presented with another stimulus mouse. Next, we studied males with a knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly reduced levels of social interaction, which were about similar as those of habituated controls. This social behavior deficit suggests that Fmr1 KO mice could possibly be used as models for autistic behaviors.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2005.11.004

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fmr1 KO mice, compared to wild-type, have lower than normal levels of initial social interactions, fail to show a preference for social novelty, and display inappropriate social responses.
“Fmr1 KO, in comparison to the wild-type (WT) strain, are described as having lower than normal levels of initial social interactions (Mineur et al., 2006), fail to show a preference for social novelty, and display inappropriate social responses (Pietropaolo et al., 2011).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Mineur et al., 2006
Fmr1 KO mice exhibit abnormal social interactions, including a general reduction in social contact and a failure to show social recognition.
“Fmr1 KO also exhibit abnormal social interactions, including a general reduction in social contact and a failure to show social recognition (Bernardet and Crusio, 2006; Mineur et al., 2006; Spencer et al., 2005; Yan et al., 2004).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Mineur et al., 2006

Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works
Fragile X Syndrome: Diagnosis, Treatment, And Research
Silverman, & Cronister, A. (1991) · Johns Hopkins University Press eBooks · Cited by 481 · see citing works
Autism: not an extremely rare disorder
Gillberg, C., & Wing, L. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb00984.x · Cited by 374 · see citing works
Prevalence of carriers of premutation-size alleles of the FMRI gene--and implications for the population genetics of the fragile X syndrome.
Rousseau, F., Rouillard, P., Morel, M. L., Khandjian, E. W., & Morgan, K. (1995) · Europe PMC (PubMed Central) · Cited by 361 · see citing works
Altered anxiety‐related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse
Mineur, Y. S., Sluyter, F., de Wit, S., Oostra, B. A., & Crusio, W. E. (2002) · Hippocampus · doi:10.1002/hipo.10005 · Cited by 216 · see citing works
Self-citation
A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse
Yan, Q. J., Asafo‐Adjei, P. K., Arnold, H. M., Brown, R. E., & Bauchwitz, R. P. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00087.x · Cited by 213 · see citing works
Mildly impaired water maze performance in maleFmr1 knockout mice
D'Hooge, R., Nagels, G., Franck, F., Bakker, C. E., Reyniers, E., Storm, K., Kooy, R. F., Oostra, B. A., Willems, P. J., & De Deyn, P. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00224-2 · Cited by 208 · see citing works
The Influence of Environmental and Genetic Factors on Behavior Problems and Autistic Symptoms in Boys and Girls With Fragile X Syndrome
Hessl, D., Dyer-Friedman, J., Glaser, B., Wisbeck, J., Barajas, R. G., Taylor, A., & Reiss, A. L. (2001) · Pediatrics · doi:10.1542/peds.108.5.e88 · Cited by 201 · see citing works
Fmr1 knockout mouse has a distinctive strain-specific learning impairment
Dobkin, C., Rabe, A., Dumas, R., El Idrissi, A., Haubenstock, H., & Ted Brown, W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00292-x · Cited by 179 · see citing works
Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice
Dam, D. V., D’Hooge, R., Hauben, E., Reyniers, E., Gantois, I., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Deyn, P. P. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00296-5 · Cited by 145 · see citing works
Flanking gene and genetic background problems in genetically manipulated mice
Crusio, W. E. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.026 · Cited by 132 · see citing works
Self-citation
Fragile X Syndrome: Diagnosis, Treatment, and Research
Schmidt, M. A. (1997) · JAMA · doi:10.1001/jama.1997.03540380083039 · Cited by 95 · see citing works
Mouse models for psychiatric disorders
Seong, E., Seasholtz, A. F., & Burmeister, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02807-x · Cited by 86 · see citing works
Molecular dissection of the amygdala and its relevance to autism
Zirlinger, M., & Anderson, D. J. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00039.x · Cited by 37 · see citing works
Fragile X premutations and (TA)n estrogen receptor polymorphism in women with ovarian dysfunction
Syrrou, M., Georgiou, I. A., Patsalis, P. C., Bouba, I., Adonakis, G., & Pagoulatos, G. N. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990528)84:3 · Cited by 33 · see citing works
Opponent strain effect on eliciting attacks in NZB mice: Physiological correlates
Francois, M.-H., Nosten‐Bertrand, M., Roubertoux, P. L., Kottler, M., & Degrelle, H. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90370-j · Cited by 20 · see citing works
Long‐term potentiation in the hippocampus of fragile X knockout mice
Godfraind, J., Reyniers, E., Boulle, K. D., D’Hooge, R., Deyn, P. P. D., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Willems, P. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960809)64:2 · Cited by 16 · see citing works
A proposed primate animal model of autism
Teitelbaum, P. (2003) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-003-0306-6 · Cited by 11 · see citing works
Behavior Problems in Adults With Mental Retardation and Maternal Well-Being: Examination of the Direction of Effects
Orsmond, G. I., Seltzer, M. M., Krauss, M. W., & Hong, J. (2003) · American Journal on Mental Retardation · doi:10.1352/0895-8017(2003)108

Flagged first, then by citations

Sorted by citations

Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812 · see citing works
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism
Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556 · see citing works
Affiliative Behavior, Ultrasonic Communication and Social Reward Are Influenced by Genetic Variation in Adolescent Mice
Panksepp, J. B., Jochman, K. A., Kim, J. U., Koy, J. J., Wilson, E. D., Chen, Q., Wilson, C. R., & Lahvis, G. P. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000351 · Cited by 295 · see citing works
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism
Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003501 · Cited by 251 · see citing works
Social approach in genetically engineered mouse lines relevant to autism
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., & Lauder, J. M. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00452.x · Cited by 246 · see citing works
Scent marking behavior as an odorant communication in mice
Arakawa, H., Blanchard, D. C., Arakawa, K., Dunlap, C., & Blanchard, R. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.012 · Cited by 229 · see citing works
Translational animal models of autism and neurodevelopmental disorders
Crawley, J. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/jcrawley · Cited by 227 · see citing works
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning
Guo, W., Allan, A. M., Zong, R.-T., Zhang, L., Johnson, E. B., Schaller, E., Murthy, A. C., Goggin, S. L., Eisch, A. J., Oostra, B. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2336 · Cited by 221 · see citing works
BALB/c mice: Low sociability and other phenotypes that may be relevant to autism
Brodkin, E. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.025 · Cited by 223 · see citing works
Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
Sato, A., Kasai, S., Kobayashi, T., Takamatsu, Y., Hino, O., Ikeda, K., & Mizuguchi, M. (2012) · Nature Communications · doi:10.1038/ncomms2295 · Cited by 219 · see citing works
Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic‐like responses
Spencer, C. M., Alekseyenko, O. V., Hamilton, S. M., Thomas, A. M., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. E. (2011) · Autism Research · doi:10.1002/aur.168 · Cited by 215 · see citing works
Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome
Pan, F., Aldridge, G. M., Greenough, W. T., & Gan, W.-B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012496107 · Cited by 208 · see citing works
GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism
Mines, M. A., Yuskaitis, C. J., King, M. K., Beurel, E., & Jope, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009706 · Cited by 208 · see citing works
Advances in behavioral genetics: mouse models of autism
Moy, S. S., & Nadler, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002082 · Cited by 197 · see citing works
Circuit and Plasticity Defects in the Developing Somatosensory Cortex ofFmr1Knock-Out Mice
Bureau, I., Shepherd, G. M. G., & Svoboda, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1076-08.2008 · Cited by 201 · see citing works
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome
Yuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., & Jope, R. S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.023 · Cited by 187 · see citing works
Behavioral phenotypes of genetic mouse models of autism
Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 179 · see citing works
Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice
Pietropaolo, S., Guilleminot, A., Martin, B., D'Amato, F. R., & Crusio, W. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017073 · Cited by 178 · see citing works
Self-citation
What Can We Learn about Autism from Studying Fragile X Syndrome?
Budimirovic, D. B., & Kaufmann, W. E. (2011) · Developmental Neuroscience · doi:10.1159/000330213 · Cited by 176 · see citing works
Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.
McNaughton, C. H., Moon, J., Strawderman, M. S., Maclean, K. N., Evans, J., & Strupp, B. J. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.293 · Cited by 174 · see citing works
Fmr1 KO Mice as a Possible Model of Autistic Features
Bernardet, M., & Crusio, W. E. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.220 · Cited by 170 · see citing works
Self-citation
Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome
Liu, Z., Chuang, D., & Smith, C. B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000520 · Cited by 159 · see citing works
Inhibition of GSK3 improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome
Guo, W., Murthy, A. C., Zhang, L., Johnson, E. B., Schaller, E., Allan, A. M., & Zhao, X. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr501 · Cited by 159 · see citing works
Enhanced synapse remodelling as a common phenotype in mouse models of autism
Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T., & Okabe, S. (2014) · Nature Communications · doi:10.1038/ncomms5742 · Cited by 152 · see citing works
Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome
Rotschafer, S. E., Trujillo, M. S., Dansie, L. E., Ethell, I. M., & Razak, K. A. (2012) · Brain Research · doi:10.1016/j.brainres.2011.12.041 · Cited by 130 · see citing works
Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism
Ellegood, J., & Crawley, J. N. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0360-z · Cited by 132 · see citing works
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 121 · see citing works
Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment
Wei, D., Dinh, D., Lee, D., Li, D., Anguren, A., Moreno-Sanz, G., Gall, C. M., & Piomelli, D. (2016) · Cannabis and Cannabinoid Research · doi:10.1089/can.2015.0008 · Cited by 122 · see citing works
Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117 · see citing works
Abnormal social behaviors in mice lacking Fgf17
Scearce-Levie, K. A., Roberson, E. D., Gerstein, H. C., Cholfin, J. A., Mandiyan, V. S., Shah, N. M., Rubenstein, J. L. R., & Mucke, L. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00357.x · Cited by 113 · see citing works
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
Goebel‐Goody, S. M., Wilson‐Wallis, E. D., Royston, S., Tagliatela, S. M., Naegele, J. R., & Lombroso, P. J. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00781.x · Cited by 108 · see citing works
Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome.
Liu, Z.-H., & Smith, C. B. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.066 · Cited by 112 · see citing works
Behavioral phenotyping of mouse models of neurodevelopmental disorders: Relevant social behavior patterns across the life span
Ricceri, L., Moles, A., & Crawley, J. N. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.024 · Cited by 108 · see citing works
Fragile X Syndrome and Targeted Treatment Trials
Hagerman, R. J., Lauterborn, J. C., Au, J., & Berry‐Kravis, E. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-21649-7_17 · Cited by 104 · see citing works
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons
Tabet, R., Moutin, E., Becker, J. A. J., Heintz, D., Fouillen, L., Flatter, E., Krężel, W., Alunni, V., Koebel, P., Dembélé, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522631113 · Cited by 103 · see citing works
Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders
Carlson, G. C. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.003 · Cited by 102 · see citing works
Altered neuroligin expression is involved in social deficits in a mouse model of the fragile X syndrome
Dahlhaus, R., & El-Husseini, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.019 · Cited by 102 · see citing works
Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments
Baker, K. B., Wray, S. P., Ritter, R., Mason, S. M., Lanthorn, T. H., & Savelieva, K. V. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00585.x · Cited by 101 · see citing works
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101 · see citing works
Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
Gantois, I., Pop, A. S., de Esch, C. E. F., Buijsen, R. A. M., Pooters, T., Gomez-Mancilla, B., Gasparini, F., Oostra, B. A., D’Hooge, R., & Willemsen, R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.059 · Cited by 100 · see citing works
Fragile X Syndrome: The FMR1 CGG Repeat Distribution Among World Populations
Peprah, E. K. (2011) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2011.00694.x · Cited by 96 · see citing works
Scopolamine-induced deficits in social memory in mice: Reversal by donepezil
Riedel, G., Kang, S. H., Choi, D.-Y., & Platt, B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.012 · Cited by 97 · see citing works
Therapeutic Potential of Metabotropic Glutamate Receptor Modulators
Hovelsø, N., Sotty, F., Montezinho, L. P., Pinheiro, P. S., Herrik, K. F., & Mørk, A. (2012) · Current Neuropharmacology · doi:10.2174/157015912799362805 · Cited by 93 · see citing works
Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus
Eadie, B. D., Zhang, W. N., Boehme, F., Gil‐Mohapel, J., Kainer, L., Simpson, J. M., & Christie, B. R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.08.001 · Cited by 94 · see citing works
Basal ganglia and autism – a translational perspective
Subramanian, K., Brandenburg, C., Orsati, F. T., Soghomonian, J., Hussman, J. P., & Blatt, G. J. (2017) · Autism Research · doi:10.1002/aur.1837 · Cited by 89 · see citing works
Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior
Poirier, R., Jacquot, S., Vaillend, C., Soutthiphong, A. A., Libbey, M., Davis, S., Laroche, S., Hanauer, A., Welzl, H., Lipp, H., et al. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9116-1 · Cited by 87 · see citing works
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation
Ma, Q., Yang, F., Frautschy, S. A., & Cole, G. M. (2012) · Cellular Logistics · doi:10.4161/cl.21602 · Cited by 85 · see citing works
Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach usPreprint
Santos, A. R., Kanellopoulos, A. K., & Bagni, C. (2014) · Learning & Memory · doi:10.1101/lm.035956.114 · Cited by 86 · see citing works
Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development
Lai, J., Sobala-Drozdowski, M., Zhou, L., Doering, L. C., Faure, P. A., & Foster, J. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.049 · Cited by 84 · see citing works
Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice
Qin, M., Xia, Z., Huang, T., & Smith, C. B. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.047 · Cited by 83 · see citing works
A new test paradigm for social recognition evidenced by urinary scent marking behavior in C57BL/6J mice
Arakawa, H., Arakawa, K., Blanchard, D. C., & Blanchard, R. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.009 · Cited by 80 · see citing works
Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome.
Yuskaitis, C. J., Beurel, E., & Jope, R. S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.015 · Cited by 79 · see citing works
Modeling autism-relevant behavioral phenotypes in rats and mice: Do ‘autistic’ rodents exist?
Servadio, M., Vanderschuren, L. J. M. J., & Trezza, V. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000163 · Cited by 76 · see citing works
Effect of Prenatal Valproic Acid Exposure on Cortical Morphology in Female Mice
Hara, Y., Maeda, Y., Kataoka, S., Ago, Y., Takuma, K., & Matsuda, T. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12025sc · Cited by 72 · see citing works
Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism
Puścian, A., Łęski, S., Kasprowicz, G., Winiarski, M., Borowska, J., Nikolaev, T., Boguszewski, P. M., Lipp, H.-P., & Knapska, E. (2016) · eLife · doi:10.7554/elife.19532 · Cited by 69 · see citing works
Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish
Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 71 · see citing works
Cerebellar and Striatal Implications in Autism Spectrum Disorders: From Clinical Observations to Animal Models
Thabault, M., Turpin, V., Maïsterrena, A., Jaber, M., Egloff, M., & Galvan, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042294 · Cited by 67 · see citing works
Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome
Mines, M. A., & Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00035 · Cited by 68 · see citing works
Impaired Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex ofFmr1Knock-out Mice
Koga, K., Liu, M., Qiu, S., Song, Q., O'Den, G., Chen, T., & Zhuo, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2644-14.2015 · Cited by 63 · see citing works
Mouse Models of Autism: Testing Hypotheses About Molecular Mechanisms
Roullet, F., & Crawley, J. N. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_113 · Cited by 65 · see citing works
Monogenic mouse models of social dysfunction: Implications for autism
Oddi, D., Crusio, W. E., D'Amato, F. R., & Pietropaolo, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.002 · Cited by 62 · see citing works
Self-citation
Anxiety, hyperactivity and stereotypy in a zebrafish model of fragile X syndrome and autism spectrum disorder
Kim, L. J., He, L., Maaswinkel, H., Zhu, L., Sirotkin, H. I., & Weng, W. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.03.007 · Cited by 61 · see citing works
What we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works
Malformation of the superior olivary complex in an animal model of autism
Lukose, R., Schmidt, E., Wolski, T. P., Murawski, N. J., & Kulesza, R. J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.013 · Cited by 59 · see citing works
Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice
Lin, C.-W., & Hsueh, Y. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.002 · Cited by 55 · see citing works
The cyclic AMP phenotype of fragile X and autism
Kelley, D. J., Bhattacharyya, A., Lahvis, G. P., YIN, J., Malter, J. S., & Davidson, R. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.005 · Cited by 56 · see citing works
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
Domanski, A. P. F., Booker, S. A., Wyllie, D. J. A., Isaac, J. T. R., & Kind, P. C. (2019) · Nature Communications · doi:10.1038/s41467-019-12736-y · Cited by 56 · see citing works
Mutant Mouse Models of Autism Spectrum Disorders
Provenzano, G., Zunino, G., Genovesi, S., Sgadó, P., & Bozzi, Y. (2012) · Disease Markers · doi:10.1155/2012/916082 · Cited by 49 · see citing works
Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal
Drew, C. J. G., Kyd, R. J., & Morton, A. J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm181 · Cited by 51 · see citing works
Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis
De Rubeis, S., Fernández, E., Buzzi, A., Di Marino, D., & Bagni, C. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_23 · Cited by 48 · see citing works
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures
Bernard, P. B., Castano, A. M., O’Leary, H., Simpson, K., Browning, M. D., & Benke, T. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.013 · Cited by 48 · see citing works
Visual Sensorial Impairments in Neurodevelopmental Disorders: Evidence for a Retinal Phenotype in Fragile X Syndrome
Rossignol, R., Ranchon‐Cole, I., Pâris, A., Herzine, A., Perche, A., Laurenceau, D., Bertrand, P., Cercy, C., Pichon, J., Mortaud, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105996 · Cited by 46 · see citing works
Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty
Ohashi, R., Takao, K., Miyakawa, T., & Shiina, N. (2016) · Scientific Reports · doi:10.1038/srep20775 · Cited by 43 · see citing works
Age‐specific autistic‐like behaviors in heterozygous Fmr1‐KO female mice
Gauducheau, M., Lemaire, V., D'Amato, F. R., Oddi, D., Crusio, W. E., & Pietropaolo, S. (2017) · Autism Research · doi:10.1002/aur.1743 · Cited by 41 · see citing works
Self-citation
Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome
Uutela, M., Lindholm, J., Rantamäki, T., Umemori, J., Hunter, K., Võikar, V., & Castrén, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00150 · Cited by 45 · see citing works
Functional Magnetic Resonance Imaging in Awake Transgenic Fragile X Rats: Evidence of Dysregulation in Reward Processing in the Mesolimbic/Habenular Neural Circuit
Kenkel, W. M., Yee, J. R., Moore, K., Madularu, D., Kulkarni, P., Gamber, K., Nedelman, M., & Ferris, C. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.15 · Cited by 39 · see citing works
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders
Kim, K. C., Gonzales, E. L., Lázaro, M. T., Choi, C. S., Bahn, G. H., Yoo, H. J., & Shin, C. Y. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.061 · Cited by 40 · see citing works
NS ‐Pten knockout mice show sex‐ and age‐specific differences in ultrasonic vocalizations
Binder, M. S., & Lugo, J. N. (2017) · Brain and Behavior · doi:10.1002/brb3.857 · Cited by 36 · see citing works
Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders
Robertson, H. R., & Feng, G. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02380.x · Cited by 33 · see citing works
Neuroanatomical Phenotypes Are Consistent With Autism‐Like Behavioral Phenotypes in the 15q11‐13 Duplication Mouse Model
Ellegood, J., Nakai, N., Nakatani, J., Henkelman, R. M., Takumi, T., & Lerch, J. P. (2015) · Autism Research · doi:10.1002/aur.1469 · Cited by 30 · see citing works
Decreased home cage movement and oromotor impairments in adult Fmr1‐ KO mice
Bonasera, S. J., Chaudoin, T. R., Goulding, E. H., Mittek, M., & Dunaevsky, A. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12374 · Cited by 30 · see citing works
Changes in Sensitivity of Reward and Motor Behavior to Dopaminergic, Glutamatergic, and Cholinergic Drugs in a Mouse Model of Fragile X Syndrome
Fish, E. W., Krouse, M. C., Stringfield, S. J., DiBerto, J. F., Robinson, J. E., & Malanga, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077896 · Cited by 29 · see citing works
Effects of Voluntary Exercise on Cell Proliferation and Neurogenesis in the Dentate Gyrus of Adult FMR1 Knockout Mice
Pinar, C., Yau, S., Sharp, Z., Shamei, A., Fontaine, C. J., Meconi, A., Lottenberg, C. P., & Christie, B. R. (2018) · Brain Plasticity · doi:10.3233/bpl-170052 · Cited by 29 · see citing works
FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability
Clifton, N. E., Thomas, K. L., Wilkinson, L. S., Hall, J., & Trent, S. (2020) · Complex Psychiatry · doi:10.1159/000506858 · Cited by 28 · see citing works
Stem cells and modeling of autism spectrum disorders
Freitas, B. C. G., Trujillo, C. A., Carromeu, C., Yusupova, M., Herai, R. H., & Muotri, A. R. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.017 · Cited by 27 · see citing works
Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice
Zerbi, V., Markicevic, M., Gasparini, F., Schroeter, A., Rudin, M., & Wenderoth, N. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.02.051 · Cited by 24 · see citing works
(S)-5-(2′-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder
Armstrong, J. L., Casey, A. B., Saraf, T. S., Mukherjee, M., Booth, R. G., & Canal, C. E. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00101 · Cited by 26 · see citing works
Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models
Arakawa, H. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100011 · Cited by 24 · see citing works
Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition
Lax, E., Carmo, S. D., Enuka, Y., Sapozhnikov, D. M., Welikovitch, L. A., Mahmood, N., Rabbani, S. A., Wang, L., Britt, J. P., Hancock, W. W., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02561-9 · Cited by 24 · see citing works
Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders
Hunsaker, M. R. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.12.001 · Cited by 25 · see citing works
Emotion Recognition and Visual-Scan Paths in Fragile X Syndrome
Shaw, T., & Porter, M. A. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1654-1 · Cited by 24 · see citing works
Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008).
Brodkin, E. S. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.483 · Cited by 23 · see citing works
A comparative study of the performance of individuals with fragile X syndrome and Fmr1 knockout mice on Hebb‐Williams mazes
MacLeod, L. S., Kogan, C. S., Collin, C. A., Berry‐Kravis, E., Messier, C., & Gandhi, R. M. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00534.x · Cited by 22 · see citing works
Chronic alcohol consumption from adolescence-to-adulthood in mice—Effect on growth and social behavior
Zou, H., Xie, Q., Zhang, M., Zhang, C., Zhao, G., Jin, M., & Yu, L. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.021 · Cited by 19 · see citing works
Prkn knockout mice show autistic-like behaviors and aberrant synapse formation
Huo, Y., Lü, W., Tian, Y., Hou, Q., & Man, H. (2022) · iScience · doi:10.1016/j.isci.2022.104573 · Cited by 19 · see citing works
Chronic minocycline treatment improves social recognition memory in adult male Fmr1 knockout mice
Yau, S., Chiu, C., Vetrici, M. A., & Christie, B. R. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.015 · Cited by 18 · see citing works
Loss of Sodium-Activated Potassium Channel Slack and FMRP Differentially Affect Social Behavior in Mice
Bausch, A. E., Ehinger, R., Straubinger, J., Zerfass, P., Nann, Y., & Łukowski, R. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.040 · Cited by 18 · see citing works

Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
Age‐specific autistic‐like behaviors in heterozygous Fmr1‐KO female mice
Gauducheau, M., Lemaire, V., D'Amato, F. R., Oddi, D., Crusio, W. E., & Pietropaolo, S. (2017) · Autism Research · doi:10.1002/aur.1743 · Cited by 41 · see citing works
Self-citation
Monogenic mouse models of social dysfunction: Implications for autism
Oddi, D., Crusio, W. E., D'Amato, F. R., & Pietropaolo, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.002 · Cited by 62 · see citing works
Self-citation
Social Behavior in FMR1 KO Mice: a Model of Fragile X Syndrome
McNaughton, C. H. (2006) · eCommons (Cornell University)
Social approach in genetically engineered mouse lines relevant to autism
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., & Lauder, J. M. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00452.x · Cited by 246 · see citing works

Authors: Mineur, Y. S., Huynh, L. X., & Crusio, W. E.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Crusio, Wim E.
ORCID: Mineur, Yann S.
Crusio, Wim E.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2006-03
Volume: 168
Issue: 1
Pages: 172-175
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2005.11.004
OpenAlex: W2032131334
Cited by: 177
References: 22
Citations by year: 2026: 3 · 2025: 12 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 20
FWCI: 4.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: March of Dimes Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: Fmr1 knockout mice, social interaction deficits, autism model, inbred mouse strains, habituation, ovariectomized females, FMR1 gene, social behavior
MeSH terms: Animals, Autistic Disorder, Female, Habituation, Psychophysiologic, Interpersonal Relations, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mutation, Ovariectomy, Pilot Projects, Social Behavior, Social Environment, Species Specificity, Mice, Fragile X Mental Retardation Protein, Fragile X Messenger Ribonucleoprotein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Social behavior deficits in the Fmr1 mutant mouse

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks