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Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) is strongly expressed in the hippocampus, where it has been associated with memory processes. In the central nervous system, some learning processes, as well as brain insults, including stress, induce modifications in BDNF mRNA expression. Because stress and memory appear to share some neuronal pathways, we studied BDNF mRNA and BDNF peptide variations in response to short times of immobilization stress. Using an RNase protection assay, we demonstrated that short-time stress application induced a significant increase (at 60 min) in BDNF mRNA levels in the whole rat hippocampus. Changes in BDNF mRNA content appear to reflect increased expression of BDNF transcripts containing exons I, II, and III, that were also significantly modified at this time. The time course of stress-induced changes in BDNF transcript levels revealed that mRNA containing exon III was the first increased, significantly elevated by 15 min, attaining maximal levels at 60 min, as BDNF transcripts containing exons I and II. However, at longer times of stress (180 min), BDNF mRNA levels were decreased as well as mRNA containing exon IV. In situ hybridization analysis of discrete hippocampal layers demonstrated that BDNF mRNA expression increased as early as 15 min in most hippocampal regions, with no modification in the number of labeled cells. The same signal pattern, although less pronounced, was determined at 60 min, but at this time a significant increase in BDNF-positive cells was visualized in the CA3 layer. The peptide, measured by immunoassay, was significantly augmented after 180 min of stress exposure whereas at 300 min, levels were similar to those measured in control animals. These data suggest that rapid changes in BDNF expression may be part of a compensatory response to preserve hippocampal homeostasis or a form of neuronal plasticity to cope with new stimuli.
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“stress triggers increased BDNF synthesis to replace depletion of BDNF caused by stress (Marmigere et al., 2003)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Marmigere et al., 2003
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“This may reflect the balance of two opposing forces, namely, that stress triggers increased BDNF synthesis to replace depletion of BDNF caused by stress.82”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [82]
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Metadata
- Authors
- Marmigère, F., Givalois, L., Rage, F., Arancibia, S., & Tapia‐Arancibia, L.
- Affiliations
- Université de Montpellier (FR)
- Corresponding author
- Tapia‐Arancibia, Lucia
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2003-01
- Volume
- 13
- Issue
- 5
- Pages
- 646-655
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2060401891
- Cited by
- 253
- References
- 68
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 16 · 2020: 6 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 13 · 2015: 11 · 2014: 12 · 2013: 13 · 2012: 17
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- CNRS
- Jeune Equipe
- NARSAD (YI 2000)
- MENRT
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- brain-derived neurotrophic factor, BDNF mRNA expression, restraint stress, stress-responsive gene expression, BDNF isoforms, CA3, neuroplasticity, memory
- MeSH terms
- Animals, Gene Expression Regulation, Hippocampus, Immunoassay, Male, Neurons, Reaction Time, Restraint, Physical, RNA, Messenger, Stress, Psychological, Up-Regulation, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, Rats
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