Cited by 126Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionPsychological Treatments and Disorders

Stressful Life Events, Chronic Difficulties, and the Symptoms of Clinical Depression

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Muscatell, Keely A., Slavich, George M., Monroe, Scott M., Gotlib, Ian H.·2009·Journal of Nervous & Mental Disease

Abstract

Major life events and chronic difficulties have been found to be associated with the onset of depression. Little is known, however, about how exposure to such stressors is related to the clinical presentation of this disorder. We addressed this issue by administering an interview-based measure of life stress, the Beck Depression Inventory, and the Global Assessment of Functioning scale to 100 adults diagnosed with major depressive disorder. Participants who experienced a preonset severe life event exhibited greater overall levels of depression severity, endorsed more cognitive and somatic symptoms of depression, and functioned at lower levels than did their counterparts without preonset severe life events. In contrast, exposure to a preonset severe difficulty was unrelated to participants' severity of depression, cognitive and somatic symptoms, or level of global functioning. These findings highlight the potentially greater importance of acute stress compared with chronic stress for influencing these key clinical features of depression.

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  • A growing body of research has taken a more refined approach to conceptualizing life stress, yielding evidence that different types of life events may have different effects on depression depending on their core features and social-psychological characteristics.

    “Emerging from this work is evidence that different types of life events may actually have different effects on depression depending on their core features and social-psychological characteristics”

    From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Muscatell, Slavich, Monroe, & Gotlib, 2009

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Research works printed but not linked: 4

  1. Brown GW Harris TO Brown GW Harris TO Depression Life Events and Illness 1989 London (NY) The Guilford Press 49 93
  2. Gotlib IH Hammen CL Psychological aspects of depression: Toward a cognitive-interpersonal integration 1992 Chichester, UK Wiley
  3. Murray C Lopez A The Global Burden of Disease, Summary 1996 Boston (MA) Harvard University Press
  4. Paykel ES Life stress and symptom pattern in outpatient depression Psychol Med 1984 14 559 568 6494364

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Authors
Muscatell, K. A., Slavich, G. M., Monroe, S. M., & Gotlib, I. H.
Affiliations
  • Boston College (US)
  • University of California, San Francisco (US)
  • University of Notre Dame (US)
  • Stanford University (US)
Corresponding author
Muscatell, Keely A.
Venue
Journal of Nervous & Mental Disease
Published
2009-03
Volume
197
Issue
3
Pages
154-160
ISSN
0022-3018 (ISSN-L)
OpenAlex
W2091240107
Cited by
126
References
51
Citations by year
2026: 2 · 2025: 2 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 11 · 2012: 6
FWCI
9.31
Type
journal article
Language
en
Open access
Locations
  • The Journal of Nervous and Mental Disease (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH-60802, MH59259, R01MH060802, R01MH059259)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
life events, major depressive disorder, depression severity, cognitive symptoms of depression, somatic symptoms of depression, global functioning, acute stress, chronic stress, Beck Depression Inventory, Global Assessment of Functioning
MeSH terms
Adaptation, Psychological, Adolescent, Adult, Age Factors, Chronic Disease, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Interview, Psychological, Life Change Events, Male, Middle Aged, Personality Inventory, Risk Factors, Socioeconomic Factors, Somatoform Disorders, Young Adult

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