Hippocampal release of dopamine and norepinephrine encodes novel contextual information
Abstract
The detection and processing of novel information encountered in our environment is crucial for proper adaptive behavior and learning. Hippocampus is a prime structure for novelty detection that receives high-level inputs including context information. It is of our interest to understand the mechanisms by which the hippocampus processes contextual information. For this, we performed in vivo microdyalisis in order to monitor extracellular changes in neurotransmitter levels during Object Location Memory (OLM), a behavioral protocol developed to evaluate contextual information processing in recognition memory. Neurotransmitter release was evaluated in the dorsal hippocampus and insular cortex during OLM in 3-month-old B6129SF2/J mice. We found a simultaneous release of dopamine and norepinephrine in hippocampus during OLM, while neurochemical activity remained unaltered in the cortex. Additionally, we administered 6-hydroxy-dopamine (6-OHDA), a neurotoxic compound selective to dopaminergic and noradrenergic neurons, in the dorsal hippocampus in a different group of mice. Depletion of catecholaminergic terminals in the hippocampus by 6-OHDA impaired OLM but did not affect novel object recognition. Our results support the relevance of hippocampal catecholaminergic neurotransmission in recognition memory. The significance of catecholaminergic function may be extended to the clinical field as it has been reported that innervation of hippocampus by the noradrenergic and dopaminergic system is reduced and atrophied in aging and Alzheimer's disease brain. © 2017 Wiley Periodicals, Inc.
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Simultaneous release of DA and NE was observed in the hippocampus during the OPP test.
“Simultaneous release of DA and NE was observed in the hippocampus during the OPP test”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Moreno-Castilla et al., 2017
Catecholamine depletion in the dorsal hippocampus induced by 6-OHDA disrupted memory for OPP but not NOP.
“catecholamine depletion in the dorsal hippocampus induced by 6-OHDA disrupted memory for OPP, but not NOP”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Moreno-Castilla et al., 2017
Hippocampal catecholaminergic neurotransmission has an active role in coding place of object.
“indicating that hippocampal catecholaminergic neurotransmission has an active role in coding place of object”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Moreno-Castilla et al., 2017
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- Authors
- Moreno‐Castilla, P., Pérez‐Ortega, R., Violante‐Soria, V., Balderas, I., & Bermúdez‐Rattoni, F.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Departamento de Neurociencia Cognitiva, División de Neurociencias Instituto de Fisiología Celular, Universidad Nacional Autónoma de México México D.F. México
- Corresponding author
- Bermúdez‐Rattoni, Federico
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2017-02-20
- Volume
- 27
- Issue
- 5
- Pages
- 547-557
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2587167145
- Cited by
- 67
- References
- 43
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 13 · 2017: 3
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CONACYT (250870)
- UNAM (IN208616)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- dopamine release, noradrenaline release, catecholaminergic neurotransmission, recognition memory, 6-hydroxydopamine, insula, novel object recognition, Alzheimer's disease, aging
- MeSH terms
- Animals, Catheters, Indwelling, Dopamine, Exploratory Behavior, Hippocampus, Immunohistochemistry, Male, Neuropsychological Tests, Norepinephrine, Oxidopamine, Microdialysis, Electrophoresis, Capillary, Recognition, Psychology, Pattern Recognition, Physiological, Mice, 129 Strain, Memory, Long-Term, Spatial Memory
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