Cited by 63Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Off-line concomitant release of dopamine and glutamate involvement in taste memory consolidation

Guzmán‐Ramos, Kioko, Osorio‐Gómez, Daniel, Moreno‐Castilla, Perla, Bermúdez‐Rattoni, Federico·2010·Journal of Neurochemistry

Abstract

It has been postulated that memory consolidation process requires post-learning molecular changes that will support long-term experiences. In the present study, we assessed with in vivo microdialysis and capillary electrophoresis whether such changes involve the release of neurotransmitters at post-acquisition stages. Using conditioned taste aversion paradigm we observed spontaneous off-line (i.e. in absence of stimulation) dopamine and glutamate reactivation within the insular cortex about 45 min after the stimuli association. These increments did not appear in control groups that were unable to acquire the task, and it seems to be dependent on amygdala activity since its reversible inactivation by tetrodotoxin impaired cortical off-line release of both neurotransmitters and memory consolidation. In addition, blockade of dopaminergic D1 and/or NMDA receptors before the off-line activity impaired long- but not short-term memory. These results suggest that off-line extracellular increments of glutamate and dopamine have a significant functional role in consolidation of taste memory.

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Crossref · 10.1111/j.1471-4159.2010.06758.x

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Authors
Guzmán‐Ramos, K., Osorio‐Gómez, D., Moreno‐Castilla, P., & Bermúdez‐Rattoni, F.
Affiliations
Universidad Nacional Autónoma de México (MX)
Corresponding author
Bermúdez‐Rattoni, Federico
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2010-06-08
Volume
114
Issue
1
Pages
226-236
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W1491252268
Cited by
63
References
73
Citations by year
2026: 2 · 2025: 1 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 9 · 2013: 6 · 2012: 7
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
memory consolidation, conditioned taste aversion, dopamine, glutamate, insula, amygdala, tetrodotoxin, dopamine D1 receptor, NMDA receptor, long-term memory, neurotransmitter release
MeSH terms
Amygdala, Animals, Avoidance Learning, Benzazepines, Cerebral Cortex, Dopamine, Male, Memory, Taste, Valine, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Receptors, Dopamine D1, Microdialysis, Cyclic AMP-Dependent Protein Kinases, Neurotransmitter Agents, Glutamic Acid, Electrophoresis, Capillary, Rats

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