Neuronal activity in the hippocampus during delayed non‐match to sample performance in rats: Evidence for hippocampal processing in recognition memory
Abstract
Neuronal activity in the CA1 of rats was explored with regard to functional correlates of performance in an odor‐guided continuous delayed non‐match to sample task. Although different CA1 cells fired in association with each identifiable trial event, these analyses focused on cells that fired selectively during the period of odor cue sampling and response generation. The firing patterns of many of these cells reflected the match or non‐match comparison between current and previous odor cues independent of the particular stimuli that composed those comparisons. Such cells were more prevalent in sessions when performance was highly accurate. Hippocampal cells did not demonstrate stimulus‐evoked firing that persisted through the memory delay, nor did they fire differentially to session‐novel vs. repeated odor presentations. These results suggest that the hippocampus contributes to recognition memory by processing comparisons between current information and representations of previous stimuli stored in parahippocampal and neocortical structures.
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Place cell activity in rats can encode information about the 'what' and 'when' of events.
“evidence suggests that place cell activity in rats can also encode information about the ‘what’ (e.g. odours and their status, i.e. match/non-match [124–126]) and ‘when’ (i.e. elapsed time [127,128]) of events.”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [124]
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- Authors
- Otto, T., & Eichenbaum, H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Otto, Tim
- ORCID
- Eichenbaum, Howard
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 1992-07
- Volume
- 2
- Issue
- 3
- Pages
- 323-334
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2117977220
- Cited by
- 232
- References
- 58
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 5
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (7r01ns026402-04)
- National Institute on Aging (NIA AG09973)
- National Institute of Neurological Disorders and Stroke (NS26402)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal CA1, neuronal firing patterns, recognition memory, odor-guided behavior, memory comparison
- MeSH terms
- Animals, Evoked Potentials, Hippocampus, Male, Memory, Neurons, Odorants, Psychomotor Performance, Pyramidal Tracts, Reward, Time Factors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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