The rodent hippocampus is essential for nonspatial object memory
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Elucidating the role of the rodent hippocampus in object recognition memory is critical for establishing the appropriateness of rodents as models of human memory and for their use in the development of memory disorder treatments. In mammals, spatial memory and nonspatial memory depend upon the hippocampus and associated medial temporal lobe (MTL) structures. Although well established in humans, the role of the rodent hippocampus in object memory remains highly debated due to conflicting findings across temporary and permanent hippocampal lesion studies and evidence that the perirhinal cortex may support object memory. In the current studies, we used intrahippocampal muscimol microinfusions to transiently inactivate the male C57BL/6J mouse hippocampus at distinct stages during the novel object recognition (NOR) task: during object memory encoding and consolidation, just consolidation, and/or retrieval. We also assessed the effect of temporary hippocampal inactivation when objects were presented in different contexts, thus eliminating the spatial or contextual components of the task. Lastly, we assessed extracellular dorsal hippocampal glutamate efflux and firing properties of hippocampal neurons while mice performed the NOR task. Our results reveal a clear and compelling role of the rodent hippocampus in nonspatial object memory.
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Pre-sample intra-hippocampus infusions of lidocaine or muscimol disrupted NOP memory tested 24 hours later in mice.
“Alternatively, pre-sample intra-hippocampus infusions of lidocaine (Hammond et al., 2004) or muscimol (Cohen et al., 2013) was reported to disrupt NOP memory tested 24 hours later in mice.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cohen et al., 2013
Post-sample intra-hippocampus infusion of muscimol impaired long-term NOP (24 hours) memory.
“Post-sample intra-hippocampus infusion of muscimol impaired long-term NOP (24 hours) memory (Cohen et al., 2013; Haettig et al., 2011), but see (Oliveira et al., 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cohen et al., 2013
Pre-test muscimol microinjections into the dorsal hippocampus impaired or did not affect NOP memory in mice.
“Pre-test muscimol microinjections into the dorsal hippocampus was reported to impair (Cohen et al., 2013; Stackman et al., 2016) or not affect (Haettig et al., 2011) NOP memory in mice.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cohen et al., 2013
Hippocampal CA1 firing rates were enhanced during NOP testing and NOP consolidation is related to an increase of hippocampal CA3-CA1 synaptic efficacy.
“Hippocampal CA1 firing rates were enhanced during NOP testing (Cohen et al., 2013) and NOP consolidation is related to an increase of the hippocampal CA3-CA1 synaptic efficacy (Clarke et al., 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cohen et al., 2013
Pre-test microinjection of muscimol into the dorsal hippocampus impaired NOP memory when encoded and recalled in different environments.
“This is consistent with a later study in which pre-test microinjection of muscimol into the dorsal hippocampus impaired NOP memory when encoded and recalled in different environments (Cohen et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cohen et al., 2013
Extracellular glutamate content in the hippocampus was increased in the NOP test.
“the extracellular glutamate content in the hippocampus was increased in the NOP test”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Cohen et al., 2013
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- Authors
- Cohen, S. J., Munchow, A. H., Rios, L. M., Zhang, G., Ásgeirsdóttir, H. N., & Stackman, R. W.
- Affiliations
- Florida Atlantic University (US)
- Max Planck Florida Institute for Neuroscience (US)
- Anhui Medical University (CN)
- Corresponding author
- Stackman, Robert W.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 23
- Issue
- 17
- Pages
- 1685-1690
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC3775586
- OpenAlex
- W2087321410
- Cited by
- 325
- References
- 54
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 15 · 2023: 21 · 2022: 29 · 2021: 33 · 2020: 33 · 2019: 26 · 2018: 37 · 2017: 23 · 2016: 26 · 2015: 19 · 2014: 22 · 2013: 3
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH086591, R01MH086591)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, object recognition memory, non-spatial memory, novel object recognition, muscimol inactivation, memory consolidation, memory encoding, memory retrieval, contextual memory, dorsal hippocampus, glutamate efflux, perirhinal cortex
- MeSH terms
- Animals, Hippocampus, Male, Memory, Mice, Inbred C57BL, Glutamic Acid, Mice
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