Cited by 354Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Towards a functional organization of episodic memory in the medial temporal lobe

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Eichenbaum, Howard, Sauvage, Magdalena, Fortin, Norbert, Komorowski, Robert, Lipton, Paul·2012·Neuroscience & Biobehavioral Reviews

Abstract

Here we describe a model of medial temporal lobe organization in which parallel "what" and "where" processing streams converge within the hippocampus to represent events in the spatio-temporal context in which they occurred; this circuitry also mediates the retrieval of context from event cues and vice versa, which are prototypes of episodic recall. Evidence from studies in animals are reviewed in support of this model, including experiments that distinguish characteristics of episodic recollection from familiarity, neuropsychological and recording studies that have identified a key role for the hippocampus in recollection and in associating events with the context in which they occurred, and distinct roles for parahippocampal region areas in separate "what" and "where" information processing that contributes to recollective and episodic memory.

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Crossref · 10.1016/j.neubiorev.2011.07.006

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  • In mammals, allocentric navigation involves an extended cortico-hippocampal network that conveys highly processed visual and multisensory information to hippocampal circuits for transformation into 'world-centered' relational spatial representations.

    “In mammals, allocentric navigation is thought to involve the operation of an extended cortico-hippocampal network that conveys highly processed visual and multisensory information to the hippocampal circuits for further processing and transformation into “world-centered” relational spatial representations [74,76,79,188,189,190,191,192].”

    From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [189]

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  • The hippocampus contributes greatly to memory.

    “The hippocampus contributes greatly to memory,7,8”

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Research works printed but not linked: 2

  1. Fyhn M Molden S Witter MP Moser EI Moser M Spatial representation in the entorhinal cortex Science 2004 305 1258 1264 15333832
  2. Wood ER Dudchenko PA Robitsek RJ Eichenbaum H Hippocampal neurons encode information about different types of memory episodes occurring in the same location Neuron 2000 27 623 633 11055443

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Authors
Eichenbaum, H., Sauvage, M., Fortin, N., Komorowski, R., & Lipton, P.
Affiliations
  • Boston University (US)
  • Ruhr University Bochum (DE)
  • University of California, Irvine (US)
Corresponding author
Eichenbaum, Howard
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2012-08
Volume
36
Issue
7
Pages
1597-1608
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2118443528
Cited by
354
References
130
Citations by year
2026: 14 · 2025: 18 · 2024: 23 · 2023: 13 · 2022: 27 · 2021: 31 · 2020: 17 · 2019: 18 · 2018: 21 · 2017: 49 · 2016: 25 · 2015: 31 · 2014: 33 · 2013: 24 · 2012: 9
FWCI
1.83
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH051570, P50MH071702, R01MH052090)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
episodic memory, medial temporal lobe, hippocampus, recollection, familiarity, parahippocampal cortex, contextual memory, event memory, memory retrieval, functional organization
MeSH terms
Animals, Hippocampus, Humans, Neurons, Mental Recall, Temporal Lobe, Recognition, Psychology, Memory, Episodic

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