Towards a functional organization of episodic memory in the medial temporal lobe
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Here we describe a model of medial temporal lobe organization in which parallel "what" and "where" processing streams converge within the hippocampus to represent events in the spatio-temporal context in which they occurred; this circuitry also mediates the retrieval of context from event cues and vice versa, which are prototypes of episodic recall. Evidence from studies in animals are reviewed in support of this model, including experiments that distinguish characteristics of episodic recollection from familiarity, neuropsychological and recording studies that have identified a key role for the hippocampus in recollection and in associating events with the context in which they occurred, and distinct roles for parahippocampal region areas in separate "what" and "where" information processing that contributes to recollective and episodic memory.
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In mammals, allocentric navigation involves an extended cortico-hippocampal network that conveys highly processed visual and multisensory information to hippocampal circuits for transformation into 'world-centered' relational spatial representations.
“In mammals, allocentric navigation is thought to involve the operation of an extended cortico-hippocampal network that conveys highly processed visual and multisensory information to the hippocampal circuits for further processing and transformation into “world-centered” relational spatial representations [74,76,79,188,189,190,191,192].”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [189]
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Experimental — accuracy not yet measuredThe hippocampus contributes greatly to memory.
“The hippocampus contributes greatly to memory,7,8”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [7]
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Morrissey, M. D., & Takehara‐Nishiuchi, K. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.006 · Cited by 39 · see citing works
Wendelken, C., Lee, J. K., Pospisil, J., Sastre, M., Ross, J. M., Bunge, S. A., & Ghetti, S. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu059 · Cited by 41 · see citing works
Carruthers, P. (2017) · Review of Philosophy and Psychology · doi:10.1007/s13164-017-0354-3 · Cited by 40 · see citing works
The Entorhinal Cortex and Adult Neurogenesis in Major Depression
Kim, I. B., & Park, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111725 · Cited by 43 · see citing works
Brain mechanisms underlying the inhibitory control of thought
Anderson, M. C., Crespo‐García, M., & Subbulakshmi, S. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00929-y · Cited by 44 · see citing works
Prefrontal Cortex Networks Shift from External to Internal Modes during Learning
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Neural Activity Patterns Underlying Spatial Coding in the Hippocampus
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Fiebig, F., & Lansner, A. (2014) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2014.00064 · Cited by 39 · see citing works
Lateral Entorhinal Cortex Lesions Impair Local Spatial Frameworks
Kuruvilla, M. V., & Ainge, J. A. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00030 · Cited by 39 · see citing works
Comparative Contemplations on the Hippocampus
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Neural Representation. A Survey-Based Analysis of the Notion
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Robust hippocampal responsivity during retrieval of consolidated associative memory
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Understanding, Explanation, and Active Inference
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Assessing mild cognitive impairment using object‐location memory in immersive virtual environments
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A pavlovian model of the amygdala and its influence within the medial temporal lobe
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- Authors
- Eichenbaum, H., Sauvage, M., Fortin, N., Komorowski, R., & Lipton, P.
- Affiliations
- Boston University (US)
- Ruhr University Bochum (DE)
- University of California, Irvine (US)
- Corresponding author
- Eichenbaum, Howard
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 36
- Issue
- 7
- Pages
- 1597-1608
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC3227798
- OpenAlex
- W2118443528
- Cited by
- 354
- References
- 130
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 23 · 2023: 13 · 2022: 27 · 2021: 31 · 2020: 17 · 2019: 18 · 2018: 21 · 2017: 49 · 2016: 25 · 2015: 31 · 2014: 33 · 2013: 24 · 2012: 9
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH051570, P50MH071702, R01MH052090)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- episodic memory, medial temporal lobe, hippocampus, recollection, familiarity, parahippocampal cortex, contextual memory, event memory, memory retrieval, functional organization
- MeSH terms
- Animals, Hippocampus, Humans, Neurons, Mental Recall, Temporal Lobe, Recognition, Psychology, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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