Recent advances in arginine metabolism: roles and regulation of the arginases

Vascular endothelial cells synthesize nitric oxide from L-arginine

Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,745 · see citing works

Arginine metabolism: nitric oxide and beyond

WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811 · see citing works

Nitric oxide: A cytotoxic activated macrophage effector molecule

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Regulation of immune responses by L-arginine metabolism

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Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

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Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

Rodrı́guez, P. C., & Ochoa, A. C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00608.x · Cited by 722 · see citing works

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 718 · see citing works

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

El Kasmi, K. C., Qualls, J. E., Pesce, J. T., Smith, A. M., Thompson, R. W., Henao-Tamayo, M., Basaraba, R. J., König, T., Schleicher, U., Koo, M.-S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1671 · Cited by 646 · see citing works

Arginine Metabolism: Boundaries of Our Knowledge

Morris, S. M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1602s · Cited by 640 · see citing works

Comparative properties of arginases

Jenkinson, C. P., Grody, W. W., & Cederbaum, S. D. (1996) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)02138-8 · Cited by 610 · see citing works

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION

Durante, W., Johnson, F. K., & Johnson, R. A. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04638.x · Cited by 577 · cited 2× · see citing works

Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

Berkowitz, D. E., White, R., Li, D., Minhas, K. M., Cernetich, A., Kim, S., Burke, S., Shoukas, A. A., Nyhan, D., Champion, H. C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000092948.04444.c7 · Cited by 486 · see citing works

Arginine: beyond protein

Morris, S. M. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.508s · Cited by 424 · see citing works

Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells

Li, H. Z., Meininger, C. J., Hawker, J. R., Haynes, T. E., Kepka‐Lenhart, D., Mistry, S. K., Morris, S. M., & Wu, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e75 · Cited by 389 · see citing works

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

Romero, M. J., Platt, D. H., Tawfik, H. E., Labazi, M., El‐Remessy, A. B., Bartoli, M., Caldwell, R. B., & Caldwell, R. W. (2007) · Circulation Research · doi:10.1161/circresaha.107.155028 · Cited by 386 · see citing works

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

Xu, W., Kaneko, F. T., Zheng, S., Comhair, S. A. A., Janocha, A. J., Goggans, T., Thunnissen, F. B. J. M., Farver, C., Hazen, S. L., Jennings, C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2317fje · Cited by 369 · see citing works

Enzymes of Arginine Metabolism

Morris, S. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2743s · Cited by 357 · see citing works

The metabolic basis of arginine nutrition and pharmacotherapy

Flynn, N. E., Meininger, C. J., Haynes, T. E., & Wu, G. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00273-1 · Cited by 337 · see citing works

THE INHIBITION OF ARGINASE BY AMINO ACIDS

Hunter, A., & Downs, C. E. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51079-6 · Cited by 324 · see citing works

Uric Acid as a Pathogenic Factor in Preeclampsia

Bainbridge, S. A., & Roberts, J. (2008) · Placenta · doi:10.1016/j.placenta.2007.11.001 · Cited by 298 · see citing works

Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production

Buga, G. M., Singh, R., Pervin, S., Rogers, N. E., Schmitz, D. A., Jenkinson, C. P., Cederbaum, S. D., & Ignarro, L. J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.5.h1988 · Cited by 257 · see citing works

Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells

Zharikov, S. I., Krotova, K. Y., Hu, H., Baylis, C., Johnson, R. J., Block, E. R., & Patel, J. M. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00075.2008 · Cited by 238 · see citing works

Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway

Ming, X., Barandiér, C., Viswambharan, H., Kwak, B. R., Mach, F., Mazzolai, L., Hayoz, D., Ruffieux, J., Rusconi, S., Montani, J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000142867.26182.32 · Cited by 237 · see citing works

Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis

Ryoo, S., Gupta, G., Benjo, A., Lim, H. K., Camara, A., Sikka, G., Lim, H. K., Sohi, J., Santhanam, L., Soucy, K., et al. (2008) · Circulation Research · doi:10.1161/circresaha.107.169573 · Cited by 236 · see citing works

Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide‐mediated vasodilatory function

Zhang, C., Hein, T. W., Wang, W., Chang, C., & Kuo, L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0681fje · Cited by 230 · see citing works

Regulation of Nitric Oxide Synthesis and Apoptosis by Arginase and Arginine Recycling

Mori, M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1616s · Cited by 221 · see citing works

Arginine availability, arginase, and the immune response

Bansal, V., & Ochoa, J. B. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200303000-00012 · Cited by 213 · see citing works

Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets.

Castillo, L., Chapman, T. E., Mendiola, M. S., Yu, Y., Burke, J. F., Ajami, A. M., Vogt, J., & Young, V. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7749 · Cited by 204 · see citing works

Upregulation of Vascular Arginase in Hypertension Decreases Nitric Oxide–Mediated Dilation of Coronary Arterioles

Zhang, C., Hein, T. W., Wang, W., Miller, M. W., Fossum, T. W., McDonald, M. M., Humphrey, J. D., & Kuo, L. (2004) · Hypertension · doi:10.1161/01.hyp.0000146907.82869.f2 · Cited by 194 · see citing works

Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells.

Singh, R., Pervin, S., Karimi, A., Cederbaum, S. D., & Chaudhuri, G. (2000) · PubMed · Cited by 185 · see citing works

Inducible NO Synthase–DependentS-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction

Santhanam, L., Lim, H. K., Lim, H. K., Miriel, V. A., Brown, T. R., Patel, M. D., Balanson, S., Ryoo, S., Anderson, M., Irani, K., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.157727 · Cited by 184 · see citing works

Arginine metabolism in mammals

Cynober, L., Boucher, J. L., & Vasson, M. (1995) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(95)00066-9 · Cited by 182 · see citing works

Ischemia‐reperfusion selectively impairs nitric oxide‐ mediated dilation in coronary arterioles: counteracting role of arginase

Hein, T. W., Zhang, C., Wang, W., Chang, C., Thengchaisri, N., & Kuo, L. (2003) · The FASEB Journal · doi:10.1096/fj.03-0115fje · Cited by 182 · see citing works

Oxidized Low-Density Lipoprotein–Dependent Endothelial Arginase II Activation Contributes to Impaired Nitric Oxide Signaling

Ryoo, S., Lemmon, C. A., Soucy, K. G., Gupta, G., White, A. R., Nyhan, D. P., Shoukas, A. A., Romer, L. H., & Berkowitz, D. E. (2006) · Circulation Research · doi:10.1161/01.res.0000247034.24662.b4 · Cited by 174 · see citing works

Nω-Hydroxy-L-Arginine, an Intermediate in the L-Arginine to Nitric Oxide Pathway, Is a Strong Inhibitor of Liver and Macrophage Arginase

Boucher, J., Custot, J., Goff, S. V., Delaforge, M., Lepoivre, M., Tenu, J., Yapo, A., & Mansuy, D. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2371 · Cited by 172 · see citing works

Mouse Model for Human Arginase Deficiency

Iyer, R. K., Yoo, P. K., Kern, R. M., Rozengurt, N., Tsoa, R. W., O’Brien, W. E., Yu, H., Grody, W. W., & Cederbaum, S. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4491-4498.2002 · Cited by 171 · see citing works

Inhibition of Rat Liver Arginase by an Intermediate in NO Biosynthesis, NG-Hydroxy-L-arginine: Implications for the Regulation of Nitric Oxide Biosynthesis by Arginase

Daghigh, F., Fukuto, J. M., & Ash, D. E. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1909 · Cited by 170 · see citing works

Arginase: Structure, Mechanism, and Physiological Role in Male and Female Sexual Arousal

Christianson, D. W. (2005) · Accounts of Chemical Research · doi:10.1021/ar040183k · Cited by 168 · see citing works

The mammalian N-end rule pathway: new insights into its components and physiological roles

Tasaki, T., & Kwon, Y. T. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.08.010 · Cited by 167 · see citing works

Arginase and vascular aging

Santhanam, L., Christianson, D. W., Nyhan, D. P., & Berkowitz, D. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90627.2008 · Cited by 166 · see citing works

IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells

Liu, W., Jacobs, A. T., Morris, S. M., & Ignarro, L. J. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.1.c248 · Cited by 157 · see citing works

Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells

Chicoine, L. G., Paffett, M. L., Young, T. L., & Nelin, L. D. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00194.2003 · Cited by 152 · see citing works

TNF-α Contributes to Endothelial Dysfunction by Upregulating Arginase in Ischemia/Reperfusion Injury

Gao, X. J., Xu, X., Belmadani, S., Park, Y., Tang, Z., Feldman, A. M., Chilian, W. M., & Zhang, C. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142521 · Cited by 151 · see citing works

Arginine Metabolic Enzymes, Nitric Oxide and Infection

Mori, M., & Gotoh, T. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2820s · Cited by 151 · see citing works

Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats

Demougeot, C., Prigent‐Tessier, A., Marie, C., & Berthelot, A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000166837.78559.93 · Cited by 149 · see citing works

Transforming Growth Factor-β 1 Stimulates l -Arginine Transport and Metabolism in Vascular Smooth Muscle Cells

Durante, W., Liao, L., Reyna, S. V., Peyton, K. J., & Schafer, A. I. (2001) · Circulation · doi:10.1161/01.cir.103.8.1121 · Cited by 145 · see citing works

Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation

Liu, W., Wu, G., Morris, S. M., & Ignarro, L. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161294898 · Cited by 144 · see citing works

Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension

Johnson, F. K., Johnson, R. A., Peyton, K. J., & Durante, W. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2004 · Cited by 143 · see citing works

Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene

Shi, O., Morris, S. M., Zoghbi, H. Y., Porter, C. W., & O’Brien, W. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.811-813.2001 · Cited by 142 · see citing works

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo

Schnorr, O., Brossette, T., Momma, T. Y., Kleinbongard, P., Keen, C. L., Schroeter, H., & Sies, H. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.040 · Cited by 127 · see citing works

Cytochrome P450 catalyzes the oxidation of Nω-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline

Boucher, J., Genet, A., Goff, S. V., Delaforge, M., Henry, Y. A., & Mansuy, D. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91279-y · Cited by 116 · see citing works

Up‐regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans

Holowatz, L. A., & Kenney, W. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.128959 · Cited by 115 · see citing works

Activities of arginase I and II are limiting for endothelial cell proliferation

Li, H. Z., Meininger, C. J., Kelly, K. A., Hawker, J. R., Morris, S. M., & Wu, G. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2002.282.1.r64 · Cited by 111 · see citing works

Overexpression and Characterization of the Human Mitochondrial and Cytosolic Branched-chain Aminotransferases

Davoodi, J., Drown, P. M., Bledsoe, R. K., Wallin, R., Reinhart, G. D., & Hutson, S. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4982 · Cited by 110 · see citing works

AMINO ACIDS, ARGINASE AND NITRIC OXIDE IN VASCULAR HEALTH

Huynh, N., & Chin-Dusting, J. P. F. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04316.x · Cited by 107 · see citing works

Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation

Maarsingh, H., Zuidhof, A. B., Bos, I. S. T., van Duin, M., Boucher, J., Zaagsma, J., & Meurs, H. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200710-1588oc · Cited by 105 · see citing works

Arginase pathway in human endothelial cells in pathophysiological conditions

Bachetti, T. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.05.004 · Cited by 103 · see citing works

Mitochondrial Arginase II Modulates Nitric-Oxide Synthesis through Nonfreely Exchangeable l-Arginine Pools in Human Endothelial Cells

Topal, G., Brunet, A., Walch, L., Boucher, J., & David‐Dufilho, M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103747 · Cited by 100 · see citing works

Detection and Identification of Novel Metabolomic Biomarkers in Preeclampsia

Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C. W. G., Kell, D. B., & Baker, P. N. (2008) · Reproductive Sciences · doi:10.1177/1933719108316908 · Cited by 96 · see citing works

Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase

Bivalacqua, T. J., Burnett, A. L. “., Hellstrom, W. J. G., & Champion, H. C. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00121.2005 · Cited by 96 · see citing works

Upregulation of Arginase by H2O2Impairs Endothelium-Dependent Nitric Oxide-Mediated Dilation of Coronary Arterioles

Thengchaisri, N., Hein, T. W., Wang, W., Xu, X. Y., Li, Z., Fossum, T. W., & Kuo, L. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000233334.24805.62 · Cited by 94 · see citing works

Physiological cyclic stretch directs L‐arginine transport and metabolism to collagen synthesis in vascular smooth muscle

Durante, W., Liao, L., Reyna, S. V., Peyton, K. J., & Schafer, A. I. (2000) · The FASEB Journal · doi:10.1096/fj.99-0960com · Cited by 93 · see citing works

Treatment with the arginase inhibitor N ω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

Bagnost, T., Berthelot, A., Bouhaddi, M., Laurant, P., André, C., Guillaume, Y. C., & Demougeot, C. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282fcc357 · Cited by 92 · see citing works

Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness

Yang, M., Rangasamy, D., MATTHAEI, K. I., Frew, A. J., Zimmmermann, N., Mahalingam, S., Webb, D. C., Tremethick, D. J., Thompson, P. J., Hogan, S. P., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5595 · Cited by 91 · see citing works

Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat

Wu, G., & Meininger, C. J. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.4.h1312 · Cited by 87 · see citing works

Arginase and autoimmune inflammation in the central nervous system

Xu, L., Hilliard, B. A., Carmody, R. J., Tsabary, G., Shin, H., Christianson, D. W., & Chen, Y. H. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01713.x · Cited by 85 · see citing works

Endothelial arginase: A new target in atherosclerosis

Yang, Z., & Ming, X. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0041-8 · Cited by 84 · see citing works

Arginine metabolism in vascular biology and disease

Morris, S. M. (2005) · Vascular Medicine · doi:10.1177/1358836x0501000112 · Cited by 83 · see citing works

Critical Role of l -Arginine in Endothelial Cell Survival During Oxidative Stress

Suschek, C. V., Schnorr, O., Hemmrich, K., Aust, O., Klotz, L., Sies, H., & Kolb-Bachofen, V. (2003) · Circulation · doi:10.1161/01.cir.0000066909.13953.f1 · Cited by 78 · see citing works

Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S -Nitrosylation and Tyrosine Nitration

Ckless, K., Lampert, A., Reiss, J. N., Kasahara, D. I., Poynter, M. E., Irvin, C. G., Lundblad, L. K. A., Norton, R. J., van der Vliet, A., & Janssen-Heininger, Y. M. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4255 · Cited by 76 · see citing works

Regulation of Arginine Availability and Its Impact on NO Synthesis

Morris, S. M. (2000) · Nitric Oxide · doi:10.1016/b978-012370420-7/50012-5 · Cited by 74 · see citing works

Ornithine deficiency in the arginase double knockout mouse

Deignan, J. L., Livesay, J. C., Yoo, P. K., GOODMAN, S., O’Brien, W. E., IYER, R., Cederbaum, S. D., & Grody, W. W. (2006) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2006.04.007 · Cited by 66 · see citing works

Mitochondrial arginase II constrains endothelial NOS-3 activity

Lim, H. K., Lim, H. K., Ryoo, S., Benjo, A., Shuleri, K., Miriel, V. A., Baraban, E. G., Camara, A., Soucy, K. G., Nyhan, D. P., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00700.2007 · Cited by 62 · see citing works

Genomic Changes in Regenerated Porcine Coronary Arterial Endothelial Cells

Lee, M. Y. K., Tse, H., Siu, C., Zhu, S., Man, R. Y. K., & Vanhoutte, P. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.141705 · Cited by 61 · see citing works

Novel Roles for Arginase in Cell Survival, Regeneration, and Translation in the Central Nervous System

Lange, P. S., Langley, B. C., Lu, P., & Ratan, R. R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2812s · Cited by 60 · see citing works

Liver I/R injury is improved by the arginase inhibitor, Nω-hydroxy-nor- l -arginine (nor-NOHA)

Reid, K. M., Tsung, A., Kaizu, T., Jeyabalan, G., Ikeda, A., Shao, L., Wu, G., Murase, N., & Geller, D. A. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00227.2006 · Cited by 57 · see citing works

α-Difluoromethylornithine (DFMO) as a Potent Arginase Activity Inhibitor in Human Colon Carcinoma Cells

Selamnia, M., Mayeur, C., Robert, V., & Blachier, F. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00572-8 · Cited by 56 · see citing works

Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity

Hölttä, E., & Pohjanpelto, P. (1982) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(82)90085-4 · Cited by 56 · see citing works

Cytokine-Induced Endothelial Arginase Expression Is Dependent on Epidermal Growth Factor Receptor

Nelin, L. D., Chicoine, L. G., Reber, K. M., English, B. K., Young, T. L., & Liu, Y. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0039oc · Cited by 53 · see citing works

Arginase blockade protects against hepatic damage in warm ischemia-reperfusion

Jeyabalan, G., Klune, J. R., Nakao, A., Martik, N., Wu, G., Tsung, A., & Geller, D. A. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.04.002 · Cited by 52 · see citing works

Lysophosphatidylcholine Regulates Cationic Amino Acid Transport and Metabolism in Vascular Smooth Muscle Cells

Durante, W., Liao, L., Peyton, K. J., & Schafer, A. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30154 · Cited by 47 · see citing works

Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin

Bratt, J. M., Franzi, L. M., Linderholm, A., Last, M. S., Kenyon, N. J., & Last, J. A. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.10.007 · Cited by 47 · see citing works

The use of arginine in clinical practice

Cynober, L. (2003) · CRC Press eBooks · doi:10.1201/9780203010266-51 · Cited by 45 · see citing works

Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia

Deignan, J. L., Marescau, B., Livesay, J. C., Iyer, R. K., Deyn, P. P. D., Cederbaum, S. D., & Grody, W. W. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.09.016 · Cited by 44 · see citing works

The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries

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Role of Arginase in the Male and Female Sexual Arousal Response

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FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1

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Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus

Burrack, K. S., Burrack, A., Oko, L. M., Montgomery, S. A., Borst, L. B., Gill, R. G., & Morrison, T. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201240 · Cited by 79 · see citing works

Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

Totoson, P., Maguin‐Gaté, K., Prati, C., Wendling, D., & Demougeot, C. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4450 · Cited by 75 · see citing works

Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

Ilies, M., Costanzo, L. D., Dowling, D., Thorn, K. J., & Christianson, D. W. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200443b · Cited by 75 · see citing works

Parenteral or Enteral Arginine Supplementation Safety and Efficacy

Rosenthal, M. D., Carrott, P. W., Patel, J. J., Kiraly, L. N., & Martindale, R. G. (2016) · Journal of Nutrition · doi:10.3945/jn.115.228544 · Cited by 73 · see citing works

A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment

Pilanc, P., Wojnicki, K., Roura, A.-J., Cyranowski, S., Ellert‐Miklaszewska, A., Ochocka, N., Gielniewski, B., Grzybowski, M. M., Błaszczyk, R., Stańczak, P. S., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.703465 · Cited by 72 · see citing works

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

Geck, R. C., Foley, J. R., Stewart, T. M., Asara, J. M., Casero, R. A., & Toker, A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012376 · Cited by 70 · see citing works

Immunohistochemical study of arginase 1 and 2 in various tissues of rats

Choi, S., Park, C., Ahn, M., Lee, J. H., & Shin, T. (2011) · Acta Histochemica · doi:10.1016/j.acthis.2011.09.002 · Cited by 70 · see citing works

Evolutionary Aspects of Macrophages Polarization

Edholm, E., Rhoo, K. H., & Robert, J. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_1 · Cited by 70 · see citing works

N -carbamylglutamate and L-arginine improved maternal and placental development in underfed ewes

Zhang, H., Sun, L., Wang, Z., Deng, M., Nie, H., Zhang, G., Ma, T., & Wang, F. (2016) · Reproduction · doi:10.1530/rep-16-0067 · Cited by 69 · see citing works

Pre-storage hot water treatment enhances chilling tolerance of zucchini (Cucurbita pepo L.) squash by regulating arginine metabolism

Bokhary, S. U. F., Wang, L., Zheng, Y., & Jin, P. (2020) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2020.111229 · Cited by 68 · see citing works

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W., & Caldwell, R. B. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.23 · Cited by 68 · see citing works

Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis

Balaña‐Fouce, R., Alvarez, E. C., Álvarez‐Velilla, R., Fernandez‐Prada, C., Pérez‐Pertejo, Y., & Reguera, R. M. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.10.007 · Cited by 67 · see citing works

Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy

Leiva, A., Pardo, F., Ramírez, M. A., Farías, M., Casanello, P. C., & Sobrevía, L. (2011) · Experimental Diabetes Research · doi:10.1155/2011/349286 · Cited by 66 · see citing works

Dietary Probiotic Effect of Lactococcus lactis WFLU12 on Low-Molecular-Weight Metabolites and Growth of Olive Flounder (Paralichythys olivaceus)

Nguyen, T. L., Chun, W., Kim, A., Kim, N., Roh, H., Lee, Y., Yi, M., Kim, S., Park, C., & Kim, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02059 · Cited by 67 · see citing works

Aqueous extract from Ficus capensis leaves inhibits key enzymes linked to erectile dysfunction and prevent oxidative stress in rats' penile tissue

Akomolafe, S. F., Oboh, G., Oyeleye, S. I., & Boligon, A. A. (2016) · NFS Journal · doi:10.1016/j.nfs.2016.06.001 · Cited by 66 · see citing works

The Role of Asymmetric Dimethylarginine and Arginine in the Failing Heart and Its Vasculature

Visser, M., Paulus, W. J., Vermeulen, M. A. R., Richir, M. C., Davids, M., Wisselink, W., de Mol, B. A. J. M., & van Leeuwen, P. A. M. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq158 · Cited by 66 · see citing works

Myeloid-derived Suppressor Cells (MDSCs) in Gliomas and Glioma-Development

Kohanbash, G., & Okada, H. (2012) · Immunological Investigations · doi:10.3109/08820139.2012.689591 · Cited by 65 · see citing works

A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy

Patra, S., Ghosh, A., Roy, S. S., Bera, S., Das, M., Talukdar, D., Ray, S., Wallimann, T., & Ray, M. (2012) · Amino Acids · doi:10.1007/s00726-011-0974-3 · Cited by 64 · see citing works

Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing

Szondi, D., Wong, J., Vardy, L., & Cruickshank, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.773866 · Cited by 54 · see citing works

Ginseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironment

Lv, Y., Li, M., Weng, L., Huang, H., Mao, Y., Yang, D. A., Wei, Q., Zhao, M., Qin, W. D., Rui, K., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02888-7 · Cited by 67 · see citing works

Metabolic reprogramming and interventions in angiogenesis

Liu, Y., Wu, Z., Li, Y., Chen, Y., Zhao, X., Wu, M., & Xia, Y. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.001 · Cited by 68 · see citing works

When Is It Appropriate to Use Arginine in Critical Illness?

Patel, J. J., Miller, K. R., Rosenthal, C. M., & Rosenthal, M. D. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616652576 · Cited by 63 · see citing works

Role of Arginase in Vessel Wall Remodeling

Durante, W. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00111 · Cited by 90 · see citing works

Arginase in vascular disease: Mechanisms, measurement, and medicine

Durante, W. (2026) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2026.09.053

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION

Durante, W., Johnson, F. K., & Johnson, R. A. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04638.x · Cited by 577 · see citing works

doi: 10.3389/fimmu.2013.00111 Role of arginase in vessel wall remodeling

Durante, W., Bendhack, L. M., Paulo, S., Barman, S. A., Health, G., & Durante, W. (2013)

Biochemistry, pharmacology, and in vivo function of arginases

Heuser, S. K., Li, J., Pudewell, S., LoBue, A., Li, Z., & Cortese-Krott, M. M. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001271 · Cited by 43 · see citing works