Tissue response to implanted polymers: The significance of sample shape
Abstract
Studies were designed to demonstrate the need for standardization of shape of samples used as implants to evaluate histotoxicity of polymer materials. Six medical‐grade polymers (polypropylene, polyethylene, polyurethane, silicone rubber, poly(vinyl chloride), and Teflon) were extruded as rods with circular‐, triangular‐, and pentagonal‐shaped crosss ections, and were implanted in rat gluteal muscles for 14 days. Evaluation of the tissue response was assessed by quantitating cellular lysosomal acid phosphatase enzyme activity by using microspectrophotometry. All triangular‐shaped implants showed the highest enzyme activity and cellular response; pentagon shapes showed less, and circular rods showed the lowest activity. The results demonstrate the need for standard sample shape for valid comparative studies of tissue response to implanted polymers.
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The degree of inflammation may influence insulin absorption.
“The degree of inflammation is dependent on catheter material, shape, and wear-time and may influence insulin absorption.”
From Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine (2017) · cites this paper as [17]
The degree of inflammation is dependent on catheter material, shape, and wear-time.
“The degree of inflammation is dependent on catheter material, shape, and wear-time and may influence insulin absorption.”
From Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine (2017) · cites this paper as [17]
Round, soft shapes are known to be better tolerated than sharp edges.
“Round, soft shapes are known to be better tolerated that sharp edges.17,25”
From Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine (2017) · cites this paper as [17]
Malaga et al. reported that in rat gluteal muscle implants, circular rod cross-sections caused the least foreign body response, then pentagonal, and triangular caused the most.
“Among the shapes tested, circular rods produced the least amount of foreign body responses followed by pentagonal, and then triangular.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [19]
Cites
The significance of implant shape in experimental testing of biological materials: Disc vs. Rod
Wood, N. K., Kaminski, E. J., & Oglesby, R. J. (1970) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820040102 · Cited by 89 · see citing works
Subacute toxicity testing of biomaterials using histopathologic evaluation of rabbit muscle tissue
Turner, J. E., Lawrence, W. H., & Autian, J. (1973) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820070104 · Cited by 85 · see citing works
The behavior of biological materials at different sites of implantation
Kaminski, E. J., Oglesby, R. J., Wood, N. K., et al. (1968) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820020106 · Cited by 53 · see citing works
Gas chromatographic determination of residual ethylene oxide by head space analysis
Romano, S. J., Renner, J. A., & Leitner, P. M. (1973) · Analytical Chemistry · doi:10.1021/ac60336a035 · Cited by 39 · see citing works
Toxicologic aspects of implants
Autian, J. (1967) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820010408 · Cited by 30 · see citing works
Salthouse, T. N., Matlaga, B. F., & O'Leary, R. K. (1973) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(73)80006-7 · Cited by 27 · see citing works
Self-citationAn Approach to the Numerical Quantitation of Acute Tissue Response to Biomaterials
Salthouse, T. N., & Matlaga, B. F. (1975) · Biomaterials Medical Devices and Artificial Organs · doi:10.3109/10731197509118613 · Cited by 14 · see citing works
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Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897 · see citing works
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706 · see citing works
Characterization of a bovine collagen–hydroxyapatite composite scaffold for bone tissue engineering
Rodrigues, C. V. M., Serricella, P., Linhares, A. B. R., Guerdes, R. M., Borojevic, R., Rossi, M. A., Duarte, M. E. L., & Farina, M. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00410-1 · Cited by 322 · see citing works
Domesticating the foreign body response: recent advances and applications
Veiseh, O., & Vegas, A. J. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.08.010 · Cited by 245 · see citing works
Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment
Chu, C., Liu, L., Rung, S., Wang, Y., Ma, Y., Hu, C., Zhao, X., Man, Y., & Qu, Y. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36798 · Cited by 131 · see citing works
Helton, K. L., Ratner, B. D., & Wisniewski, N. A. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500317 · Cited by 125 · see citing works
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity
Kyriakides, T. R., Kim, H.-J., Zheng, C., Harkins, L., Tao, W., & Deschenes, E. (2022) · Biomedical Materials · doi:10.1088/1748-605x/ac5574 · Cited by 106 · see citing works
Helton, K. L., Ratner, B. D., & Wisniewski, N. A. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500318 · Cited by 102 · see citing works
Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities
Wang, D., Tan, J., Zhu, H., Mei, Y., & Liu, X. (2021) · Advanced Science · doi:10.1002/advs.202004393 · Cited by 49 · see citing works
Hauzenberger, J. R., Hipszer, B. R., Loeum, C., McCue, P. A., DeStefano, M., Torjman, M. C., Kaner, M. T., Dinesen, A. R., Chervoneva, I., Pieber, T. R., et al. (2017) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2017.0175 · Cited by 39 · see citing works
“Round, soft shapes are known to be better tolerated that sharp edges.(17,25) In general, the ICs produced a similar, yet more pronounced, tissue response characterized by a central core of adipose tissue debris surrounded by a layer of fibrin thrombus infiltrated with inflammatory cells.”
Background
- Authors
- Matlaga, B. F., Yasenchak, L. P., & Salthouse, T. N.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1976-05
- Volume
- 10
- Issue
- 3
- Pages
- 391-397
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1985656444
- Cited by
- 295
- References
- 7
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 9 · 2021: 16 · 2020: 20 · 2019: 18 · 2018: 9 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- sample shape, histotoxicity, lysosomal acid phosphatase, enzyme activity, polypropylene, polyethylene, polyurethane, silicone rubber, polyvinyl chloride, polytetrafluoroethylene
- MeSH terms
- Acid Phosphatase, Animals, Female, Lysosomes, Muscles, Polyethylenes, Polymers, Polypropylenes, Polytetrafluoroethylene, Polyvinyl Chloride, Silicone Elastomers, Rats
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