Cited by 102Diabetes Management and ResearchElectrochemical sensors and biosensorsNeuroscience and Neural Engineering

Biomechanics of the Sensor-Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and Foreign Body Response—Part II: Examples and Application

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Helton, Kristen L., Ratner, Buddy D., Wisniewski, Natalie A.·2011·Journal of Diabetes Science and Technology

Abstract

This article is the second part of a two-part review in which we explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I, featured in this issue of Journal of Diabetes Science and Technology, describes a theoretical framework of how biomechanical factors such as motion and pressure (typically micromotion and micropressure) affect tissue physiology around a sensor and in turn, impact sensor performance. Here in Part II, a literature review is presented that summarizes examples of motion or pressure affecting sensor performance. Data are presented that show how both acute and chronic forces can impact continuous glucose monitor signals. Also presented are potential strategies for countering the ill effects of motion and pressure on glucose sensors. Improved engineering and optimized chemical biocompatibility have advanced sensor design and function, but we believe that mechanical biocompatibility, a rarely considered factor, must also be optimized in order to achieve an accurate, long-term, implantable sensor.

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Crossref · 10.1177/193229681100500318

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58 of 58 references verified0 citation errors · 0 not checkable

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  • The erratic outputs with posture changes were attributed in part to blood occlusion from pressures applied to tissue adjacent to the sensor.

    “Such behavior was attributed in part to blood occlusion due to pressures applied to tissue adjacent to the sensor.86–87”

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Authors
Helton, K. L., Ratner, B. D., & Wisniewski, N. A.
Affiliations
  • University of Washington (US)
  • Profusa (United States) (US)
Corresponding author
Wisniewski, Natalie A.
Venue
Journal of Diabetes Science and Technology
Published
2011-05
Volume
5
Issue
3
Pages
647-656
ISSN
1932-2968 (ISSN-L)
OpenAlex
W2092619316
Cited by
102
References
60
Citations by year
2026: 5 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 4
Type
conference abstract
Language
en
Open access
Locations
  • Journal of Diabetes Science and Technology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords
continuous glucose monitoring, micromotion, foreign body reaction, implantable glucose sensor, sensor design
MeSH terms
Animals, Biocompatible Materials, Biomechanical Phenomena, Blood Glucose, Diabetes Mellitus, Dogs, Equipment Design, Glucose, Humans, Motion, Pressure, Self Care, Swine, Blood Glucose Self-Monitoring, Reproducibility of Results, Porosity, Rats

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