Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries
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Cytokines, chemokines, and growth factors were assayed from the supernatants of monocytes and macrophages cultured on common biomaterials with a range of surface chemistries. TNF‐α, MCP‐1, MIP‐1α, IL‐8, IL‐6, IL‐1β, VEGF, IL‐1ra, and IL‐10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2‐hydroxyethyl methacrylate, 1‐vinyl‐2‐pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates. Empty TCPS wells and organo‐tin polyvinyl chloride served as “blanks” and positive controls, respectively. Results showed an overall increase in cytokine, chemokine, and growth factor production as monocytes are activated or differentiated into macrophages and that proinflammatory and anti‐wound healing cytokines and chemokines dominate this profile. However, cytokine production was only modestly affected by the surface chemistry of these four stable and noncytotoxic biomaterials. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
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The severity of the foreign body reaction depends on numerous factors, including material chemistry and topography.
“its severity depends on numerous factors, such as material chemistry18 and topography.19”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the <i>in vitro</i> activation of macrophages and <i>in vivo</i> host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [18]
There are no differences between inert, nondegradable materials with different surface chemistries one month post-implantation, and any short-term effect observed is inconsequential.
“For example, Schutte et al. and Castner et al. argued that there are no differences between inert, nondegradable materials with different surface chemistries one month post-implantation and hence any short-term effect observed is inconsequential [53,54].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [53]
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- Authors
- Schutte, R. J., Parisi‐Amon, A., & Reichert, W. M.
- Affiliations
- Duke University (US)
- Corresponding author
- Reichert, W. Monty
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2008-02-07
- Volume
- 88A
- Issue
- 1
- Pages
- 128-139
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- PMC
- PMC4070304
- OpenAlex
- W1998418263
- Cited by
- 161
- References
- 32
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 18 · 2016: 9 · 2015: 14 · 2014: 14 · 2013: 3 · 2012: 10
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008555)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK54932, R01DK054932, R56DK054932)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- cytokine profiling, monocytes, macrophages, biomaterials, monocyte activation, macrophage differentiation, inflammatory cytokines, chemokines, growth factors, wound healing, tissue culture polystyrene, polyethylene, polyurethane, expanded polytetrafluoroethylene, poly(methyl methacrylate)
- MeSH terms
- Biocompatible Materials, Cell Differentiation, Humans, Macrophage Activation, Macrophages, Methods, Monocytes, Polymers, Surface Properties, Cytokines, Chemokines, Cell Culture Techniques, Intercellular Signaling Peptides and Proteins
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