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Bone mineral loss and recovery after 17 weeks of bed rest
Abstract
The purpose of this work was to determine the rate and extent of bone loss and recovery from long-term disuse and in particular from disuse after exposure to weightlessness. For this purpose, bed rest is used to simulate the reduced stress and strain on the skeleton. This study reports on the bone loss and recovery after 17 weeks of continuous bed rest and 6 months of reambulation in six normal male volunteers. Bone regions measured were the lumbar spine, hip, tibia, forearm, calcaneus, total body, and segmental regions from the total-body scan. The total body, lumbar spine, femoral neck, trochanter, tibia, and calcaneus demonstrated significant loss, p < 0.05. Expressed as the percentage change from baseline, these were 1.4, 3.9, 3.6, 4.6, 2.2, and 10.4, respectively. Although several areas showed positive slopes during reambulation, only the calcaneus was significant (p < 0.05), with nearly 100% recovery. Segmental analysis of the total-body scans showed significant loss (p < 0.05) in the lumbar spine, total spine, pelvis, trunk, and legs. During reambulation, the majority of the regions demonstrated positive slopes, although only the pelvis and trunk were significant (p < 0.05). Potential redistribution of bone mineral was observed: during bed rest the bone mineral increased in the skull of all subjects. The change in total BMD and calcium from calcium balance were significantly (p < 0.05) correlated, R = 0.88.
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Lang, T., LeBlanc, A., Evans, H., Lu, Y., Genant, H., & Yu, A. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040307 · Cited by 828
Self-citationKearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824
Vico, L., Collet, P., Guignandon, A., Lafage-Proust, M.-H., Thomas, T., Rehailia, M., & Alexandre, C. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02217-0 · Cited by 821
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Pathophysiology of Osteoporosis
Armas, L. A. G., & Recker, R. R. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.04.006 · Cited by 466
Changes in musculoskeletal structure and function with prolonged bed rest
BLOOMFIELD, S. A. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199702000-00006 · Cited by 443
Mueller, M. J., & Maluf, K. S. (2002) · Physical Therapy · doi:10.1093/ptj/82.4.383 · Cited by 413
Resistance exercise as a countermeasure to disuse-induced bone loss
Shackelford, L. C., LeBlanc, A. D., Driscoll, T. B., Evans, H. J., Rianon, N. J., Smith, S. M., Spector, E., Feeback, D. L., & Lai, D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00741.2003 · Cited by 392
Self-citation(2007) · PubMed · Cited by 337
Gaudio, A., Pennisi, P., Bratengeier, C., Torrisi, V., Lindner, B., Mangiafico, R. A., Pulvirenti, I., Hawa, G., Tringali, G., & Fiore, C. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0067 · Cited by 315
Secondary Causes of Osteoporosis
FITZPATRICK, L. A. (2002) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)62214-3 · Cited by 311
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Self-citationOsteoporosis after spinal cord injury.
Jiang, S.-D., Dai, L.-Y., & Jiang, L.-S. (2006) · Osteoporosis International · doi:10.1007/s00198-005-2028-8 · Cited by 282
Sibonga, J. D., Evans, H. J., Sung, H. G., Spector, E. R., Lang, T. F., Oganov, V. S., Bakulin, A. V., Shackelford, L. C., & LeBlanc, A. D. (2007) · Bone · doi:10.1016/j.bone.2007.08.022 · Cited by 242
Self-citationSkeletal changes during and after spaceflight
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Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review
Vernikos, J., & Schneider, V. S. (2010) · Gerontology · doi:10.1159/000252852 · Cited by 223
Self-citationA systematic review and meta-analysis of bone loss in space travelers
Stavnichuk, M., Mikolajewicz, N., Corlett, T., Morris, M., & Komarova, S. V. (2020) · npj Microgravity · doi:10.1038/s41526-020-0103-2 · Cited by 217
Vitamin K Nutrition and Osteoporosis
Binkley, N. C., & Suttie, J. W. (1995) · The Journal of Nutrition · doi:10.1093/jn/125.7.1812 · Cited by 185
Continuous Loss of Bone During Chronic Immobilization: A Monozygotic Twin Study
Bauman, W. A., Spungen, A. M., Wang, J., Pierson Jr, R. N., & Schwartz, E. (1999) · Osteoporosis International · doi:10.1007/s001980050206 · Cited by 158
Giangregorio, L., & Blimkie, C. J. (2002) · Sports Medicine · doi:10.2165/00007256-200232070-00005 · Cited by 135
Antepartum Bed Rest for Pregnancy Complications: Efficacy and Safety for Preventing Preterm Birth
Maloni, J. A. (2010) · Biological Research For Nursing · doi:10.1177/1099800410375978 · Cited by 135
Recovery of muscle atrophy and bone loss from 90 days bed rest: Results from a one-year follow-up
Rittweger, J., & Felsenberg, D. (2009) · Bone · doi:10.1016/j.bone.2008.10.044 · Cited by 120
Fifty Years of Human Space Travel: Implications for Bone and Calcium Research
Smith, S. M., Abrams, S. A., Davis-Street, J. E., Heer, M., O'Brien, K. O., Wastney, M. E., & Zwart, S. R. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105440 · Cited by 111
BMD and Bone Geometry in Transtibial and Transfemoral Amputees
Sherk, V. D., Bemben, M. G., & Bemben, D. A. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080402 · Cited by 104
Skeletal Effects of Long-Duration Head-Down Bed Rest
Spector, E. R., Smith, S. M., & Sibonga, J. D. (2009) · Aviation, Space, and Environmental Medicine · doi:10.3357/asem.br02.2009 · Cited by 93
Zwart, S. R., Hargens, A. R., Lee, S. M. C., Macias, B. R., Watenpaugh, D. E., Tse, K., & Smith, S. M. (2007) · Bone · doi:10.1016/j.bone.2006.09.014 · Cited by 86
Maternal activity restriction and the prevention of preterm birth
Sciscione, A. C. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.005 · Cited by 79
Modlesky, C. M., Slade, J. M., Bickel, C. S., Meyer, R. A., & Dudley, G. A. (2005) · Bone · doi:10.1016/j.bone.2004.10.012 · Cited by 67
Adaptation of the Skeletal System During Long-Duration Spaceflight
Sibonga, J. D., Cavanagh, P. R., Lang, T. F., LeBlanc, A. D., Schneider, V. S., Shackelford, L. C., Smith, S. M., & Vico, L. (2007) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-008-9012-8 · Cited by 67
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Frings-Meuthen, P., Buehlmeier, J., Baecker, N., Stehle, P., Fimmers, R., May, F., Kluge, G., & Heer, M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00454.2011 · Cited by 66
Beller, G., Belavý, D. L., Sun, L., Armbrecht, G., Alexandre, C., & Felsenberg, D. (2011) · Bone · doi:10.1016/j.bone.2011.06.021 · Cited by 60
Bed rest and other determinants of bone loss during pregnancy
Promislow, J. H. E., Hertz-Picciotto, I., Schramm, M., Watt-Morse, M., & Anderson, J. J. B. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.058 · Cited by 57
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Peterman, M. M., Hamel, A. J., Cavanagh, P. R., Piazza, S. J., & Sharkey, N. A. (2001) · Journal of Biomechanics · doi:10.1016/s0021-9290(01)00004-5 · Cited by 50
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Kaji, T., Yasui, T., Suto, M., Mitani, R., Morine, M., Uemura, H., Maeda, K., & Irahara, M. (2007) · Bone · doi:10.1016/j.bone.2006.11.018 · Cited by 40
Rittweger, J., Debevec, T., Frings-Meuthen, P., Lau, P., Mittag, U., Ganse, B., Ferstl, P. G., Simpson, E. J., Macdonald, I. A., Eiken, O., et al. (2016) · Bone · doi:10.1016/j.bone.2016.07.013 · Cited by 35
(2015) · PubMed · Cited by 28
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Goswami, N., Blaber, A. P., Valenti, G., Hinghofer-Szalkay, H., Evans, J., Bailey, D. M., Vernikos, J., Choukér, A., Green, D. A., White, O., et al. (2026) · Physiological Reviews · doi:10.1152/physrev.00055.2024 · Cited by 25
Nutrition and Bone Health in Space
Smith, S. M., Heer, M., & Zwart, S. R. (2015) · Nutrition and Bone Health · doi:10.1007/978-1-4939-2001-3_41 · Cited by 14
Metadata
- Authors
- Leblanc, A. D., Schneider, V. S., Evans, H. J., Engelbretson, D. A., & Krebs, J. M.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-08-01
- Volume
- 5
- Issue
- 8
- Pages
- 843-850
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2052204645
- Cited by
- 772
- References
- 0
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
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