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Cited by 1,065

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

New approaches for interpreting projected bone densitometry data

Professor Carter, Dennis R., Bouxsein, Mary L., Marcus, Robert·1992·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.5650070204
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Abstract

Bone densitometry using dual-photon absorptiometry (DPA) or dual-energy x-ray absorptiometry (DXA) has become a standard method for assessing bone mineral content in the spine and other skeletal regions. A projected areal density, referred to as bone mineral density (BMD,g/cm2), is normally calculated to assess regional bone density and strength. We demonstrate that this measure can be misleading when used to compare bones of different sizes due to inherent biases caused by bone thickness differences. For example, assuming that volumetric bone density remains constant and bony linear dimensions are proportional to height, a 20% increase in height would result in a 20% increase in both the thickness and the BMD of any bone. We describe new analysis methods to reduce the confounding effect of bone size, and we introduce a parameter, bone mineral apparent density (BMAD, g/cm3), that better reflects bone apparent density. Using this parameter, we calculate a quantity that serves as an index of bone strength (IBS, g2/cm4) for whole vertebral bodies. These analyses were applied to lumbar spine (L2–4) DXA measurements in a population of women 17–40 years old and appear to offer advantages to conventional techniques.

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Metadata

Authors
Professor Carter, D. R., Bouxsein, M. L., & Marcus, R.
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
1992-02-01
Volume
7
Issue
2
Pages
137-145
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.5650070204
OpenAlex
W2017165492
Cited by
1,065
References
1
FWCI
20.75
Type
journal article
Language
en
Open access
closed

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