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Cited by 344

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?

Open access
Radisky, Derek C., Kenny, Paraic A., Bissell, Mina J.·2007·Journal of Cellular Biochemistry
DOI 10.1002/jcb.21186
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Abstract

Myofibroblasts produce and modify the extracellular matrix (ECM), secrete angiogenic and pro‐inflammatory factors, and stimulate epithelial cell proliferation and invasion. Myofibroblasts are normally induced transiently during wound healing, but inappropriate induction of myofibroblasts causes organ fibrosis, which greatly enhances the risk of subsequent cancer development. As myofibroblasts are also found in the reactive tumor stroma, the processes involved in their development and activation are an area of active investigation. Emerging evidence suggests that a major source of fibrosis‐ and tumor‐associated myofibroblasts is through transdifferentiation from non‐malignant epithelial or epithelial‐derived carcinoma cells through epithelial‐mesenchymal transition (EMT). This review will focus on the role of EMT in fibrosis, considered in the context of recent studies showing that exposure of epithelial cells to matrix metalloproteinases (MMPs) can lead to increased levels of cellular reactive oxygen species (ROS) that stimulate transdifferentiation to myofibroblast‐like cells. As deregulated MMP expression and increased cellular ROS are characteristic of both fibrosis and malignancy, these studies suggest that increased MMP expression may stimulate fibrosis, tumorigenesis, and tumor progression by inducing a specialized EMT in which epithelial cells transdifferentiate into activated myofibroblasts. This connection provides a new perspective on the development of the fibrosis and tumor microenvironments. J. Cell. Biochem. 101: 830–839, 2007. © 2007 Wiley‐Liss, Inc.

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Metadata

Authors
Radisky, D. C., Kenny, P. A., & Bissell, M. J.
Venue
Journal of Cellular Biochemistry
Publisher
Wiley
Published
2007-01-08
Volume
101
Issue
4
Pages
830-839
ISSN
  • 0730-2312 (ISSN-L)
  • 1097-4644
DOI
10.1002/jcb.21186
OpenAlex
W2145968706
Cited by
344
References
88
FWCI
9.10
Type
journal article
Language
en
Open access
green

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