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Cited by 1,611Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyRheumatoid Arthritis Research and Therapies

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.

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Iyer, Shankar Subramanian, Cheng, Gehong·2012·Critical Reviews™ in Immunology
DOI 10.1615/critrevimmunol.v32.i1.30PMC PMC3410706
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Abstract

Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases. Thus a fundamental understanding of IL-10 gene expression is critical for our comprehension of disease progression and resolution of host inflammatory response. In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.

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Authors
Iyer, S. S., & Cheng, G.
Affiliations
University of California, Los Angeles (US)
Venue
Critical Reviews™ in Immunology
Publisher
Begell House
Published
2012
Volume
32
Issue
1
Pages
23-63
ISSN
  • 0197-3355 (ISSN-L)
  • 2162-6472
DOI
10.1615/critrevimmunol.v32.i1.30
PMC
PMC3410706
OpenAlex
W2017749666
Cited by
1,611
References
0
Citations by year
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FWCI
13.14
Type
journal article
Language
en
Open access
Locations
  • Critical Reviews in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI056154)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
IL-10, IL-10 gene expression, transcriptional regulation, inflammation, autoimmune disease, immunopathology, epigenetics, promoter architecture, post-transcriptional regulation, signal transduction, host immune response to infection, cytokine imbalance
MeSH terms
Animals, Autoimmune Diseases, Gene Expression Regulation, Humans, Inflammation, Transcription, Genetic, Signal Transduction, Interleukin-10

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