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Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction

Chung, Hae Young, Kim, Hyon Jeen, Kim, Kyu Won, Choi, Jae Sue, Yu, Byung Pal·2002·Microscopy Research and Technique
DOI 10.1002/jemt.10203
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Abstract

Accumulating evidence strongly suggests that oxidative stress underlies aging processes. Research provides consistent evidence that calorie restriction (CR) reduces age‐related oxidative stress and has anti‐inflammatory properties. However, information is lacking on the molecular mechanism that would better define the interrelation of reactive oxygen species and nitrogen species and the pro‐inflammatory states of the aging process. In this review, the biochemical and molecular bases of the inflammatory process in the aging process are analyzed to delineate the molecular inflammation hypothesis of aging. The key players involved in the proposed hypothesis are the age‐related upregulation of NF‐κB, IL‐1β, IL‐6, TNFα, cyclooxygenase‐2, and inducible NO synthase, all of which are attenuated by CR. Furthermore, age‐related NFκB activation is associated with phosphorylation by IκB kinase/NIK and MAPKs, while CR blocked these activation processes. The modulation of these factors provides molecular insights of the anti‐inflammatory action of CR in relation to the aging process. Based on available finding and our recent supporting evidence, we prefer to use “molecular inflammation” to emphasize the importance of the molecular reaction mechanisms and their aberrance, predisposing to fully expressed chronic inflammatory phenomena. It was further proposed that CR's major force of the regulation of redox‐sensitive inflammation may well be its life‐prolonging action. Microsc. Res. Tech. 59:264–272, 2002. © 2002 Wiley‐Liss, Inc.

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Metadata

Authors
Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P.
Venue
Microscopy Research and Technique
Publisher
Wiley
Published
2002-11-06
Volume
59
Issue
4
Pages
264-272
ISSN
  • 1059-910X (ISSN-L)
  • 1097-0029
DOI
10.1002/jemt.10203
OpenAlex
W2072661983
Cited by
297
References
10
FWCI
4.55
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction. https://app.cochat.ai/papers/10.1002/jemt.10203
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Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002). Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction. Microscopy Research and Technique. https://doi.org/10.1002/jemt.10203

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