Human immunopathogenesis of severe acute respiratory syndrome (SARS)

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923 · see citing works

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676 · see citing works

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445 · see citing works

A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong

Lee, N. L. S., Hui, D. S. C., Wu, A. K. L., Chan, P. K. S., Cameron, P. A., Joynt, G. M., Ahuja, A. T., Yung, M. Y., Leung, C. B., To, K. F., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030685 · Cited by 2,631 · see citing works

Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study

Peiris, J., Chu, C., Cheng, V., Chan, K., Hung, I., Poon, L., Law, K., Tang, B., Hon, T., Chan, C., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13412-5 · Cited by 2,375 · see citing works

Clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto Area

Booth, C. M. (2003) · JAMA · doi:10.1001/jama.289.21.joc30885 · Cited by 1,405 · see citing works

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

Wong, C. K., LAM, C. W. K., Wu, A. K. L., Ip, W., Lee, N. L. S., Chan, I., Lit, L. C. W., Hui, D. S. C., Chan, M. H. M., CHUNG, S. S. C., et al. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02415.x · Cited by 1,270 · see citing works

SARS: systematic review of treatment effects

Stockman, L. J., Bellamy, R., & Garner, P. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030343 · Cited by 1,217 · see citing works

Lung pathology of fatal severe acute respiratory syndrome

Nicholls, J. M., Poon, L. L., Lee, K. C., Ng, W. F., Lai, S. T., Leung, C. Y., Chu, C. M., Hui, P. K., Mak, K. L., Lim, W., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13413-7 · Cited by 1,076 · see citing works

Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways

Ding, Y., He, L., Zhang, Q., Huang, Z., Che, X., Hou, J., Wang, H., Shen, H., Qiu, L., Li, Z., et al. (2004) · The Journal of Pathology · doi:10.1002/path.1560 · Cited by 1,068 · see citing works

Functional classification of interferon-stimulated genes identified using microarrays

de Veer, M. J., Holko, M., Frevel, M. A. E., Walker, E. M., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.912 · Cited by 902 · see citing works

An interferon‐γ‐related cytokine storm in SARS patients

Huang, K., Su, I., Theron, M., Wu, Y., Lai, S., Liu, C., & Lei, H. (2005) · Journal of Medical Virology · doi:10.1002/jmv.20255 · Cited by 679 · see citing works

Interferon signalling network in innate defence

Takaoka, A., & Yanai, H. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00716.x · Cited by 586 · see citing works

Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis

Wong, R., Wu, A., To, K.-F., Lee, N., Lam, C., Wong, C., Chan, P. K., Ng, M., Yu, L., Hui, D., et al. (2003) · British medical journal · doi:10.1136/bmj.326.7403.1358 · Cited by 566 · see citing works

Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis

Cheung, C. Y., Poon, L. L. M., Ng, I. H. Y., Luk, W., Sia, S. F., Wu, M. H. S., Chan, K., Yuen, K., Gordon, S., Guan, Y., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7819-7826.2005 · Cited by 461 · see citing works

Induction and Regulation of IFNs During Viral Infections

Malmgaard, L. (2004) · Journal of Interferon & Cytokine Research · doi:10.1089/1079990041689665 · Cited by 455 · see citing works

Acute Respiratory Distress Syndrome in Critically Ill Patients With Severe Acute Respiratory Syndrome

Lew, T. W. K. (2003) · JAMA · doi:10.1001/jama.290.3.374 · Cited by 423 · see citing works

Pulmonary pathology of severe acute respiratory syndrome in Toronto

Hwang, D. M., Chamberlain, D. W., Poutanen, S. M., Low, D. E., Asa, S. L., & Butany, J. (2005) · Modern Pathology · doi:10.1038/modpathol.3800247 · Cited by 332 · see citing works

Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome

Jiang, Y., Xu, J., Zhou, C., Wu, Z., Zhong, S.-Q., Liu, J., Luo, W., Chen, T., Qin, Q., & Deng, P. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-857oc · Cited by 317 · see citing works

Critically Ill Patients With Severe Acute Respiratory Syndrome

Fowler, R. (2003) · JAMA · doi:10.1001/jama.290.3.367 · Cited by 315 · see citing works

Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome

Reghunathan, R., Jayapal, M., Hsu, L. Y., Chng, H. H., Tai, D. Y. H., Leung, B. P. L., & Melendez, A. J. (2005) · BMC Immunology · doi:10.1186/1471-2172-6-2 · Cited by 295 · see citing works

Severe Acute Respiratory Syndrome: Radiographic Appearances and Pattern of Progression in 138 Patients

Wong, K. T., Antonio, G. E., Hui, D. S. C., Lee, N. L. S., Yuen, E. H. Y., Wu, A. K. L., Leung, C. B., Rainer, T. H., Cameron, P. A., Chung, S. S. C., et al. (2003) · Radiology · doi:10.1148/radiol.2282030593 · Cited by 289 · see citing works

Thin-Section CT of Severe Acute Respiratory Syndrome: Evaluation of 73 Patients Exposed to or with the Disease

Wong, K. T., Antonio, G. E., Hui, D. S. C., Lee, N. L. S., Yuen, E. H. Y., Wu, A. K. L., Leung, C. B., Rainer, T. H., Cameron, P. A., Chung, S. S. C., et al. (2003) · Radiology · doi:10.1148/radiol.2283030541 · Cited by 239 · see citing works

Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome

Tang, N. L. S., Chan, P. K. S., Wong, C.-K., To, K., Wu, A. K. L., Sung, Y.-M., Hui, D. S. C., Sung, J. J. �., & Lam, C. W. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.054460 · Cited by 231 · see citing works

Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome

Chien, J., Hsueh, P., Cheng, W., Yu, C., & Yang, P. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00942.x · Cited by 225 · see citing works

Severe Acute Respiratory Syndrome

Christian, M. D., Poutanen, S. M., Loutfy, M. R., Muller, M. P., & Low, D. E. (2004) · Clinical Infectious Diseases · doi:10.1086/420743 · Cited by 224 · see citing works

Pathogenesis of severe acute respiratory syndrome

Lau, Y., & Peiris, M. J. S. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.05.009 · Cited by 168 · see citing works

Fatal Severe Acute Respiratory Syndrome Is Associated with Multiorgan Involvement by Coronavirus

Farcas, G. A., Poutanen, S. M., Mazzulli, T., Willey, B. M., BUTANY, J. W., Asa, S. L., Faure, P., Akhavan, P., Low, D. E., & Kain, K. C. (2004) · The Journal of Infectious Diseases · doi:10.1086/426870 · Cited by 168 · see citing works

Evaluation of WHO criteria for identifying patients with severe acute respiratory syndrome out of hospital: prospective observational study

Rainer, T. H., Cameron, P. A., Smit, D., Ong, K. L., Hung, A. N. W., Nin, D. C. P., Ahuja, A. T., Si, L. C. Y., & Sung, J. J. Y. (2003) · BMJ · doi:10.1136/bmj.326.7403.1354 · Cited by 135 · see citing works

Gene Expression Profiling of Host Response in Models of Acute HIV Infection

Bosinger, S. E., Hosiawa, K. A., Cameron, M. J., Persad, D., Ran, L., Xu, L., Boulassel, M. R., Parenteau, M., Fournier, J., Rud, E. W., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.6858 · Cited by 98 · see citing works

Severe Acute Respiratory Syndrome Coronavirus Fails To Activate Cytokine-Mediated Innate Immune Responses in Cultured Human Monocyte-Derived Dendritic Cells

Ziegler, T. T., Matikainen, S., Rönkkö, E., Österlund, P., Sillanpää, M., Sirén, J., Fagerlund, R., Immonen, M., Melén, K., & Julkunen, I. (2005) · Journal of Virology · doi:10.1128/jvi.79.21.13800-13805.2005 · Cited by 78 · see citing works

Gene expression profiles in peripheral blood mononuclear cells of SARS patients

Yu, S.-Y. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i32.5037 · Cited by 49 · see citing works

Early diagnosis of SARS: lessons from the Toronto SARS outbreak

Muller, M. P., Richardson, S. E., McGeer, A., Dresser, L., Raboud, J., Mazzulli, T., Loeb, M. B., & Louie, M. (2006) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-006-0127-x · Cited by 42 · see citing works

Coordinate induction of IFN-α and -γ by SARS-CoV also in the absence of virus replication

Castilletti, C., Bordi, L., Lalle, E., Rozera, G., Poccia, F., Agrati, C., Abbate, I., & Capobianchi, M. R. (2005) · Virology · doi:10.1016/j.virol.2005.07.015 · Cited by 41 · see citing works

Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)

Lee, Y.-S., Chen, C., Chao, A., Chen, E.-S., Wei, M., Chen, L.-K., Yang, K. D., Lin, M.-C., Wang, Y.-H., Liu, J.-W., et al. (2005) · BMC Genomics · doi:10.1186/1471-2164-6-132 · Cited by 39 · see citing works

Radiographic-Clinical Correlation in Severe Acute Respiratory Syndrome: Study of 1373 Patients in Hong Kong

Antonio, G. E., Ooi, C. G. C., Wong, K. T., Tsui, E. L. H., Wong, J. S. W., Sy, A. N. L., Hui, J. Y. H., Chan, C. Y., Huang, H. Y. H., Chan, Y. F., et al. (2005) · Radiology · doi:10.1148/radiol.2373041919 · Cited by 36 · see citing works

Preventing local transmission of SARS: lessons from Singapore

Fisher, D. A., Chew, M. H. L., Lim, Y.-T., & Tambyah, P. A. (2003) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2003.tb05358.x · Cited by 24 · see citing works

ARDS in SARS: cytokine mediators and treatment implications

Salto‐Tellez, M., Tan, E. L. C., & Lim, B. (2004) · Cytokine · doi:10.1016/j.cyto.2004.09.002 · Cited by 12 · see citing works

Open season

Mandavilli, A. (2006) · Nature · doi:10.1038/439382a · Cited by 3 · see citing works

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

Ye, Q., Wang, B., & Mao, J. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.03.037 · Cited by 2,761 · see citing works

Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology

Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524 · see citing works

Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors

Mazza, M. G., De Lorenzo, R., Conte, C., Poletti, S., Vai, B., Bollettini, I., Melloni, E. M. T., Furlan, R., Ciceri, F., Rovere-Querini, P., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.037 · Cited by 1,804 · see citing works

Molecular immune pathogenesis and diagnosis of COVID-19

Li, X., Geng, M., Peng, Y., Meng, L., & Lu, S. (2020) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2020.03.001 · Cited by 1,723 · see citing works

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

Channappanavar, R., Fehr, A. R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K., & Perlman, S. M. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.007 · Cited by 1,400 · see citing works

The cytokine storm in COVID-19: an overview of the involvement of the chemokine/chemokine-receptor system

Coperchini, F., Chiovato, L., Croce, L., Magri, F., & Rotondi, M. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.05.003 · Cited by 1,288 · see citing works

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

Ni, L., Ye, F., Cheng, M., Yu, F., Deng, Y., Zhao, H. J., Peng, W., Ge, J., Gou, M., Li, X., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.023 · Cited by 1,069 · see citing works

COVID-19: Transmission, prevention, and potential therapeutic opportunities

Lotfi, M., Hamblin, M. R., & Rezaei, N. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.044 · Cited by 1,029 · see citing works

SARS‐coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

Oudit, G. Y., Kassiri, Z., Jiang, C., Liu, P. P., Poutanen, S. M., Penninger, J. M., & BUTANY, J. W. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02153.x · Cited by 896 · see citing works

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Sahin, U., Muik, A., Vogler, I., Derhovanessian, E., Kranz, L. M., Vormehr, M., Quandt, J., Bidmon, N., Ulges, A., Baum, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03653-6 · Cited by 845 · see citing works

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Huang, A. T., Garcia-Carreras, B., Hitchings, M. D. T., Yang, B., Katzelnick, L. C., Rattigan, S. M., Borgert, B. A., Moreno, C. A., Solomon, B. D., Trimmer-Smith, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18450-4 · Cited by 1,026 · see citing works

Cardiac and arrhythmic complications in patients with COVID‐19

Kochi, A. N., Tagliari, A. P., Forleo, G. B., Fassini, G. M., & Tondo, C. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14479 · Cited by 666 · see citing works

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

Nikolich-Zugich, J., Knox, K. S., Rios, C. T., Natt, B., Bhattacharya, D., & Fain, M. J. (2020) · GeroScience · doi:10.1007/s11357-020-00186-0 · Cited by 577 · see citing works

T cell-mediated immune response to respiratory coronaviruses

Channappanavar, R., Zhao, J., & Perlman, S. (2014) · Immunologic Research · doi:10.1007/s12026-014-8534-z · Cited by 512 · see citing works

Myocardial injury and COVID-19: Possible mechanisms

Babapoor-Farrokhran, S., Gill, D., Walker, J., Rasekhi, R. T., Bozorgnia, B., & Amanullah, A. M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117723 · Cited by 483 · see citing works

Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past

Shah, V. K., Firmal, P., Alam, A., Ganguly, D., & Chattopadhyay, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01949 · Cited by 471 · see citing works

COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge

Baj, J., Karakuła‐Juchnowicz, H., Teresiński, G., Buszewicz, G., Ciesielka, M., Sitarz, R., Forma, A., Karakuła, K. H., Flieger, W., Portincasa, P., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061753 · Cited by 458 · see citing works

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection

Ng, O.-W., Chia, A., Tan, A. T., Jadi, R. S., Leong, H. N., Bertoletti, A., & Tan, Y.-J. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.02.063 · Cited by 436 · see citing works

Lessons from the host defences of bats, a unique viral reservoir

Irving, A. T., Ahn, M., Goh, G., Anderson, D. E., & Wang, L. (2021) · Nature · doi:10.1038/s41586-020-03128-0 · Cited by 413 · see citing works

Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China

Chen, R., Sang, L., Jiang, M., Yang, Z., Jia, N., Fu, W., Xie, J., Guan, W., Liang, W., Ni, Z., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.003 · Cited by 376 · see citing works

Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza

Bermejo-Martín, J. F., de Lejarazu, R. O., Pumarola, T., Rello, J., Almansa, R., Ramírez, P., Martín‐Loeches, I., Varillas‐Delgado, D., Gallegos, M. C., Arbeloa, C. S., et al. (2009) · Critical Care · doi:10.1186/cc8208 · Cited by 373 · see citing works

The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2

Muralidar, S., Ambi, S. V., Sekaran, S., & Krishnan, U. M. (2020) · Biochimie · doi:10.1016/j.biochi.2020.09.018 · Cited by 357 · see citing works

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

Ahn, M., Anderson, D. E., Zhang, Q., Tan, C. W., Lim, B. L., Luko, K., Wen, M., Chia, W. N., Mani, S., Wang, L. C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0371-3 · Cited by 334 · see citing works

Lymphopenia in COVID‐19: Therapeutic opportunities

Fathi, N., & Rezaei, N. (2020) · Cell Biology International · doi:10.1002/cbin.11403 · Cited by 324 · see citing works

Lessons for COVID-19 immunity from other coronavirus infections

Sariol, A., & Perlman, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.005 · Cited by 317 · see citing works

Prediction of the Development of Pulmonary Fibrosis Using Serial Thin-Section CT and Clinical Features in Patients Discharged after Treatment for COVID-19 Pneumonia

Yu, M., Liu, Y., Xu, D., Zhang, R., Lan, L., & Xu, H. (2020) · Korean Journal of Radiology · doi:10.3348/kjr.2020.0215 · Cited by 265 · see citing works

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Bermejo-Martín, J. F., González‐Rivera, M., Almansa, R., Micheloud, D., Tedim, A. P., Domínguez‐Gil, M., Resino, S., Martín-Fernández, M., Ryan, P., Pérez‐García, F., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03398-0 · Cited by 264 · see citing works

The clinical course and its correlated immune status in COVID-19 pneumonia

He, R., Lu, Z., Zhang, L., Fan, T. T., Xiong, R., Shen, X., Feng, H., Meng, H., Lin, W., Jiang, W., et al. (2020) · Journal of Clinical Virology · doi:10.1016/j.jcv.2020.104361 · Cited by 235 · see citing works

Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019

Barlow, A., Landolf, K. M., Barlow, B., Yeung, S. Y. A., Heavner, J. J., Claassen, C. W., & Heavner, M. S. (2020) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2398 · Cited by 239 · see citing works

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors

Shomuradova, A. S., Vagida, M. S., Sheetikov, S. A., Zornikova, K. V., Kiryukhin, D. O., Titov, A., Peshkova, I. O., Khmelevskaya, A. A., Dianov, D. V., Malasheva, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.004 · Cited by 222 · see citing works

Immunogenicity of the BNT162b2 COVID-19 mRNA vaccine and early clinical outcomes in patients with haematological malignancies in Lithuania: a national prospective cohort study

Maneikis, K., Šablauskas, K., Ringelevičiūtė, U., Vaitekėnaitė, V., Čekauskienė, R., Kryžauskaitė, L., Naumovas, D., Banys, V., Pečeliūnas, V., Beinortas, T., et al. (2021) · The Lancet Haematology · doi:10.1016/s2352-3026(21)00169-1 · Cited by 226 · see citing works

Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection

Martín‐Loeches, I., Lisboa, T. C., Rhodes, A., Moreno, R. P., Silva, E., Sprung, C. L., Chiche, J., Barahona, D., Villabon, M., Balasini, C., et al. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-2078-z · Cited by 211 · see citing works

The Immune Response and Immunopathology of COVID-19

Mortaz, E., Tabarsi, P., Varahram, M., Folkerts, G., & Adcock, I. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02037 · Cited by 206 · see citing works

JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

Seif, F., Aazami, H., Khoshmirsafa, M., Kamali, M., Mohsenzadegan, M., Pornour, M., & Mansouri, D. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000508247 · Cited by 198 · see citing works

Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets

Cameron, C., Cameron, M. J., Bermejo-Martín, J. F., Ran, L., Xu, L., Turner, P. V., Ran, R., Danesh, A., Yuan, F., Chan, P.-K., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00691-08 · Cited by 176 · see citing works

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

Rockx, B., Baas, T., Zornetzer, G. A., Haagmans, B. L., Sheahan, T. P., Frieman, M. B., Dyer, M. D., Teal, T. H., Proll, S. C., van den Brand, J. M. A., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00127-09 · Cited by 175 · see citing works

Immunology of COVID‐19: Mechanisms, clinical outcome, diagnostics, and perspectives—A report of the European Academy of Allergy and Clinical Immunology (EAACI)

Sokołowska, M., Łukasik, Z. M., Agache, I. O., Akdiş, C. A., Akdiş, D., Akdiş, M., Barcik, W., Brough, H. A., Eiwegger, T., Eljaszewicz, A., et al. (2020) · Allergy · doi:10.1111/all.14462 · Cited by 169 · see citing works

Clinical Outcome of Henipavirus Infection in Hamsters Is Determined by the Route and Dose of Infection

Rockx, B., Brining, D. L., Kramer, J. A., Callison, J. A., Ebihara, H., Mansfield, K. G., & Feldmann, H. (2011) · Journal of Virology · doi:10.1128/jvi.00473-11 · Cited by 168 · see citing works

Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective

Malik, Y. S., Kumar, N., Sircar, S., Kaushik, R., Bhat, S., Dhama, K., Gupta, P., Goyal, K., Singh, M. P., Ghoshal, U., et al. (2020) · Pathogens · doi:10.3390/pathogens9070519 · Cited by 164 · see citing works

Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy

Lee, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020388 · Cited by 161 · see citing works

COVID-19: Complement, Coagulation, and Collateral Damage

Lo, M. W., Kemper, C., & Woodruff, T. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000644 · Cited by 157 · see citing works

Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics

Gomes, C. P., Fernandes, D. E., da Fonseca, F. M. C., da Mata, G. F., Riguetti, M. T. P., Varela, P., Kirsztajn, G. M., & Pesquero, J. B. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.589505 · Cited by 156 · see citing works

Reservoir Host Immune Responses to Emerging Zoonotic Viruses

Mandl, J. N., Ahmed, R., Barreiro, L. B., Daszak, P., Epstein, J. H., Virgin, H. W., & Feinberg, M. B. (2014) · Cell · doi:10.1016/j.cell.2014.12.003 · Cited by 147 · see citing works

Virology, pathogenesis, diagnosis and in-line treatment of COVID-19

Samudrala, P. K., Kumar, P., Choudhary, K., Thakur, N., Wadekar, G. S., Dayaramani, R. A., Agrawal, M., & Alexander, A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173375 · Cited by 150 · see citing works

Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections

Quesada‐Gómez, J. M., Castillo, M. E., & Bouillon, R. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105719 · Cited by 145 · see citing works

Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection

Paquette, S. G., Banner, D., Zhao, Z., Yuan, F., Huang, S. S. H., Leon, A. J., Ng, D. C. K., Almansa, R., Martín‐Loeches, I., Ramírez, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038214 · Cited by 144 · see citing works

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

Luan, Y., Yin, C., & Yao, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720363 · Cited by 141 · see citing works

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

Day, C. W., Baric, R. S., Cai, S. X., Frieman, M. B., Kumaki, Y., Morrey, J. D., Smee, D. F., & Barnard, D. L. (2009) · Virology · doi:10.1016/j.virol.2009.09.023 · Cited by 139 · see citing works

Depression and Anxiety During the COVID-19 Pandemic: Epidemiology, Mechanism, and Treatment

Zhu, C., Zhang, T., Li, Q., Chen, X., & Wang, K. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00970-2 · Cited by 152 · see citing works

Immunity against COVID-19: Potential role of Ayush Kwath

Gautam, S., Gautam, A., Chhetri, S., & Bhattarai, U. (2020) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2020.08.003 · Cited by 138 · see citing works

Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response

Li, Y., Chen, M., Cao, H., Zhu, Y., Zheng, J., & Zhou, H. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.10.008 · Cited by 127 · see citing works

Cytokine Storm in COVID-19: “When You Come Out of the Storm, You Won’t Be the Same Person Who Walked in”

Castelli, V., Cimini, A., & Ferri, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02132 · Cited by 126 · see citing works

COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies

Rauf, A., Abu‐Izneid, T., Olatunde, A., Khalil, A. A., Alhumaydhi, F. A., Tufail, T., Shariati, M. A., Ребезов, М. Б., Almarhoon, Z. M., Mabkhot, Y. N., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218155 · Cited by 130 · see citing works

Recently Discovered Human Coronaviruses

Wevers, B. A., & van der Hoek, L. (2009) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2009.07.007 · Cited by 123 · see citing works

A current review of COVID-19 for the cardiovascular specialist

Lang, J. P., Wang, X., Moura, F. A., Siddiqi, H. K., Morrow, D. A., & Bohula, E. A. (2020) · American Heart Journal · doi:10.1016/j.ahj.2020.04.025 · Cited by 120 · see citing works

The dynamics of inflammatory markers in coronavirus disease-2019 (COVID-19) patients: A systematic review and meta-analysis

Mahat, R. K., Panda, S., Rathore, V., Swain, S., Yadav, L., & Sah, S. (2021) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2021.100727 · Cited by 117 · see citing works

Psychological Symptoms in COVID-19 Patients: Insights into Pathophysiology and Risk Factors of Long COVID-19

Thye, A. Y.-K., Law, J. W., Tan, L. T., Pusparajah, P., Ser, H., Thurairajasingam, S., Letchumanan, V., & Lee, L. (2022) · Biology · doi:10.3390/biology11010061 · Cited by 115 · see citing works

Cytokine and Chemokine Profiles in Lung Tissues from Fatal Cases of 2009 Pandemic Influenza A (H1N1)

Gao, R., Bhatnagar, J., Blau, D. M., Greer, P. W., Rollin, D. C., Denison, A. M., DeLeon-Carnes, M., Shieh, W., Sambhara, S. R., Tumpey, T. M., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.06.023 · Cited by 112 · see citing works

MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract

Alosaimi, B., Hamed, M. E., Naeem, A., Alsharef, A. A., Alqahtani, S. Y., Aldosari, K., Alamri, A. A., Al-Eisa, K., Khojah, T., Assiri, A. M., et al. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154895 · Cited by 116 · see citing works

SARS‐CoV‐2: A comprehensive review from pathogenicity of the virus to clinical consequences

Lotfi, M., & Rezaei, N. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26123 · Cited by 117 · see citing works

Cytokine Immunopathogenesis of Enterovirus 71 Brain Stem Encephalitis

Wang, S.-M., Lei, H., & Liu, C. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/876241 · Cited by 113 · see citing works

Tackling the cytokine storm in COVID-19, challenges and hopes

Abdin, S. M., Elgendy, S. M., Alyammahi, S. K., Alhamad, D. W., & Omar, H. A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118054 · Cited by 112 · see citing works

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

Zhao, Y., Sui, L., Wu, P., Wang, W., Wang, Z., Yu, Y., Hou, Z., Tan, G., Liu, Q., & Wang, G. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00742-w · Cited by 112 · see citing works

Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections

Jung, K., Renukaradhya, G. J., Alekseev, K. P., Fāng, Y., Tang, Y., & Saif, L. J. (2009) · Journal of General Virology · doi:10.1099/vir.0.014001-0 · Cited by 112 · see citing works

Coronavirus Infection Modulates the Unfolded Protein Response and Mediates Sustained Translational Repression

Bechill, J., Chen, Z., Brewer, J. W., & Baker, S. C. (2008) · Journal of Virology · doi:10.1128/jvi.00017-08 · Cited by 106 · see citing works

Long COVID and neuropsychiatric manifestations (Review)

Efstathiou, V., Stefanou, M., Demetriou, M., Siafakas, N., Makris, M. P., Tsivgoulis, G. K., Zoumpourlis, V., Kympouropoulos, S. P., Tsoporis, J. N., Spandidos, D. A., et al. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11290 · Cited by 113 · see citing works

Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders

Samidurai, A., Xi, L., Das, A., & Kukreja, R. C. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-040122-034745 · Cited by 109 · see citing works

SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19

Fiscon, G., Conte, F., Farina, L., & Paci, P. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008686 · Cited by 106 · see citing works

From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry

Kanduc, D. (2020) · Antibodies · doi:10.3390/antib9030033 · Cited by 104 · see citing works

A chronicle of SARS-CoV-2: Part-I - Epidemiology, diagnosis, prognosis, transmission and treatment

Kumar, M., Taki, K., Gahlot, R., Sharma, A., & Dhangar, K. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139278 · Cited by 103 · see citing works

Comparative Pathogenesis of Bovine and Porcine Respiratory Coronaviruses in the Animal Host Species and SARS-CoV-2 in Humans

Saif, L. J., & Jung, K. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.01355-20 · Cited by 107 · see citing works

Variants in ACE2; potential influences on virus infection and COVID-19 severity

Bakhshandeh, B., Sorboni, S. G., Javanmard, A., Mottaghi, S. S., Mehrabi, M., Sorouri, F., Abbasi, A., & Jahanafrooz, Z. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104773 · Cited by 99 · see citing works

Increased Serum Levels of Soluble TNF-α Receptor Is Associated With ICU Mortality in COVID-19 Patients

Mortaz, E., Tabarsi, P., Jamaati, H., Roofchayee, N. D., Dezfuli, N. K., Hashemian, S. M. R., Moniri, A., Marjani, M., Malekmohammad, M., Mansouri, D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.592727 · Cited by 93 · see citing works

Enfermedades Infecciosas y Microbiología Clínica

Viasus, D., Antón, A., Pumarola, T., & Carratalà, J. (2016) · Cited by 90 · see citing works

Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus

Fukushi, M., Yoshinaka, Y., Matsuoka, Y., Hatakeyama, S., Ishizaka, Y., Kirikae, T., Sasazuki, T., & Miyoshi‐Akiyama, T. (2012) · Journal of Virology · doi:10.1128/jvi.01250-12 · Cited by 89 · see citing works

Dysregulated adaptive immune response contributes to severe COVID-19

Yu, K., 吴永坚, He, J., Liu, X., Wei, B., Wen, W., Wen, X., Xu, W., Dong, X., Yan, Y., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0391-9 · Cited by 89 · see citing works

Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19

Angelopoulou, A., Alexandris, N., Konstantinou, E. K., Mesiakaris, K., Zanidis, C., Farsalinos, K. E., & Poulas, K. A. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109858 · Cited by 85 · see citing works

Underlying Vulnerabilities to the Cytokine Storm and Adverse COVID-19 Outcomes in the Aging Immune System

Nidadavolu, L. S., & Walston, J. D. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa209 · Cited by 84 · see citing works

Suppression of Innate Immune Pathology by Regulatory T Cells during Influenza A Virus Infection of Immunodeficient Mice

Antunes, I., & Kassiotis, G. (2010) · Journal of Virology · doi:10.1128/jvi.01559-10 · Cited by 84 · see citing works

Metabolic disturbances and inflammatory dysfunction predict severity of coronavirus disease 2019 (COVID-19): a retrospective studyPreprint

Nie, S., Zhao, X., Zhao, K. F., Zhang, Z., Zhang, Z., & Zhang, Z. (2020) · medRxiv · doi:10.1101/2020.03.24.20042283 · Cited by 83 · see citing works

Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice

Nagata, N., Iwata, N., Hasegawa, H., Fukushi, S., Harashima, A., Sato, Y., Saijo, M., Taguchi, F., Morikawa, S., & Sata, T. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071060 · Cited by 82 · see citing works

Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection

Batty, C. J., Heise, M. T., Bachelder, E. M., & Ainslie, K. M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.006 · Cited by 80 · see citing works

nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics

Kabir, M. T., Uddin, M. S., Hossain, M. F., Abdulhakim, J. A., Alam, M. A., Ashraf, G. M., BUNGAU, S. G., Bin-Jumah, M. N., Abdel‐Daim, M. M., & Aleya, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00616 · Cited by 80 · see citing works

Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analyses

do Nascimento, I. J. B., von Groote, T., O’Mathúna, D. P., Abdulazeem, H. M., Henderson, C., Jayarajah, U., Weerasekara, I., Peričić, T. P., Klapproth, H., Puljak, L., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239235 · Cited by 81 · see citing works

Advances in the relationship between coronavirus infection and cardiovascular diseases

Zhao, M., Wang, M., Zhang, J., Ye, J., Xu, Y. Q., Wang, Z., Ye, D., Liu, J., & Wan, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110230 · Cited by 78 · see citing works

Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19

Khazdair, M. R., Ghafari, S., & Sadeghi, M. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1931353 · Cited by 77 · see citing works

Cytokines and COVID-19: friends or foes?

Rokni, M., Hamblin, M. R., & Rezaei, N. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1799669 · Cited by 77 · see citing works

H5N1 infection causes rapid mortality and high cytokine levels in chickens compared to ducks

Burggraaf, S., Karpala, A. J., Bingham, J., Lowther, S., Selleck, P., Kimpton, W. G., & Bean, A. G. D. (2014) · Virus Research · doi:10.1016/j.virusres.2014.03.012 · Cited by 73 · see citing works

Severe Acute Respiratory Syndrome and Coronavirus

Hui, D. S. C., & Chan, P. K. S. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.04.009 · Cited by 72 · see citing works

Coronaviruses and the central nervous system

Morgello, S. (2020) · Journal of NeuroVirology · doi:10.1007/s13365-020-00868-7 · Cited by 72 · see citing works

Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy

Pillaiyar, T., & Laufer, S. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00335 · Cited by 70 · see citing works

Altered Pathogenesis of Porcine Respiratory Coronavirus in Pigs due to Immunosuppressive Effects of Dexamethasone: Implications for Corticosteroid Use in Treatment of Severe Acute Respiratory Syndrome Coronavirus

Jung, K., Alekseev, K. P., Zhang, X., Cheon, D., Vlasova, A. N., & Saif, L. J. (2007) · Journal of Virology · doi:10.1128/jvi.01702-07 · Cited by 70 · see citing works

Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy

Boroujeni, M. E., Sekrecka, A., Antonczyk, A., Hassani, S., Sekrecki, M., Nowicka, H., Łopacinska, N., Olya, A., Kluzek, K., Wesoły, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.888897 · Cited by 71 · see citing works

Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model

Cameron, M. J., Kelvin, A. A., Leon, A. J., Cameron, C., Ran, L., Xu, L., Chu, Y.-K., Danesh, A., Yuan, F., Li, Q., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045842 · Cited by 68 · see citing works

Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study

Vultaggio, A., Vivarelli, E., Virgili, G., Lucenteforte, E., Bartoloni, A., Nozzoli, C., Morettini, A., Berni, A., Malandrino, D., Rossi, O., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.06.013 · Cited by 67 · see citing works

Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages

Bao, S., Zou, Y., Wang, B., Li, Y., Zhu, J., Luo, Y., & Li, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.06.022 · Cited by 65 · see citing works

Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019

Khazdair, M. R., Anaeigoudari, A., & Agbor, G. A. (2021) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.319567 · Cited by 64 · see citing works

Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID‐19

Ni, M., Tian, F., Xiang, D., & Yu, B. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26070 · Cited by 63 · see citing works

COVID-19, frailty and long-term care: Implications for policy and practice

Andrew, M. K., Searle, S. D., McElhaney, J. E., McNeil, S., Clarke, B., Rockwood, K. J., & Kelvin, D. J. (2020) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.13003 · Cited by 60 · see citing works

Current Understanding of Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 and Its Distinction from Kawasaki Disease

Bükülmez, H. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-01028-4 · Cited by 59 · see citing works

Interferon-Mediated Immunopathological Events Are Associated with Atypical Innate and Adaptive Immune Responses in Patients with Severe Acute Respiratory Syndrome

Cameron, M. J., Ran, L., Xu, L., Danesh, A., Bermejo-Martin, J. F., Cameron, C. M., Muller, M. P., Gold, W. L., Richardson, S. E., Poutanen, S. M., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00527-07 · Cited by 386 · see citing works

Immunopathogenesis of coronavirus infections: implications for SARS

Dandekar, A. A., & Perlman, S. M. (2005) · Nature reviews. Immunology · doi:10.1038/nri1732 · Cited by 499 · see citing works

Interferon and cytokine responses to SARS-coronavirus infection

Thiel, V., & Weber, F. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.01.001 · Cited by 149 · see citing works

SARS coronavirus and innate immunity

Frieman, M. B., Heise, M. T., & Baric, R. S. (2007) · Virus Research · doi:10.1016/j.virusres.2007.03.015 · Cited by 236 · see citing works

Host Immune Responses to SARS Coronavirus in Humans

Li, C. K.-F., & Xu, X. (2009) · Springer eBooks · doi:10.1007/978-3-642-03683-5_16 · Cited by 26 · see citing works