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Cited by 167Parkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsBalance, Gait, and Falls Prevention

Self‐management rehabilitation and health‐related quality of life in Parkinson's disease: A randomized controlled trial

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Tickle‐Degnen, Linda, Ellis, Terry, Saint‐Hilaire, Marie H., Thomas, Cathi A., Wagenaar, Robert C.·2010·Movement Disorders
DOI 10.1002/mds.22940PMC PMC2831132
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Abstract

The purpose of this randomized controlled trial was to determine whether increasing hours of self‐management rehabilitation had increasing benefits for health‐related quality of life (HRQOL) in Parkinson's disease beyond best medical treatment, whether effects persisted at 2 and 6 months of follow‐up, and whether targeted compared with nontargeted HRQOL domains responded more to rehabilitation. Participants on best medication therapy were randomly assigned to one of three conditions for 6 weeks intervention: 0 hours of rehabilitation; 18 hours of clinic group rehabilitation plus 9 hours of attention control social sessions; and 27 hours of rehabilitation, with 18 in clinic group rehabilitation and 9 hours of rehabilitation designed to transfer clinic training into home and community routines. Results (N = 116) showed that at 6 weeks, there was a beneficial effect of increased rehabilitation hours on HRQOL measured with the Parkinson's Disease Questionnaire‐39 summary index (F(1,112) = 6.48, η = 0.23, CI = 0.05–0.40, P = 0.01). Benefits persisted at follow‐up. The difference between 18 and 27 hours was not significant. Clinically relevant improvement occurred at a greater rate for 18 and 27 hours (54% improved) than for 0 hours (18% improved), a significant 36% difference in rates (95% CI = 20–52% difference). Effects were largest in two targeted domains: communication and mobility. More concerns with mobility and activities of daily living at baseline predicted more benefit from rehabilitation. © 2010 Movement Disorder Society

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  • These results underscore the reliability of smartphone-based interventions.

    “Consistent with prior studies, these results underscore the reliability of smartphone-based interventions [55,56].”

    From Smartphone-Based Speech Therapy for Poststroke Dysarthria: Pilot Randomized Controlled Trial Evaluating Efficacy and Feasibility (2024) · cites this paper as [56]

    The Methods > Intervention passage describes therapist-led clinic and home or community rehabilitation, not a smartphone-based intervention. The Results report adherence and health-related quality-of-life outcomes, but do not address the reliability of smartphone-based interventions. Searches for smartphone and mobile interventions found no passage on that point; page numbers were unavailable. (LLM, conf=0.76)

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Research works printed but not linked: 3

  1. [4]Livneh H Antonak RF Review of research on psychosocial adaptation to neuromuscular disorders: I. Cerebral Palsy, Muscular Dystrophy, and Parkinson's Disease J Soc Behav Pers 1994 9 201 230
  2. [38]De Muth JE Basic statistics and pharmaceutical applications 2006 Chapman & Hall/CRC – Taylor & Francis Group Boca Raton, FL 2nd ed.
  3. [44]Huang P-C Social behavior, gender, and quality of life in Parkinson's disease [dissertation] 2009 Boston University Boston (MA)

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Authors
Tickle‐Degnen, L., Ellis, T., Saint‐Hilaire, M. H., Thomas, C. A., & Wagenaar, R. C.
Affiliations
  • Tufts University (US)
  • Boston University (US)
Corresponding author
Tickle‐Degnen, Linda
ORCID
Venue
Movement Disorders
Publisher
Wiley
Published
2010-01-30
Volume
25
Issue
2
Pages
194-204
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
DOI
10.1002/mds.22940
PMC
PMC2831132
OpenAlex
W2101319411
Cited by
167
References
42
Citations by year
2026: 4 · 2025: 1 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 7 · 2020: 13 · 2019: 15 · 2018: 8 · 2017: 13 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 12
FWCI
8.59
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Movement Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging of the National Institutes of Health (NAG21152)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords
Parkinson's disease, health-related quality of life, group rehabilitation, pharmacotherapy, communication, mobility (physical function), activities of daily living, treatment effects over time
MeSH terms
Aged, Combined Modality Therapy, Disability Evaluation, Exercise Therapy, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Parkinson Disease, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, Self Care, Severity of Illness Index, Social Support, Time Factors, Treatment Outcome

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