Efficacy of a physical therapy program in patients with Parkinson’s disease: A randomized controlled trial
Abstract
Objective To investigate the effects of a physical therapy (PT) program in groups of people with Parkinson's disease (PD).Design Randomized controlled trial with a crossover design.Setting Two outpatient rehabilitation clinics in Boston and Amsterdam, respectively.Participants Sixty-eight subjects diagnosed with typical, idiopathic PD, Hoehn and Yahr stage II or III, and stable medication use.Intervention Group A received PT and medication therapy (MT) for the first 6 weeks, followed by MT only for the second 6 weeks. Group B received only MT for the first 6 weeks and PT and MT for the second 6 weeks.Main outcome measures The Sickness Impact Profile (SIP-68), the mobility portion of the SIP-68, the Unified Parkinson's Disease Rating Scale (UPDRS), and comfortable walking speed (CWS) at baseline, 6-week, 12-week, and 3-month follow-up.Results At 6 weeks, differences between groups were significant for the SIP mobility ( P =.015; effect size [ES]=.55), for CWS ( P =.012; ES=.49), for the activities of daily living (ADL) section of the UPDRS ( P =.014; ES=.45), and for the total UPDRS ( P =.007; ES=.56). The total SIP and the mentation and motor sections of the UPDRS did not differ significantly between groups. Significant differences were found at 3 months compared with baseline for CWS, the UPDRS ADL, and total scores.Conclusions People with PD derive benefits in the short term from PT group treatment, in addition to their MT, for quality of life related to mobility, CWS, and ADLs; long-term benefits were found in CWS, UPDRS ADL, and total scores but varied between groups.
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Exercise programs and physical therapy have been shown to improve motor problems, daily functioning, and quality of life in patients with Parkinson's disease.
“These have been shown to improve motor problems, daily functioning, and quality of life in patients with PD [18–21].”
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Self-citation
- Authors
- Ellis, T., de Goede, C. J., Feldman, R. G., Wolters, E. C., Kwakkel, G., & Wagenaar, R. C.
- Affiliations
- Boston University (US)
- Boston Medical Center (US)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Ellis, Terry
- Venue
- Archives of Physical Medicine and Rehabilitation
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 86
- Issue
- 4
- Pages
- 626-632
- ISSN
- 0003-9993 (ISSN-L)
- OpenAlex
- W2118519309
- Cited by
- 242
- References
- 37
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 15 · 2017: 13 · 2016: 8 · 2015: 17 · 2014: 9 · 2013: 20 · 2012: 21
- FWCI
- 33.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physical Medicine and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Parkinson's disease, physiotherapy, group therapy, pharmacotherapy, mobility (physical function), activities of daily living, quality of life, Unified Parkinson's Disease Rating Scale, Sickness Impact Profile, outpatient rehabilitation
- MeSH terms
- Activities of Daily Living, Aged, Gait, Health Status Indicators, Humans, Middle Aged, Parkinson Disease, Quality of Life, Treatment Outcome, Sickness Impact Profile, Cross-Over Studies, Physical Therapy Modalities
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