Recording and stimulating properties of chronically implanted longitudinal intrafascicular electrodes in peripheral fascicles in an animal model
Abstract
The purpose of this experiment was to study the recording and stimulating properties, and biocompatibility of longitudinally implanted intrafascicular electrodes (LIFEs) in a rabbit sciatic nerve model when they were chronically implanted into peripheral fascicles. LIFEs were implanted chronically into sciatic nerve fascicles of rabbits as recording and stimulating electrodes. Motor‐evoked potentials (MEPs) and cortical somatosensory‐evoked potentials (CSEPs) were recorded by using a transcranial stimulation system (TCS) over 6‐month period to observe the change of the signals recorded. At the end of the experiment, the fascicles at the electrodes implanted site were anatomized for histological examination under light microscope and transmission electron microscope. Results showed onset latency (OL) of MEPs and CSEPs had no obvious change during the first month. However, OL significantly increased during the second month, and then became stable 3 months after implantation. The interpeak amplitudes (IPAs) of MEPs had no distinct change during the first month, but significantly decreased over the next period, and then became stable 3 months after implantation. The IPAs of CSEPs, however, decreased slowly over the 6‐month period of the study. At the end of the experiment, histological examination indicated that a typical foreign body reaction developed, and electrodes caused mild damage to the fascicles, though inflammatory cells and neuroma were not seen around the electrodes. In conclusion, LIFEs have excellent recording and stimulating characters in addition to biocompatibility with peripheral fascicles. They can be implanted chronically into fascicles and record signals. © 2008 Wiley‐Liss, Inc. Microsurgery, 2008.
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A 6-month rat study showed electrode breakage in a small percent of the electrodes leading to failure.
“A 6-month rat study showed electrode breakage in a small percent of the electrodes leading to failure [95].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [95]
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- Authors
- Zheng, X., Zhang, J., Chen, T., & Chen, Z.
- Affiliations
- Qingdao University (CN)
- Fudan University (CN)
- Corresponding author
- Zheng, Xiujun
- ORCID
- Zhang, Jian
- Venue
- Microsurgery
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 28
- Issue
- 3
- Pages
- 203-209
- ISSN
- 0738-1085 (ISSN-L)
- 1098-2752
- OpenAlex
- W1990084364
- Cited by
- 14
- References
- 17
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microsurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Intraoperative Neuromonitoring and Anesthetic Effects
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peripheral nerve recording, peripheral nerve stimulation, sciatic nerve, chronic implantation, motor evoked potentials, somatosensory evoked potentials, onset latency, biocompatibility, foreign body reaction, neuroma, rabbit model
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Somatosensory, Foreign-Body Reaction, Materials Testing, Microsurgery, Neural Conduction, Rabbits, Sciatic Nerve, Time Factors, Evoked Potentials, Motor, Models, Animal
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