Long‐term biocompatibility of implanted polymer‐based intrafascicular electrodes
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Polymer-based longitudinal intrafascicular electrodes (polyLIFEs) were chronically implanted into the sciatic nerve of white New Zealand rabbits (n=8) for a period of 6 months (hereafter referred to as the long-term group). The impact of the implantation procedure, as observed 6 months post surgery, was evaluated in a sham-treated control group (n=9). The contralateral sciatic nerve served as the control for each animal. Nerve-fiber counts, fiber diameters, and myelin thickness were estimated at the level of the implant site, 1.5 cm proximally, and 1.5 cm distally for both nerves in sham-treated and long-term groups. Implantation of polyLIFEs had no significant effect on fiber counts, nerve-fiber diameter, or myelin thickness. A slight increase in connective tissue in the vicinity of the implant site was evident in the long-term group, including a thin but dense capsule immediately surrounding the implanted electrode.
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Histology of animal nerves with metal or polymer longitudinal intrafascicular electrodes implanted for six months showed the implants were biocompatible and caused no damage, although a slight increase in connective tissue around the implant site was evident long-term.
“The histology of animal nerves that had metal or polymer LIFEs implanted for a period of 6 months revealed that the implants are biocompatible and that no damage was caused by the presence of the electrode, although a slight increase in connective tissue surrounding the implant site was evident in the longterm (Lefurge et al., 1991; Lawrence et al., 2002) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Lawrence et al., 2002
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“…2014), TIME-2 and TIME-3 with different chemical properties (Badia et al., 2011b), LIFE (Zheng et al., 2008), polyimide, platinum intra-fascicular electrodes (Lago et al., 2007b), and polymer-based longitudinal intra-fascicular electrodes polyLIFEs (Malmstrom et al., 1998; Lawrence et al., 2002).”
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- Authors
- Lawrence, S. M., Larsen, J. O., Horch, K. W., Riso, R., & Sinkjær, T.
- Affiliations
- University of Utah (US)
- Aarhus University (DK)
- Aalborg University (DK)
- Corresponding author
- Lawrence, Stephen M.
- ORCID
- Sinkjær, Thomas
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 63
- Issue
- 5
- Pages
- 501-506
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1985286658
- Cited by
- 55
- References
- 62
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- The Danish National Research Foundation
- U.S. National Institute of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- intrafascicular electrodes, chronic implantation, biocompatibility, sciatic nerve, nerve fiber count, myelin thickness, connective tissue capsule, peripheral nerve stimulation, rabbit model
- MeSH terms
- Animals, Biocompatible Materials, Connective Tissue, Electrodes, Implanted, Humans, Myelin Sheath, Polymers, Rabbits, Random Allocation, Sciatic Nerve, Time Factors
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